GREMLIN Database
ADHB - Uncharacterized zinc-type alcohol dehydrogenase-like protein AdhB
UniProt: O06012 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 378 (309)
Sequences: 50675 (34432)
Seq/√Len: 1958.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T154_D2.9781.00
31_K67_E2.9311.00
33_T65_I2.8881.00
356_E359_H2.7141.00
7_Q15_K2.6341.00
181_T205_R2.6271.00
29_I67_E2.4951.00
77_K80_D2.4471.00
80_D145_K2.3441.00
81_R146_I2.3351.00
19_D133_Y2.3211.00
7_Q13_V2.2871.00
28_M143_H2.2791.00
199_W225_V2.2771.00
187_C208_A2.2701.00
352_L363_I2.2031.00
350_H363_I2.1991.00
5_T15_K2.1711.00
31_K133_Y2.1631.00
177_K180_D2.1511.00
31_K65_I2.1451.00
239_Y242_E2.1371.00
182_V198_C2.1361.00
62_P129_G2.0851.00
151_E156_K2.0841.00
25_S71_S2.0771.00
25_S72_G2.0641.00
155_E351_V2.0611.00
216_L220_K2.0511.00
205_R226_E2.0501.00
172_D201_K2.0191.00
23_E27_D1.9841.00
62_P84_I1.9791.00
149_S338_S1.9671.00
67_E133_Y1.9461.00
29_I135_R1.9421.00
26_D72_G1.9361.00
75_K138_F1.9171.00
200_L341_K1.8881.00
195_Q224_K1.8691.00
362_D366_S1.8521.00
217_Q221_R1.8431.00
335_E339_T1.8341.00
216_L227_I1.8301.00
46_H365_D1.8291.00
217_Q220_K1.8271.00
353_P356_E1.8231.00
151_E155_E1.7951.00
81_R154_D1.7671.00
293_T318_N1.7471.00
63_M154_D1.7431.00
363_I368_M1.7221.00
164_M193_F1.7121.00
172_D332_Y1.7021.00
183_I209_V1.6991.00
249_D289_R1.6981.00
226_E243_I1.6791.00
218_H221_R1.6771.00
293_T320_R1.6751.00
183_I248_A1.6731.00
146_I154_D1.6271.00
359_H363_I1.6141.00
359_H362_D1.6111.00
207_I248_A1.5991.00
21_K68_E1.5971.00
4_V357_A1.5751.00
29_I133_Y1.5631.00
65_I81_R1.5541.00
210_D216_L1.5431.00
68_E78_K1.5321.00
352_L360_G1.5251.00
213_N229_N1.5251.00
288_V294_I1.5041.00
69_V78_K1.4921.00
234_E239_Y1.4881.00
358_K362_D1.4821.00
205_R225_V1.4731.00
251_V288_V1.4631.00
213_N217_Q1.4621.00
29_I68_E1.4541.00
76_L80_D1.4531.00
185_L284_A1.4351.00
27_D137_P1.4301.00
26_D137_P1.4271.00
288_V317_V1.4251.00
130_Q361_Y1.4201.00
32_V62_P1.4101.00
174_A250_V1.4051.00
27_D135_R1.4021.00
3_A17_V1.3991.00
235_N238_N1.3951.00
76_L145_K1.3861.00
200_L336_L1.3681.00
349_S363_I1.3681.00
65_I154_D1.3651.00
288_V292_G1.3611.00
213_N216_L1.3501.00
2_K16_D1.3321.00
70_G73_V1.3271.00
81_R148_E1.3261.00
4_V14_V1.3131.00
213_N232_D1.3131.00
22_I29_I1.3091.00
22_I135_R1.3081.00
251_V284_A1.3071.00
335_E338_S1.3061.00
211_Y230_F1.3051.00
2_K355_S1.3041.00
28_M76_L1.3021.00
146_I157_L1.2961.00
181_T207_I1.2901.00
180_D293_T1.2881.00
66_V76_L1.2851.00
34_S155_E1.2581.00
168_F172_D1.2581.00
229_N232_D1.2511.00
238_N242_E1.2451.00
194_A252_I1.2431.00
239_Y243_I1.2411.00
33_T81_R1.2411.00
32_V134_L1.2371.00
185_L209_V1.2301.00
8_G11_N1.2101.00
19_D29_I1.1991.00
216_L229_N1.1981.00
45_I361_Y1.1971.00
195_Q208_A1.1841.00
26_D138_F1.1721.00
336_L341_K1.1691.00
76_L143_H1.1531.00
5_T17_V1.1391.00
181_T249_D1.1281.00
220_K227_I1.1241.00
237_G286_Q1.1211.00
196_K343_D1.1141.00
286_Q311_D1.1141.00
176_V203_A1.0971.00
332_Y335_E1.0931.00
235_N239_Y1.0861.00
180_D249_D1.0851.00
2_K132_E1.0561.00
169_W329_Y1.0541.00
211_Y231_E1.0531.00
237_G283_I1.0521.00
30_I82_V1.0521.00
167_G194_A1.0441.00
34_S154_D1.0401.00
218_H371_C1.0351.00
136_V143_H1.0321.00
14_V355_S1.0321.00
198_C203_A1.0311.00
172_D329_Y1.0301.00
174_A295_Q1.0251.00
237_G241_K1.0211.00
362_D365_D1.0201.00
37_I360_G1.0171.00
357_A376_L1.0131.00
176_V180_D1.0091.00
207_I226_E1.0071.00
208_A219_A1.0061.00
30_I64_G1.0041.00
35_T130_Q1.0011.00
67_E78_K1.0001.00
168_F332_Y0.9971.00
352_L356_E0.9901.00
73_V138_F0.9871.00
45_I365_D0.9831.00
22_I27_D0.9821.00
283_I286_Q0.9781.00
220_K226_E0.9771.00
4_V354_L0.9661.00
332_Y336_L0.9591.00
164_M333_M0.9541.00
9_I54_E0.9531.00
7_Q11_N0.9521.00
232_D239_Y0.9501.00
331_P335_E0.9491.00
180_D250_V0.9441.00
156_K343_D0.9421.00
170_S252_I0.9381.00
209_V230_F0.9351.00
69_V77_K0.9281.00
214_Y217_Q0.9261.00
187_C195_Q0.9241.00
311_D315_R0.9221.00
195_Q206_V0.9221.00
42_L364_F0.9181.00
170_S297_T0.9111.00
363_I374_V0.9091.00
187_C210_D0.9091.00
74_T138_F0.9091.00
187_C219_A0.9071.00
192_L218_H0.9051.00
210_D227_I0.9041.00
130_Q357_A0.9041.00
167_G197_F0.9021.00
212_V215_R0.9021.00
240_L248_A0.8971.00
151_E154_D0.8941.00
83_I334_F0.8891.00
215_R371_C0.8891.00
35_T129_G0.8851.00
282_V286_Q0.8841.00
139_A142_T0.8791.00
23_E135_R0.8781.00
291_G316_N0.8781.00
208_A224_K0.8761.00
2_K14_V0.8751.00
183_I287_A0.8741.00
33_T63_M0.8671.00
17_V127_P0.8651.00
328_H332_Y0.8571.00
244_T247_G0.8561.00
4_V12_V0.8561.00
56_Y127_P0.8521.00
5_T57_V0.8511.00
31_K132_E0.8511.00
253_D256_G0.8471.00
19_D68_E0.8451.00
34_S375_V0.8421.00
207_I228_V0.8421.00
19_D67_E0.8411.00
69_V73_V0.8361.00
165_T329_Y0.8351.00
303_R306_G0.8351.00
184_V198_C0.8321.00
185_L251_V0.8231.00
150_C157_L0.8211.00
352_L374_V0.8191.00
38_C61_E0.8151.00
129_G134_L0.8151.00
336_L339_T0.8131.00
175_G293_T0.8111.00
308_P311_D0.8111.00
160_I337_V0.8101.00
284_A294_I0.8071.00
201_K332_Y0.8061.00
251_V294_I0.8051.00
350_H359_H0.8021.00
3_A57_V0.8011.00
198_C206_V0.7981.00
36_A61_E0.7951.00
236_T283_I0.7941.00
207_I243_I0.7921.00
328_H331_P0.7881.00
17_V57_V0.7861.00
207_I240_L0.7851.00
206_V225_V0.7821.00
84_I136_V0.7791.00
182_V203_A0.7791.00
171_V198_C0.7791.00
147_P338_S0.7781.00
219_A224_K0.7771.00
144_F331_P0.7771.00
28_M138_F0.7761.00
197_F333_M0.7741.00
130_Q376_L0.7741.00
312_I319_I0.7741.00
181_T248_A0.7731.00
344_P347_V0.7721.00
238_N241_K0.7721.00
148_E338_S0.7711.00
14_V354_L0.7701.00
184_V194_A0.7641.00
62_P134_L0.7641.00
254_A297_T0.7551.00
37_I364_F0.7541.00
348_V351_V0.7521.00
237_G287_A0.7481.00
370_D374_V0.7471.00
77_K145_K0.7441.00
21_K29_I0.7441.00
82_V143_H0.7421.00
363_I366_S0.7361.00
42_L365_D0.7341.00
226_E239_Y0.7301.00
296_I319_I0.7291.00
175_G318_N0.7281.00
334_F338_S0.7241.00
176_V250_V0.7241.00
352_L376_L0.7131.00
282_V311_D0.7121.00
210_D219_A0.7111.00
38_C41_D0.7111.00
26_D71_S0.7101.00
167_G193_F0.7101.00
38_C60_H0.7091.00
218_H347_V0.7031.00
232_D235_N0.7011.00
170_S194_A0.6981.00
303_R308_P0.6981.00
221_R347_V0.6981.00
144_F330_M0.6961.00
197_F336_L0.6951.00
26_D139_A0.6951.00
184_V208_A0.6941.00
40_S60_H0.6921.00
312_I321_S0.6901.00
235_N283_I0.6891.00
211_Y216_L0.6871.00
175_G320_R0.6871.00
218_H222_T0.6871.00
23_E26_D0.6851.00
26_D70_G0.6831.00
221_R343_D0.6831.00
22_I68_E0.6831.00
83_I146_I0.6811.00
159_V375_V0.6801.00
34_S351_V0.6801.00
4_V358_K0.6791.00
192_L347_V0.6751.00
312_I317_V0.6741.00
203_A250_V0.6701.00
168_F336_L0.6691.00
236_T240_L0.6691.00
178_K202_G0.6631.00
22_I70_G0.6621.00
168_F333_M0.6611.00
248_A251_V0.6591.00
196_K222_T0.6581.00
28_M66_V0.6571.00
364_F374_V0.6571.00
52_M56_Y0.6561.00
150_C337_V0.6561.00
80_D148_E0.6551.00
83_I161_A0.6551.00
53_Q56_Y0.6521.00
290_K315_R0.6491.00
336_L340_G0.6481.00
34_S63_M0.6471.00
168_F329_Y0.6451.00
32_V35_T0.6441.00
250_V293_T0.6421.00
63_M81_R0.6421.00
144_F334_F0.6421.00
11_N358_K0.6411.00
20_P135_R0.6391.00
169_W316_N0.6381.00
63_M146_I0.6371.00
172_D197_F0.6361.00
167_G190_V0.6351.00
203_A206_V0.6351.00
311_D314_Q0.6351.00
42_L46_H0.6321.00
250_V295_Q0.6321.00
350_H374_V0.6311.00
329_Y332_Y0.6301.00
253_D294_I0.6261.00
199_W206_V0.6261.00
241_K247_G0.6251.00
210_D230_F0.6241.00
169_W173_N0.6241.00
38_C163_A0.6231.00
228_V243_I0.6211.00
166_T190_V0.6201.00
170_S295_Q0.6201.00
30_I143_H0.6201.00
195_Q222_T0.6191.00
212_V229_N0.6171.00
81_R149_S0.6171.00
30_I84_I0.6141.00
363_I370_D0.6141.00
173_N329_Y0.6121.00
258_D282_V0.6101.00
173_N318_N0.6091.00
316_N326_V0.6041.00
281_L294_I0.6031.00
84_I143_H0.6001.00
178_K201_K0.5991.00
240_L287_A0.5981.00
10_K45_I0.5951.00
35_T376_L0.5951.00
85_P144_F0.5941.00
350_H371_C0.5931.00
174_A293_T0.5931.00
259_G283_I0.5911.00
163_A193_F0.5901.00
40_S44_L0.5871.00
43_H48_F0.5871.00
228_V239_Y0.5861.00
60_H162_D0.5851.00
216_L219_A0.5831.00
219_A227_I0.5821.00
38_C162_D0.5791.00
8_G13_V0.5781.00
12_V361_Y0.5771.00
75_K78_K0.5771.00
61_E162_D0.5761.00
330_M334_F0.5761.00
182_V250_V0.5731.00
181_T226_E0.5721.00
59_G130_Q0.5711.00
181_T244_T0.5701.00
6_Y9_I0.5691.00
20_P133_Y0.5681.00
183_I251_V0.5681.00
167_G171_V0.5681.00
6_Y11_N0.5671.00
210_D215_R0.5651.00
18_P21_K0.5641.00
69_V80_D0.5631.00
248_A287_A0.5631.00
197_F201_K0.5591.00
192_L222_T0.5581.00
171_V197_F0.5581.00
282_V306_G0.5551.00
163_A189_P0.5551.00
199_W224_K0.5551.00
74_T77_K0.5541.00
337_V344_P0.5521.00
194_A297_T0.5491.00
350_H356_E0.5491.00
37_I130_Q0.5481.00
361_Y365_D0.5471.00
20_P27_D0.5461.00
39_G43_H0.5451.00
76_L138_F0.5451.00
251_V287_A0.5441.00
331_P334_F0.5431.00
352_L359_H0.5411.00
193_F197_F0.5401.00
184_V195_Q0.5401.00
196_K342_I0.5381.00
194_A254_A0.5381.00
348_V375_V0.5341.00
146_I158_S0.5331.00
84_I129_G0.5331.00
63_M158_S0.5321.00
168_F197_F0.5311.00
170_S322_G0.5311.00
311_D317_V0.5311.00
195_Q219_A0.5291.00
40_S43_H0.5241.00
159_V344_P0.5241.00
310_G314_Q0.5211.00
295_Q322_G0.5191.00
215_R368_M0.5191.00
193_F342_I0.5171.00
171_V194_A0.5161.00
22_I25_S0.5151.00
210_D229_N0.5151.00
244_T248_A0.5131.00
214_Y368_M0.5131.00
162_D166_T0.5121.00
295_Q320_R0.5121.00
175_G201_K0.5111.00
19_D135_R0.5101.00
281_L296_I0.5091.00
27_D126_Y0.5091.00
258_D306_G0.5081.00
137_P142_T0.5081.00
150_C338_S0.5051.00
168_F201_K0.5051.00
195_Q199_W0.5041.00
55_D59_G0.5041.00
69_V76_L0.5041.00
322_G327_I0.5031.00
371_C374_V0.5031.00
283_I287_A0.5031.00
213_N220_K0.5011.00
241_K244_T0.5001.00
314_Q323_Q0.5001.00
166_T297_T0.5001.00
349_S372_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cpdA 2 0.9101 100 0.215 Contact Map
4ej6A 1 0.8862 100 0.218 Contact Map
1h2bA 4 0.8862 100 0.22 Contact Map
3ukoA 4 0.9259 100 0.223 Contact Map
4ilkA 2 0.8836 100 0.224 Contact Map
1cdoA 2 0.9153 100 0.226 Contact Map
1vj0A 4 0.9048 100 0.226 Contact Map
1f8fA 4 0.9153 100 0.226 Contact Map
4oh1A 4 0.873 100 0.229 Contact Map
1rjwA 4 0.881 100 0.23 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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