GREMLIN Database
YFNF - Uncharacterized protein YfnF
UniProt: O06484 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (281)
Sequences: 304 (272)
Seq/√Len: 16.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L87_F4.3601.00
81_W191_G3.6091.00
153_Y206_V3.3820.99
32_P98_L3.1340.99
10_S80_C3.0770.99
100_R122_P3.0760.99
155_S196_L3.0160.98
125_S163_D2.9820.98
157_F243_F2.9110.98
107_D245_H2.7880.97
156_G215_N2.7060.97
102_T159_S2.6880.97
81_W155_S2.6230.96
131_G154_N2.6040.96
228_W270_F2.3960.94
13_R107_D2.2970.92
9_L17_A2.2890.92
84_K215_N2.2420.91
89_Q171_E2.2350.91
71_K79_Y2.1510.89
108_L243_F2.1130.88
131_G217_G2.1120.88
32_P55_N2.0960.88
81_W196_L2.0710.87
154_N215_N1.9980.85
19_A282_I1.9740.85
81_W106_G1.9630.84
194_G197_D1.9360.83
106_G155_S1.9180.83
56_L152_R1.8700.81
254_I258_K1.8250.79
4_A34_F1.8080.79
86_I174_K1.8000.78
6_C88_L1.7930.78
7_T23_S1.7450.76
6_C87_F1.7160.75
85_P170_L1.6930.74
156_G247_S1.6680.73
13_R155_S1.6580.72
64_N174_K1.6560.72
89_Q174_K1.6520.72
11_K39_D1.6420.72
70_L74_R1.6400.71
84_K156_G1.6350.71
117_I214_V1.6340.71
152_R201_E1.6330.71
212_P239_S1.6290.71
169_C196_L1.6140.70
200_S208_D1.5920.69
162_H167_T1.5770.68
107_D181_C1.5640.68
172_W188_G1.5620.68
81_W245_H1.5510.67
107_D154_N1.5470.67
84_K247_S1.5420.67
9_L180_E1.4950.64
153_Y196_L1.4900.64
10_S155_S1.4850.64
89_Q93_N1.4840.64
87_F92_L1.4800.63
231_G235_L1.4800.63
84_K155_S1.4780.63
81_W177_C1.4740.63
107_D243_F1.4660.63
154_N245_H1.4620.62
131_G247_S1.4540.62
13_R181_C1.4420.61
198_Y202_L1.4380.61
181_C245_H1.4170.60
80_C191_G1.4130.60
165_A168_D1.4110.59
212_P238_G1.3870.58
77_S154_N1.3810.58
21_F33_I1.3630.57
126_V203_F1.3570.56
37_C56_L1.3450.56
164_D168_D1.3370.55
81_W107_D1.3320.55
96_P162_H1.3200.54
5_Y28_D1.3190.54
130_R189_K1.3160.54
244_Y257_I1.3140.54
107_D131_G1.3100.54
163_D166_G1.3070.54
131_G243_F1.3020.53
215_N247_S1.2990.53
88_L170_L1.2930.53
94_S168_D1.2820.52
103_Y172_W1.2750.52
126_V169_C1.2680.51
203_F206_V1.2630.51
151_G275_Y1.2590.51
40_E60_A1.2480.50
213_G241_L1.2450.50
7_T39_D1.2440.50
5_Y24_L1.2400.50
154_N243_F1.2390.50
5_Y31_S1.2350.49
8_V74_R1.2260.49
74_R82_T1.2230.49
241_L246_F1.2220.49
81_W154_N1.2210.49
13_R131_G1.2210.49
107_D194_G1.2210.49
5_Y160_F1.2190.48
115_S119_E1.2180.48
62_L83_M1.2050.48
121_Q127_L1.1990.47
13_R245_H1.1850.46
154_N247_S1.1800.46
203_F216_I1.1730.46
128_L184_A1.1730.46
172_W203_F1.1720.46
74_R147_Q1.1660.45
19_A211_T1.1650.45
26_Q66_L1.1570.45
129_S215_N1.1550.45
171_E277_E1.1550.45
74_R195_Y1.1380.44
7_T20_L1.1340.43
129_S157_F1.1320.43
131_G155_S1.1290.43
74_R218_H1.1280.43
105_D219_W1.1180.43
101_V157_F1.1130.42
113_D240_P1.1070.42
125_S205_N1.1050.42
19_A110_F1.0980.41
94_S229_K1.0940.41
34_F208_D1.0910.41
65_E211_T1.0910.41
35_I54_L1.0810.40
10_S84_K1.0680.40
229_K232_R1.0610.39
92_L167_T1.0600.39
283_I287_Q1.0490.39
85_P173_W1.0470.39
150_L183_N1.0400.38
105_D151_G1.0370.38
107_D215_N1.0340.38
176_R249_Y1.0300.38
227_S238_G1.0270.37
13_R217_G1.0270.37
13_R81_W1.0240.37
249_Y276_Q1.0230.37
77_S81_W1.0200.37
36_L88_L1.0150.37
153_Y255_N1.0000.36
106_G191_G0.9990.36
38_M80_C0.9970.36
74_R160_F0.9960.36
169_C199_M0.9930.36
14_L279_L0.9780.35
88_L158_I0.9780.35
57_V225_T0.9770.35
153_Y168_D0.9760.35
116_P178_L0.9760.35
127_L157_F0.9630.34
106_G189_K0.9630.34
92_L248_G0.9610.34
102_T155_S0.9600.34
176_R203_F0.9590.34
171_E175_E0.9580.34
83_M196_L0.9490.33
20_L33_I0.9490.33
82_T177_C0.9480.33
8_V80_C0.9470.33
147_Q260_I0.9460.33
124_C161_K0.9460.33
7_T14_L0.9370.33
190_F197_D0.9370.33
115_S162_H0.9350.33
121_Q172_W0.9350.33
84_K172_W0.9270.32
130_R224_H0.9240.32
91_V98_L0.9140.31
61_A65_E0.9120.31
108_L224_H0.9110.31
85_P106_G0.9090.31
109_F278_T0.9060.31
82_T181_C0.9000.31
126_V286_M0.8980.31
107_D155_S0.8960.31
191_G196_L0.8950.31
92_L162_H0.8870.30
17_A161_K0.8810.30
238_G270_F0.8800.30
151_G193_Q0.8800.30
6_C202_L0.8730.29
105_D245_H0.8670.29
8_V156_G0.8660.29
172_W192_D0.8640.29
33_I70_L0.8620.29
74_R126_V0.8580.29
160_F166_G0.8580.29
8_V215_N0.8550.29
131_G245_H0.8540.29
92_L185_P0.8520.28
166_G199_M0.8490.28
238_G246_F0.8440.28
108_L197_D0.8400.28
104_I154_N0.8390.28
117_I204_P0.8380.28
107_D219_W0.8370.28
22_K281_H0.8360.28
70_L82_T0.8310.27
28_D113_D0.8280.27
90_A93_N0.8270.27
88_L92_L0.8230.27
151_G192_D0.8170.27
278_T281_H0.8150.27
76_Q83_M0.8130.27
163_D205_N0.8110.27
105_D157_F0.8100.27
40_E67_L0.8090.26
84_K159_S0.8060.26
10_S191_G0.7950.26
20_L251_I0.7930.26
16_Q218_H0.7930.26
156_G200_S0.7900.26
126_V160_F0.7880.26
284_Q288_T0.7870.25
23_S235_L0.7780.25
125_S165_A0.7750.25
84_K105_D0.7730.25
11_K42_T0.7710.25
105_D220_N0.7690.25
26_Q91_V0.7670.25
93_N277_E0.7660.25
76_Q84_K0.7660.25
204_P210_T0.7650.25
66_L164_D0.7610.24
81_W173_W0.7570.24
135_I165_A0.7550.24
202_L217_G0.7490.24
155_S191_G0.7480.24
37_C195_Y0.7430.24
144_D195_Y0.7420.24
78_E176_R0.7410.23
155_S217_G0.7330.23
5_Y14_L0.7330.23
8_V159_S0.7310.23
38_M83_M0.7280.23
104_I249_Y0.7270.23
82_T195_Y0.7260.23
130_R152_R0.7260.23
93_N111_Y0.7260.23
120_N127_L0.7250.23
86_I101_V0.7240.23
225_T231_G0.7240.23
120_N207_C0.7210.23
92_L160_F0.7200.23
36_L129_S0.7200.23
25_E53_Q0.7200.23
155_S177_C0.7200.23
209_I214_V0.7190.23
107_D193_Q0.7160.22
22_K26_Q0.7150.22
31_S235_L0.7150.22
8_V155_S0.7140.22
123_D126_V0.7090.22
13_R243_F0.7080.22
154_N248_G0.7050.22
83_M155_S0.7020.22
32_P153_Y0.7010.22
48_K52_K0.7000.22
157_F247_S0.6980.22
269_P273_E0.6970.22
180_E184_A0.6950.22
167_T171_E0.6940.22
154_N181_C0.6940.22
166_G197_D0.6930.22
99_E115_S0.6930.22
77_S155_S0.6890.21
230_D281_H0.6860.21
66_L168_D0.6830.21
8_V191_G0.6820.21
24_L33_I0.6820.21
27_V228_W0.6800.21
125_S166_G0.6780.21
62_L215_N0.6780.21
230_D285_H0.6760.21
226_F234_V0.6730.21
161_K176_R0.6700.21
78_E219_W0.6650.20
59_V67_L0.6630.20
24_L244_Y0.6610.20
117_I127_L0.6600.20
254_I257_I0.6590.20
97_E162_H0.6580.20
220_N224_H0.6570.20
74_R223_Q0.6560.20
105_D172_W0.6560.20
92_L97_E0.6540.20
24_L31_S0.6530.20
134_V244_Y0.6530.20
84_K154_N0.6500.20
195_Y203_F0.6500.20
135_I158_I0.6480.20
107_D247_S0.6450.20
9_L79_Y0.6450.20
27_V283_I0.6440.20
117_I209_I0.6410.20
193_Q275_Y0.6390.19
33_I211_T0.6380.19
209_I212_P0.6360.19
131_G214_V0.6350.19
154_N157_F0.6290.19
68_L71_K0.6280.19
83_M117_I0.6240.19
105_D243_F0.6200.19
159_S210_T0.6190.19
159_S164_D0.6190.19
78_E107_D0.6130.19
218_H260_I0.6120.19
168_D279_L0.6120.19
9_L183_N0.6100.18
8_V218_H0.6090.18
88_L160_F0.6070.18
107_D192_D0.6070.18
21_F31_S0.6040.18
177_C196_L0.6020.18
84_K130_R0.6000.18
148_R215_N0.5990.18
35_I87_F0.5990.18
81_W195_Y0.5990.18
241_L271_V0.5990.18
121_Q131_G0.5960.18
129_S172_W0.5960.18
12_G155_S0.5940.18
128_L210_T0.5930.18
147_Q150_L0.5920.18
13_R190_F0.5920.18
191_G245_H0.5910.18
181_C275_Y0.5880.18
127_L273_E0.5870.18
84_K128_L0.5850.18
69_K242_I0.5850.18
71_K191_G0.5850.18
215_N220_N0.5830.18
105_D131_G0.5820.17
68_L153_Y0.5820.17
63_E132_D0.5820.17
94_S225_T0.5800.17
225_T278_T0.5770.17
129_S260_I0.5770.17
120_N211_T0.5770.17
205_N263_T0.5760.17
171_E229_K0.5760.17
74_R79_Y0.5750.17
76_Q81_W0.5750.17
6_C36_L0.5740.17
17_A21_F0.5720.17
216_I237_D0.5700.17
55_N75_D0.5700.17
144_D203_F0.5670.17
88_L103_Y0.5670.17
171_E264_T0.5670.17
107_D156_G0.5660.17
6_C9_L0.5650.17
107_D177_C0.5640.17
100_R159_S0.5640.17
69_K281_H0.5630.17
217_G243_F0.5610.17
194_G208_D0.5610.17
100_R126_V0.5610.17
254_I261_H0.5590.17
132_D147_Q0.5550.17
105_D217_G0.5540.17
197_D254_I0.5520.16
19_A109_F0.5520.16
52_K117_I0.5480.16
14_L112_A0.5470.16
38_M150_L0.5460.16
76_Q80_C0.5440.16
90_A94_S0.5440.16
121_Q130_R0.5420.16
128_L159_S0.5410.16
205_N237_D0.5410.16
179_E288_T0.5400.16
181_C193_Q0.5400.16
65_E161_K0.5380.16
56_L99_E0.5370.16
152_R157_F0.5360.16
35_I39_D0.5350.16
49_L52_K0.5350.16
181_C190_F0.5350.16
69_K268_L0.5330.16
231_G246_F0.5310.16
85_P288_T0.5290.16
189_K194_G0.5290.16
74_R181_C0.5280.16
51_M54_L0.5240.16
110_F114_P0.5240.16
74_R252_V0.5230.16
28_D114_P0.5220.16
257_I271_V0.5210.16
250_R254_I0.5200.15
30_D33_I0.5200.15
102_T141_E0.5180.15
156_G159_S0.5170.15
74_R132_D0.5160.15
33_I244_Y0.5160.15
76_Q196_L0.5130.15
14_L17_A0.5130.15
56_L111_Y0.5110.15
30_D243_F0.5110.15
15_Y130_R0.5110.15
13_R103_Y0.5090.15
165_A210_T0.5090.15
105_D193_Q0.5080.15
103_Y160_F0.5060.15
24_L181_C0.5050.15
103_Y192_D0.5050.15
98_L162_H0.5040.15
226_F237_D0.5030.15
231_G287_Q0.5030.15
167_T280_P0.5020.15
126_V195_Y0.5010.15
111_Y132_D0.5010.15
7_T12_G0.5010.15
9_L155_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tztA 2 0.7492 99.8 0.801 Contact Map
1g9rA 1 0.8614 99.8 0.812 Contact Map
4uegA 4 0.7888 99.6 0.836 Contact Map
1ll2A 2 0.7921 99.6 0.843 Contact Map
3u2uA 2 0.8053 99.5 0.845 Contact Map
2p6wA 1 0.6139 97.9 0.915 Contact Map
1xhbA 1 0.8746 65.7 0.961 Contact Map
4mixA 1 0.7426 48.6 0.964 Contact Map
3zf8A 2 0.7393 48 0.965 Contact Map
2d7iA 1 0.901 42.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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