ADHB - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

ADHB - Uncharacterized zinc-type alcohol dehydrogenase-like protein AdhB

UniProt:	O06012	Sequences: MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHLIHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLESQCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVIADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQHAKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGGTMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMFELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	378 (309)
Sequences:	50675 (34432)
Seq/√Len:	1958.8

ECOLI - YBDR GATD FRMA YAHK YPHC YDJL RSPB YGGP AHR ADHP YJJN YDJJ TDH IDND QOR1 YCJQ ACUI CURA
BACSU - ADHB YYCR YJMD TDH BDHA DHSO ADHA YOGA YHFP YFMJ
HALSA - Q9HMB6 Q9HP38 GLCDH Q9HR85 Q9HQS8
SULSO - Q7LXK1 ADH Q97XR4 Q97ZV3 Q97YT7 Q97VV5 Q97V32 Q97YM2 Q97VW0 Q97WA1 Q97TZ4 GLCD2 GLCD1 GLCD3 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_T	154_D	2.978	1.00
31_K	67_E	2.931	1.00
33_T	65_I	2.888	1.00
356_E	359_H	2.714	1.00
7_Q	15_K	2.634	1.00
181_T	205_R	2.627	1.00
29_I	67_E	2.495	1.00
77_K	80_D	2.447	1.00
80_D	145_K	2.344	1.00
81_R	146_I	2.335	1.00
19_D	133_Y	2.321	1.00
7_Q	13_V	2.287	1.00
28_M	143_H	2.279	1.00
199_W	225_V	2.277	1.00
187_C	208_A	2.270	1.00
352_L	363_I	2.203	1.00
350_H	363_I	2.199	1.00
5_T	15_K	2.171	1.00
31_K	133_Y	2.163	1.00
177_K	180_D	2.151	1.00
31_K	65_I	2.145	1.00
239_Y	242_E	2.137	1.00
182_V	198_C	2.136	1.00
62_P	129_G	2.085	1.00
151_E	156_K	2.084	1.00
25_S	71_S	2.077	1.00
25_S	72_G	2.064	1.00
155_E	351_V	2.061	1.00
216_L	220_K	2.051	1.00
205_R	226_E	2.050	1.00
172_D	201_K	2.019	1.00
23_E	27_D	1.984	1.00
62_P	84_I	1.979	1.00
149_S	338_S	1.967	1.00
67_E	133_Y	1.946	1.00
29_I	135_R	1.942	1.00
26_D	72_G	1.936	1.00
75_K	138_F	1.917	1.00
200_L	341_K	1.888	1.00
195_Q	224_K	1.869	1.00
362_D	366_S	1.852	1.00
217_Q	221_R	1.843	1.00
335_E	339_T	1.834	1.00
216_L	227_I	1.830	1.00
46_H	365_D	1.829	1.00
217_Q	220_K	1.827	1.00
353_P	356_E	1.823	1.00
151_E	155_E	1.795	1.00
81_R	154_D	1.767	1.00
293_T	318_N	1.747	1.00
63_M	154_D	1.743	1.00
363_I	368_M	1.722	1.00
164_M	193_F	1.712	1.00
172_D	332_Y	1.702	1.00
183_I	209_V	1.699	1.00
249_D	289_R	1.698	1.00
226_E	243_I	1.679	1.00
218_H	221_R	1.677	1.00
293_T	320_R	1.675	1.00
183_I	248_A	1.673	1.00
146_I	154_D	1.627	1.00
359_H	363_I	1.614	1.00
359_H	362_D	1.611	1.00
207_I	248_A	1.599	1.00
21_K	68_E	1.597	1.00
4_V	357_A	1.575	1.00
29_I	133_Y	1.563	1.00
65_I	81_R	1.554	1.00
210_D	216_L	1.543	1.00
68_E	78_K	1.532	1.00
352_L	360_G	1.525	1.00
213_N	229_N	1.525	1.00
288_V	294_I	1.504	1.00
69_V	78_K	1.492	1.00
234_E	239_Y	1.488	1.00
358_K	362_D	1.482	1.00
205_R	225_V	1.473	1.00
251_V	288_V	1.463	1.00
213_N	217_Q	1.462	1.00
29_I	68_E	1.454	1.00
76_L	80_D	1.453	1.00
185_L	284_A	1.435	1.00
27_D	137_P	1.430	1.00
26_D	137_P	1.427	1.00
288_V	317_V	1.425	1.00
130_Q	361_Y	1.420	1.00
32_V	62_P	1.410	1.00
174_A	250_V	1.405	1.00
27_D	135_R	1.402	1.00
3_A	17_V	1.399	1.00
235_N	238_N	1.395	1.00
76_L	145_K	1.386	1.00
200_L	336_L	1.368	1.00
349_S	363_I	1.368	1.00
65_I	154_D	1.365	1.00
288_V	292_G	1.361	1.00
213_N	216_L	1.350	1.00
2_K	16_D	1.332	1.00
70_G	73_V	1.327	1.00
81_R	148_E	1.326	1.00
4_V	14_V	1.313	1.00
213_N	232_D	1.313	1.00
22_I	29_I	1.309	1.00
22_I	135_R	1.308	1.00
251_V	284_A	1.307	1.00
335_E	338_S	1.306	1.00
211_Y	230_F	1.305	1.00
2_K	355_S	1.304	1.00
28_M	76_L	1.302	1.00
146_I	157_L	1.296	1.00
181_T	207_I	1.290	1.00
180_D	293_T	1.288	1.00
66_V	76_L	1.285	1.00
34_S	155_E	1.258	1.00
168_F	172_D	1.258	1.00
229_N	232_D	1.251	1.00
238_N	242_E	1.245	1.00
194_A	252_I	1.243	1.00
239_Y	243_I	1.241	1.00
33_T	81_R	1.241	1.00
32_V	134_L	1.237	1.00
185_L	209_V	1.230	1.00
8_G	11_N	1.210	1.00
19_D	29_I	1.199	1.00
216_L	229_N	1.198	1.00
45_I	361_Y	1.197	1.00
195_Q	208_A	1.184	1.00
26_D	138_F	1.172	1.00
336_L	341_K	1.169	1.00
76_L	143_H	1.153	1.00
5_T	17_V	1.139	1.00
181_T	249_D	1.128	1.00
220_K	227_I	1.124	1.00
237_G	286_Q	1.121	1.00
196_K	343_D	1.114	1.00
286_Q	311_D	1.114	1.00
176_V	203_A	1.097	1.00
332_Y	335_E	1.093	1.00
235_N	239_Y	1.086	1.00
180_D	249_D	1.085	1.00
2_K	132_E	1.056	1.00
169_W	329_Y	1.054	1.00
211_Y	231_E	1.053	1.00
237_G	283_I	1.052	1.00
30_I	82_V	1.052	1.00
167_G	194_A	1.044	1.00
34_S	154_D	1.040	1.00
218_H	371_C	1.035	1.00
136_V	143_H	1.032	1.00
14_V	355_S	1.032	1.00
198_C	203_A	1.031	1.00
172_D	329_Y	1.030	1.00
174_A	295_Q	1.025	1.00
237_G	241_K	1.021	1.00
362_D	365_D	1.020	1.00
37_I	360_G	1.017	1.00
357_A	376_L	1.013	1.00
176_V	180_D	1.009	1.00
207_I	226_E	1.007	1.00
208_A	219_A	1.006	1.00
30_I	64_G	1.004	1.00
35_T	130_Q	1.001	1.00
67_E	78_K	1.000	1.00
168_F	332_Y	0.997	1.00
352_L	356_E	0.990	1.00
73_V	138_F	0.987	1.00
45_I	365_D	0.983	1.00
22_I	27_D	0.982	1.00
283_I	286_Q	0.978	1.00
220_K	226_E	0.977	1.00
4_V	354_L	0.966	1.00
332_Y	336_L	0.959	1.00
164_M	333_M	0.954	1.00
9_I	54_E	0.953	1.00
7_Q	11_N	0.952	1.00
232_D	239_Y	0.950	1.00
331_P	335_E	0.949	1.00
180_D	250_V	0.944	1.00
156_K	343_D	0.942	1.00
170_S	252_I	0.938	1.00
209_V	230_F	0.935	1.00
69_V	77_K	0.928	1.00
214_Y	217_Q	0.926	1.00
187_C	195_Q	0.924	1.00
311_D	315_R	0.922	1.00
195_Q	206_V	0.922	1.00
42_L	364_F	0.918	1.00
170_S	297_T	0.911	1.00
363_I	374_V	0.909	1.00
187_C	210_D	0.909	1.00
74_T	138_F	0.909	1.00
187_C	219_A	0.907	1.00
192_L	218_H	0.905	1.00
210_D	227_I	0.904	1.00
130_Q	357_A	0.904	1.00
167_G	197_F	0.902	1.00
212_V	215_R	0.902	1.00
240_L	248_A	0.897	1.00
151_E	154_D	0.894	1.00
83_I	334_F	0.889	1.00
215_R	371_C	0.889	1.00
35_T	129_G	0.885	1.00
282_V	286_Q	0.884	1.00
139_A	142_T	0.879	1.00
23_E	135_R	0.878	1.00
291_G	316_N	0.878	1.00
208_A	224_K	0.876	1.00
2_K	14_V	0.875	1.00
183_I	287_A	0.874	1.00
33_T	63_M	0.867	1.00
17_V	127_P	0.865	1.00
328_H	332_Y	0.857	1.00
244_T	247_G	0.856	1.00
4_V	12_V	0.856	1.00
56_Y	127_P	0.852	1.00
5_T	57_V	0.851	1.00
31_K	132_E	0.851	1.00
253_D	256_G	0.847	1.00
19_D	68_E	0.845	1.00
34_S	375_V	0.842	1.00
207_I	228_V	0.842	1.00
19_D	67_E	0.841	1.00
69_V	73_V	0.836	1.00
165_T	329_Y	0.835	1.00
303_R	306_G	0.835	1.00
184_V	198_C	0.832	1.00
185_L	251_V	0.823	1.00
150_C	157_L	0.821	1.00
352_L	374_V	0.819	1.00
38_C	61_E	0.815	1.00
129_G	134_L	0.815	1.00
336_L	339_T	0.813	1.00
175_G	293_T	0.811	1.00
308_P	311_D	0.811	1.00
160_I	337_V	0.810	1.00
284_A	294_I	0.807	1.00
201_K	332_Y	0.806	1.00
251_V	294_I	0.805	1.00
350_H	359_H	0.802	1.00
3_A	57_V	0.801	1.00
198_C	206_V	0.798	1.00
36_A	61_E	0.795	1.00
236_T	283_I	0.794	1.00
207_I	243_I	0.792	1.00
328_H	331_P	0.788	1.00
17_V	57_V	0.786	1.00
207_I	240_L	0.785	1.00
206_V	225_V	0.782	1.00
84_I	136_V	0.779	1.00
182_V	203_A	0.779	1.00
171_V	198_C	0.779	1.00
147_P	338_S	0.778	1.00
219_A	224_K	0.777	1.00
144_F	331_P	0.777	1.00
28_M	138_F	0.776	1.00
197_F	333_M	0.774	1.00
130_Q	376_L	0.774	1.00
312_I	319_I	0.774	1.00
181_T	248_A	0.773	1.00
344_P	347_V	0.772	1.00
238_N	241_K	0.772	1.00
148_E	338_S	0.771	1.00
14_V	354_L	0.770	1.00
184_V	194_A	0.764	1.00
62_P	134_L	0.764	1.00
254_A	297_T	0.755	1.00
37_I	364_F	0.754	1.00
348_V	351_V	0.752	1.00
237_G	287_A	0.748	1.00
370_D	374_V	0.747	1.00
77_K	145_K	0.744	1.00
21_K	29_I	0.744	1.00
82_V	143_H	0.742	1.00
363_I	366_S	0.736	1.00
42_L	365_D	0.734	1.00
226_E	239_Y	0.730	1.00
296_I	319_I	0.729	1.00
175_G	318_N	0.728	1.00
334_F	338_S	0.724	1.00
176_V	250_V	0.724	1.00
352_L	376_L	0.713	1.00
282_V	311_D	0.712	1.00
210_D	219_A	0.711	1.00
38_C	41_D	0.711	1.00
26_D	71_S	0.710	1.00
167_G	193_F	0.710	1.00
38_C	60_H	0.709	1.00
218_H	347_V	0.703	1.00
232_D	235_N	0.701	1.00
170_S	194_A	0.698	1.00
303_R	308_P	0.698	1.00
221_R	347_V	0.698	1.00
144_F	330_M	0.696	1.00
197_F	336_L	0.695	1.00
26_D	139_A	0.695	1.00
184_V	208_A	0.694	1.00
40_S	60_H	0.692	1.00
312_I	321_S	0.690	1.00
235_N	283_I	0.689	1.00
211_Y	216_L	0.687	1.00
175_G	320_R	0.687	1.00
218_H	222_T	0.687	1.00
23_E	26_D	0.685	1.00
26_D	70_G	0.683	1.00
221_R	343_D	0.683	1.00
22_I	68_E	0.683	1.00
83_I	146_I	0.681	1.00
159_V	375_V	0.680	1.00
34_S	351_V	0.680	1.00
4_V	358_K	0.679	1.00
192_L	347_V	0.675	1.00
312_I	317_V	0.674	1.00
203_A	250_V	0.670	1.00
168_F	336_L	0.669	1.00
236_T	240_L	0.669	1.00
178_K	202_G	0.663	1.00
22_I	70_G	0.662	1.00
168_F	333_M	0.661	1.00
248_A	251_V	0.659	1.00
196_K	222_T	0.658	1.00
28_M	66_V	0.657	1.00
364_F	374_V	0.657	1.00
52_M	56_Y	0.656	1.00
150_C	337_V	0.656	1.00
80_D	148_E	0.655	1.00
83_I	161_A	0.655	1.00
53_Q	56_Y	0.652	1.00
290_K	315_R	0.649	1.00
336_L	340_G	0.648	1.00
34_S	63_M	0.647	1.00
168_F	329_Y	0.645	1.00
32_V	35_T	0.644	1.00
250_V	293_T	0.642	1.00
63_M	81_R	0.642	1.00
144_F	334_F	0.642	1.00
11_N	358_K	0.641	1.00
20_P	135_R	0.639	1.00
169_W	316_N	0.638	1.00
63_M	146_I	0.637	1.00
172_D	197_F	0.636	1.00
167_G	190_V	0.635	1.00
203_A	206_V	0.635	1.00
311_D	314_Q	0.635	1.00
42_L	46_H	0.632	1.00
250_V	295_Q	0.632	1.00
350_H	374_V	0.631	1.00
329_Y	332_Y	0.630	1.00
253_D	294_I	0.626	1.00
199_W	206_V	0.626	1.00
241_K	247_G	0.625	1.00
210_D	230_F	0.624	1.00
169_W	173_N	0.624	1.00
38_C	163_A	0.623	1.00
228_V	243_I	0.621	1.00
166_T	190_V	0.620	1.00
170_S	295_Q	0.620	1.00
30_I	143_H	0.620	1.00
195_Q	222_T	0.619	1.00
212_V	229_N	0.617	1.00
81_R	149_S	0.617	1.00
30_I	84_I	0.614	1.00
363_I	370_D	0.614	1.00
173_N	329_Y	0.612	1.00
258_D	282_V	0.610	1.00
173_N	318_N	0.609	1.00
316_N	326_V	0.604	1.00
281_L	294_I	0.603	1.00
84_I	143_H	0.600	1.00
178_K	201_K	0.599	1.00
240_L	287_A	0.598	1.00
10_K	45_I	0.595	1.00
35_T	376_L	0.595	1.00
85_P	144_F	0.594	1.00
350_H	371_C	0.593	1.00
174_A	293_T	0.593	1.00
259_G	283_I	0.591	1.00
163_A	193_F	0.590	1.00
40_S	44_L	0.587	1.00
43_H	48_F	0.587	1.00
228_V	239_Y	0.586	1.00
60_H	162_D	0.585	1.00
216_L	219_A	0.583	1.00
219_A	227_I	0.582	1.00
38_C	162_D	0.579	1.00
8_G	13_V	0.578	1.00
12_V	361_Y	0.577	1.00
75_K	78_K	0.577	1.00
61_E	162_D	0.576	1.00
330_M	334_F	0.576	1.00
182_V	250_V	0.573	1.00
181_T	226_E	0.572	1.00
59_G	130_Q	0.571	1.00
181_T	244_T	0.570	1.00
6_Y	9_I	0.569	1.00
20_P	133_Y	0.568	1.00
183_I	251_V	0.568	1.00
167_G	171_V	0.568	1.00
6_Y	11_N	0.567	1.00
210_D	215_R	0.565	1.00
18_P	21_K	0.564	1.00
69_V	80_D	0.563	1.00
248_A	287_A	0.563	1.00
197_F	201_K	0.559	1.00
192_L	222_T	0.558	1.00
171_V	197_F	0.558	1.00
282_V	306_G	0.555	1.00
163_A	189_P	0.555	1.00
199_W	224_K	0.555	1.00
74_T	77_K	0.554	1.00
337_V	344_P	0.552	1.00
194_A	297_T	0.549	1.00
350_H	356_E	0.549	1.00
37_I	130_Q	0.548	1.00
361_Y	365_D	0.547	1.00
20_P	27_D	0.546	1.00
39_G	43_H	0.545	1.00
76_L	138_F	0.545	1.00
251_V	287_A	0.544	1.00
331_P	334_F	0.543	1.00
352_L	359_H	0.541	1.00
193_F	197_F	0.540	1.00
184_V	195_Q	0.540	1.00
196_K	342_I	0.538	1.00
194_A	254_A	0.538	1.00
348_V	375_V	0.534	1.00
146_I	158_S	0.533	1.00
84_I	129_G	0.533	1.00
63_M	158_S	0.532	1.00
168_F	197_F	0.531	1.00
170_S	322_G	0.531	1.00
311_D	317_V	0.531	1.00
195_Q	219_A	0.529	1.00
40_S	43_H	0.524	1.00
159_V	344_P	0.524	1.00
310_G	314_Q	0.521	1.00
295_Q	322_G	0.519	1.00
215_R	368_M	0.519	1.00
193_F	342_I	0.517	1.00
171_V	194_A	0.516	1.00
22_I	25_S	0.515	1.00
210_D	229_N	0.515	1.00
244_T	248_A	0.513	1.00
214_Y	368_M	0.513	1.00
162_D	166_T	0.512	1.00
295_Q	320_R	0.512	1.00
175_G	201_K	0.511	1.00
19_D	135_R	0.510	1.00
281_L	296_I	0.509	1.00
27_D	126_Y	0.509	1.00
258_D	306_G	0.508	1.00
137_P	142_T	0.508	1.00
150_C	338_S	0.505	1.00
168_F	201_K	0.505	1.00
195_Q	199_W	0.504	1.00
55_D	59_G	0.504	1.00
69_V	76_L	0.504	1.00
322_G	327_I	0.503	1.00
371_C	374_V	0.503	1.00
283_I	287_A	0.503	1.00
213_N	220_K	0.501	1.00
241_K	244_T	0.500	1.00
314_Q	323_Q	0.500	1.00
166_T	297_T	0.500	1.00
349_S	372_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cpdA	2	0.9101	100	0.215	Contact Map
4ej6A	1	0.8862	100	0.218	Contact Map
1h2bA	4	0.8862	100	0.22	Contact Map
3ukoA	4	0.9259	100	0.223	Contact Map
4ilkA	2	0.8836	100	0.224	Contact Map
1cdoA	2	0.9153	100	0.226	Contact Map
1vj0A	4	0.9048	100	0.226	Contact Map
1f8fA	4	0.9153	100	0.226	Contact Map
4oh1A	4	0.873	100	0.229	Contact Map
1rjwA	4	0.881	100	0.23	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.