GREMLIN Database
RFBF - Probable glucose-1-phosphate cytidylyltransferase
UniProt: O06486 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (222)
Sequences: 22384 (13860)
Seq/√Len: 930.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_K39_K3.3531.00
163_T171_T2.7541.00
48_E93_K2.6721.00
165_E168_M2.6721.00
163_T170_K2.6671.00
35_W63_Y2.6231.00
103_T107_G2.5901.00
196_Y216_D2.3791.00
120_T190_S2.3611.00
146_A220_A2.2661.00
141_H149_T2.2341.00
3_A46_V2.2281.00
168_M220_A2.2071.00
165_E170_K2.1681.00
48_E95_T2.1361.00
3_A41_Y2.1101.00
38_M49_F2.0481.00
152_G180_G2.0321.00
110_L113_K1.9981.00
58_E62_E1.9511.00
196_Y212_N1.9341.00
169_A221_V1.8871.00
97_L111_Q1.8341.00
212_N216_D1.8161.00
41_Y124_T1.7921.00
120_T142_Q1.7891.00
211_K215_K1.7791.00
53_L57_G1.7761.00
7_C51_L1.7681.00
35_W39_K1.7601.00
171_T211_K1.7591.00
144_K220_A1.7491.00
135_F139_S1.7301.00
21_I27_M1.7301.00
146_A218_E1.7271.00
181_I223_R1.7141.00
140_Y222_Y1.7111.00
15_S19_N1.6881.00
208_E211_K1.6821.00
50_I115_Y1.6461.00
140_Y144_K1.6451.00
153_I156_V1.6321.00
229_T239_E1.6311.00
164_V181_I1.6261.00
152_G223_R1.6251.00
109_I123_L1.6161.00
61_K98_E1.6151.00
147_A150_V1.6081.00
212_N215_K1.6011.00
21_I59_K1.5691.00
25_L59_K1.5621.00
59_K62_E1.5581.00
32_P35_W1.5491.00
136_H139_S1.5451.00
4_V112_A1.5151.00
151_T156_V1.4971.00
162_L169_A1.4491.00
227_F243_M1.4471.00
168_M218_E1.4381.00
116_I121_F1.4291.00
147_A190_S1.4221.00
237_L241_N1.4131.00
107_G111_Q1.3931.00
192_K195_D1.3761.00
57_G61_K1.3661.00
42_Q92_W1.3591.00
57_G98_E1.3531.00
50_I97_L1.3451.00
125_Y185_G1.3401.00
120_T188_V1.3401.00
233_T236_N1.3361.00
160_G174_E1.3291.00
95_T115_Y1.3051.00
120_T191_P1.2971.00
139_S143_T1.2901.00
119_E191_P1.2831.00
10_K102_D1.2591.00
53_L61_K1.2471.00
14_M26_A1.2461.00
173_S178_S1.2341.00
65_L96_F1.2321.00
121_F191_P1.2311.00
238_L242_K1.2221.00
49_F92_W1.2131.00
164_V221_V1.1911.00
53_L98_E1.1641.00
207_D211_K1.1581.00
8_G52_L1.1571.00
131_N227_F1.1511.00
50_I112_A1.1441.00
25_L63_Y1.1361.00
231_I240_V1.1321.00
163_T173_S1.1301.00
137_L188_V1.1291.00
147_A218_E1.1261.00
152_G156_V1.1201.00
35_W67_Y1.1121.00
133_N136_H1.1121.00
229_T243_M1.1111.00
169_A219_L1.1061.00
122_L188_V1.1061.00
107_G110_L1.1031.00
209_P212_N1.0881.00
34_L64_F1.0871.00
236_N239_E1.0751.00
189_L210_L1.0671.00
46_V122_L1.0631.00
123_L189_L1.0501.00
56_K59_K1.0451.00
152_G155_K1.0451.00
146_A149_T1.0301.00
136_H140_Y1.0291.00
53_L96_F1.0211.00
196_Y209_P1.0201.00
146_A150_V1.0141.00
34_L51_L1.0131.00
31_K36_H1.0071.00
183_N187_F0.9981.00
53_L60_I0.9971.00
155_K158_Q0.9951.00
239_E242_K0.9941.00
220_A223_R0.9911.00
54_G57_G0.9801.00
157_S175_K0.9681.00
33_I231_I0.9581.00
50_I95_T0.9581.00
67_Y90_E0.9501.00
140_Y220_A0.9451.00
161_T182_I0.9431.00
33_I37_I0.9411.00
113_K194_F0.9411.00
167_G223_R0.9401.00
4_V121_F0.9401.00
158_Q236_N0.9401.00
5_I126_G0.9391.00
34_L60_I0.9381.00
145_G149_T0.9361.00
235_K239_E0.9341.00
140_Y143_T0.9321.00
27_M32_P0.9281.00
31_K35_W0.9241.00
58_E61_K0.9231.00
242_K245_N0.9221.00
229_T240_V0.9221.00
14_M18_T0.9161.00
61_K96_F0.9111.00
138_I141_H0.9011.00
105_T125_Y0.8991.00
198_P201_G0.8961.00
148_A189_L0.8951.00
24_P126_G0.8941.00
141_H190_S0.8821.00
118_D191_P0.8821.00
128_G228_W0.8791.00
145_G190_S0.8781.00
32_P63_Y0.8731.00
239_E243_M0.8711.00
62_E65_L0.8641.00
39_K42_Q0.8641.00
117_G191_P0.8631.00
44_Y135_F0.8631.00
238_L241_N0.8601.00
97_L112_A0.8561.00
241_N245_N0.8501.00
122_L138_I0.8461.00
43_Y132_I0.8431.00
201_G205_F0.8361.00
32_P36_H0.8301.00
141_H188_V0.8251.00
61_K65_L0.8241.00
6_L125_Y0.8121.00
158_Q175_K0.8091.00
52_L108_R0.8031.00
110_L197_L0.7991.00
210_L219_L0.7971.00
157_S177_S0.7961.00
139_S142_Q0.7931.00
46_V138_I0.7841.00
137_L222_Y0.7801.00
18_T26_A0.7791.00
26_A237_L0.7721.00
136_H222_Y0.7691.00
29_G241_N0.7681.00
68_E90_E0.7621.00
36_H244_W0.7591.00
145_G150_V0.7581.00
151_T155_K0.7571.00
40_I44_Y0.7571.00
42_Q49_F0.7531.00
124_T134_L0.7521.00
97_L115_Y0.7511.00
135_F138_I0.7491.00
109_I193_V0.7471.00
162_L221_V0.7461.00
4_V52_L0.7441.00
39_K90_E0.7431.00
118_D192_K0.7381.00
22_P59_K0.7311.00
145_G148_A0.7311.00
65_L68_E0.7301.00
172_F183_N0.7271.00
54_G102_D0.7271.00
38_M64_F0.7251.00
67_Y96_F0.7241.00
53_L58_E0.7191.00
4_V50_I0.7191.00
29_G36_H0.7171.00
17_V21_I0.7131.00
192_K196_Y0.7111.00
27_M30_G0.7101.00
104_L207_D0.7041.00
138_I142_Q0.7031.00
42_Q47_N0.7031.00
206_E209_P0.7021.00
129_L240_V0.7011.00
203_T206_E0.6981.00
28_I241_N0.6901.00
144_K149_T0.6881.00
199_K202_N0.6791.00
36_H39_K0.6791.00
99_T108_R0.6781.00
130_A133_N0.6781.00
146_A168_M0.6771.00
51_L64_F0.6761.00
134_L137_L0.6741.00
30_G36_H0.6721.00
125_Y128_G0.6721.00
47_N93_K0.6691.00
40_I132_I0.6671.00
153_I180_G0.6651.00
102_D107_G0.6641.00
170_K173_S0.6611.00
230_A236_N0.6601.00
42_Q91_T0.6561.00
211_K214_A0.6531.00
173_S176_T0.6531.00
38_M94_I0.6501.00
17_V20_D0.6491.00
129_L132_I0.6491.00
42_Q67_Y0.6491.00
52_L112_A0.6471.00
117_G120_T0.6471.00
35_W64_F0.6461.00
193_V197_L0.6431.00
105_T183_N0.6411.00
11_G23_K0.6401.00
116_I194_F0.6391.00
124_T186_F0.6381.00
36_H40_I0.6351.00
38_M51_L0.6331.00
137_L149_T0.6301.00
134_L141_H0.6291.00
41_Y122_L0.6271.00
99_T107_G0.6251.00
181_I221_V0.6251.00
6_L105_T0.6191.00
192_K218_E0.6161.00
171_T215_K0.6161.00
101_V107_G0.6141.00
5_I124_T0.6121.00
151_T154_D0.6081.00
47_N91_T0.6051.00
204_M207_D0.6031.00
210_L214_A0.6031.00
64_F94_I0.6031.00
95_T98_E0.6031.00
5_I37_I0.5981.00
17_V26_A0.5981.00
158_Q233_T0.5941.00
192_K216_D0.5941.00
238_L245_N0.5941.00
193_V213_L0.5931.00
151_T182_I0.5931.00
29_G244_W0.5901.00
138_I188_V0.5901.00
142_Q145_G0.5871.00
113_K121_F0.5861.00
134_L138_I0.5861.00
38_M92_W0.5851.00
207_D210_L0.5821.00
192_K217_G0.5821.00
210_L213_L0.5821.00
103_T204_M0.5801.00
10_K15_S0.5771.00
191_P194_F0.5721.00
51_L94_I0.5701.00
17_V234_Y0.5681.00
37_I40_I0.5671.00
39_K67_Y0.5661.00
40_I186_F0.5661.00
41_Y46_V0.5641.00
132_I135_F0.5621.00
63_Y66_D0.5611.00
152_G181_I0.5611.00
137_L141_H0.5601.00
13_R23_K0.5591.00
198_P203_T0.5591.00
8_G102_D0.5571.00
24_P60_I0.5521.00
234_Y238_L0.5521.00
43_Y135_F0.5481.00
51_L96_F0.5481.00
199_K203_T0.5441.00
9_G13_R0.5421.00
235_K238_L0.5401.00
208_E212_N0.5391.00
20_D56_K0.5341.00
112_A115_Y0.5321.00
52_L99_T0.5321.00
22_P56_K0.5291.00
26_A241_N0.5221.00
213_L217_G0.5221.00
144_K218_E0.5201.00
96_F99_T0.5201.00
92_W96_F0.5181.00
209_P214_A0.5171.00
229_T236_N0.5171.00
100_G111_Q0.5161.00
163_T180_G0.5161.00
38_M42_Q0.5131.00
159_F174_E0.5121.00
221_V224_H0.5111.00
172_F207_D0.5091.00
7_C34_L0.5081.00
209_P213_L0.5081.00
37_I124_T0.5071.00
113_K195_D0.5061.00
234_Y237_L0.5051.00
23_K127_D0.5051.00
40_I43_Y0.5051.00
59_K63_Y0.5021.00
6_L123_L0.5011.00
10_K19_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tzfA 4 0.9646 100 0.298 Contact Map
3jukA 3 0.9488 100 0.32 Contact Map
2ux8A 4 0.9921 100 0.327 Contact Map
2e3dA 3 0.9921 100 0.329 Contact Map
2pa4A 3 1 100 0.346 Contact Map
3brkX 2 0.9055 100 0.354 Contact Map
4y7uA 1 0.8819 100 0.355 Contact Map
1iimA 3 0.9213 100 0.357 Contact Map
4ho4A 3 0.9213 100 0.358 Contact Map
1lvwA 3 0.9213 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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