GREMLIN Database
YFNG - Putative sugar dehydratase/epimerase YfnG
UniProt: O06485 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (289)
Sequences: 61474 (43004)
Seq/√Len: 2529.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_C35_G3.2971.00
8_N32_N3.0161.00
262_K306_D2.7321.00
228_A248_F2.7031.00
25_E227_Q2.6931.00
244_E292_K2.6471.00
246_F296_L2.5661.00
69_E116_K2.5181.00
101_E105_L2.4441.00
79_T233_A2.2961.00
126_A229_Y2.2761.00
265_K306_D2.2561.00
36_L60_G2.2521.00
64_D67_V2.2411.00
304_T307_E2.1981.00
82_H125_V2.1891.00
95_N98_S2.1631.00
12_T82_H2.1571.00
122_R173_P2.1561.00
294_R300_T2.1081.00
183_Y308_G2.0921.00
25_E29_Q2.0861.00
141_D144_M2.0381.00
81_F233_A2.0191.00
60_G67_V2.0131.00
227_Q302_A2.0001.00
11_V23_V1.9781.00
10_F77_I1.9751.00
25_E230_L1.9361.00
257_L261_E1.9071.00
29_Q234_E1.8931.00
266_K310_E1.8641.00
8_N34_T1.8531.00
34_T56_N1.8501.00
32_N56_N1.8281.00
179_C229_Y1.8251.00
163_S174_V1.8141.00
223_E311_K1.8031.00
34_T77_I1.8001.00
227_Q231_L1.7941.00
262_K265_K1.7701.00
255_T258_E1.7141.00
177_T232_L1.6641.00
65_L112_E1.6611.00
63_E101_E1.6611.00
34_T58_V1.6611.00
22_L226_V1.6561.00
22_L81_F1.6341.00
127_S131_A1.6191.00
221_Y311_K1.6181.00
251_E294_R1.6121.00
69_E113_A1.6061.00
39_D57_I1.5851.00
199_Q203_N1.5781.00
108_W112_E1.5591.00
108_W162_I1.5481.00
293_A297_L1.5111.00
132_Y247_N1.5101.00
22_L83_L1.4991.00
142_E292_K1.4931.00
25_E28_E1.4861.00
78_D121_K1.4861.00
18_L182_L1.4741.00
29_Q230_L1.4641.00
82_H107_T1.4551.00
100_F158_C1.4551.00
9_V31_A1.4521.00
115_R170_Y1.4501.00
230_L234_E1.4441.00
258_E261_E1.4411.00
262_K266_K1.4371.00
105_L108_W1.4321.00
221_Y308_G1.4301.00
103_N155_S1.4131.00
290_A294_R1.4041.00
97_I101_E1.4031.00
179_C225_A1.4011.00
23_V35_G1.3891.00
152_Y156_K1.3811.00
80_V114_C1.3801.00
83_L126_A1.3711.00
200_L205_E1.3701.00
81_F229_Y1.3701.00
157_S161_L1.3631.00
25_E226_V1.3571.00
122_R175_C1.3561.00
67_V70_R1.3541.00
177_T229_Y1.3541.00
180_G288_L1.3491.00
107_T159_A1.3321.00
222_I226_V1.3211.00
231_L235_K1.3141.00
69_E117_H1.3131.00
65_L109_N1.2991.00
110_I123_V1.2981.00
126_A179_C1.2931.00
146_L157_S1.2741.00
15_T37_V1.2631.00
62_L106_G1.2571.00
307_E310_E1.2531.00
161_L164_H1.2511.00
218_D251_E1.2381.00
31_A234_E1.2331.00
24_K186_G1.2251.00
14_C23_V1.2101.00
65_L69_E1.2081.00
307_E311_K1.2011.00
290_A301_P1.1901.00
72_L80_V1.1741.00
140_Y144_M1.1701.00
112_E115_R1.1701.00
111_L166_Y1.1691.00
114_C123_V1.1691.00
141_D289_S1.1611.00
125_V159_A1.1581.00
257_L275_V1.1561.00
9_V26_L1.1551.00
220_F225_A1.1531.00
216_V253_Q1.1491.00
244_E296_L1.1401.00
70_R73_G1.1281.00
178_R245_A1.1271.00
73_G117_H1.1251.00
137_N141_D1.1241.00
137_N144_M1.1191.00
8_N78_D1.1081.00
17_L184_G1.1011.00
26_L230_L1.0981.00
125_V163_S1.0911.00
112_E116_K1.0911.00
62_L84_A1.0861.00
27_I55_M1.0861.00
9_V79_T1.0851.00
72_L77_I1.0841.00
164_H176_I1.0781.00
178_R247_N1.0751.00
154_V158_C1.0731.00
21_Y223_E1.0681.00
164_H245_A1.0671.00
160_D178_R1.0671.00
10_F36_L1.0631.00
143_N292_K1.0571.00
35_G55_M1.0541.00
24_K28_E1.0521.00
254_L305_I1.0501.00
264_L270_N1.0501.00
292_K296_L1.0451.00
224_D250_N1.0391.00
69_E73_G1.0341.00
83_L229_Y1.0321.00
208_E274_K1.0321.00
124_I177_T1.0301.00
228_A293_A1.0261.00
20_S186_G1.0181.00
214_T257_L1.0181.00
227_Q299_W1.0181.00
25_E223_E1.0171.00
183_Y221_Y1.0141.00
111_L123_V1.0061.00
221_Y224_D1.0061.00
68_I113_A1.0031.00
167_F174_V0.9921.00
261_E264_L0.9921.00
12_T84_A0.9811.00
102_A106_G0.9811.00
162_I165_T0.9761.00
306_D310_E0.9731.00
17_L222_I0.9721.00
66_A69_E0.9681.00
266_K313_I0.9661.00
115_R172_L0.9591.00
66_A70_R0.9571.00
125_V176_I0.9531.00
164_H174_V0.9531.00
86_Q102_A0.9521.00
182_L225_A0.9511.00
8_N77_I0.9501.00
34_T76_E0.9501.00
113_A117_H0.9491.00
193_I197_T0.9441.00
27_I54_K0.9421.00
39_D42_P0.9321.00
276_L279_G0.9321.00
206_A274_K0.9311.00
246_F292_K0.9301.00
105_L109_N0.9271.00
249_S288_L0.9261.00
165_T169_T0.9241.00
173_P242_A0.9221.00
91_V95_N0.9221.00
9_V81_F0.9211.00
123_V163_S0.9151.00
127_S160_D0.9141.00
72_L113_A0.9101.00
36_L71_A0.9061.00
36_L68_I0.9061.00
114_C120_I0.9011.00
235_K240_N0.8991.00
267_M313_I0.8961.00
109_N112_E0.8951.00
111_L162_I0.8901.00
199_Q202_L0.8891.00
206_A272_K0.8851.00
58_V71_A0.8831.00
228_A299_W0.8801.00
21_Y222_I0.8771.00
231_L297_L0.8691.00
22_L26_L0.8651.00
232_L297_L0.8621.00
266_K309_L0.8611.00
216_V255_T0.8611.00
214_T255_T0.8611.00
67_V71_A0.8591.00
253_Q285_H0.8581.00
111_L163_S0.8581.00
38_R61_S0.8571.00
164_H168_H0.8571.00
100_F104_I0.8561.00
27_I33_V0.8521.00
249_S290_A0.8521.00
79_T122_R0.8491.00
232_L293_A0.8471.00
253_Q287_Y0.8381.00
177_T248_F0.8361.00
254_L258_E0.8361.00
175_C232_L0.8351.00
65_L116_K0.8341.00
182_L220_F0.8301.00
241_L244_E0.8261.00
12_T110_I0.8251.00
21_Y24_K0.8251.00
248_F293_A0.8191.00
37_V57_I0.8191.00
23_V33_V0.8181.00
99_T155_S0.8181.00
129_D180_G0.8161.00
72_L117_H0.8161.00
176_I245_A0.8151.00
196_Q200_L0.8131.00
231_L234_E0.8121.00
113_A116_K0.8111.00
21_Y25_E0.8111.00
266_K306_D0.8091.00
104_I158_C0.8081.00
138_L144_M0.8061.00
40_H59_R0.8041.00
264_L271_L0.8021.00
36_L67_V0.7931.00
100_F105_L0.7911.00
31_A78_D0.7801.00
9_V233_A0.7781.00
8_N31_A0.7761.00
63_E102_A0.7761.00
254_L259_L0.7761.00
72_L114_C0.7711.00
158_C161_L0.7631.00
10_F60_G0.7631.00
106_G109_N0.7621.00
192_R195_P0.7621.00
180_G249_S0.7601.00
100_F155_S0.7571.00
196_Q199_Q0.7561.00
39_D59_R0.7541.00
109_N113_A0.7521.00
261_E265_K0.7511.00
148_G153_D0.7471.00
264_L269_S0.7441.00
131_A160_D0.7401.00
142_E293_A0.7401.00
251_E290_A0.7341.00
21_Y226_V0.7331.00
73_G76_E0.7291.00
231_L298_N0.7261.00
166_Y170_Y0.7241.00
213_G257_L0.7211.00
231_L299_W0.7191.00
107_T111_L0.7131.00
115_R171_G0.7091.00
86_Q103_N0.7081.00
227_Q230_L0.7071.00
185_G311_K0.7061.00
107_T163_S0.7051.00
80_V110_I0.7051.00
68_I109_N0.7031.00
98_S101_E0.7021.00
186_G189_N0.7011.00
18_L225_A0.7011.00
30_G54_K0.7001.00
159_A163_S0.7001.00
112_E166_Y0.6991.00
22_L229_Y0.6981.00
32_N54_K0.6951.00
185_G189_N0.6931.00
10_F80_V0.6931.00
92_A99_T0.6921.00
26_L233_A0.6921.00
93_N151_P0.6901.00
96_P154_V0.6891.00
291_E294_R0.6861.00
216_V285_H0.6851.00
64_D68_I0.6851.00
20_S24_K0.6831.00
252_I304_T0.6821.00
205_E208_E0.6821.00
80_V123_V0.6821.00
86_Q99_T0.6791.00
61_S64_D0.6781.00
197_T200_L0.6731.00
235_K241_L0.6631.00
161_L165_T0.6621.00
82_H110_I0.6591.00
8_N76_E0.6591.00
129_D288_L0.6571.00
198_I202_L0.6531.00
121_K173_P0.6521.00
135_Q140_Y0.6491.00
259_L305_I0.6491.00
86_Q98_S0.6481.00
262_K305_I0.6481.00
201_V264_L0.6471.00
130_K153_D0.6471.00
294_R301_P0.6441.00
224_D302_A0.6371.00
158_C162_I0.6351.00
85_A103_N0.6341.00
185_G221_Y0.6321.00
218_D250_N0.6321.00
224_D227_Q0.6281.00
34_T71_A0.6281.00
136_E144_M0.6271.00
128_S156_K0.6231.00
258_E262_K0.6201.00
37_V41_V0.6191.00
142_E247_N0.6181.00
103_N152_Y0.6171.00
277_N280_S0.6151.00
10_F71_A0.6151.00
241_L296_L0.6121.00
181_N217_R0.6121.00
115_R166_Y0.6101.00
293_A296_L0.6091.00
252_I306_D0.6071.00
100_F154_V0.6051.00
24_K52_I0.6041.00
98_S102_A0.6001.00
200_L203_N0.6001.00
150_H153_D0.5971.00
82_H123_V0.5971.00
226_V230_L0.5941.00
174_V243_G0.5941.00
58_V67_V0.5941.00
139_P289_S0.5931.00
133_G147_Q0.5921.00
154_V161_L0.5911.00
30_G33_V0.5871.00
183_Y250_N0.5871.00
155_S159_A0.5831.00
31_A79_T0.5821.00
29_Q227_Q0.5811.00
302_A307_E0.5811.00
215_F256_V0.5751.00
198_I263_I0.5741.00
154_V165_T0.5731.00
79_T124_I0.5731.00
71_A77_I0.5701.00
198_I313_I0.5681.00
52_I55_M0.5671.00
114_C117_H0.5641.00
151_P155_S0.5641.00
107_T125_V0.5611.00
68_I72_L0.5581.00
124_I233_A0.5571.00
271_L274_K0.5571.00
117_H120_I0.5561.00
11_V26_L0.5551.00
163_S176_I0.5541.00
60_G71_A0.5541.00
177_T228_A0.5531.00
162_I166_Y0.5511.00
124_I229_Y0.5501.00
148_G157_S0.5501.00
11_V35_G0.5501.00
197_T201_V0.5501.00
152_Y155_S0.5491.00
10_F72_L0.5471.00
126_A177_T0.5471.00
151_P154_V0.5471.00
117_H121_K0.5471.00
225_A248_F0.5461.00
15_T39_D0.5461.00
179_C182_L0.5451.00
124_I232_L0.5451.00
204_G269_S0.5451.00
204_G207_P0.5441.00
218_D253_Q0.5431.00
83_L179_C0.5431.00
260_V264_L0.5421.00
23_V27_I0.5411.00
96_P151_P0.5401.00
264_L273_P0.5381.00
240_N244_E0.5361.00
262_K309_L0.5351.00
79_T121_K0.5341.00
200_L204_G0.5321.00
193_I196_Q0.5311.00
180_G218_D0.5311.00
264_L267_M0.5301.00
216_V287_Y0.5301.00
17_L21_Y0.5271.00
201_V207_P0.5261.00
128_S131_A0.5251.00
200_L208_E0.5221.00
175_C240_N0.5211.00
38_R41_V0.5201.00
246_F293_A0.5191.00
26_L81_F0.5181.00
131_A178_R0.5151.00
135_Q138_L0.5141.00
29_Q231_L0.5141.00
24_K223_E0.5131.00
181_N219_Y0.5121.00
146_L161_L0.5091.00
156_K159_A0.5081.00
185_G223_E0.5081.00
254_L262_K0.5071.00
26_L31_A0.5061.00
175_C244_E0.5041.00
131_A146_L0.5031.00
166_Y172_L0.5021.00
280_S283_I0.5021.00
73_G116_K0.5011.00
221_Y312_T0.5011.00
308_G311_K0.5001.00
240_N243_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rkxA 3 0.9845 100 0.185 Contact Map
1sb8A 2 0.9783 100 0.185 Contact Map
3rufA 2 0.9689 100 0.189 Contact Map
2hunA 2 0.9658 100 0.198 Contact Map
4wokA 1 0.9503 100 0.203 Contact Map
1rpnA 4 0.9658 100 0.205 Contact Map
1orrA 3 0.9658 100 0.205 Contact Map
2q1sA 2 0.9348 100 0.206 Contact Map
2z1mA 4 0.9658 100 0.208 Contact Map
1gy8A 2 0.9845 100 0.21 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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