GREMLIN Database
YFNB - Putative HAD-hydrolase YfnB
UniProt: O06480 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (201)
Sequences: 28983 (22878)
Seq/√Len: 1613.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_R175_H4.2161.00
134_R139_F2.8631.00
163_Y167_R2.8581.00
153_F157_M2.7871.00
180_G186_D2.6051.00
190_G197_T2.5571.00
126_S130_Y2.4381.00
110_S141_F2.3701.00
106_F110_S2.3281.00
6_T171_F2.3181.00
4_Y196_D2.3131.00
117_D143_K2.2591.00
122_T129_Q2.2461.00
163_Y166_E2.2151.00
126_S150_D2.1981.00
119_Y144_D2.1701.00
191_Q214_T2.1161.00
165_F176_T2.1061.00
218_R222_E2.0411.00
121_V160_Y2.0341.00
153_F159_E2.0061.00
9_F118_L1.9391.00
144_D167_R1.9291.00
172_S175_H1.8851.00
187_I197_T1.8771.00
188_K192_L1.8161.00
7_L116_F1.7591.00
196_D214_T1.7221.00
113_Q143_K1.6911.00
165_F195_L1.6641.00
113_Q141_F1.6601.00
8_L178_I1.6451.00
177_L198_C1.6131.00
111_N224_Y1.5991.00
111_N115_Q1.5851.00
105_A220_L1.5821.00
118_L142_F1.5721.00
178_I190_G1.5701.00
32_D90_K1.5531.00
4_Y177_L1.5441.00
8_L121_V1.4981.00
171_F176_T1.4851.00
201_N218_R1.4781.00
165_F173_A1.4711.00
6_T168_I1.4641.00
8_L164_V1.4611.00
7_L112_L1.3901.00
7_L179_I1.3871.00
198_C217_I1.3541.00
102_I202_P1.3521.00
130_Y139_F1.3431.00
108_L220_L1.3421.00
219_K222_E1.3371.00
119_Y168_I1.3271.00
111_N114_Q1.3251.00
46_K49_N1.3231.00
86_L90_K1.3151.00
32_D86_L1.3131.00
91_Y95_L1.2841.00
108_L224_Y1.2841.00
28_L32_D1.2521.00
90_K93_R1.2511.00
11_V16_L1.2481.00
130_Y134_R1.2351.00
201_N216_E1.2331.00
14_T179_I1.2271.00
198_C215_Y1.2261.00
90_K94_F1.2131.00
104_G107_D1.2021.00
15_I105_A1.1981.00
158_K162_N1.1931.00
146_F167_R1.1911.00
88_E92_R1.1871.00
11_V120_I1.1841.00
28_L90_K1.1831.00
8_L176_T1.1811.00
69_T72_S1.1451.00
87_L95_L1.1451.00
11_V129_Q1.1251.00
161_F178_I1.1231.00
129_Q147_V1.1191.00
87_L91_Y1.1161.00
28_L94_F1.1101.00
176_T195_L1.1021.00
86_L89_Q1.0991.00
107_D221_E1.0981.00
146_F164_V1.0951.00
161_F189_G1.0951.00
101_L138_L1.0841.00
89_Q93_R1.0641.00
12_D18_F1.0621.00
162_N166_E1.0581.00
85_A89_Q1.0491.00
29_L33_Q1.0451.00
39_N43_A1.0441.00
6_T117_D1.0391.00
161_F195_L1.0341.00
110_S114_Q1.0261.00
120_I142_F1.0161.00
121_V164_V1.0141.00
113_Q118_L1.0031.00
126_S147_V0.9971.00
191_Q197_T0.9961.00
137_G140_P0.9961.00
6_T176_T0.9951.00
109_I142_F0.9931.00
24_L27_R0.9881.00
159_E163_Y0.9821.00
44_Q47_T0.9691.00
11_V124_G0.9671.00
24_L28_L0.9651.00
28_L31_E0.9631.00
76_K79_G0.9541.00
187_I213_P0.9521.00
27_R31_E0.9491.00
40_D44_Q0.9461.00
164_V168_I0.9391.00
106_F141_F0.9281.00
72_S76_K0.9261.00
131_K135_D0.9241.00
84_G88_E0.9241.00
79_G82_A0.9231.00
161_F180_G0.9211.00
144_D168_I0.9181.00
159_E162_N0.9181.00
24_L98_G0.9001.00
69_T73_A0.8981.00
12_D124_G0.8981.00
110_S140_P0.8951.00
162_N193_A0.8931.00
33_Q86_L0.8901.00
107_D110_S0.8871.00
178_I195_L0.8821.00
151_T163_Y0.8801.00
8_L168_I0.8771.00
122_T147_V0.8741.00
196_D215_Y0.8661.00
6_T119_Y0.8641.00
129_Q132_R0.8601.00
126_S149_E0.8591.00
68_N72_S0.8581.00
104_G219_K0.8521.00
131_K134_R0.8521.00
185_A188_K0.8521.00
162_N173_A0.8481.00
96_E131_K0.8451.00
217_I223_L0.8451.00
109_I141_F0.8431.00
73_A76_K0.8351.00
101_L106_F0.8301.00
191_Q212_I0.8281.00
152_G159_E0.8281.00
173_A195_L0.8261.00
41_M46_K0.8251.00
30_F35_I0.8241.00
8_L195_L0.8221.00
189_G193_A0.8131.00
177_L196_D0.8091.00
12_D122_T0.8091.00
112_L116_F0.8081.00
179_I198_C0.8061.00
168_I171_F0.8051.00
146_F163_Y0.8031.00
38_T41_M0.7921.00
102_I105_A0.7921.00
102_I200_M0.7901.00
118_L141_F0.7871.00
23_A27_R0.7861.00
119_Y164_V0.7851.00
12_D181_D0.7811.00
39_N42_K0.7761.00
85_A88_E0.7761.00
7_L177_L0.7731.00
11_V132_R0.7711.00
112_L118_L0.7691.00
106_F137_G0.7691.00
197_T214_T0.7611.00
87_L90_K0.7581.00
171_F175_H0.7561.00
4_Y116_F0.7551.00
147_V150_D0.7541.00
182_S185_A0.7511.00
46_K50_Q0.7501.00
45_Y48_I0.7501.00
199_W216_E0.7491.00
160_Y164_V0.7481.00
16_L132_R0.7431.00
5_R116_F0.7381.00
42_K45_Y0.7361.00
4_Y175_H0.7331.00
42_K46_K0.7311.00
16_L136_S0.7291.00
178_I186_D0.7281.00
42_K48_I0.7221.00
25_A29_L0.7211.00
5_R117_D0.7191.00
79_G83_D0.7191.00
14_T186_D0.7181.00
101_L136_S0.7171.00
106_F140_P0.7141.00
75_L78_Y0.7131.00
208_V212_I0.7101.00
161_F186_D0.7091.00
187_I199_W0.7081.00
123_N154_Q0.7071.00
150_D167_R0.7061.00
124_G129_Q0.7041.00
40_D43_A0.7021.00
70_R74_L0.6971.00
104_G221_E0.6951.00
202_P220_L0.6921.00
5_R171_F0.6891.00
198_C223_L0.6841.00
93_R96_E0.6841.00
179_I223_L0.6821.00
118_L143_K0.6811.00
31_E36_P0.6771.00
91_Y94_F0.6721.00
44_Q48_I0.6661.00
41_M48_I0.6651.00
41_M44_Q0.6581.00
129_Q145_I0.6571.00
20_A100_Q0.6561.00
151_T160_Y0.6531.00
8_L119_Y0.6521.00
107_D111_N0.6511.00
160_Y189_G0.6501.00
188_K191_Q0.6491.00
73_A77_E0.6481.00
89_Q92_R0.6411.00
133_L139_F0.6411.00
217_I220_L0.6411.00
22_E26_L0.6411.00
75_L80_Y0.6391.00
158_K192_L0.6351.00
208_V211_I0.6331.00
45_Y49_N0.6281.00
144_D164_V0.6251.00
71_F75_L0.6241.00
130_Y145_I0.6211.00
123_N185_A0.6201.00
217_I224_Y0.6191.00
22_E124_G0.6191.00
17_D100_Q0.6191.00
92_R95_L0.6181.00
71_F74_L0.6181.00
121_V178_I0.6161.00
104_G108_L0.6161.00
13_D19_Q0.6141.00
146_F160_Y0.6141.00
200_M220_L0.6131.00
12_D132_R0.6111.00
117_D171_F0.6101.00
21_A99_H0.6081.00
148_S160_Y0.6031.00
123_N156_P0.6001.00
88_E95_L0.5991.00
17_D20_A0.5991.00
220_L224_Y0.5971.00
173_A176_T0.5911.00
24_L94_F0.5881.00
42_K49_N0.5831.00
16_L99_H0.5811.00
207_N210_E0.5781.00
43_A47_T0.5751.00
84_G87_L0.5731.00
108_L179_I0.5721.00
9_F108_L0.5691.00
165_F171_F0.5671.00
110_S113_Q0.5641.00
113_Q140_P0.5621.00
162_N165_F0.5611.00
221_E224_Y0.5611.00
92_R96_E0.5611.00
165_F193_A0.5581.00
142_F145_I0.5581.00
201_N206_P0.5571.00
185_A189_G0.5551.00
178_I189_G0.5541.00
199_W213_P0.5541.00
8_L161_F0.5531.00
104_G202_P0.5511.00
124_G180_G0.5481.00
41_M45_Y0.5451.00
108_L112_L0.5441.00
121_V146_F0.5431.00
70_R73_A0.5421.00
18_F124_G0.5421.00
134_R140_P0.5331.00
76_K80_Y0.5301.00
22_E87_L0.5291.00
14_T200_M0.5281.00
7_L118_L0.5261.00
44_Q77_E0.5201.00
103_D221_E0.5201.00
88_E91_Y0.5181.00
199_W208_V0.5181.00
161_F190_G0.5111.00
133_L138_L0.5091.00
105_A108_L0.5041.00
190_G193_A0.5021.00
87_L94_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ed5A 1 0.9872 100 0.26 Contact Map
3iruA 4 0.9872 100 0.304 Contact Map
1swvA 2 0.966 100 0.311 Contact Map
2om6A 2 0.9617 100 0.319 Contact Map
3qnmA 1 0.9574 100 0.322 Contact Map
3l5kA 1 0.9149 100 0.325 Contact Map
4uw9A 1 0.8511 100 0.327 Contact Map
2fdrA 1 0.8894 100 0.332 Contact Map
2no4A 4 0.9489 100 0.335 Contact Map
1zrnA 2 0.9277 100 0.336 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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