ALDH5 - BACSU - GREMLIN Contacts

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ALDH5 - Putative aldehyde dehydrogenase YfmT

UniProt:	O06478	Sequences: MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATADDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKAAFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLSMKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSFVEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAVFSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQTDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKFDSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGGEKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	485 (449)
Sequences:	36327 (21745)
Seq/√Len:	1026.2

ECOLI - PUUC GABD BETB ALDA FEAB ALDB ABDH ASTD SAD EUTE PUTA PAAZ PROA
BACSU - ALDH5 ALDH4 ALDH1 ALDY ROCA ROCA2 IOLA BETB GABD ALDH3 ALDH2 PROA
HALSA - Q9HMJ6 Q9HQZ2 Q9HRB5 Q9HR91
SULSO - Q97YT9 KGSDH GAPN Q97XS9 Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
297_S	393_D	5.047	1.00
241_Q	245_K	3.960	1.00
297_S	391_K	3.185	1.00
269_E	306_L	3.125	1.00
300_Y	391_K	2.949	1.00
26_E	38_T	2.818	1.00
357_G	364_E	2.810	1.00
55_A	223_V	2.779	1.00
264_E	296_H	2.750	1.00
372_K	375_M	2.689	1.00
273_N	310_K	2.590	1.00
344_Q	376_S	2.588	1.00
332_S	336_D	2.584	1.00
343_E	347_E	2.530	1.00
304_L	389_F	2.507	1.00
189_L	192_K	2.485	1.00
264_E	298_S	2.464	1.00
83_N	86_A	2.429	1.00
81_E	114_K	2.411	1.00
415_T	421_G	2.340	1.00
26_E	35_T	2.336	1.00
195_E	201_A	2.261	1.00
342_V	363_V	2.246	1.00
55_A	225_R	2.222	1.00
43_T	46_D	2.205	1.00
339_M	343_E	2.140	1.00
84_E	107_G	2.136	1.00
79_Y	196_N	2.085	1.00
216_D	220_E	2.046	1.00
395_E	420_R	2.040	1.00
406_P	453_Q	2.040	1.00
142_V	472_K	2.020	1.00
220_E	242_L	2.013	1.00
351_V	370_D	2.006	1.00
181_E	331_N	2.002	1.00
76_A	194_F	1.996	1.00
329_L	338_L	1.948	1.00
344_Q	348_E	1.943	1.00
339_M	363_V	1.937	1.00
308_Q	312_E	1.935	1.00
260_F	275_A	1.932	1.00
353_V	369_K	1.907	1.00
141_R	466_E	1.900	1.00
423_A	427_R	1.896	1.00
302_K	306_L	1.884	1.00
346_I	352_P	1.874	1.00
48_D	217_S	1.866	1.00
72_I	199_I	1.863	1.00
238_Y	241_Q	1.816	1.00
265_D	420_R	1.813	1.00
52_R	223_V	1.800	1.00
237_S	453_Q	1.795	1.00
86_A	189_L	1.779	1.00
294_L	401_I	1.777	1.00
210_D	213_E	1.767	1.00
79_Y	82_E	1.752	1.00
85_E	103_A	1.744	1.00
141_R	469_T	1.743	1.00
83_N	196_N	1.740	1.00
429_E	452_K	1.735	1.00
378_A	390_M	1.710	1.00
368_L	377_I	1.683	1.00
48_D	52_R	1.678	1.00
296_H	392_F	1.658	1.00
395_E	423_A	1.654	1.00
35_T	38_T	1.652	1.00
373_P	401_I	1.650	1.00
311_V	367_I	1.640	1.00
351_V	369_K	1.633	1.00
308_Q	353_V	1.621	1.00
397_E	400_D	1.618	1.00
294_L	398_A	1.611	1.00
74_E	114_K	1.609	1.00
393_D	397_E	1.583	1.00
79_Y	197_A	1.577	1.00
300_Y	304_L	1.574	1.00
275_A	303_F	1.568	1.00
81_E	110_K	1.560	1.00
305_E	309_A	1.558	1.00
113_I	165_A	1.552	1.00
280_F	311_V	1.551	1.00
58_K	62_D	1.547	1.00
340_K	376_S	1.542	1.00
65_N	68_E	1.540	1.00
192_K	196_N	1.539	1.00
78_T	82_E	1.539	1.00
332_S	361_T	1.538	1.00
376_S	380_E	1.538	1.00
191_A	206_V	1.538	1.00
79_Y	193_I	1.529	1.00
306_L	309_A	1.527	1.00
268_I	306_L	1.519	1.00
173_G	203_L	1.515	1.00
48_D	221_H	1.514	1.00
272_V	306_L	1.488	1.00
75_K	78_T	1.484	1.00
24_V	38_T	1.483	1.00
68_E	71_T	1.463	1.00
293_V	387_V	1.463	1.00
301_D	391_K	1.461	1.00
263_L	420_R	1.449	1.00
63_A	427_R	1.440	1.00
90_L	189_L	1.435	1.00
74_E	121_I	1.432	1.00
294_L	392_F	1.431	1.00
33_Q	359_N	1.429	1.00
300_Y	369_K	1.428	1.00
89_Y	93_E	1.423	1.00
274_A	414_H	1.420	1.00
77_V	114_K	1.413	1.00
302_K	305_E	1.407	1.00
264_E	420_R	1.405	1.00
352_P	368_L	1.402	1.00
275_A	293_V	1.402	1.00
85_E	89_Y	1.399	1.00
295_V	303_F	1.398	1.00
310_K	313_S	1.397	1.00
411_G	430_T	1.387	1.00
64_V	68_E	1.387	1.00
140_Y	426_K	1.387	1.00
396_D	427_R	1.386	1.00
343_E	346_I	1.383	1.00
397_E	401_I	1.379	1.00
28_K	35_T	1.367	1.00
119_F	122_R	1.364	1.00
78_T	114_K	1.357	1.00
113_I	161_M	1.355	1.00
46_D	49_E	1.348	1.00
149_V	174_V	1.344	1.00
338_L	384_G	1.335	1.00
240_G	456_L	1.332	1.00
315_K	323_D	1.330	1.00
23_N	41_K	1.330	1.00
89_Y	320_M	1.322	1.00
92_M	102_A	1.316	1.00
341_T	382_L	1.316	1.00
34_K	359_N	1.311	1.00
216_D	242_L	1.304	1.00
263_L	392_F	1.304	1.00
226_I	251_L	1.303	1.00
335_T	363_V	1.298	1.00
83_N	189_L	1.292	1.00
335_T	339_M	1.288	1.00
392_F	401_I	1.279	1.00
336_D	340_K	1.279	1.00
29_N	32_T	1.278	1.00
348_E	376_S	1.266	1.00
160_S	176_L	1.263	1.00
263_L	424_F	1.262	1.00
301_D	305_E	1.261	1.00
220_E	245_K	1.257	1.00
58_K	173_G	1.257	1.00
309_A	312_E	1.252	1.00
394_S	397_E	1.247	1.00
99_R	103_A	1.245	1.00
304_L	308_Q	1.244	1.00
332_S	335_T	1.241	1.00
191_A	204_L	1.236	1.00
312_E	354_K	1.233	1.00
180_E	210_D	1.227	1.00
51_Y	221_H	1.223	1.00
261_I	398_A	1.223	1.00
399_V	424_F	1.211	1.00
296_H	394_S	1.207	1.00
77_V	81_E	1.205	1.00
44_A	217_S	1.205	1.00
299_I	302_K	1.193	1.00
374_F	379_K	1.191	1.00
463_W	466_E	1.191	1.00
296_H	299_I	1.182	1.00
315_K	325_I	1.180	1.00
350_A	368_L	1.180	1.00
141_R	471_L	1.178	1.00
52_R	56_L	1.177	1.00
51_Y	223_V	1.175	1.00
306_L	310_K	1.174	1.00
340_K	344_Q	1.173	1.00
216_D	238_Y	1.171	1.00
462_E	466_E	1.169	1.00
138_R	422_V	1.169	1.00
89_Y	99_R	1.167	1.00
202_G	205_N	1.163	1.00
47_V	214_I	1.160	1.00
317_G	324_T	1.154	1.00
373_P	404_E	1.143	1.00
92_M	319_P	1.142	1.00
64_V	72_I	1.142	1.00
304_L	369_K	1.141	1.00
307_Y	387_V	1.132	1.00
425_A	474_I	1.132	1.00
51_Y	224_P	1.130	1.00
303_F	307_Y	1.125	1.00
194_F	204_L	1.123	1.00
411_G	433_I	1.122	1.00
421_G	435_V	1.111	1.00
126_K	462_E	1.111	1.00
75_K	79_Y	1.106	1.00
396_D	423_A	1.105	1.00
53_A	205_N	1.105	1.00
238_Y	242_L	1.104	1.00
304_L	353_V	1.104	1.00
449_G	458_R	1.104	1.00
345_A	368_L	1.103	1.00
309_A	313_S	1.100	1.00
144_A	226_I	1.099	1.00
318_D	321_D	1.094	1.00
74_E	118_T	1.093	1.00
235_V	238_Y	1.084	1.00
379_K	406_P	1.083	1.00
234_K	238_Y	1.083	1.00
164_V	204_L	1.083	1.00
84_E	103_A	1.082	1.00
396_D	400_D	1.079	1.00
76_A	199_I	1.079	1.00
25_L	41_K	1.078	1.00
76_A	193_I	1.077	1.00
180_E	212_A	1.069	1.00
188_T	208_V	1.069	1.00
379_K	404_E	1.067	1.00
260_F	290_A	1.063	1.00
31_Y	319_P	1.061	1.00
29_N	318_D	1.060	1.00
37_T	184_I	1.059	1.00
149_V	228_S	1.059	1.00
240_G	250_P	1.057	1.00
442_D	445_N	1.056	1.00
312_E	364_E	1.055	1.00
463_W	471_L	1.054	1.00
217_S	221_H	1.054	1.00
267_D	416_S	1.053	1.00
148_G	218_F	1.051	1.00
261_I	424_F	1.051	1.00
335_T	361_T	1.050	1.00
76_A	113_I	1.050	1.00
399_V	427_R	1.047	1.00
458_R	470_T	1.045	1.00
87_I	189_L	1.038	1.00
148_G	224_P	1.034	1.00
417_N	420_R	1.034	1.00
164_V	174_V	1.032	1.00
355_L	364_E	1.026	1.00
237_S	247_F	1.024	1.00
126_K	463_W	1.023	1.00
308_Q	354_K	1.022	1.00
261_I	402_A	1.018	1.00
41_K	210_D	1.015	1.00
155_F	286_I	1.015	1.00
41_K	213_E	1.009	1.00
60_K	64_V	1.007	1.00
392_F	398_A	1.005	1.00
314_L	326_I	1.003	1.00
355_L	366_T	0.998	1.00
33_Q	361_T	0.996	1.00
257_N	291_N	0.996	1.00
348_E	375_M	0.994	1.00
70_R	121_I	0.994	1.00
192_K	195_E	0.988	1.00
82_E	196_N	0.988	1.00
395_E	424_F	0.987	1.00
267_D	270_Y	0.987	1.00
338_L	386_V	0.981	1.00
59_K	400_D	0.976	1.00
120_P	169_G	0.972	1.00
57_A	173_G	0.972	1.00
191_A	195_E	0.972	1.00
83_N	192_K	0.970	1.00
44_A	213_E	0.969	1.00
59_K	429_E	0.967	1.00
109_V	161_M	0.966	1.00
140_Y	474_I	0.962	1.00
146_V	173_G	0.959	1.00
451_E	470_T	0.956	1.00
55_A	59_K	0.952	1.00
144_A	249_K	0.950	1.00
259_A	411_G	0.949	1.00
86_A	89_Y	0.947	1.00
270_Y	274_A	0.944	1.00
371_V	375_M	0.941	1.00
240_G	244_M	0.939	1.00
412_A	438_T	0.935	1.00
93_E	320_M	0.932	1.00
344_Q	347_E	0.930	1.00
276_V	310_K	0.930	1.00
400_D	404_E	0.926	1.00
269_E	302_K	0.926	1.00
74_E	117_A	0.926	1.00
29_N	93_E	0.925	1.00
87_I	193_I	0.922	1.00
341_T	344_Q	0.921	1.00
44_A	48_D	0.921	1.00
278_S	290_A	0.920	1.00
83_N	193_I	0.917	1.00
188_T	206_V	0.915	1.00
340_K	343_E	0.909	1.00
137_N	446_V	0.906	1.00
279_R	291_N	0.902	1.00
142_V	426_K	0.901	1.00
225_R	429_E	0.899	1.00
147_V	226_I	0.899	1.00
79_Y	83_N	0.899	1.00
422_V	426_K	0.897	1.00
142_V	451_E	0.890	1.00
260_F	414_H	0.885	1.00
71_T	75_K	0.883	1.00
59_K	63_A	0.883	1.00
70_R	74_E	0.881	1.00
346_I	368_L	0.881	1.00
97_G	105_E	0.880	1.00
146_V	224_P	0.879	1.00
268_I	272_V	0.879	1.00
29_N	34_K	0.879	1.00
301_D	304_L	0.879	1.00
95_L	182_T	0.878	1.00
300_Y	389_F	0.878	1.00
62_D	429_E	0.877	1.00
66_P	70_R	0.875	1.00
47_V	148_G	0.872	1.00
263_L	395_E	0.870	1.00
237_S	241_Q	0.868	1.00
390_M	401_I	0.867	1.00
350_A	375_M	0.865	1.00
341_T	376_S	0.865	1.00
49_E	53_A	0.864	1.00
28_K	361_T	0.864	1.00
109_V	157_F	0.863	1.00
263_L	415_T	0.862	1.00
232_S	235_V	0.861	1.00
272_V	307_Y	0.860	1.00
240_G	243_A	0.859	1.00
181_E	333_R	0.857	1.00
31_Y	362_I	0.857	1.00
356_G	366_T	0.850	1.00
373_P	390_M	0.850	1.00
188_T	192_K	0.845	1.00
338_L	382_L	0.842	1.00
249_K	470_T	0.841	1.00
272_V	310_K	0.840	1.00
80_I	109_V	0.840	1.00
163_S	459_L	0.839	1.00
446_V	473_W	0.838	1.00
25_L	210_D	0.838	1.00
77_V	117_A	0.835	1.00
411_G	428_I	0.834	1.00
240_G	247_F	0.832	1.00
227_I	243_A	0.831	1.00
70_R	117_A	0.821	1.00
63_A	426_K	0.820	1.00
418_L	421_G	0.819	1.00
166_P	464_S	0.818	1.00
170_A	469_T	0.817	1.00
144_A	470_T	0.817	1.00
45_D	48_D	0.814	1.00
176_L	186_G	0.812	1.00
60_K	63_A	0.809	1.00
57_A	203_L	0.809	1.00
413_V	424_F	0.808	1.00
45_D	49_E	0.805	1.00
398_A	401_I	0.805	1.00
272_V	303_F	0.804	1.00
271_A	275_A	0.804	1.00
212_A	216_D	0.801	1.00
236_G	254_L	0.800	1.00
336_D	339_M	0.799	1.00
305_E	308_Q	0.799	1.00
144_A	172_N	0.797	1.00
392_F	397_E	0.797	1.00
42_A	46_D	0.796	1.00
262_V	303_F	0.796	1.00
54_A	205_N	0.796	1.00
227_I	239_I	0.795	1.00
369_K	391_K	0.795	1.00
399_V	403_N	0.793	1.00
49_E	52_R	0.793	1.00
167_A	174_V	0.790	1.00
160_S	164_V	0.789	1.00
219_V	239_I	0.788	1.00
349_G	375_M	0.788	1.00
61_W	203_L	0.783	1.00
53_A	202_G	0.781	1.00
430_T	433_I	0.780	1.00
178_P	208_V	0.777	1.00
56_L	59_K	0.776	1.00
209_T	214_I	0.772	1.00
342_V	386_V	0.770	1.00
67_F	121_I	0.769	1.00
74_E	78_T	0.768	1.00
88_I	103_A	0.767	1.00
100_L	325_I	0.767	1.00
36_F	93_E	0.763	1.00
333_R	336_D	0.762	1.00
236_G	252_L	0.762	1.00
95_L	330_I	0.761	1.00
258_S	291_N	0.760	1.00
307_Y	367_I	0.760	1.00
338_L	363_V	0.759	1.00
300_Y	370_D	0.758	1.00
199_I	204_L	0.758	1.00
219_V	242_L	0.756	1.00
199_I	203_L	0.754	1.00
161_M	190_I	0.754	1.00
73_L	169_G	0.752	1.00
229_F	235_V	0.749	1.00
103_A	107_G	0.748	1.00
92_M	99_R	0.747	1.00
80_I	110_K	0.747	1.00
93_E	184_I	0.747	1.00
148_G	227_I	0.745	1.00
81_E	84_E	0.745	1.00
42_A	50_A	0.744	1.00
268_I	299_I	0.740	1.00
259_A	402_A	0.739	1.00
157_F	185_C	0.739	1.00
29_N	320_M	0.737	1.00
233_T	453_Q	0.736	1.00
237_S	245_K	0.735	1.00
99_R	320_M	0.734	1.00
271_A	303_F	0.730	1.00
314_L	325_I	0.729	1.00
243_A	250_P	0.729	1.00
296_H	395_E	0.728	1.00
149_V	163_S	0.727	1.00
272_V	276_V	0.726	1.00
81_E	107_G	0.724	1.00
88_I	92_M	0.724	1.00
311_V	354_K	0.724	1.00
72_I	197_A	0.717	1.00
219_V	227_I	0.716	1.00
88_I	99_R	0.715	1.00
341_T	380_E	0.714	1.00
321_D	324_T	0.713	1.00
75_K	197_A	0.713	1.00
269_E	310_K	0.712	1.00
137_N	473_W	0.709	1.00
59_K	62_D	0.703	1.00
295_V	299_I	0.703	1.00
23_N	213_E	0.703	1.00
242_L	245_K	0.700	1.00
276_V	307_Y	0.700	1.00
346_I	357_G	0.699	1.00
61_W	72_I	0.699	1.00
144_A	225_R	0.697	1.00
160_S	186_G	0.695	1.00
308_Q	311_V	0.694	1.00
241_Q	244_M	0.693	1.00
181_E	330_I	0.691	1.00
217_S	220_E	0.689	1.00
54_A	173_G	0.688	1.00
28_K	33_Q	0.686	1.00
176_L	204_L	0.684	1.00
86_A	192_K	0.683	1.00
263_L	296_H	0.682	1.00
55_A	58_K	0.681	1.00
47_V	217_S	0.680	1.00
416_S	419_E	0.679	1.00
90_L	184_I	0.678	1.00
189_L	193_I	0.676	1.00
172_N	469_T	0.674	1.00
345_A	382_L	0.671	1.00
148_G	215_G	0.670	1.00
151_S	160_S	0.670	1.00
57_A	60_K	0.669	1.00
331_N	334_Q	0.669	1.00
394_S	400_D	0.669	1.00
283_Q	326_I	0.668	1.00
294_L	378_A	0.666	1.00
425_A	435_V	0.665	1.00
78_T	81_E	0.664	1.00
311_V	314_L	0.663	1.00
47_V	51_Y	0.663	1.00
24_V	40_R	0.662	1.00
61_W	168_L	0.662	1.00
66_P	120_P	0.662	1.00
337_G	340_K	0.661	1.00
91_I	94_E	0.661	1.00
316_V	326_I	0.660	1.00
249_K	467_E	0.658	1.00
334_Q	337_G	0.658	1.00
62_D	427_R	0.654	1.00
276_V	314_L	0.653	1.00
418_L	422_V	0.653	1.00
294_L	373_P	0.653	1.00
33_Q	332_S	0.649	1.00
212_A	238_Y	0.649	1.00
137_N	475_S	0.649	1.00
373_P	378_A	0.648	1.00
318_D	324_T	0.648	1.00
466_E	469_T	0.647	1.00
77_V	110_K	0.645	1.00
395_E	399_V	0.644	1.00
59_K	427_R	0.642	1.00
48_D	223_V	0.642	1.00
293_V	303_F	0.640	1.00
429_E	451_E	0.640	1.00
136_E	422_V	0.639	1.00
275_A	307_Y	0.639	1.00
53_A	201_A	0.637	1.00
415_T	420_R	0.636	1.00
97_G	101_K	0.636	1.00
85_E	99_R	0.636	1.00
401_I	404_E	0.636	1.00
265_D	415_T	0.635	1.00
466_E	471_L	0.635	1.00
363_V	366_T	0.635	1.00
262_V	271_A	0.634	1.00
356_G	364_E	0.634	1.00
270_Y	273_N	0.633	1.00
333_R	337_G	0.632	1.00
68_E	72_I	0.632	1.00
123_M	469_T	0.632	1.00
190_I	194_F	0.631	1.00
175_V	205_N	0.631	1.00
307_Y	389_F	0.628	1.00
40_R	208_V	0.628	1.00
251_L	467_E	0.627	1.00
140_Y	472_K	0.626	1.00
270_Y	416_S	0.625	1.00
106_I	110_K	0.623	1.00
138_R	474_I	0.622	1.00
160_S	190_I	0.622	1.00
180_E	337_G	0.620	1.00
84_E	88_I	0.619	1.00
62_D	143_P	0.619	1.00
87_I	157_F	0.618	1.00
421_G	425_A	0.618	1.00
268_I	302_K	0.618	1.00
213_E	216_D	0.615	1.00
342_V	368_L	0.613	1.00
194_F	199_I	0.613	1.00
265_D	416_S	0.613	1.00
50_A	207_V	0.611	1.00
97_G	155_F	0.608	1.00
92_M	320_M	0.608	1.00
62_D	142_V	0.608	1.00
27_N	37_T	0.606	1.00
354_K	367_I	0.605	1.00
288_M	442_D	0.605	1.00
180_E	238_Y	0.604	1.00
339_M	342_V	0.604	1.00
163_S	228_S	0.604	1.00
79_Y	198_G	0.602	1.00
52_R	55_A	0.602	1.00
371_V	378_A	0.602	1.00
123_M	465_L	0.601	1.00
91_I	185_C	0.601	1.00
27_N	94_E	0.600	1.00
265_D	417_N	0.599	1.00
399_V	423_A	0.598	1.00
348_E	374_F	0.596	1.00
164_V	176_L	0.596	1.00
39_F	183_P	0.595	1.00
91_I	105_E	0.595	1.00
66_P	169_G	0.595	1.00
419_E	422_V	0.594	1.00
44_A	220_E	0.592	1.00
42_A	207_V	0.590	1.00
209_T	215_G	0.589	1.00
278_S	438_T	0.588	1.00
240_G	252_L	0.588	1.00
382_L	386_V	0.586	1.00
341_T	345_A	0.586	1.00
80_I	113_I	0.585	1.00
419_E	423_A	0.585	1.00
91_I	102_A	0.585	1.00
147_V	172_N	0.585	1.00
89_Y	92_M	0.582	1.00
173_G	205_N	0.579	1.00
279_R	387_V	0.577	1.00
342_V	366_T	0.577	1.00
413_V	421_G	0.577	1.00
308_Q	367_I	0.576	1.00
36_F	184_I	0.575	1.00
103_A	322_P	0.575	1.00
115_E	119_F	0.574	1.00
72_I	198_G	0.573	1.00
339_M	346_I	0.573	1.00
371_V	377_I	0.573	1.00
226_I	467_E	0.572	1.00
295_V	300_Y	0.572	1.00
329_L	334_Q	0.571	1.00
118_T	121_I	0.570	1.00
370_D	391_K	0.569	1.00
80_I	157_F	0.568	1.00
432_M	441_N	0.567	1.00
413_V	435_V	0.566	1.00
215_G	219_V	0.566	1.00
295_V	389_F	0.564	1.00
269_E	309_A	0.563	1.00
260_F	293_V	0.561	1.00
233_T	237_S	0.560	1.00
157_F	190_I	0.556	1.00
398_A	402_A	0.556	1.00
106_I	157_F	0.556	1.00
260_F	412_A	0.553	1.00
88_I	106_I	0.553	1.00
433_I	472_K	0.552	1.00
373_P	400_D	0.550	1.00
352_P	366_T	0.550	1.00
399_V	428_I	0.549	1.00
286_I	289_S	0.548	1.00
23_N	43_T	0.548	1.00
54_A	175_V	0.548	1.00
77_V	113_I	0.548	1.00
402_A	428_I	0.548	1.00
268_I	303_F	0.548	1.00
268_I	271_A	0.547	1.00
66_P	124_E	0.546	1.00
55_A	146_V	0.546	1.00
219_V	246_H	0.546	1.00
53_A	57_A	0.546	1.00
56_L	60_K	0.545	1.00
352_P	355_L	0.545	1.00
146_V	225_R	0.545	1.00
80_I	190_I	0.545	1.00
368_L	371_V	0.544	1.00
195_E	198_G	0.544	1.00
87_I	106_I	0.543	1.00
353_V	370_D	0.543	1.00
170_A	465_L	0.543	1.00
168_L	204_L	0.542	1.00
348_E	372_K	0.542	1.00
107_G	110_K	0.542	1.00
76_A	79_Y	0.540	1.00
264_E	392_F	0.540	1.00
50_A	205_N	0.538	1.00
258_S	410_S	0.538	1.00
147_V	174_V	0.536	1.00
67_F	71_T	0.535	1.00
293_V	389_F	0.535	1.00
228_S	468_F	0.534	1.00
80_I	87_I	0.533	1.00
250_P	456_L	0.532	1.00
329_L	363_V	0.532	1.00
149_V	164_V	0.530	1.00
434_H	437_D	0.530	1.00
234_K	333_R	0.529	1.00
395_E	427_R	0.529	1.00
108_L	158_F	0.529	1.00
116_A	166_P	0.528	1.00
71_T	74_E	0.528	1.00
346_I	349_G	0.527	1.00
162_K	460_N	0.526	1.00
352_P	356_G	0.525	1.00
105_E	155_F	0.524	1.00
266_A	271_A	0.524	1.00
280_F	314_L	0.524	1.00
119_F	462_E	0.524	1.00
317_G	321_D	0.524	1.00
158_F	162_K	0.523	1.00
180_E	234_K	0.523	1.00
27_N	183_P	0.522	1.00
297_S	300_Y	0.520	1.00
424_F	428_I	0.519	1.00
60_K	173_G	0.519	1.00
377_I	382_L	0.519	1.00
72_I	76_A	0.518	1.00
54_A	146_V	0.517	1.00
429_E	470_T	0.517	1.00
168_L	199_I	0.516	1.00
272_V	299_I	0.515	1.00
95_L	282_H	0.514	1.00
75_K	198_G	0.514	1.00
39_F	184_I	0.511	1.00
290_A	412_A	0.511	1.00
142_V	429_E	0.510	1.00
411_G	424_F	0.508	1.00
400_D	427_R	0.507	1.00
337_G	341_T	0.507	1.00
112_I	460_N	0.506	1.00
27_N	36_F	0.505	1.00
23_N	210_D	0.504	1.00
84_E	110_K	0.504	1.00
316_V	325_I	0.502	1.00
282_H	286_I	0.500	1.00
273_N	277_F	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a4sA	4	0.9918	100	0.029	Contact Map
4o5hA	4	0.9835	100	0.03	Contact Map
4qtoA	4	0.9959	100	0.031	Contact Map
4yweA	5	0.9649	100	0.031	Contact Map
3ek1A	5	0.9856	100	0.033	Contact Map
2d4eA	4	0.9876	100	0.033	Contact Map
4qf6A	4	0.9814	100	0.033	Contact Map
3prlA	4	0.9773	100	0.034	Contact Map
3u4jA	4	0.9959	100	0.035	Contact Map
4lihA	5	0.9773	100	0.035	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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