GREMLIN Database
ALDH5 - Putative aldehyde dehydrogenase YfmT
UniProt: O06478 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (449)
Sequences: 36327 (21745)
Seq/√Len: 1026.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
297_S393_D5.0471.00
241_Q245_K3.9601.00
297_S391_K3.1851.00
269_E306_L3.1251.00
300_Y391_K2.9491.00
26_E38_T2.8181.00
357_G364_E2.8101.00
55_A223_V2.7791.00
264_E296_H2.7501.00
372_K375_M2.6891.00
273_N310_K2.5901.00
344_Q376_S2.5881.00
332_S336_D2.5841.00
343_E347_E2.5301.00
304_L389_F2.5071.00
189_L192_K2.4851.00
264_E298_S2.4641.00
83_N86_A2.4291.00
81_E114_K2.4111.00
415_T421_G2.3401.00
26_E35_T2.3361.00
195_E201_A2.2611.00
342_V363_V2.2461.00
55_A225_R2.2221.00
43_T46_D2.2051.00
339_M343_E2.1401.00
84_E107_G2.1361.00
79_Y196_N2.0851.00
216_D220_E2.0461.00
395_E420_R2.0401.00
406_P453_Q2.0401.00
142_V472_K2.0201.00
220_E242_L2.0131.00
351_V370_D2.0061.00
181_E331_N2.0021.00
76_A194_F1.9961.00
329_L338_L1.9481.00
344_Q348_E1.9431.00
339_M363_V1.9371.00
308_Q312_E1.9351.00
260_F275_A1.9321.00
353_V369_K1.9071.00
141_R466_E1.9001.00
423_A427_R1.8961.00
302_K306_L1.8841.00
346_I352_P1.8741.00
48_D217_S1.8661.00
72_I199_I1.8631.00
238_Y241_Q1.8161.00
265_D420_R1.8131.00
52_R223_V1.8001.00
237_S453_Q1.7951.00
86_A189_L1.7791.00
294_L401_I1.7771.00
210_D213_E1.7671.00
79_Y82_E1.7521.00
85_E103_A1.7441.00
141_R469_T1.7431.00
83_N196_N1.7401.00
429_E452_K1.7351.00
378_A390_M1.7101.00
368_L377_I1.6831.00
48_D52_R1.6781.00
296_H392_F1.6581.00
395_E423_A1.6541.00
35_T38_T1.6521.00
373_P401_I1.6501.00
311_V367_I1.6401.00
351_V369_K1.6331.00
308_Q353_V1.6211.00
397_E400_D1.6181.00
294_L398_A1.6111.00
74_E114_K1.6091.00
393_D397_E1.5831.00
79_Y197_A1.5771.00
300_Y304_L1.5741.00
275_A303_F1.5681.00
81_E110_K1.5601.00
305_E309_A1.5581.00
113_I165_A1.5521.00
280_F311_V1.5511.00
58_K62_D1.5471.00
340_K376_S1.5421.00
65_N68_E1.5401.00
192_K196_N1.5391.00
78_T82_E1.5391.00
332_S361_T1.5381.00
376_S380_E1.5381.00
191_A206_V1.5381.00
79_Y193_I1.5291.00
306_L309_A1.5271.00
268_I306_L1.5191.00
173_G203_L1.5151.00
48_D221_H1.5141.00
272_V306_L1.4881.00
75_K78_T1.4841.00
24_V38_T1.4831.00
68_E71_T1.4631.00
293_V387_V1.4631.00
301_D391_K1.4611.00
263_L420_R1.4491.00
63_A427_R1.4401.00
90_L189_L1.4351.00
74_E121_I1.4321.00
294_L392_F1.4311.00
33_Q359_N1.4291.00
300_Y369_K1.4281.00
89_Y93_E1.4231.00
274_A414_H1.4201.00
77_V114_K1.4131.00
302_K305_E1.4071.00
264_E420_R1.4051.00
352_P368_L1.4021.00
275_A293_V1.4021.00
85_E89_Y1.3991.00
295_V303_F1.3981.00
310_K313_S1.3971.00
411_G430_T1.3871.00
64_V68_E1.3871.00
140_Y426_K1.3871.00
396_D427_R1.3861.00
343_E346_I1.3831.00
397_E401_I1.3791.00
28_K35_T1.3671.00
119_F122_R1.3641.00
78_T114_K1.3571.00
113_I161_M1.3551.00
46_D49_E1.3481.00
149_V174_V1.3441.00
338_L384_G1.3351.00
240_G456_L1.3321.00
315_K323_D1.3301.00
23_N41_K1.3301.00
89_Y320_M1.3221.00
92_M102_A1.3161.00
341_T382_L1.3161.00
34_K359_N1.3111.00
216_D242_L1.3041.00
263_L392_F1.3041.00
226_I251_L1.3031.00
335_T363_V1.2981.00
83_N189_L1.2921.00
335_T339_M1.2881.00
392_F401_I1.2791.00
336_D340_K1.2791.00
29_N32_T1.2781.00
348_E376_S1.2661.00
160_S176_L1.2631.00
263_L424_F1.2621.00
301_D305_E1.2611.00
220_E245_K1.2571.00
58_K173_G1.2571.00
309_A312_E1.2521.00
394_S397_E1.2471.00
99_R103_A1.2451.00
304_L308_Q1.2441.00
332_S335_T1.2411.00
191_A204_L1.2361.00
312_E354_K1.2331.00
180_E210_D1.2271.00
51_Y221_H1.2231.00
261_I398_A1.2231.00
399_V424_F1.2111.00
296_H394_S1.2071.00
77_V81_E1.2051.00
44_A217_S1.2051.00
299_I302_K1.1931.00
374_F379_K1.1911.00
463_W466_E1.1911.00
296_H299_I1.1821.00
315_K325_I1.1801.00
350_A368_L1.1801.00
141_R471_L1.1781.00
52_R56_L1.1771.00
51_Y223_V1.1751.00
306_L310_K1.1741.00
340_K344_Q1.1731.00
216_D238_Y1.1711.00
462_E466_E1.1691.00
138_R422_V1.1691.00
89_Y99_R1.1671.00
202_G205_N1.1631.00
47_V214_I1.1601.00
317_G324_T1.1541.00
373_P404_E1.1431.00
92_M319_P1.1421.00
64_V72_I1.1421.00
304_L369_K1.1411.00
307_Y387_V1.1321.00
425_A474_I1.1321.00
51_Y224_P1.1301.00
303_F307_Y1.1251.00
194_F204_L1.1231.00
411_G433_I1.1221.00
421_G435_V1.1111.00
126_K462_E1.1111.00
75_K79_Y1.1061.00
396_D423_A1.1051.00
53_A205_N1.1051.00
238_Y242_L1.1041.00
304_L353_V1.1041.00
449_G458_R1.1041.00
345_A368_L1.1031.00
309_A313_S1.1001.00
144_A226_I1.0991.00
318_D321_D1.0941.00
74_E118_T1.0931.00
235_V238_Y1.0841.00
379_K406_P1.0831.00
234_K238_Y1.0831.00
164_V204_L1.0831.00
84_E103_A1.0821.00
396_D400_D1.0791.00
76_A199_I1.0791.00
25_L41_K1.0781.00
76_A193_I1.0771.00
180_E212_A1.0691.00
188_T208_V1.0691.00
379_K404_E1.0671.00
260_F290_A1.0631.00
31_Y319_P1.0611.00
29_N318_D1.0601.00
37_T184_I1.0591.00
149_V228_S1.0591.00
240_G250_P1.0571.00
442_D445_N1.0561.00
312_E364_E1.0551.00
463_W471_L1.0541.00
217_S221_H1.0541.00
267_D416_S1.0531.00
148_G218_F1.0511.00
261_I424_F1.0511.00
335_T361_T1.0501.00
76_A113_I1.0501.00
399_V427_R1.0471.00
458_R470_T1.0451.00
87_I189_L1.0381.00
148_G224_P1.0341.00
417_N420_R1.0341.00
164_V174_V1.0321.00
355_L364_E1.0261.00
237_S247_F1.0241.00
126_K463_W1.0231.00
308_Q354_K1.0221.00
261_I402_A1.0181.00
41_K210_D1.0151.00
155_F286_I1.0151.00
41_K213_E1.0091.00
60_K64_V1.0071.00
392_F398_A1.0051.00
314_L326_I1.0031.00
355_L366_T0.9981.00
33_Q361_T0.9961.00
257_N291_N0.9961.00
348_E375_M0.9941.00
70_R121_I0.9941.00
192_K195_E0.9881.00
82_E196_N0.9881.00
395_E424_F0.9871.00
267_D270_Y0.9871.00
338_L386_V0.9811.00
59_K400_D0.9761.00
120_P169_G0.9721.00
57_A173_G0.9721.00
191_A195_E0.9721.00
83_N192_K0.9701.00
44_A213_E0.9691.00
59_K429_E0.9671.00
109_V161_M0.9661.00
140_Y474_I0.9621.00
146_V173_G0.9591.00
451_E470_T0.9561.00
55_A59_K0.9521.00
144_A249_K0.9501.00
259_A411_G0.9491.00
86_A89_Y0.9471.00
270_Y274_A0.9441.00
371_V375_M0.9411.00
240_G244_M0.9391.00
412_A438_T0.9351.00
93_E320_M0.9321.00
344_Q347_E0.9301.00
276_V310_K0.9301.00
400_D404_E0.9261.00
269_E302_K0.9261.00
74_E117_A0.9261.00
29_N93_E0.9251.00
87_I193_I0.9221.00
341_T344_Q0.9211.00
44_A48_D0.9211.00
278_S290_A0.9201.00
83_N193_I0.9171.00
188_T206_V0.9151.00
340_K343_E0.9091.00
137_N446_V0.9061.00
279_R291_N0.9021.00
142_V426_K0.9011.00
225_R429_E0.8991.00
147_V226_I0.8991.00
79_Y83_N0.8991.00
422_V426_K0.8971.00
142_V451_E0.8901.00
260_F414_H0.8851.00
71_T75_K0.8831.00
59_K63_A0.8831.00
70_R74_E0.8811.00
346_I368_L0.8811.00
97_G105_E0.8801.00
146_V224_P0.8791.00
268_I272_V0.8791.00
29_N34_K0.8791.00
301_D304_L0.8791.00
95_L182_T0.8781.00
300_Y389_F0.8781.00
62_D429_E0.8771.00
66_P70_R0.8751.00
47_V148_G0.8721.00
263_L395_E0.8701.00
237_S241_Q0.8681.00
390_M401_I0.8671.00
350_A375_M0.8651.00
341_T376_S0.8651.00
49_E53_A0.8641.00
28_K361_T0.8641.00
109_V157_F0.8631.00
263_L415_T0.8621.00
232_S235_V0.8611.00
272_V307_Y0.8601.00
240_G243_A0.8591.00
181_E333_R0.8571.00
31_Y362_I0.8571.00
356_G366_T0.8501.00
373_P390_M0.8501.00
188_T192_K0.8451.00
338_L382_L0.8421.00
249_K470_T0.8411.00
272_V310_K0.8401.00
80_I109_V0.8401.00
163_S459_L0.8391.00
446_V473_W0.8381.00
25_L210_D0.8381.00
77_V117_A0.8351.00
411_G428_I0.8341.00
240_G247_F0.8321.00
227_I243_A0.8311.00
70_R117_A0.8211.00
63_A426_K0.8201.00
418_L421_G0.8191.00
166_P464_S0.8181.00
170_A469_T0.8171.00
144_A470_T0.8171.00
45_D48_D0.8141.00
176_L186_G0.8121.00
60_K63_A0.8091.00
57_A203_L0.8091.00
413_V424_F0.8081.00
45_D49_E0.8051.00
398_A401_I0.8051.00
272_V303_F0.8041.00
271_A275_A0.8041.00
212_A216_D0.8011.00
236_G254_L0.8001.00
336_D339_M0.7991.00
305_E308_Q0.7991.00
144_A172_N0.7971.00
392_F397_E0.7971.00
42_A46_D0.7961.00
262_V303_F0.7961.00
54_A205_N0.7961.00
227_I239_I0.7951.00
369_K391_K0.7951.00
399_V403_N0.7931.00
49_E52_R0.7931.00
167_A174_V0.7901.00
160_S164_V0.7891.00
219_V239_I0.7881.00
349_G375_M0.7881.00
61_W203_L0.7831.00
53_A202_G0.7811.00
430_T433_I0.7801.00
178_P208_V0.7771.00
56_L59_K0.7761.00
209_T214_I0.7721.00
342_V386_V0.7701.00
67_F121_I0.7691.00
74_E78_T0.7681.00
88_I103_A0.7671.00
100_L325_I0.7671.00
36_F93_E0.7631.00
333_R336_D0.7621.00
236_G252_L0.7621.00
95_L330_I0.7611.00
258_S291_N0.7601.00
307_Y367_I0.7601.00
338_L363_V0.7591.00
300_Y370_D0.7581.00
199_I204_L0.7581.00
219_V242_L0.7561.00
199_I203_L0.7541.00
161_M190_I0.7541.00
73_L169_G0.7521.00
229_F235_V0.7491.00
103_A107_G0.7481.00
92_M99_R0.7471.00
80_I110_K0.7471.00
93_E184_I0.7471.00
148_G227_I0.7451.00
81_E84_E0.7451.00
42_A50_A0.7441.00
268_I299_I0.7401.00
259_A402_A0.7391.00
157_F185_C0.7391.00
29_N320_M0.7371.00
233_T453_Q0.7361.00
237_S245_K0.7351.00
99_R320_M0.7341.00
271_A303_F0.7301.00
314_L325_I0.7291.00
243_A250_P0.7291.00
296_H395_E0.7281.00
149_V163_S0.7271.00
272_V276_V0.7261.00
81_E107_G0.7241.00
88_I92_M0.7241.00
311_V354_K0.7241.00
72_I197_A0.7171.00
219_V227_I0.7161.00
88_I99_R0.7151.00
341_T380_E0.7141.00
321_D324_T0.7131.00
75_K197_A0.7131.00
269_E310_K0.7121.00
137_N473_W0.7091.00
59_K62_D0.7031.00
295_V299_I0.7031.00
23_N213_E0.7031.00
242_L245_K0.7001.00
276_V307_Y0.7001.00
346_I357_G0.6991.00
61_W72_I0.6991.00
144_A225_R0.6971.00
160_S186_G0.6951.00
308_Q311_V0.6941.00
241_Q244_M0.6931.00
181_E330_I0.6911.00
217_S220_E0.6891.00
54_A173_G0.6881.00
28_K33_Q0.6861.00
176_L204_L0.6841.00
86_A192_K0.6831.00
263_L296_H0.6821.00
55_A58_K0.6811.00
47_V217_S0.6801.00
416_S419_E0.6791.00
90_L184_I0.6781.00
189_L193_I0.6761.00
172_N469_T0.6741.00
345_A382_L0.6711.00
148_G215_G0.6701.00
151_S160_S0.6701.00
57_A60_K0.6691.00
331_N334_Q0.6691.00
394_S400_D0.6691.00
283_Q326_I0.6681.00
294_L378_A0.6661.00
425_A435_V0.6651.00
78_T81_E0.6641.00
311_V314_L0.6631.00
47_V51_Y0.6631.00
24_V40_R0.6621.00
61_W168_L0.6621.00
66_P120_P0.6621.00
337_G340_K0.6611.00
91_I94_E0.6611.00
316_V326_I0.6601.00
249_K467_E0.6581.00
334_Q337_G0.6581.00
62_D427_R0.6541.00
276_V314_L0.6531.00
418_L422_V0.6531.00
294_L373_P0.6531.00
33_Q332_S0.6491.00
212_A238_Y0.6491.00
137_N475_S0.6491.00
373_P378_A0.6481.00
318_D324_T0.6481.00
466_E469_T0.6471.00
77_V110_K0.6451.00
395_E399_V0.6441.00
59_K427_R0.6421.00
48_D223_V0.6421.00
293_V303_F0.6401.00
429_E451_E0.6401.00
136_E422_V0.6391.00
275_A307_Y0.6391.00
53_A201_A0.6371.00
415_T420_R0.6361.00
97_G101_K0.6361.00
85_E99_R0.6361.00
401_I404_E0.6361.00
265_D415_T0.6351.00
466_E471_L0.6351.00
363_V366_T0.6351.00
262_V271_A0.6341.00
356_G364_E0.6341.00
270_Y273_N0.6331.00
333_R337_G0.6321.00
68_E72_I0.6321.00
123_M469_T0.6321.00
190_I194_F0.6311.00
175_V205_N0.6311.00
307_Y389_F0.6281.00
40_R208_V0.6281.00
251_L467_E0.6271.00
140_Y472_K0.6261.00
270_Y416_S0.6251.00
106_I110_K0.6231.00
138_R474_I0.6221.00
160_S190_I0.6221.00
180_E337_G0.6201.00
84_E88_I0.6191.00
62_D143_P0.6191.00
87_I157_F0.6181.00
421_G425_A0.6181.00
268_I302_K0.6181.00
213_E216_D0.6151.00
342_V368_L0.6131.00
194_F199_I0.6131.00
265_D416_S0.6131.00
50_A207_V0.6111.00
97_G155_F0.6081.00
92_M320_M0.6081.00
62_D142_V0.6081.00
27_N37_T0.6061.00
354_K367_I0.6051.00
288_M442_D0.6051.00
180_E238_Y0.6041.00
339_M342_V0.6041.00
163_S228_S0.6041.00
79_Y198_G0.6021.00
52_R55_A0.6021.00
371_V378_A0.6021.00
123_M465_L0.6011.00
91_I185_C0.6011.00
27_N94_E0.6001.00
265_D417_N0.5991.00
399_V423_A0.5981.00
348_E374_F0.5961.00
164_V176_L0.5961.00
39_F183_P0.5951.00
91_I105_E0.5951.00
66_P169_G0.5951.00
419_E422_V0.5941.00
44_A220_E0.5921.00
42_A207_V0.5901.00
209_T215_G0.5891.00
278_S438_T0.5881.00
240_G252_L0.5881.00
382_L386_V0.5861.00
341_T345_A0.5861.00
80_I113_I0.5851.00
419_E423_A0.5851.00
91_I102_A0.5851.00
147_V172_N0.5851.00
89_Y92_M0.5821.00
173_G205_N0.5791.00
279_R387_V0.5771.00
342_V366_T0.5771.00
413_V421_G0.5771.00
308_Q367_I0.5761.00
36_F184_I0.5751.00
103_A322_P0.5751.00
115_E119_F0.5741.00
72_I198_G0.5731.00
339_M346_I0.5731.00
371_V377_I0.5731.00
226_I467_E0.5721.00
295_V300_Y0.5721.00
329_L334_Q0.5711.00
118_T121_I0.5701.00
370_D391_K0.5691.00
80_I157_F0.5681.00
432_M441_N0.5671.00
413_V435_V0.5661.00
215_G219_V0.5661.00
295_V389_F0.5641.00
269_E309_A0.5631.00
260_F293_V0.5611.00
233_T237_S0.5601.00
157_F190_I0.5561.00
398_A402_A0.5561.00
106_I157_F0.5561.00
260_F412_A0.5531.00
88_I106_I0.5531.00
433_I472_K0.5521.00
373_P400_D0.5501.00
352_P366_T0.5501.00
399_V428_I0.5491.00
286_I289_S0.5481.00
23_N43_T0.5481.00
54_A175_V0.5481.00
77_V113_I0.5481.00
402_A428_I0.5481.00
268_I303_F0.5481.00
268_I271_A0.5471.00
66_P124_E0.5461.00
55_A146_V0.5461.00
219_V246_H0.5461.00
53_A57_A0.5461.00
56_L60_K0.5451.00
352_P355_L0.5451.00
146_V225_R0.5451.00
80_I190_I0.5451.00
368_L371_V0.5441.00
195_E198_G0.5441.00
87_I106_I0.5431.00
353_V370_D0.5431.00
170_A465_L0.5431.00
168_L204_L0.5421.00
348_E372_K0.5421.00
107_G110_K0.5421.00
76_A79_Y0.5401.00
264_E392_F0.5401.00
50_A205_N0.5381.00
258_S410_S0.5381.00
147_V174_V0.5361.00
67_F71_T0.5351.00
293_V389_F0.5351.00
228_S468_F0.5341.00
80_I87_I0.5331.00
250_P456_L0.5321.00
329_L363_V0.5321.00
149_V164_V0.5301.00
434_H437_D0.5301.00
234_K333_R0.5291.00
395_E427_R0.5291.00
108_L158_F0.5291.00
116_A166_P0.5281.00
71_T74_E0.5281.00
346_I349_G0.5271.00
162_K460_N0.5261.00
352_P356_G0.5251.00
105_E155_F0.5241.00
266_A271_A0.5241.00
280_F314_L0.5241.00
119_F462_E0.5241.00
317_G321_D0.5241.00
158_F162_K0.5231.00
180_E234_K0.5231.00
27_N183_P0.5221.00
297_S300_Y0.5201.00
424_F428_I0.5191.00
60_K173_G0.5191.00
377_I382_L0.5191.00
72_I76_A0.5181.00
54_A146_V0.5171.00
429_E470_T0.5171.00
168_L199_I0.5161.00
272_V299_I0.5151.00
95_L282_H0.5141.00
75_K198_G0.5141.00
39_F184_I0.5111.00
290_A412_A0.5111.00
142_V429_E0.5101.00
411_G424_F0.5081.00
400_D427_R0.5071.00
337_G341_T0.5071.00
112_I460_N0.5061.00
27_N36_F0.5051.00
23_N210_D0.5041.00
84_E110_K0.5041.00
316_V325_I0.5021.00
282_H286_I0.5001.00
273_N277_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a4sA 4 0.9918 100 0.029 Contact Map
4o5hA 4 0.9835 100 0.03 Contact Map
4qtoA 4 0.9959 100 0.031 Contact Map
4yweA 5 0.9649 100 0.031 Contact Map
3ek1A 5 0.9856 100 0.033 Contact Map
2d4eA 4 0.9876 100 0.033 Contact Map
4qf6A 4 0.9814 100 0.033 Contact Map
3prlA 4 0.9773 100 0.034 Contact Map
3u4jA 4 0.9959 100 0.035 Contact Map
4lihA 5 0.9773 100 0.035 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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