GREMLIN Database
YFMS - Putative sensory transducer protein YfmS
UniProt: O06477 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (270)
Sequences: 28789 (23037)
Seq/√Len: 1402.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_S35_I2.4361.00
27_S32_D2.3671.00
53_S56_V2.3101.00
41_E46_N2.1731.00
169_E172_D2.0641.00
22_A47_I2.0281.00
166_S236_L1.9681.00
36_G60_D1.9631.00
114_S117_E1.9271.00
165_E168_G1.8781.00
151_T155_G1.8521.00
166_S232_K1.8351.00
175_V179_G1.8041.00
43_L46_N1.7811.00
162_K236_L1.7581.00
161_K165_E1.7451.00
22_A51_T1.7401.00
28_L56_V1.7211.00
137_A141_D1.7181.00
144_E148_G1.6961.00
21_V49_A1.6871.00
141_D144_E1.6781.00
164_S168_G1.6691.00
166_S169_E1.6441.00
25_L55_N1.6381.00
134_Q137_A1.6341.00
178_K227_D1.6301.00
126_E130_A1.6271.00
26_N47_I1.6241.00
165_E169_E1.6221.00
214_K217_T1.6191.00
217_T221_E1.6171.00
238_K242_E1.6141.00
119_S123_D1.6111.00
130_A134_Q1.5921.00
227_D231_K1.5841.00
158_S162_K1.5801.00
162_K165_E1.5791.00
25_L52_F1.5691.00
252_D256_A1.5671.00
53_S57_K1.5631.00
260_Q263_A1.5581.00
155_G158_S1.5491.00
140_S144_E1.5351.00
120_K123_D1.5291.00
26_N51_T1.5251.00
164_S241_E1.5121.00
267_E270_G1.5101.00
26_N54_L1.4991.00
224_G228_Q1.4921.00
147_N151_T1.4881.00
148_G151_T1.4861.00
239_G242_E1.4851.00
127_S130_A1.4841.00
133_E137_A1.4831.00
172_D175_V1.4721.00
61_P64_E1.4691.00
221_E225_Q1.4681.00
136_A140_S1.4531.00
22_A26_N1.4511.00
253_G256_A1.4431.00
259_E263_A1.4421.00
123_D127_S1.4361.00
28_L55_N1.4251.00
242_E245_E1.4081.00
154_S158_S1.4061.00
19_I22_A1.4021.00
176_T222_N1.3991.00
151_T154_S1.3991.00
152_Q246_S1.3931.00
159_Q239_G1.3931.00
220_K224_G1.3861.00
36_G53_S1.3781.00
113_T117_E1.3651.00
96_I99_H1.3651.00
158_S161_K1.3521.00
58_A61_P1.3511.00
123_D126_E1.3471.00
249_Q253_G1.3461.00
274_H277_K1.3441.00
36_G57_K1.3411.00
249_Q252_D1.3411.00
242_E246_S1.3391.00
99_H103_G1.3391.00
73_R77_K1.3291.00
74_S78_K1.3281.00
219_S223_V1.3271.00
100_D103_G1.3271.00
36_G56_V1.3261.00
130_A133_E1.3181.00
92_I96_I1.3081.00
60_D63_Q1.3021.00
143_S147_N1.2891.00
66_D70_D1.2831.00
76_Q79_T1.2821.00
137_A140_S1.2801.00
266_Q270_G1.2751.00
221_E224_G1.2751.00
148_G250_H1.2741.00
129_S133_E1.2721.00
70_D74_S1.2721.00
256_A260_Q1.2651.00
161_K164_S1.2611.00
47_I50_K1.2611.00
263_A267_E1.2581.00
160_A240_L1.2481.00
144_E147_N1.2471.00
67_I71_A1.2421.00
32_D35_I1.2421.00
110_G114_S1.2371.00
26_N30_Q1.2301.00
56_V60_D1.2271.00
240_L244_I1.2241.00
235_S239_G1.2101.00
169_E225_Q1.2091.00
152_Q155_G1.2081.00
225_Q228_Q1.2041.00
89_F93_A1.2001.00
269_S273_Q1.1921.00
245_E249_Q1.1921.00
179_G218_H1.1841.00
169_E229_I1.1771.00
171_A234_H1.1691.00
232_K236_L1.1591.00
210_D213_R1.1571.00
96_I100_D1.1531.00
150_S154_S1.1511.00
67_I70_D1.1481.00
59_G62_L1.1421.00
182_D193_I1.1411.00
82_V86_L1.1351.00
24_Y37_I1.1331.00
25_L51_T1.1311.00
162_K166_S1.1211.00
247_I254_Q1.1131.00
262_S266_Q1.1081.00
277_K281_K1.1051.00
131_V134_Q1.1001.00
106_I110_G1.0981.00
141_D257_A1.0931.00
85_E89_F1.0921.00
246_S249_Q1.0871.00
69_T76_Q1.0851.00
117_E120_K1.0741.00
148_G152_Q1.0701.00
277_K280_E1.0621.00
74_S77_K1.0521.00
103_G107_G1.0471.00
86_L89_F1.0451.00
20_K24_Y1.0421.00
39_D49_A1.0401.00
157_S161_K1.0391.00
218_H221_E1.0351.00
228_Q231_K1.0341.00
235_S238_K1.0341.00
270_G274_H1.0331.00
273_Q277_K1.0281.00
107_G110_G1.0261.00
23_P27_S1.0251.00
263_A266_Q1.0191.00
173_I222_N1.0171.00
57_K61_P1.0111.00
192_A210_D1.0101.00
21_V52_F1.0081.00
145_S253_G1.0031.00
24_Y35_I0.9991.00
103_G106_I0.9971.00
64_E67_I0.9971.00
63_Q67_I0.9931.00
88_G92_I0.9891.00
71_A74_S0.9891.00
152_Q250_H0.9881.00
232_K235_S0.9871.00
178_K182_D0.9801.00
20_K38_Y0.9781.00
20_K23_P0.9771.00
13_D17_A0.9711.00
274_H278_M0.9681.00
224_G227_D0.9651.00
161_K245_E0.9641.00
27_S30_Q0.9601.00
248_N252_D0.9601.00
159_Q243_S0.9471.00
54_L58_A0.9471.00
89_F92_I0.9471.00
131_V267_E0.9451.00
63_Q66_D0.9381.00
259_E262_S0.9311.00
256_A259_E0.9281.00
93_A96_I0.9271.00
15_L19_I0.9271.00
46_N50_K0.9271.00
37_I53_S0.9251.00
155_G159_Q0.9251.00
29_V54_L0.9231.00
101_E105_V0.9231.00
23_P26_N0.9191.00
17_A41_E0.9181.00
234_H238_K0.9131.00
168_G172_D0.9121.00
167_A237_L0.9111.00
87_F91_L0.9101.00
250_H253_G0.9101.00
24_Y27_S0.9091.00
146_I149_F0.9041.00
65_G69_T0.9001.00
127_S131_V0.9001.00
93_A97_P0.8981.00
90_P94_R0.8981.00
253_G257_A0.8971.00
178_K224_G0.8911.00
178_K223_V0.8901.00
133_E136_A0.8881.00
18_F45_V0.8861.00
100_D104_R0.8861.00
97_P100_D0.8831.00
75_N78_K0.8781.00
82_V85_E0.8781.00
141_D145_S0.8781.00
257_A260_Q0.8781.00
143_S262_S0.8731.00
138_A141_D0.8711.00
149_F254_Q0.8681.00
154_S248_N0.8671.00
164_S238_K0.8661.00
173_I176_T0.8661.00
73_R76_Q0.8631.00
231_K235_S0.8591.00
101_E108_G0.8511.00
69_T72_I0.8481.00
122_H126_E0.8451.00
182_D220_K0.8431.00
185_N213_R0.8431.00
267_E271_S0.8371.00
104_R107_G0.8341.00
168_G171_A0.8341.00
145_S148_G0.8321.00
146_I254_Q0.8301.00
87_F90_P0.8241.00
21_V48_P0.8181.00
94_R108_G0.8161.00
54_L57_K0.8161.00
189_L197_R0.8111.00
45_V49_A0.8091.00
39_D50_K0.8091.00
22_A48_P0.8041.00
25_L48_P0.8041.00
145_S250_H0.8011.00
110_G113_T0.8001.00
150_S255_A0.8001.00
21_V25_L0.8001.00
174_S178_K0.7991.00
132_V135_T0.7981.00
192_A213_R0.7941.00
157_S245_E0.7891.00
15_L45_V0.7891.00
39_D53_S0.7891.00
271_S275_L0.7881.00
14_I17_A0.7861.00
157_S248_N0.7841.00
49_A53_S0.7841.00
24_Y52_F0.7841.00
68_I71_A0.7831.00
19_I23_P0.7831.00
240_L247_I0.7801.00
134_Q138_A0.7801.00
37_I49_A0.7791.00
121_L279_A0.7771.00
38_Y53_S0.7761.00
270_G273_Q0.7751.00
71_A75_N0.7661.00
75_N79_T0.7641.00
64_E68_I0.7631.00
167_A233_I0.7601.00
136_A266_Q0.7551.00
94_R101_E0.7551.00
24_Y28_L0.7521.00
55_N59_G0.7511.00
159_Q240_L0.7501.00
18_F48_P0.7501.00
236_L239_G0.7501.00
86_L90_P0.7461.00
138_A260_Q0.7461.00
155_G243_S0.7421.00
94_R98_L0.7421.00
234_H237_L0.7351.00
15_L18_F0.7341.00
169_E232_K0.7321.00
233_I236_L0.7281.00
255_A259_E0.7261.00
50_K53_S0.7251.00
124_V127_S0.7221.00
153_M156_I0.7211.00
216_A219_S0.7201.00
65_G68_I0.7191.00
29_V51_T0.7181.00
174_S227_D0.7131.00
251_T254_Q0.7091.00
170_I230_T0.7061.00
153_M247_I0.7021.00
243_S246_S0.6961.00
147_N150_S0.6961.00
128_L251_T0.6931.00
179_G182_D0.6911.00
46_N49_A0.6881.00
261_I265_M0.6881.00
175_V178_K0.6881.00
173_I229_I0.6871.00
39_D46_N0.6801.00
213_R217_T0.6801.00
24_Y56_V0.6781.00
87_F101_E0.6771.00
210_D214_K0.6751.00
33_I59_G0.6751.00
252_D255_A0.6711.00
233_I237_L0.6681.00
21_V24_Y0.6671.00
41_E49_A0.6641.00
159_Q236_L0.6631.00
228_Q232_K0.6621.00
35_I56_V0.6601.00
218_H225_Q0.6571.00
87_F98_L0.6561.00
183_Q218_H0.6561.00
254_Q275_L0.6541.00
50_K54_L0.6511.00
52_F56_V0.6501.00
35_I39_D0.6451.00
178_K220_K0.6421.00
244_I247_I0.6421.00
15_L22_A0.6381.00
136_A269_S0.6381.00
183_Q211_E0.6351.00
160_A244_I0.6341.00
153_M251_T0.6321.00
172_D225_Q0.6321.00
239_G243_S0.6271.00
70_D73_R0.6261.00
42_K46_N0.6241.00
159_Q162_K0.6201.00
16_D20_K0.6091.00
71_A76_Q0.6081.00
62_L65_G0.6071.00
69_T73_R0.6031.00
172_D176_T0.5981.00
101_E104_R0.5971.00
30_Q54_L0.5951.00
241_E245_E0.5951.00
254_Q257_A0.5951.00
132_V269_S0.5931.00
14_I18_F0.5921.00
41_E45_V0.5841.00
26_N29_V0.5831.00
28_L52_F0.5831.00
22_A25_L0.5821.00
145_S257_A0.5791.00
111_L114_S0.5771.00
16_D19_I0.5741.00
17_A45_V0.5741.00
154_S252_D0.5741.00
72_I76_Q0.5731.00
266_Q269_S0.5711.00
254_Q268_I0.5671.00
250_H254_Q0.5661.00
13_D16_D0.5621.00
90_P93_A0.5611.00
126_E129_S0.5601.00
95_A99_H0.5591.00
275_L278_M0.5581.00
81_M85_E0.5541.00
135_T265_M0.5541.00
149_F251_T0.5531.00
114_S118_S0.5501.00
154_S157_S0.5491.00
128_L135_T0.5491.00
19_I47_I0.5481.00
77_K82_V0.5481.00
134_Q264_T0.5431.00
139_I143_S0.5431.00
254_Q261_I0.5431.00
27_S55_N0.5421.00
180_I219_S0.5421.00
129_S276_A0.5411.00
25_L28_L0.5391.00
147_N255_A0.5381.00
141_D253_G0.5381.00
20_K39_D0.5371.00
109_V113_T0.5371.00
135_T149_F0.5351.00
139_I142_I0.5351.00
120_K278_M0.5321.00
233_I240_L0.5291.00
72_I79_T0.5261.00
140_S262_S0.5251.00
21_V45_V0.5231.00
140_S143_S0.5191.00
163_V240_L0.5181.00
78_K82_V0.5141.00
200_E203_K0.5131.00
168_G234_H0.5101.00
174_S226_I0.5071.00
142_I258_V0.5051.00
150_S252_D0.5041.00
91_L94_R0.5031.00
28_L33_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.9126 100 0.154 Contact Map
1qu7A 2 0.6434 100 0.337 Contact Map
2ch7A 2 0.8427 100 0.348 Contact Map
3g67A 2 0.6818 100 0.368 Contact Map
4i3mA 2 0.5245 99.7 0.674 Contact Map
3zccA 2 0.3811 98.1 0.832 Contact Map
4cq4A 4 0.2483 97.7 0.847 Contact Map
2f95B 2 0.0245 97.6 0.849 Contact Map
4gycB 2 0.0385 97.5 0.853 Contact Map
2rm8A 1 0.2343 95.8 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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