GREMLIN Database
GATA - Glutamyl-tRNA(Gln) amidotransferase subunit A
UniProt: O06491 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (443)
Sequences: 14541 (10209)
Seq/√Len: 485.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_S56_K4.3321.00
104_D112_Q4.0601.00
27_D52_R3.4871.00
285_K288_E3.2241.00
146_N149_T2.9501.00
398_V468_V2.8831.00
265_K296_E2.8651.00
439_I469_A2.8531.00
133_T156_G2.8441.00
104_D109_Q2.7831.00
34_Q48_E2.7511.00
58_L72_F2.7121.00
169_F226_L2.7091.00
458_K461_D2.6451.00
14_L20_I2.6231.00
22_I59_D2.6081.00
158_S170_S2.5831.00
217_T223_N2.5561.00
109_Q113_D2.4981.00
188_V216_I2.4371.00
461_D464_T2.4121.00
47_D50_R2.3041.00
457_G461_D2.3011.00
431_V456_I2.2971.00
14_L19_E2.2841.00
179_I190_G2.2391.00
295_E396_Y2.2201.00
30_Y48_E2.2031.00
262_A396_Y2.1911.00
111_L116_A2.1681.00
45_A88_R2.1591.00
189_V223_N2.1331.00
76_I169_F2.1111.00
61_A72_F1.9961.00
260_K293_T1.9811.00
470_H474_Q1.9501.00
455_I465_V1.9481.00
47_D87_L1.9341.00
277_R281_L1.9341.00
261_I398_V1.9301.00
23_S27_D1.9271.00
69_G72_F1.9191.00
133_T141_T1.9071.00
78_V108_V1.9061.00
457_G465_V1.9001.00
144_P186_C1.8971.00
13_Q17_K1.8941.00
7_K10_E1.8841.00
221_E470_H1.8741.00
224_A470_H1.8721.00
43_F77_G1.8421.00
11_L25_L1.8411.00
30_Y46_L1.8301.00
191_L462_E1.8241.00
77_G122_L1.7851.00
110_R232_G1.7851.00
407_P446_A1.7601.00
371_Y374_Y1.7561.00
438_G456_I1.7211.00
26_V51_A1.7181.00
263_V284_L1.7081.00
15_I25_L1.6841.00
149_T449_L1.6841.00
88_R98_N1.6701.00
33_I166_E1.6651.00
189_V220_V1.6611.00
70_L114_A1.6561.00
36_V166_E1.6441.00
284_L294_W1.6351.00
162_V216_I1.6111.00
400_V455_I1.5861.00
61_A68_H1.5841.00
83_V89_T1.5811.00
89_T121_K1.5781.00
189_V439_I1.5591.00
410_K413_E1.5561.00
219_T222_D1.5521.00
41_Q139_K1.5431.00
40_V164_A1.5411.00
12_K16_H1.5401.00
76_I118_T1.5391.00
149_T410_K1.5391.00
54_Y112_Q1.5311.00
266_E298_S1.5131.00
91_C204_V1.5111.00
198_V230_I1.5061.00
148_D410_K1.4971.00
286_V289_G1.4851.00
77_G167_V1.4851.00
9_T221_E1.4671.00
12_K74_M1.4661.00
203_L213_I1.4541.00
403_T440_S1.4531.00
189_V473_E1.4501.00
192_K432_N1.4471.00
53_A56_K1.4461.00
472_F476_T1.4451.00
60_E64_G1.4451.00
191_L466_Y1.4431.00
8_I169_F1.4431.00
23_S52_R1.4371.00
80_D121_K1.4361.00
40_V160_A1.4351.00
279_S451_L1.4251.00
197_R227_L1.4251.00
81_N124_M1.4231.00
284_L400_V1.4121.00
26_V52_R1.4121.00
27_D31_K1.4101.00
82_I213_I1.4091.00
47_D54_Y1.4031.00
26_V117_V1.3951.00
172_G216_I1.3821.00
77_G161_A1.3741.00
56_K60_E1.3661.00
401_G456_I1.3631.00
106_T109_Q1.3541.00
82_I171_L1.3511.00
114_A229_A1.3501.00
295_E395_K1.3451.00
134_E412_G1.3441.00
159_A186_C1.3401.00
11_L168_P1.3271.00
33_I46_L1.3201.00
68_H72_F1.3151.00
281_L285_K1.3091.00
54_Y57_E1.3081.00
145_W445_L1.3071.00
81_N128_A1.3071.00
45_A87_L1.3021.00
185_F404_T1.2981.00
22_I26_V1.2971.00
279_S444_G1.2951.00
53_A57_E1.2851.00
112_Q118_T1.2821.00
142_K411_I1.2801.00
436_V456_I1.2791.00
285_K289_G1.2781.00
265_K281_L1.2781.00
256_I292_A1.2741.00
7_K221_E1.2661.00
31_K35_A1.2631.00
290_L475_A1.2591.00
390_E459_H1.2571.00
123_N135_N1.2571.00
183_A216_I1.2521.00
160_A164_A1.2441.00
258_G292_A1.2431.00
26_V119_I1.2331.00
241_A460_F1.2331.00
152_G181_Q1.2291.00
258_G293_T1.2281.00
57_E60_E1.2211.00
107_V171_L1.2211.00
12_K15_I1.2181.00
15_I62_V1.2171.00
279_S443_C1.2131.00
33_I119_I1.2121.00
272_V427_L1.2121.00
50_R87_L1.2091.00
94_K97_E1.2051.00
8_I74_M1.2031.00
21_K24_D1.1991.00
223_N466_Y1.1931.00
84_T89_T1.1921.00
391_D394_E1.1861.00
18_K63_D1.1841.00
275_E446_A1.1811.00
283_A453_L1.1811.00
18_K62_V1.1811.00
32_R36_V1.1771.00
278_E282_A1.1751.00
43_F120_G1.1741.00
142_K147_L1.1721.00
171_L230_I1.1691.00
57_E61_A1.1671.00
84_T101_P1.1651.00
75_P168_P1.1631.00
155_S158_S1.1631.00
29_S119_I1.1611.00
109_Q112_Q1.1571.00
174_D180_R1.1511.00
308_T381_V1.1491.00
7_K219_T1.1441.00
179_I215_P1.1441.00
106_T110_R1.1441.00
194_T459_H1.1381.00
77_G158_S1.1371.00
439_I465_V1.1371.00
83_V101_P1.1321.00
83_V99_F1.1251.00
260_K295_E1.1241.00
51_A117_V1.1221.00
215_P226_L1.1201.00
37_D166_E1.1191.00
9_T225_F1.1181.00
283_A472_F1.1161.00
140_L411_I1.1101.00
37_D42_A1.1081.00
220_V473_E1.1031.00
187_G445_L1.1021.00
23_S59_D1.0991.00
438_G454_Q1.0991.00
261_I292_A1.0951.00
297_V392_V1.0901.00
71_L116_A1.0901.00
280_V284_L1.0891.00
87_L101_P1.0891.00
93_S127_F1.0861.00
61_A66_S1.0751.00
191_L227_L1.0751.00
44_L92_S1.0681.00
276_A451_L1.0671.00
58_L61_A1.0661.00
50_R54_Y1.0611.00
44_L123_N1.0611.00
356_K360_M1.0591.00
15_I22_I1.0531.00
84_T121_K1.0501.00
77_G170_S1.0491.00
301_H388_D1.0481.00
165_G218_R1.0461.00
110_R113_D1.0461.00
162_V170_S1.0431.00
388_D391_D1.0321.00
197_R231_S1.0311.00
29_S166_E1.0281.00
50_R112_Q1.0261.00
209_S316_E1.0241.00
259_L468_V1.0231.00
288_E293_T1.0211.00
431_V438_G1.0211.00
107_V213_I1.0201.00
347_R350_G1.0201.00
387_K391_D1.0191.00
172_G179_I1.0161.00
84_T87_L1.0121.00
440_S452_G1.0091.00
446_A451_L1.0081.00
30_Y34_Q1.0071.00
274_K278_E1.0061.00
262_A392_V1.0041.00
16_H67_E1.0041.00
384_L388_D1.0001.00
261_I400_V0.9941.00
88_R100_D0.9931.00
173_S213_I0.9921.00
455_I468_V0.9881.00
259_L292_A0.9841.00
144_P160_A0.9831.00
304_Y381_V0.9781.00
284_L288_E0.9691.00
259_L464_T0.9681.00
29_S168_P0.9671.00
256_I259_L0.9641.00
167_V170_S0.9631.00
191_L439_I0.9601.00
78_V118_T0.9571.00
62_V68_H0.9571.00
185_F408_A0.9551.00
265_K298_S0.9541.00
194_T462_E0.9501.00
263_V280_V0.9481.00
286_V290_L0.9451.00
282_A285_K0.9441.00
124_M128_A0.9441.00
22_I58_L0.9431.00
32_R35_A0.9431.00
85_K104_D0.9431.00
29_S167_V0.9361.00
22_I72_F0.9341.00
40_V147_L0.9341.00
441_V455_I0.9331.00
109_Q236_M0.9301.00
264_P267_Y0.9291.00
106_T201_Y0.9221.00
458_K464_T0.9191.00
39_K147_L0.9181.00
105_A108_V0.9181.00
175_T211_D0.9151.00
141_T160_A0.9141.00
123_N138_Y0.9121.00
103_Y109_Q0.9121.00
279_S282_A0.9091.00
262_A297_V0.9051.00
189_V441_V0.9041.00
191_L223_N0.9031.00
82_I173_S0.9031.00
194_T460_F0.9031.00
259_L398_V0.9001.00
141_T151_P0.8991.00
381_V384_L0.8981.00
251_S467_R0.8971.00
8_I225_F0.8921.00
443_C451_L0.8921.00
287_L472_F0.8911.00
272_V277_R0.8901.00
198_V227_L0.8891.00
161_A166_E0.8891.00
379_Q382_R0.8891.00
251_S463_S0.8851.00
375_Y379_Q0.8811.00
37_D41_Q0.8801.00
67_E72_F0.8781.00
192_K212_Q0.8781.00
20_I25_L0.8761.00
122_L158_S0.8751.00
58_L62_V0.8741.00
30_Y52_R0.8741.00
282_A286_V0.8731.00
383_T387_K0.8721.00
463_S467_R0.8721.00
87_L121_K0.8701.00
184_S404_T0.8691.00
220_V469_A0.8691.00
33_I37_D0.8681.00
171_L213_I0.8651.00
76_I226_L0.8651.00
183_A190_G0.8641.00
197_R462_E0.8621.00
226_L230_I0.8611.00
150_V185_F0.8601.00
82_I203_L0.8531.00
25_L74_M0.8511.00
65_R69_G0.8461.00
82_I105_A0.8461.00
357_R360_M0.8451.00
21_K59_D0.8441.00
76_I116_A0.8401.00
84_T104_D0.8391.00
286_V475_A0.8371.00
107_V198_V0.8351.00
286_V476_T0.8351.00
43_F122_L0.8351.00
15_I20_I0.8341.00
311_L378_A0.8331.00
25_L29_S0.8321.00
386_K390_E0.8321.00
22_I62_V0.8311.00
455_I472_F0.8271.00
62_V72_F0.8251.00
43_F167_V0.8241.00
208_S320_N0.8221.00
443_C453_L0.8221.00
10_E14_L0.8181.00
59_D63_D0.8181.00
34_Q46_L0.8161.00
131_S181_Q0.8151.00
49_E53_A0.8131.00
8_I12_K0.8121.00
227_L462_E0.8111.00
221_E473_E0.8111.00
149_T408_A0.8101.00
201_Y236_M0.8091.00
176_G309_Y0.8081.00
286_V472_F0.8051.00
90_T98_N0.8041.00
162_V188_V0.8031.00
352_G355_V0.8021.00
398_V464_T0.8001.00
31_K34_Q0.7981.00
142_K148_D0.7981.00
110_R199_S0.7971.00
301_H304_Y0.7971.00
33_I43_F0.7941.00
26_V30_Y0.7931.00
15_I72_F0.7931.00
103_Y201_Y0.7931.00
93_S126_E0.7921.00
189_V469_A0.7921.00
15_I74_M0.7921.00
77_G120_G0.7911.00
52_R56_K0.7891.00
84_T118_T0.7881.00
376_K380_K0.7871.00
54_Y58_L0.7871.00
184_S452_G0.7841.00
233_V240_S0.7831.00
11_L15_I0.7831.00
151_P160_A0.7781.00
318_S363_T0.7751.00
149_T409_F0.7741.00
280_V443_C0.7711.00
273_G407_P0.7701.00
78_V84_T0.7701.00
123_N139_K0.7701.00
122_L161_A0.7691.00
149_T447_D0.7681.00
382_R386_K0.7671.00
185_F424_N0.7641.00
462_E465_V0.7631.00
275_E447_D0.7631.00
179_I214_G0.7611.00
464_T467_R0.7581.00
151_P186_C0.7541.00
304_Y307_A0.7541.00
390_E458_K0.7531.00
106_T199_S0.7521.00
81_N173_S0.7481.00
78_V171_L0.7461.00
12_K62_V0.7461.00
50_R53_A0.7451.00
159_A216_I0.7431.00
387_K390_E0.7411.00
261_I287_L0.7381.00
274_K277_R0.7351.00
71_L225_F0.7351.00
108_V118_T0.7321.00
221_E225_F0.7301.00
10_E13_Q0.7291.00
393_F458_K0.7261.00
390_E436_V0.7261.00
83_V103_Y0.7261.00
158_S161_A0.7241.00
408_A449_L0.7231.00
83_V121_K0.7201.00
439_I466_Y0.7191.00
16_H62_V0.7171.00
260_K396_Y0.7161.00
287_L468_V0.7151.00
122_L170_S0.7151.00
28_E31_K0.7121.00
26_V29_S0.7111.00
273_G446_A0.7101.00
40_V166_E0.7101.00
290_L471_A0.7081.00
197_R463_S0.7031.00
281_L288_E0.7031.00
389_F434_A0.7011.00
398_V455_I0.6991.00
12_K225_F0.6981.00
360_M363_T0.6971.00
394_E458_K0.6951.00
27_D56_K0.6951.00
278_E281_L0.6941.00
374_Y377_K0.6941.00
82_I107_V0.6941.00
441_V476_T0.6931.00
8_I168_P0.6921.00
181_Q404_T0.6901.00
219_T223_N0.6851.00
224_A228_Q0.6831.00
248_F252_L0.6801.00
105_A202_G0.6761.00
125_D130_G0.6761.00
14_L17_K0.6751.00
227_L248_F0.6751.00
8_I15_I0.6741.00
20_I24_D0.6731.00
268_L280_V0.6731.00
198_V215_P0.6731.00
436_V459_H0.6731.00
281_L296_E0.6721.00
372_D375_Y0.6721.00
380_K384_L0.6721.00
87_L118_T0.6701.00
191_L465_V0.6701.00
206_F313_S0.6701.00
150_V411_I0.6671.00
173_S203_L0.6651.00
86_G100_D0.6631.00
133_T151_P0.6611.00
322_A326_G0.6601.00
70_L229_A0.6601.00
386_K459_H0.6601.00
393_F436_V0.6601.00
163_A188_V0.6581.00
42_A166_E0.6561.00
431_V436_V0.6561.00
97_E137_A0.6521.00
275_E279_S0.6491.00
62_V67_E0.6491.00
297_V396_Y0.6471.00
61_A115_E0.6461.00
84_T112_Q0.6441.00
267_Y302_S0.6431.00
407_P447_D0.6411.00
288_E296_E0.6401.00
169_F217_T0.6381.00
119_I167_V0.6371.00
262_A296_E0.6371.00
255_D467_R0.6371.00
36_V164_A0.6371.00
288_E294_W0.6371.00
37_D46_L0.6351.00
48_E52_R0.6341.00
252_L470_H0.6341.00
231_S248_F0.6331.00
125_D133_T0.6301.00
372_D376_K0.6291.00
406_T424_N0.6291.00
85_K103_Y0.6281.00
258_G471_A0.6271.00
400_V453_L0.6231.00
383_T386_K0.6231.00
461_D465_V0.6231.00
457_G464_T0.6231.00
81_N91_C0.6221.00
290_L472_F0.6200.99
224_A467_R0.6200.99
263_V296_E0.6190.99
256_I471_A0.6180.99
401_G438_G0.6170.99
323_R327_I0.6170.99
287_L400_V0.6150.99
42_A161_A0.6150.99
13_Q16_H0.6130.99
30_Y33_I0.6120.99
275_E451_L0.6120.99
24_D27_D0.6120.99
227_L466_Y0.6120.99
470_H473_E0.6120.99
58_L68_H0.6120.99
263_V294_W0.6110.99
43_F166_E0.6100.99
287_L292_A0.6100.99
292_A471_A0.6080.99
50_R85_K0.6080.99
69_G114_A0.6070.99
443_C472_F0.6070.99
417_D420_T0.6060.99
91_C96_L0.6050.99
9_T219_T0.6040.99
145_W187_G0.6030.99
159_A163_A0.6010.99
254_G467_R0.6010.99
348_A360_M0.6000.99
276_A407_P0.5990.99
172_G215_P0.5980.99
106_T236_M0.5980.99
37_D43_F0.5980.99
37_D141_T0.5980.99
321_L351_F0.5970.99
309_Y313_S0.5960.99
220_V470_H0.5950.99
275_E407_P0.5950.99
299_L392_V0.5940.99
215_P230_I0.5920.99
384_L387_K0.5900.99
45_A121_K0.5900.99
23_S55_A0.5890.99
308_T385_I0.5890.99
185_F409_F0.5880.99
11_L14_L0.5870.99
171_L226_L0.5850.99
297_V399_I0.5850.99
403_T452_G0.5850.99
251_S254_G0.5840.99
56_K59_D0.5840.99
225_F228_Q0.5830.99
145_W163_A0.5820.99
88_R97_E0.5810.99
273_G276_A0.5800.99
321_L324_F0.5800.99
145_W450_P0.5780.99
389_F436_V0.5780.99
128_A211_D0.5780.99
79_K178_S0.5770.99
370_Y374_Y0.5770.99
41_Q141_T0.5760.99
158_S171_L0.5760.99
283_A443_C0.5760.99
262_A393_F0.5760.99
132_S150_V0.5750.99
399_I456_I0.5750.99
473_E476_T0.5750.99
259_L467_R0.5740.99
370_Y375_Y0.5730.99
96_L99_F0.5720.99
38_D41_Q0.5710.99
94_K137_A0.5700.99
44_L90_T0.5690.99
225_F229_A0.5680.99
200_R213_I0.5670.99
52_R55_A0.5660.99
128_A175_T0.5650.99
462_E466_Y0.5640.99
106_T234_D0.5630.99
47_D51_A0.5630.99
129_M317_A0.5630.99
36_V39_K0.5620.99
79_K154_S0.5620.99
72_F115_E0.5610.99
43_F46_L0.5590.99
51_A119_I0.5590.99
94_K350_G0.5570.99
303_K307_A0.5570.99
407_P449_L0.5570.99
195_Y212_Q0.5570.99
465_V468_V0.5540.99
55_A59_D0.5540.99
441_V453_L0.5540.99
18_K24_D0.5530.99
142_K146_N0.5520.99
464_T468_V0.5510.99
264_P268_L0.5510.99
233_V242_N0.5510.99
40_V141_T0.5500.99
195_Y435_G0.5500.99
65_R72_F0.5490.99
398_V457_G0.5490.99
273_G406_T0.5490.99
11_L20_I0.5470.99
125_D156_G0.5470.99
403_T428_T0.5470.99
260_K397_D0.5450.99
260_K395_K0.5450.99
9_T13_Q0.5450.99
348_A356_K0.5420.99
29_S165_G0.5420.99
323_R326_G0.5410.99
160_A186_C0.5410.99
262_A397_D0.5400.99
201_Y234_D0.5380.99
85_K102_I0.5380.99
181_Q428_T0.5380.99
264_P299_L0.5370.99
312_L378_A0.5360.99
54_Y118_T0.5350.99
61_A67_E0.5340.99
194_T437_P0.5340.99
134_E140_L0.5340.99
125_D132_S0.5320.98
70_L228_Q0.5320.98
184_S403_T0.5310.98
161_A167_V0.5310.98
111_L226_L0.5290.98
121_K124_M0.5290.98
123_N141_T0.5270.98
200_R237_D0.5270.98
60_E63_D0.5260.98
288_E291_G0.5250.98
255_D258_G0.5250.98
143_N151_P0.5230.98
132_S409_F0.5220.98
261_I294_W0.5220.98
179_I216_I0.5210.98
168_P222_D0.5200.98
120_G161_A0.5190.98
392_V396_Y0.5180.98
89_T101_P0.5180.98
287_L290_L0.5180.98
392_V395_K0.5140.98
322_A377_K0.5110.98
101_P121_K0.5110.98
81_N203_L0.5110.98
379_Q383_T0.5110.98
74_M168_P0.5100.98
224_A466_Y0.5090.98
179_I183_A0.5080.98
27_D48_E0.5080.98
84_T108_V0.5070.98
37_D40_V0.5070.98
11_L29_S0.5070.98
275_E278_E0.5060.98
348_A352_G0.5060.98
34_Q38_D0.5060.98
74_M222_D0.5050.98
70_L115_E0.5030.98
282_A476_T0.5030.98
116_A226_L0.5010.98
280_V400_V0.5010.98
377_K380_K0.5010.98
253_T470_H0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4A 1 0.9979 100 0.042 Contact Map
4wj3A 1 0.9959 100 0.054 Contact Map
3h0lA 1 0.9856 100 0.062 Contact Map
3kfuE 1 0.9608 100 0.08 Contact Map
2gi3A 2 0.9175 100 0.088 Contact Map
1m22A 1 0.9608 100 0.097 Contact Map
3a2qA 2 0.9402 100 0.097 Contact Map
2dc0A 2 0.8845 100 0.11 Contact Map
4cp8A 2 0.9196 100 0.133 Contact Map
4issA 2 0.9299 100 0.141 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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