GREMLIN Database
YETM - Putative oxidoreductase YetM
UniProt: O06489 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (341)
Sequences: 27462 (20935)
Seq/√Len: 1133.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_T121_K4.0941.00
32_A125_K3.5521.00
12_G301_A3.4601.00
5_L148_A3.3001.00
3_H26_S3.2451.00
3_H149_D3.2021.00
326_Y330_A2.9651.00
128_A164_K2.6551.00
23_A313_Q2.5991.00
125_K141_E2.5731.00
30_C146_M2.5561.00
112_H115_A2.5461.00
16_A152_A2.5011.00
124_K142_D2.4711.00
137_T145_K2.4661.00
61_D111_K2.4001.00
19_S309_A2.3801.00
5_L30_C2.3481.00
107_D111_K2.2821.00
137_T147_Q2.2281.00
130_E137_T2.2041.00
128_A139_L2.1861.00
5_L138_A2.1701.00
139_L145_K2.1271.00
121_K124_K2.0871.00
12_G283_G2.0731.00
15_S302_I2.0611.00
153_G161_V2.0381.00
239_K243_S2.0221.00
54_K59_F1.9841.00
135_S147_Q1.9751.00
233_T236_D1.9571.00
4_M25_F1.9331.00
127_V141_E1.9091.00
124_K140_C1.8871.00
311_E328_R1.8771.00
26_S119_D1.8601.00
34_S123_G1.8591.00
3_H28_T1.8551.00
153_G282_I1.8431.00
61_D112_H1.8401.00
112_H116_V1.7951.00
52_V306_I1.7821.00
305_A309_A1.7721.00
132_T137_T1.7711.00
18_I112_H1.7681.00
4_M20_L1.7531.00
130_E139_L1.7501.00
154_F283_G1.7321.00
25_F313_Q1.7231.00
140_C146_M1.7211.00
330_A334_L1.7161.00
126_V138_A1.7131.00
30_C140_C1.7051.00
113_A118_V1.6821.00
21_R118_V1.6801.00
49_A299_A1.6751.00
311_E324_A1.6731.00
274_P277_K1.6681.00
276_H323_Q1.6471.00
155_D159_S1.6201.00
131_E277_K1.6111.00
129_Y151_L1.5941.00
55_E306_I1.5901.00
307_V311_E1.5891.00
60_E64_K1.5741.00
61_D64_K1.5611.00
28_T146_M1.5611.00
61_D115_A1.5541.00
18_I22_K1.5541.00
160_V164_K1.5481.00
132_T147_Q1.5441.00
132_T135_S1.5371.00
110_M122_W1.5261.00
5_L146_M1.5261.00
22_K116_V1.5211.00
276_H281_I1.5171.00
16_A305_A1.4951.00
17_A29_L1.4731.00
239_K242_L1.4651.00
275_W333_A1.4571.00
150_I322_L1.4461.00
274_P326_Y1.4311.00
19_S56_L1.4291.00
317_D320_T1.4281.00
165_M280_V1.4231.00
304_D329_R1.4151.00
238_V242_L1.4001.00
110_M114_E1.3961.00
307_V328_R1.3921.00
235_F239_K1.3921.00
11_I298_A1.3831.00
268_Q341_S1.3691.00
59_F63_C1.3661.00
303_E332_R1.3621.00
152_A283_G1.3561.00
49_A302_I1.3501.00
81_L84_Q1.3501.00
7_A126_V1.3481.00
18_I116_V1.3391.00
275_W326_Y1.3361.00
7_A155_D1.3361.00
281_I308_L1.3351.00
65_H104_T1.3291.00
311_E321_A1.3271.00
185_E257_K1.3141.00
310_E328_R1.3141.00
160_V163_D1.3061.00
6_I16_A1.2951.00
18_I113_A1.2661.00
236_D239_K1.2651.00
240_E244_G1.2611.00
130_E145_K1.2601.00
243_S246_R1.2551.00
111_K114_E1.2531.00
126_V161_V1.2531.00
127_V139_L1.2521.00
240_E243_S1.2511.00
71_W84_Q1.2491.00
121_K146_M1.2441.00
5_L28_T1.2291.00
36_N122_W1.2221.00
60_E63_C1.2211.00
16_A20_L1.2161.00
185_E214_A1.2131.00
126_V129_Y1.2051.00
288_H304_D1.1931.00
237_R240_E1.1921.00
3_H25_F1.1891.00
28_T119_D1.1771.00
131_E279_R1.1621.00
7_A161_V1.1581.00
138_A148_A1.1381.00
282_I286_A1.1201.00
216_Y220_L1.1141.00
152_A281_I1.1111.00
148_A151_L1.1071.00
104_T107_D1.1021.00
15_S19_S1.0981.00
179_A182_F1.0941.00
50_L59_F1.0881.00
15_S56_L1.0871.00
157_I289_A1.0841.00
43_I298_A1.0831.00
9_G14_L1.0811.00
129_Y164_K1.0811.00
178_G182_F1.0811.00
124_K144_E1.0801.00
6_I17_A1.0751.00
233_T237_R1.0721.00
61_D108_I1.0691.00
30_C121_K1.0681.00
168_K273_E1.0611.00
136_V279_R1.0571.00
22_K112_H1.0551.00
311_E314_N1.0531.00
167_Q272_Q1.0521.00
234_R238_V1.0521.00
290_G300_M1.0421.00
29_L120_I1.0411.00
27_V118_V1.0381.00
101_L104_T1.0321.00
65_H107_D1.0281.00
236_D240_E1.0281.00
58_V112_H1.0261.00
73_K81_L1.0251.00
65_H108_I1.0241.00
16_A283_G1.0221.00
232_D236_D1.0211.00
179_A183_Y1.0201.00
76_D80_N1.0161.00
170_T273_E1.0161.00
334_L338_N1.0151.00
55_E310_E1.0141.00
111_K115_A1.0141.00
17_A27_V1.0111.00
131_E136_V1.0101.00
252_T255_M1.0091.00
129_Y165_M1.0051.00
6_I27_V1.0041.00
258_Q261_V0.9981.00
140_C143_G0.9961.00
40_G43_I0.9931.00
71_W194_A0.9931.00
276_H319_E0.9921.00
126_V160_V0.9911.00
30_C124_K0.9901.00
276_H326_Y0.9891.00
290_G337_Q0.9791.00
70_E193_D0.9791.00
153_G280_V0.9761.00
66_G98_N0.9761.00
110_M120_I0.9741.00
62_C108_I0.9711.00
283_G325_Y0.9671.00
307_V310_E0.9651.00
269_V289_A0.9621.00
61_D65_H0.9591.00
35_E122_W0.9581.00
323_Q327_K0.9541.00
14_L113_A0.9521.00
43_I102_R0.9491.00
48_N303_E0.9491.00
272_Q282_I0.9431.00
277_K280_V0.9421.00
108_I111_K0.9411.00
24_G27_V0.9401.00
217_V220_L0.9391.00
7_A151_L0.9291.00
324_A327_K0.9271.00
126_V164_K0.9251.00
314_N324_A0.9221.00
18_I56_L0.9201.00
20_L25_F0.9191.00
50_L98_N0.9181.00
341_S345_R0.9171.00
186_L189_Y0.9131.00
21_R116_V0.9131.00
206_G218_F0.9091.00
41_A102_R0.9081.00
136_V151_L0.9051.00
14_L110_M0.8971.00
62_C105_L0.8961.00
235_F238_V0.8961.00
28_T148_A0.8931.00
19_S23_A0.8921.00
36_N110_M0.8841.00
51_A54_K0.8831.00
242_L246_R0.8821.00
114_E119_D0.8801.00
276_H322_L0.8791.00
108_I112_H0.8731.00
58_V108_I0.8721.00
48_N296_Q0.8701.00
73_K194_A0.8651.00
14_L106_N0.8641.00
234_R237_R0.8641.00
242_L245_F0.8561.00
185_E256_S0.8551.00
21_R117_G0.8521.00
281_I325_Y0.8521.00
138_A151_L0.8521.00
31_E122_W0.8501.00
9_G31_E0.8481.00
11_I302_I0.8471.00
237_R242_L0.8461.00
306_I310_E0.8451.00
21_R27_V0.8441.00
114_E117_G0.8421.00
21_R113_A0.8411.00
75_F196_F0.8411.00
131_E278_G0.8341.00
129_Y280_V0.8321.00
161_V280_V0.8311.00
48_N51_A0.8261.00
309_A313_Q0.8241.00
3_H148_A0.8221.00
17_A118_V0.8211.00
54_K63_C0.8191.00
237_R246_R0.8181.00
324_A328_R0.8131.00
159_S162_R0.8111.00
44_L97_R0.8041.00
17_A113_A0.8021.00
250_F253_K0.8011.00
30_C148_A0.8011.00
73_K84_Q0.7981.00
150_I281_I0.7981.00
264_N267_E0.7971.00
261_V264_N0.7951.00
19_S22_K0.7931.00
222_P225_S0.7911.00
319_E323_Q0.7871.00
30_C138_A0.7871.00
3_H146_M0.7861.00
129_Y161_V0.7851.00
193_D196_F0.7841.00
182_F185_E0.7831.00
44_L99_N0.7831.00
101_L211_A0.7831.00
282_I287_A0.7801.00
140_C144_E0.7801.00
275_W287_A0.7781.00
136_V140_C0.7781.00
318_H322_L0.7771.00
102_R106_N0.7761.00
20_L309_A0.7721.00
250_F254_H0.7721.00
294_L340_S0.7581.00
217_V221_Q0.7571.00
152_A308_L0.7551.00
275_W330_A0.7531.00
106_N110_M0.7521.00
180_W183_Y0.7511.00
266_L291_A0.7491.00
53_L302_I0.7491.00
21_R114_E0.7481.00
20_L312_L0.7481.00
272_Q275_W0.7481.00
290_G294_L0.7461.00
289_A304_D0.7451.00
167_Q277_K0.7441.00
238_V241_I0.7431.00
244_G247_G0.7411.00
104_T211_A0.7401.00
79_G82_L0.7331.00
50_L54_K0.7321.00
165_M277_K0.7311.00
49_A52_V0.7301.00
241_I245_F0.7291.00
23_A309_A0.7271.00
177_M181_R0.7261.00
15_S109_L0.7251.00
75_F81_L0.7221.00
328_R331_P0.7201.00
100_I105_L0.7181.00
21_R119_D0.7171.00
113_A117_G0.7151.00
182_F217_V0.7141.00
53_L58_V0.7131.00
331_P335_K0.7111.00
52_V56_L0.7101.00
186_L190_T0.7081.00
161_V164_K0.7041.00
19_S52_V0.7001.00
153_G159_S0.7001.00
16_A309_A0.7001.00
33_A37_R0.6981.00
48_N332_R0.6981.00
217_V222_P0.6971.00
125_K160_V0.6911.00
298_A302_I0.6911.00
333_A337_Q0.6901.00
178_G181_R0.6891.00
234_R261_V0.6891.00
124_K141_E0.6881.00
46_P299_A0.6861.00
216_Y221_Q0.6841.00
315_H318_H0.6811.00
300_M333_A0.6801.00
232_D237_R0.6801.00
195_T198_Y0.6781.00
296_Q300_M0.6771.00
215_G218_F0.6771.00
19_S306_I0.6751.00
193_D198_Y0.6741.00
283_G305_A0.6741.00
338_N342_E0.6731.00
271_V334_L0.6731.00
232_D240_E0.6711.00
162_R282_I0.6661.00
298_A301_A0.6651.00
181_R185_E0.6651.00
318_H321_A0.6641.00
200_S203_T0.6621.00
114_E118_V0.6581.00
343_I346_R0.6561.00
194_A197_M0.6561.00
251_V254_H0.6551.00
300_M336_V0.6541.00
172_K175_L0.6531.00
271_V330_A0.6501.00
176_G180_W0.6491.00
9_G29_L0.6471.00
4_M150_I0.6451.00
185_E213_H0.6451.00
121_K144_E0.6441.00
293_T344_V0.6441.00
323_Q326_Y0.6431.00
229_D232_D0.6421.00
320_T324_A0.6411.00
290_G340_S0.6381.00
27_V113_A0.6381.00
317_D321_A0.6371.00
185_E188_D0.6361.00
196_F199_R0.6351.00
155_D282_I0.6351.00
278_G319_E0.6331.00
180_W184_I0.6311.00
151_L280_V0.6311.00
53_L62_C0.6281.00
237_R245_F0.6281.00
129_Y136_V0.6261.00
216_Y219_V0.6261.00
18_I21_R0.6251.00
195_T199_R0.6241.00
135_S149_D0.6241.00
14_L29_L0.6231.00
73_K76_D0.6211.00
16_A312_L0.6191.00
135_S140_C0.6191.00
169_E173_E0.6181.00
101_L214_A0.6151.00
238_V244_G0.6121.00
150_I312_L0.6111.00
291_A294_L0.6101.00
271_V275_W0.6071.00
14_L120_I0.6071.00
186_L215_G0.6041.00
150_I318_H0.6031.00
16_A19_S0.6021.00
281_I322_L0.6011.00
187_P254_H0.6011.00
294_L343_I0.6011.00
335_K338_N0.6001.00
320_T323_Q0.6001.00
237_R241_I0.5981.00
113_A120_I0.5971.00
327_K331_P0.5951.00
153_G160_V0.5951.00
173_E176_G0.5941.00
65_H100_I0.5931.00
113_A116_V0.5901.00
153_G165_M0.5891.00
303_E307_V0.5891.00
92_D95_P0.5891.00
4_M16_A0.5871.00
242_L247_G0.5861.00
303_E329_R0.5861.00
19_S305_A0.5861.00
179_A184_I0.5831.00
288_H329_R0.5831.00
15_S53_L0.5831.00
296_Q299_A0.5831.00
185_E189_Y0.5821.00
45_Q49_A0.5791.00
182_F186_L0.5791.00
53_L105_L0.5791.00
54_K60_E0.5781.00
262_I267_E0.5771.00
130_E133_A0.5761.00
310_E314_N0.5761.00
180_W185_E0.5741.00
62_C98_N0.5731.00
181_R189_Y0.5721.00
149_D279_R0.5701.00
126_V140_C0.5691.00
131_E134_E0.5671.00
138_A146_M0.5671.00
203_T244_G0.5661.00
36_N106_N0.5661.00
163_D168_K0.5651.00
315_H319_E0.5651.00
51_A55_E0.5641.00
8_G13_G0.5611.00
242_L256_S0.5611.00
249_D252_T0.5601.00
178_G183_Y0.5591.00
285_D301_A0.5591.00
26_S149_D0.5581.00
182_F189_Y0.5571.00
12_G152_A0.5571.00
25_F312_L0.5571.00
301_A305_A0.5551.00
151_L279_R0.5541.00
39_T43_I0.5541.00
104_T108_I0.5521.00
192_E195_T0.5491.00
281_I326_Y0.5491.00
198_Y201_G0.5481.00
263_F266_L0.5481.00
155_D162_R0.5471.00
158_H163_D0.5461.00
69_T99_N0.5441.00
27_V119_D0.5431.00
233_T238_V0.5431.00
257_K260_P0.5411.00
16_A154_F0.5391.00
251_V255_M0.5371.00
63_C66_G0.5361.00
307_V325_Y0.5361.00
151_L161_V0.5351.00
18_I118_V0.5351.00
59_F62_C0.5321.00
246_R250_F0.5321.00
177_M183_Y0.5321.00
158_H267_E0.5321.00
73_K196_F0.5311.00
181_R184_I0.5311.00
269_V272_Q0.5311.00
221_Q225_S0.5291.00
179_A189_Y0.5281.00
193_D197_M0.5271.00
18_I58_V0.5261.00
338_N341_S0.5221.00
283_G301_A0.5211.00
36_N107_D0.5211.00
233_T240_E0.5201.00
237_R247_G0.5201.00
206_G210_L0.5191.00
231_E234_R0.5171.00
23_A310_E0.5161.00
131_E135_S0.5161.00
214_A217_V0.5141.00
169_E172_K0.5131.00
279_R315_H0.5111.00
296_Q336_V0.5101.00
309_A312_L0.5081.00
341_S344_V0.5081.00
114_E122_W0.5071.00
232_D238_V0.5061.00
34_S122_W0.5061.00
63_C68_Q0.5061.00
230_E233_T0.5061.00
249_D253_K0.5051.00
192_E196_F0.5051.00
16_A308_L0.5041.00
241_I244_G0.5031.00
7_A129_Y0.5021.00
234_R246_R0.5021.00
176_G182_F0.5021.00
32_A158_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qa1A 2 0.9431 100 0.285 Contact Map
4n9xA 5 0.9241 100 0.289 Contact Map
2qa2A 2 0.9566 100 0.289 Contact Map
4bjzA 2 0.9864 100 0.293 Contact Map
3rp8A 1 0.9756 100 0.295 Contact Map
2x3nA 1 0.9377 100 0.297 Contact Map
1pn0A 3 0.9729 100 0.298 Contact Map
4k5sA 2 0.9566 100 0.298 Contact Map
3aljA 1 0.9512 100 0.301 Contact Map
3c96A 1 0.9566 100 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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