YETM - BACSU - GREMLIN Contacts

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YETM - Putative oxidoreductase YetM

UniProt:	O06489	Sequences: MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGILQPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILRKTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSVVRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVFVLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWHKGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRALKVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	369 (341)
Sequences:	27462 (20935)
Seq/√Len:	1133.7

ECOLI - MHPA UBIH UBII UBIF FIXC YDIS YGCN CBRA
BACSU - YETM YHJG
HALSA - Q9HS01 Q9HS24 Q9HMA0 Q9HQE5
SULSO - Q97V18 Q97V59 Q97ZK8 Q97W89 Q97W83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
28_T	121_K	4.094	1.00
32_A	125_K	3.552	1.00
12_G	301_A	3.460	1.00
5_L	148_A	3.300	1.00
3_H	26_S	3.245	1.00
3_H	149_D	3.202	1.00
326_Y	330_A	2.965	1.00
128_A	164_K	2.655	1.00
23_A	313_Q	2.599	1.00
125_K	141_E	2.573	1.00
30_C	146_M	2.556	1.00
112_H	115_A	2.546	1.00
16_A	152_A	2.501	1.00
124_K	142_D	2.471	1.00
137_T	145_K	2.466	1.00
61_D	111_K	2.400	1.00
19_S	309_A	2.380	1.00
5_L	30_C	2.348	1.00
107_D	111_K	2.282	1.00
137_T	147_Q	2.228	1.00
130_E	137_T	2.204	1.00
128_A	139_L	2.186	1.00
5_L	138_A	2.170	1.00
139_L	145_K	2.127	1.00
121_K	124_K	2.087	1.00
12_G	283_G	2.073	1.00
15_S	302_I	2.061	1.00
153_G	161_V	2.038	1.00
239_K	243_S	2.022	1.00
54_K	59_F	1.984	1.00
135_S	147_Q	1.975	1.00
233_T	236_D	1.957	1.00
4_M	25_F	1.933	1.00
127_V	141_E	1.909	1.00
124_K	140_C	1.887	1.00
311_E	328_R	1.877	1.00
26_S	119_D	1.860	1.00
34_S	123_G	1.859	1.00
3_H	28_T	1.855	1.00
153_G	282_I	1.843	1.00
61_D	112_H	1.840	1.00
112_H	116_V	1.795	1.00
52_V	306_I	1.782	1.00
305_A	309_A	1.772	1.00
132_T	137_T	1.771	1.00
18_I	112_H	1.768	1.00
4_M	20_L	1.753	1.00
130_E	139_L	1.750	1.00
154_F	283_G	1.732	1.00
25_F	313_Q	1.723	1.00
140_C	146_M	1.721	1.00
330_A	334_L	1.716	1.00
126_V	138_A	1.713	1.00
30_C	140_C	1.705	1.00
113_A	118_V	1.682	1.00
21_R	118_V	1.680	1.00
49_A	299_A	1.675	1.00
311_E	324_A	1.673	1.00
274_P	277_K	1.668	1.00
276_H	323_Q	1.647	1.00
155_D	159_S	1.620	1.00
131_E	277_K	1.611	1.00
129_Y	151_L	1.594	1.00
55_E	306_I	1.590	1.00
307_V	311_E	1.589	1.00
60_E	64_K	1.574	1.00
61_D	64_K	1.561	1.00
28_T	146_M	1.561	1.00
61_D	115_A	1.554	1.00
18_I	22_K	1.554	1.00
160_V	164_K	1.548	1.00
132_T	147_Q	1.544	1.00
132_T	135_S	1.537	1.00
110_M	122_W	1.526	1.00
5_L	146_M	1.526	1.00
22_K	116_V	1.521	1.00
276_H	281_I	1.517	1.00
16_A	305_A	1.495	1.00
17_A	29_L	1.473	1.00
239_K	242_L	1.465	1.00
275_W	333_A	1.457	1.00
150_I	322_L	1.446	1.00
274_P	326_Y	1.431	1.00
19_S	56_L	1.429	1.00
317_D	320_T	1.428	1.00
165_M	280_V	1.423	1.00
304_D	329_R	1.415	1.00
238_V	242_L	1.400	1.00
110_M	114_E	1.396	1.00
307_V	328_R	1.392	1.00
235_F	239_K	1.392	1.00
11_I	298_A	1.383	1.00
268_Q	341_S	1.369	1.00
59_F	63_C	1.366	1.00
303_E	332_R	1.362	1.00
152_A	283_G	1.356	1.00
49_A	302_I	1.350	1.00
81_L	84_Q	1.350	1.00
7_A	126_V	1.348	1.00
18_I	116_V	1.339	1.00
275_W	326_Y	1.336	1.00
7_A	155_D	1.336	1.00
281_I	308_L	1.335	1.00
65_H	104_T	1.329	1.00
311_E	321_A	1.327	1.00
185_E	257_K	1.314	1.00
310_E	328_R	1.314	1.00
160_V	163_D	1.306	1.00
6_I	16_A	1.295	1.00
18_I	113_A	1.266	1.00
236_D	239_K	1.265	1.00
240_E	244_G	1.261	1.00
130_E	145_K	1.260	1.00
243_S	246_R	1.255	1.00
111_K	114_E	1.253	1.00
126_V	161_V	1.253	1.00
127_V	139_L	1.252	1.00
240_E	243_S	1.251	1.00
71_W	84_Q	1.249	1.00
121_K	146_M	1.244	1.00
5_L	28_T	1.229	1.00
36_N	122_W	1.222	1.00
60_E	63_C	1.221	1.00
16_A	20_L	1.216	1.00
185_E	214_A	1.213	1.00
126_V	129_Y	1.205	1.00
288_H	304_D	1.193	1.00
237_R	240_E	1.192	1.00
3_H	25_F	1.189	1.00
28_T	119_D	1.177	1.00
131_E	279_R	1.162	1.00
7_A	161_V	1.158	1.00
138_A	148_A	1.138	1.00
282_I	286_A	1.120	1.00
216_Y	220_L	1.114	1.00
152_A	281_I	1.111	1.00
148_A	151_L	1.107	1.00
104_T	107_D	1.102	1.00
15_S	19_S	1.098	1.00
179_A	182_F	1.094	1.00
50_L	59_F	1.088	1.00
15_S	56_L	1.087	1.00
157_I	289_A	1.084	1.00
43_I	298_A	1.083	1.00
9_G	14_L	1.081	1.00
129_Y	164_K	1.081	1.00
178_G	182_F	1.081	1.00
124_K	144_E	1.080	1.00
6_I	17_A	1.075	1.00
233_T	237_R	1.072	1.00
61_D	108_I	1.069	1.00
30_C	121_K	1.068	1.00
168_K	273_E	1.061	1.00
136_V	279_R	1.057	1.00
22_K	112_H	1.055	1.00
311_E	314_N	1.053	1.00
167_Q	272_Q	1.052	1.00
234_R	238_V	1.052	1.00
290_G	300_M	1.042	1.00
29_L	120_I	1.041	1.00
27_V	118_V	1.038	1.00
101_L	104_T	1.032	1.00
65_H	107_D	1.028	1.00
236_D	240_E	1.028	1.00
58_V	112_H	1.026	1.00
73_K	81_L	1.025	1.00
65_H	108_I	1.024	1.00
16_A	283_G	1.022	1.00
232_D	236_D	1.021	1.00
179_A	183_Y	1.020	1.00
76_D	80_N	1.016	1.00
170_T	273_E	1.016	1.00
334_L	338_N	1.015	1.00
55_E	310_E	1.014	1.00
111_K	115_A	1.014	1.00
17_A	27_V	1.011	1.00
131_E	136_V	1.010	1.00
252_T	255_M	1.009	1.00
129_Y	165_M	1.005	1.00
6_I	27_V	1.004	1.00
258_Q	261_V	0.998	1.00
140_C	143_G	0.996	1.00
40_G	43_I	0.993	1.00
71_W	194_A	0.993	1.00
276_H	319_E	0.992	1.00
126_V	160_V	0.991	1.00
30_C	124_K	0.990	1.00
276_H	326_Y	0.989	1.00
290_G	337_Q	0.979	1.00
70_E	193_D	0.979	1.00
153_G	280_V	0.976	1.00
66_G	98_N	0.976	1.00
110_M	120_I	0.974	1.00
62_C	108_I	0.971	1.00
283_G	325_Y	0.967	1.00
307_V	310_E	0.965	1.00
269_V	289_A	0.962	1.00
61_D	65_H	0.959	1.00
35_E	122_W	0.958	1.00
323_Q	327_K	0.954	1.00
14_L	113_A	0.952	1.00
43_I	102_R	0.949	1.00
48_N	303_E	0.949	1.00
272_Q	282_I	0.943	1.00
277_K	280_V	0.942	1.00
108_I	111_K	0.941	1.00
24_G	27_V	0.940	1.00
217_V	220_L	0.939	1.00
7_A	151_L	0.929	1.00
324_A	327_K	0.927	1.00
126_V	164_K	0.925	1.00
314_N	324_A	0.922	1.00
18_I	56_L	0.920	1.00
20_L	25_F	0.919	1.00
50_L	98_N	0.918	1.00
341_S	345_R	0.917	1.00
186_L	189_Y	0.913	1.00
21_R	116_V	0.913	1.00
206_G	218_F	0.909	1.00
41_A	102_R	0.908	1.00
136_V	151_L	0.905	1.00
14_L	110_M	0.897	1.00
62_C	105_L	0.896	1.00
235_F	238_V	0.896	1.00
28_T	148_A	0.893	1.00
19_S	23_A	0.892	1.00
36_N	110_M	0.884	1.00
51_A	54_K	0.883	1.00
242_L	246_R	0.882	1.00
114_E	119_D	0.880	1.00
276_H	322_L	0.879	1.00
108_I	112_H	0.873	1.00
58_V	108_I	0.872	1.00
48_N	296_Q	0.870	1.00
73_K	194_A	0.865	1.00
14_L	106_N	0.864	1.00
234_R	237_R	0.864	1.00
242_L	245_F	0.856	1.00
185_E	256_S	0.855	1.00
21_R	117_G	0.852	1.00
281_I	325_Y	0.852	1.00
138_A	151_L	0.852	1.00
31_E	122_W	0.850	1.00
9_G	31_E	0.848	1.00
11_I	302_I	0.847	1.00
237_R	242_L	0.846	1.00
306_I	310_E	0.845	1.00
21_R	27_V	0.844	1.00
114_E	117_G	0.842	1.00
21_R	113_A	0.841	1.00
75_F	196_F	0.841	1.00
131_E	278_G	0.834	1.00
129_Y	280_V	0.832	1.00
161_V	280_V	0.831	1.00
48_N	51_A	0.826	1.00
309_A	313_Q	0.824	1.00
3_H	148_A	0.822	1.00
17_A	118_V	0.821	1.00
54_K	63_C	0.819	1.00
237_R	246_R	0.818	1.00
324_A	328_R	0.813	1.00
159_S	162_R	0.811	1.00
44_L	97_R	0.804	1.00
17_A	113_A	0.802	1.00
250_F	253_K	0.801	1.00
30_C	148_A	0.801	1.00
73_K	84_Q	0.798	1.00
150_I	281_I	0.798	1.00
264_N	267_E	0.797	1.00
261_V	264_N	0.795	1.00
19_S	22_K	0.793	1.00
222_P	225_S	0.791	1.00
319_E	323_Q	0.787	1.00
30_C	138_A	0.787	1.00
3_H	146_M	0.786	1.00
129_Y	161_V	0.785	1.00
193_D	196_F	0.784	1.00
182_F	185_E	0.783	1.00
44_L	99_N	0.783	1.00
101_L	211_A	0.783	1.00
282_I	287_A	0.780	1.00
140_C	144_E	0.780	1.00
275_W	287_A	0.778	1.00
136_V	140_C	0.778	1.00
318_H	322_L	0.777	1.00
102_R	106_N	0.776	1.00
20_L	309_A	0.772	1.00
250_F	254_H	0.772	1.00
294_L	340_S	0.758	1.00
217_V	221_Q	0.757	1.00
152_A	308_L	0.755	1.00
275_W	330_A	0.753	1.00
106_N	110_M	0.752	1.00
180_W	183_Y	0.751	1.00
266_L	291_A	0.749	1.00
53_L	302_I	0.749	1.00
21_R	114_E	0.748	1.00
20_L	312_L	0.748	1.00
272_Q	275_W	0.748	1.00
290_G	294_L	0.746	1.00
289_A	304_D	0.745	1.00
167_Q	277_K	0.744	1.00
238_V	241_I	0.743	1.00
244_G	247_G	0.741	1.00
104_T	211_A	0.740	1.00
79_G	82_L	0.733	1.00
50_L	54_K	0.732	1.00
165_M	277_K	0.731	1.00
49_A	52_V	0.730	1.00
241_I	245_F	0.729	1.00
23_A	309_A	0.727	1.00
177_M	181_R	0.726	1.00
15_S	109_L	0.725	1.00
75_F	81_L	0.722	1.00
328_R	331_P	0.720	1.00
100_I	105_L	0.718	1.00
21_R	119_D	0.717	1.00
113_A	117_G	0.715	1.00
182_F	217_V	0.714	1.00
53_L	58_V	0.713	1.00
331_P	335_K	0.711	1.00
52_V	56_L	0.710	1.00
186_L	190_T	0.708	1.00
161_V	164_K	0.704	1.00
19_S	52_V	0.700	1.00
153_G	159_S	0.700	1.00
16_A	309_A	0.700	1.00
33_A	37_R	0.698	1.00
48_N	332_R	0.698	1.00
217_V	222_P	0.697	1.00
125_K	160_V	0.691	1.00
298_A	302_I	0.691	1.00
333_A	337_Q	0.690	1.00
178_G	181_R	0.689	1.00
234_R	261_V	0.689	1.00
124_K	141_E	0.688	1.00
46_P	299_A	0.686	1.00
216_Y	221_Q	0.684	1.00
315_H	318_H	0.681	1.00
300_M	333_A	0.680	1.00
232_D	237_R	0.680	1.00
195_T	198_Y	0.678	1.00
296_Q	300_M	0.677	1.00
215_G	218_F	0.677	1.00
19_S	306_I	0.675	1.00
193_D	198_Y	0.674	1.00
283_G	305_A	0.674	1.00
338_N	342_E	0.673	1.00
271_V	334_L	0.673	1.00
232_D	240_E	0.671	1.00
162_R	282_I	0.666	1.00
298_A	301_A	0.665	1.00
181_R	185_E	0.665	1.00
318_H	321_A	0.664	1.00
200_S	203_T	0.662	1.00
114_E	118_V	0.658	1.00
343_I	346_R	0.656	1.00
194_A	197_M	0.656	1.00
251_V	254_H	0.655	1.00
300_M	336_V	0.654	1.00
172_K	175_L	0.653	1.00
271_V	330_A	0.650	1.00
176_G	180_W	0.649	1.00
9_G	29_L	0.647	1.00
4_M	150_I	0.645	1.00
185_E	213_H	0.645	1.00
121_K	144_E	0.644	1.00
293_T	344_V	0.644	1.00
323_Q	326_Y	0.643	1.00
229_D	232_D	0.642	1.00
320_T	324_A	0.641	1.00
290_G	340_S	0.638	1.00
27_V	113_A	0.638	1.00
317_D	321_A	0.637	1.00
185_E	188_D	0.636	1.00
196_F	199_R	0.635	1.00
155_D	282_I	0.635	1.00
278_G	319_E	0.633	1.00
180_W	184_I	0.631	1.00
151_L	280_V	0.631	1.00
53_L	62_C	0.628	1.00
237_R	245_F	0.628	1.00
129_Y	136_V	0.626	1.00
216_Y	219_V	0.626	1.00
18_I	21_R	0.625	1.00
195_T	199_R	0.624	1.00
135_S	149_D	0.624	1.00
14_L	29_L	0.623	1.00
73_K	76_D	0.621	1.00
16_A	312_L	0.619	1.00
135_S	140_C	0.619	1.00
169_E	173_E	0.618	1.00
101_L	214_A	0.615	1.00
238_V	244_G	0.612	1.00
150_I	312_L	0.611	1.00
291_A	294_L	0.610	1.00
271_V	275_W	0.607	1.00
14_L	120_I	0.607	1.00
186_L	215_G	0.604	1.00
150_I	318_H	0.603	1.00
16_A	19_S	0.602	1.00
281_I	322_L	0.601	1.00
187_P	254_H	0.601	1.00
294_L	343_I	0.601	1.00
335_K	338_N	0.600	1.00
320_T	323_Q	0.600	1.00
237_R	241_I	0.598	1.00
113_A	120_I	0.597	1.00
327_K	331_P	0.595	1.00
153_G	160_V	0.595	1.00
173_E	176_G	0.594	1.00
65_H	100_I	0.593	1.00
113_A	116_V	0.590	1.00
153_G	165_M	0.589	1.00
303_E	307_V	0.589	1.00
92_D	95_P	0.589	1.00
4_M	16_A	0.587	1.00
242_L	247_G	0.586	1.00
303_E	329_R	0.586	1.00
19_S	305_A	0.586	1.00
179_A	184_I	0.583	1.00
288_H	329_R	0.583	1.00
15_S	53_L	0.583	1.00
296_Q	299_A	0.583	1.00
185_E	189_Y	0.582	1.00
45_Q	49_A	0.579	1.00
182_F	186_L	0.579	1.00
53_L	105_L	0.579	1.00
54_K	60_E	0.578	1.00
262_I	267_E	0.577	1.00
130_E	133_A	0.576	1.00
310_E	314_N	0.576	1.00
180_W	185_E	0.574	1.00
62_C	98_N	0.573	1.00
181_R	189_Y	0.572	1.00
149_D	279_R	0.570	1.00
126_V	140_C	0.569	1.00
131_E	134_E	0.567	1.00
138_A	146_M	0.567	1.00
203_T	244_G	0.566	1.00
36_N	106_N	0.566	1.00
163_D	168_K	0.565	1.00
315_H	319_E	0.565	1.00
51_A	55_E	0.564	1.00
8_G	13_G	0.561	1.00
242_L	256_S	0.561	1.00
249_D	252_T	0.560	1.00
178_G	183_Y	0.559	1.00
285_D	301_A	0.559	1.00
26_S	149_D	0.558	1.00
182_F	189_Y	0.557	1.00
12_G	152_A	0.557	1.00
25_F	312_L	0.557	1.00
301_A	305_A	0.555	1.00
151_L	279_R	0.554	1.00
39_T	43_I	0.554	1.00
104_T	108_I	0.552	1.00
192_E	195_T	0.549	1.00
281_I	326_Y	0.549	1.00
198_Y	201_G	0.548	1.00
263_F	266_L	0.548	1.00
155_D	162_R	0.547	1.00
158_H	163_D	0.546	1.00
69_T	99_N	0.544	1.00
27_V	119_D	0.543	1.00
233_T	238_V	0.543	1.00
257_K	260_P	0.541	1.00
16_A	154_F	0.539	1.00
251_V	255_M	0.537	1.00
63_C	66_G	0.536	1.00
307_V	325_Y	0.536	1.00
151_L	161_V	0.535	1.00
18_I	118_V	0.535	1.00
59_F	62_C	0.532	1.00
246_R	250_F	0.532	1.00
177_M	183_Y	0.532	1.00
158_H	267_E	0.532	1.00
73_K	196_F	0.531	1.00
181_R	184_I	0.531	1.00
269_V	272_Q	0.531	1.00
221_Q	225_S	0.529	1.00
179_A	189_Y	0.528	1.00
193_D	197_M	0.527	1.00
18_I	58_V	0.526	1.00
338_N	341_S	0.522	1.00
283_G	301_A	0.521	1.00
36_N	107_D	0.521	1.00
233_T	240_E	0.520	1.00
237_R	247_G	0.520	1.00
206_G	210_L	0.519	1.00
231_E	234_R	0.517	1.00
23_A	310_E	0.516	1.00
131_E	135_S	0.516	1.00
214_A	217_V	0.514	1.00
169_E	172_K	0.513	1.00
279_R	315_H	0.511	1.00
296_Q	336_V	0.510	1.00
309_A	312_L	0.508	1.00
341_S	344_V	0.508	1.00
114_E	122_W	0.507	1.00
232_D	238_V	0.506	1.00
34_S	122_W	0.506	1.00
63_C	68_Q	0.506	1.00
230_E	233_T	0.506	1.00
249_D	253_K	0.505	1.00
192_E	196_F	0.505	1.00
16_A	308_L	0.504	1.00
241_I	244_G	0.503	1.00
7_A	129_Y	0.502	1.00
234_R	246_R	0.502	1.00
176_G	182_F	0.502	1.00
32_A	158_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qa1A	2	0.9431	100	0.285	Contact Map
4n9xA	5	0.9241	100	0.289	Contact Map
2qa2A	2	0.9566	100	0.289	Contact Map
4bjzA	2	0.9864	100	0.293	Contact Map
3rp8A	1	0.9756	100	0.295	Contact Map
2x3nA	1	0.9377	100	0.297	Contact Map
1pn0A	3	0.9729	100	0.298	Contact Map
4k5sA	2	0.9566	100	0.298	Contact Map
3aljA	1	0.9512	100	0.301	Contact Map
3c96A	1	0.9566	100	0.301	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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