GREMLIN Database
YFNE - Uncharacterized glycosyltransferase YfnE
UniProt: O06483 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (322)
Sequences: 693 (659)
Seq/√Len: 36.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A45_T5.2301.00
156_E160_K4.8391.00
27_E100_A4.4191.00
73_R89_D3.5971.00
7_I23_L3.5091.00
28_C31_E3.4961.00
73_R87_F3.4621.00
28_C103_I3.3611.00
17_Y51_S3.3551.00
18_N199_F3.0151.00
12_S90_S2.9211.00
11_N41_S2.8591.00
36_V49_L2.7001.00
86_I99_V2.6871.00
4_S82_G2.6541.00
23_L88_H2.5701.00
63_I72_G2.5611.00
7_I19_S2.5161.00
83_D107_E2.5001.00
46_L49_L2.4861.00
64_K67_R2.4781.00
21_L52_F2.4651.00
33_E82_G2.4611.00
4_S33_E2.4541.00
34_V59_I2.4291.00
16_L45_T2.4111.00
40_G58_L2.4051.00
3_A99_V2.3100.99
10_Y66_N2.2900.99
4_S80_A2.2560.99
28_C32_F2.2500.99
159_I177_D2.2480.99
13_K44_G2.1920.99
75_Q79_N2.1620.99
40_G59_I2.1620.99
40_G64_K2.1190.99
17_Y21_L2.1160.99
3_A103_I2.0640.99
3_A153_L1.9880.98
77_L85_L1.9800.98
38_D46_L1.9770.98
46_L63_I1.8870.98
70_A74_N1.8830.98
12_S201_I1.8800.98
58_L62_R1.8720.98
40_G62_R1.8550.98
44_G47_S1.8390.97
59_I62_R1.8300.97
38_D63_I1.8240.97
33_E80_A1.8110.97
32_F99_V1.8070.97
112_L116_G1.8070.97
67_R71_Y1.8010.97
100_A104_K1.7980.97
5_V23_L1.7550.97
73_R173_T1.7420.96
87_F173_T1.7240.96
97_D101_K1.7180.96
46_L50_E1.6620.95
40_G72_G1.6180.94
39_N66_N1.6130.94
6_I76_A1.6050.94
58_L64_K1.6020.94
9_A36_V1.5750.94
38_D41_S1.5640.93
201_I204_N1.5580.93
37_A72_G1.5540.93
6_I37_A1.5510.93
92_M174_D1.5470.93
7_I88_H1.5440.93
94_A98_L1.5390.93
101_K193_Y1.5320.93
11_N42_E1.5280.93
37_A76_A1.4980.92
59_I64_K1.4890.92
50_E63_I1.4810.91
3_A28_C1.4760.91
19_S93_L1.4570.91
61_T79_N1.4540.91
69_I173_T1.4520.91
166_D169_F1.4500.90
39_N89_D1.4090.89
31_E103_I1.3940.89
177_D181_K1.3880.88
36_V45_T1.3650.88
28_C83_D1.3600.87
157_A161_N1.3590.87
64_K71_Y1.3590.87
12_S15_R1.3460.87
13_K48_M1.3430.87
98_L102_H1.3420.87
20_L34_V1.3410.87
152_K173_T1.3360.86
16_L52_F1.3320.86
70_A73_R1.2930.85
95_A197_W1.2730.84
26_Q92_M1.2690.83
88_H94_A1.2670.83
39_N68_G1.2630.83
20_L24_N1.2580.83
102_H106_H1.2470.82
154_L178_V1.2450.82
89_D173_T1.2270.81
111_N116_G1.2180.81
9_A49_L1.2160.81
53_Q56_F1.2130.81
38_D62_R1.2090.80
21_L51_S1.1960.80
106_H153_L1.1940.79
24_N52_F1.1910.79
39_N72_G1.1820.79
158_D185_E1.1590.77
62_R75_Q1.1510.77
86_I98_L1.1390.76
8_P90_S1.1100.74
19_S94_A1.1030.74
88_H98_L1.1020.74
69_I73_R1.0990.73
16_L47_S1.0950.73
196_P199_F1.0850.73
80_A156_E1.0710.72
39_N73_R1.0630.71
70_A89_D1.0610.71
26_Q32_F1.0560.70
70_A173_T1.0530.70
9_A90_S1.0500.70
102_H153_L1.0470.70
45_T90_S1.0370.69
154_L181_K1.0340.69
70_A172_D1.0340.69
4_S7_I1.0320.69
23_L94_A1.0290.68
17_Y52_F1.0290.68
82_G85_L1.0260.68
112_L117_L1.0180.68
99_V153_L1.0170.68
159_I181_K1.0120.67
173_T196_P1.0110.67
113_V116_G1.0080.67
69_I169_F1.0060.67
103_I106_H1.0050.67
3_A102_H1.0040.66
77_L80_A1.0040.66
36_V46_L1.0030.66
314_Y317_L1.0010.66
40_G60_F1.0000.66
24_N56_F0.9970.66
37_A61_T0.9970.66
111_N114_V0.9900.65
11_N45_T0.9850.65
109_E189_D0.9810.65
105_A189_D0.9770.64
9_A16_L0.9720.64
105_A109_E0.9680.64
19_S88_H0.9660.63
165_L168_S0.9660.63
158_D181_K0.9650.63
69_I89_D0.9640.63
25_Q100_A0.9620.63
8_P73_R0.9600.63
28_C56_F0.9510.62
3_A26_Q0.9470.62
26_Q30_E0.9450.62
94_A196_P0.9440.62
64_K75_Q0.9420.61
16_L36_V0.9380.61
72_G89_D0.9370.61
312_Q317_L0.9360.61
84_I92_M0.9330.61
92_M196_P0.9330.61
19_S90_S0.9270.60
9_A12_S0.9260.60
58_L61_T0.9250.60
78_R187_G0.9240.60
69_I87_F0.9180.59
38_D66_N0.9160.59
45_T63_I0.9150.59
35_I61_T0.9130.59
76_A80_A0.9120.59
321_F324_L0.9110.59
10_Y39_N0.9100.59
19_S45_T0.9100.59
148_K151_Q0.9030.58
20_L36_V0.8990.58
48_M52_F0.8960.58
3_A27_E0.8960.58
324_L327_V0.8960.58
169_F172_D0.8890.57
181_K185_E0.8870.57
88_H196_P0.8840.57
115_C195_M0.8840.57
74_N77_L0.8830.56
49_L63_I0.8800.56
38_D69_I0.8800.56
6_I80_A0.8740.56
84_I91_D0.8740.56
94_A99_V0.8700.55
111_N117_L0.8630.55
37_A79_N0.8600.54
32_F56_F0.8570.54
67_R72_G0.8560.54
10_Y41_S0.8550.54
152_K185_E0.8430.53
86_I94_A0.8420.53
47_S50_E0.8390.53
164_F179_L0.8350.52
12_S66_N0.8290.52
7_I34_V0.8270.52
40_G61_T0.8240.51
150_K173_T0.8230.51
23_L36_V0.8190.51
202_T205_S0.8190.51
10_Y13_K0.8190.51
24_N34_V0.8180.51
43_D74_N0.8130.50
65_E85_L0.8090.50
6_I85_L0.8050.50
6_I77_L0.8030.49
18_N93_L0.8020.49
19_S106_H0.7990.49
312_Q321_F0.7970.49
19_S172_D0.7950.49
95_A195_M0.7950.49
317_L321_F0.7940.49
9_A38_D0.7900.48
58_L63_I0.7890.48
318_L322_L0.7880.48
119_W124_S0.7870.48
149_D152_K0.7860.48
149_D178_V0.7850.48
69_I149_D0.7770.47
64_K72_G0.7750.47
310_E317_L0.7740.47
37_A172_D0.7740.47
122_I127_Y0.7700.47
315_D318_L0.7690.46
83_D86_I0.7690.46
147_K175_F0.7670.46
49_L61_T0.7670.46
15_R84_I0.7660.46
72_G181_K0.7650.46
59_I63_I0.7640.46
20_L31_E0.7630.46
5_V139_A0.7610.46
34_V45_T0.7590.46
323_E327_V0.7580.46
150_K201_I0.7530.45
19_S34_V0.7530.45
12_S45_T0.7500.45
26_Q31_E0.7500.45
154_L159_I0.7440.44
209_R213_V0.7430.44
28_C99_V0.7370.44
169_F179_L0.7360.44
168_S172_D0.7330.43
106_H152_K0.7320.43
185_E188_D0.7310.43
36_V110_E0.7310.43
110_E155_E0.7300.43
269_N272_Y0.7250.43
112_L115_C0.7230.43
45_T48_M0.7220.42
41_S66_N0.7210.42
150_K154_L0.7200.42
4_S31_E0.7190.42
319_N322_L0.7180.42
16_L24_N0.7180.42
179_L185_E0.7160.42
26_Q100_A0.7140.42
8_P174_D0.7130.42
20_L52_F0.7110.41
235_R273_M0.7110.41
311_S318_L0.7100.41
23_L32_F0.7100.41
303_A306_Q0.7090.41
24_N32_F0.7080.41
42_E75_Q0.7040.41
322_L327_V0.7040.41
86_I153_L0.7020.41
10_Y45_T0.6950.40
38_D72_G0.6900.40
13_K66_N0.6890.40
92_M198_R0.6880.40
6_I128_E0.6860.39
69_I72_G0.6850.39
312_Q319_N0.6850.39
262_S285_V0.6840.39
20_L49_L0.6840.39
173_T201_I0.6830.39
39_N92_M0.6830.39
57_P161_N0.6810.39
40_G65_E0.6800.39
5_V99_V0.6790.39
3_A32_F0.6780.39
289_F311_S0.6780.39
58_L93_L0.6770.39
59_I67_R0.6760.39
37_A189_D0.6750.38
69_I205_S0.6710.38
74_N164_F0.6700.38
26_Q91_D0.6690.38
313_K322_L0.6690.38
160_K222_I0.6680.38
3_A19_S0.6670.38
172_D176_I0.6650.38
323_E326_H0.6650.38
165_L169_F0.6650.38
55_D59_I0.6640.38
99_V156_E0.6590.37
89_D92_M0.6570.37
39_N198_R0.6560.37
319_N324_L0.6540.37
114_V117_L0.6530.37
113_V117_L0.6520.37
87_F177_D0.6490.36
229_D234_I0.6490.36
69_I171_L0.6480.36
274_C283_L0.6470.36
69_I172_D0.6460.36
64_K68_G0.6450.36
45_T68_G0.6450.36
20_L23_L0.6440.36
134_H138_L0.6430.36
80_A154_L0.6430.36
123_Y158_D0.6410.36
15_R201_I0.6400.36
5_V17_Y0.6390.36
36_V73_R0.6370.35
15_R124_S0.6360.35
52_F55_D0.6360.35
105_A108_N0.6340.35
4_S85_L0.6300.35
92_M188_D0.6300.35
13_K45_T0.6270.35
25_Q242_T0.6270.35
87_F152_K0.6270.35
151_Q171_L0.6260.34
293_F298_T0.6230.34
83_D155_E0.6230.34
176_I180_K0.6230.34
12_S36_V0.6210.34
122_I126_Y0.6200.34
64_K198_R0.6190.34
172_D175_F0.6180.34
32_F103_I0.6180.34
3_A114_V0.6140.34
30_E56_F0.6110.33
54_A236_L0.6100.33
73_R152_K0.6090.33
50_E61_T0.6090.33
27_E32_F0.6080.33
10_Y91_D0.6060.33
51_S55_D0.6060.33
46_L61_T0.6050.33
81_R159_I0.6050.33
282_S300_R0.6050.33
9_A72_G0.6050.33
19_S22_S0.6010.33
48_M321_F0.6010.33
88_H99_V0.5970.32
26_Q206_S0.5960.32
4_S156_E0.5950.32
40_G66_N0.5950.32
72_G87_F0.5940.32
95_A98_L0.5930.32
88_H177_D0.5920.32
49_L59_I0.5910.32
158_D184_D0.5890.32
40_G74_N0.5880.32
308_L319_N0.5870.31
218_F253_H0.5870.31
53_Q63_I0.5860.31
70_A87_F0.5850.31
167_K177_D0.5850.31
111_N195_M0.5840.31
53_Q57_P0.5800.31
60_F64_K0.5780.31
70_A191_K0.5770.31
3_A58_L0.5770.31
314_Y321_F0.5760.31
55_D293_F0.5730.30
8_P72_G0.5710.30
41_S46_L0.5710.30
111_N115_C0.5700.30
314_Y319_N0.5700.30
74_N91_D0.5690.30
99_V187_G0.5680.30
135_K138_L0.5650.30
16_L124_S0.5650.30
12_S150_K0.5640.30
98_L161_N0.5620.30
16_L48_M0.5620.30
243_F246_R0.5620.30
11_N43_D0.5620.30
34_V121_R0.5610.30
11_N38_D0.5610.30
89_D152_K0.5590.29
13_K230_Y0.5590.29
80_A85_L0.5580.29
142_T145_M0.5580.29
69_I90_S0.5570.29
320_L325_L0.5570.29
148_K198_R0.5550.29
312_Q316_M0.5550.29
28_C106_H0.5550.29
281_R287_L0.5530.29
75_Q78_R0.5530.29
231_D286_H0.5530.29
309_L314_Y0.5520.29
70_A169_F0.5520.29
159_I172_D0.5500.29
139_A236_L0.5480.29
154_L177_D0.5470.28
35_I59_I0.5460.28
12_S88_H0.5460.28
33_E60_F0.5450.28
103_I107_E0.5450.28
19_S84_I0.5450.28
10_Y43_D0.5450.28
201_I205_S0.5450.28
318_L323_E0.5440.28
20_L100_A0.5410.28
9_A89_D0.5410.28
94_A173_T0.5390.28
84_I103_I0.5380.28
63_I75_Q0.5360.28
9_A73_R0.5360.28
24_N59_I0.5350.28
13_K43_D0.5340.28
177_D180_K0.5320.27
281_R284_D0.5300.27
23_L76_A0.5300.27
272_Y279_N0.5300.27
87_F205_S0.5300.27
41_S49_L0.5300.27
74_N177_D0.5280.27
257_P303_A0.5280.27
140_K302_M0.5260.27
182_I206_S0.5250.27
4_S81_R0.5250.27
108_N284_D0.5250.27
52_F309_L0.5240.27
281_R293_F0.5230.27
167_K172_D0.5230.27
34_V141_L0.5220.27
312_Q315_D0.5220.27
106_H194_H0.5220.27
28_C93_L0.5210.27
318_L327_V0.5190.27
26_Q174_D0.5180.26
58_L72_G0.5160.26
13_K54_A0.5150.26
147_K153_L0.5140.26
99_V151_Q0.5140.26
16_L90_S0.5140.26
20_L204_N0.5140.26
124_S204_N0.5130.26
41_S45_T0.5120.26
177_D188_D0.5120.26
35_I80_A0.5120.26
155_E170_D0.5110.26
124_S306_Q0.5100.26
28_C98_L0.5100.26
30_E219_D0.5090.26
15_R45_T0.5090.26
312_Q318_L0.5090.26
102_H179_L0.5060.26
32_F81_R0.5060.26
106_H185_E0.5050.26
289_F305_I0.5040.26
279_N300_R0.5040.26
10_Y68_G0.5040.26
104_K111_N0.5040.26
85_L154_L0.5030.25
285_V301_I0.5030.25
15_R174_D0.5030.25
177_D317_L0.5030.25
167_K171_L0.5020.25
7_I167_K0.5010.25
311_S321_F0.5010.25
271_A277_Y0.5000.25
23_L27_E0.5000.25
210_K213_V0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.4464 100 0.513 Contact Map
3l7iA 4 0.1658 100 0.539 Contact Map
1qg8A 1 0.5561 100 0.553 Contact Map
2d7iA 1 0.8469 100 0.556 Contact Map
1xhbA 1 0.8827 100 0.559 Contact Map
2z86A 2 0.6301 100 0.565 Contact Map
5ajoA 1 0.8929 100 0.576 Contact Map
4fixA 3 0.8903 100 0.635 Contact Map
3ckjA 2 0.6403 100 0.646 Contact Map
2nxvA 4 0.5816 100 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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