GREMLIN Database
ADHR - HTH-type transcriptional regulator AdhR
UniProt: O06008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (113)
Sequences: 11907 (8321)
Seq/√Len: 782.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_I102_I3.5181.00
40_D43_D3.5111.00
19_Y23_V2.6921.00
15_A22_R2.5721.00
95_R99_D2.5511.00
88_R106_D2.3411.00
85_A109_I2.2701.00
32_K38_D2.0801.00
14_A18_R1.9191.00
2_N38_D1.8531.00
87_E90_R1.8331.00
88_R92_I1.8231.00
81_K85_A1.8221.00
4_A8_K1.7851.00
54_R60_I1.7791.00
6_V44_I1.7041.00
23_V64_I1.6851.00
59_S62_A1.6771.00
6_V47_I1.5911.00
90_R94_K1.5791.00
46_W67_T1.5561.00
51_K54_R1.5251.00
102_I106_D1.4971.00
94_K97_E1.4891.00
46_W71_T1.4831.00
93_E97_E1.4831.00
2_N5_Q1.4171.00
85_A113_D1.3951.00
3_I18_R1.3921.00
84_L109_I1.3731.00
5_Q8_K1.3481.00
25_L50_I1.3341.00
96_K99_D1.3001.00
99_D102_I1.2751.00
92_I106_D1.2731.00
91_L95_R1.2441.00
88_R102_I1.2351.00
79_A82_N1.2021.00
9_Q44_I1.2011.00
107_T111_D1.1751.00
64_I68_T1.1561.00
62_A65_E1.1511.00
6_V43_D1.1421.00
62_A87_E1.1301.00
95_R98_I1.1301.00
21_E27_P1.1101.00
55_N97_E1.1001.00
5_Q9_Q1.0991.00
50_I63_L1.0941.00
30_K40_D1.0901.00
13_T16_T1.0841.00
92_I95_R1.0831.00
17_L39_Y1.0781.00
10_F47_I1.0781.00
7_A14_A1.0781.00
81_K113_D1.0511.00
95_R102_I1.0081.00
92_I96_K1.0081.00
23_V61_E1.0041.00
96_K100_E1.0011.00
30_K38_D0.9951.00
51_K55_N0.9871.00
88_R109_I0.9861.00
4_A14_A0.9741.00
20_Y47_I0.9701.00
93_E96_K0.9521.00
17_L47_I0.9511.00
89_Q92_I0.9451.00
19_Y60_I0.9401.00
72_E75_R0.9311.00
85_A88_R0.9261.00
16_T19_Y0.9251.00
89_Q93_E0.9211.00
61_E64_I0.9171.00
56_A101_T0.8951.00
57_G94_K0.8871.00
44_I48_E0.8791.00
90_R93_E0.8781.00
10_F44_I0.8711.00
99_D103_K0.8661.00
10_F17_L0.8631.00
32_K36_I0.8621.00
82_N86_D0.8591.00
81_K99_D0.8571.00
26_I43_D0.8491.00
26_I50_I0.8431.00
58_L66_Y0.8291.00
21_E26_I0.8201.00
34_S38_D0.8191.00
76_T80_R0.8161.00
29_V39_Y0.8091.00
29_V43_D0.8081.00
2_N36_I0.8061.00
12_L51_K0.8031.00
85_A89_Q0.7991.00
9_Q41_E0.7981.00
94_K98_I0.7981.00
9_Q48_E0.7941.00
41_E45_K0.7921.00
7_A17_L0.7901.00
86_D89_Q0.7851.00
98_I102_I0.7851.00
108_K111_D0.7841.00
80_R83_I0.7641.00
47_I54_R0.7541.00
76_T79_A0.7481.00
6_V10_F0.7431.00
12_L47_I0.7421.00
104_R108_K0.7361.00
110_K113_D0.7361.00
3_I7_A0.7311.00
21_E39_Y0.7241.00
65_E68_T0.7001.00
19_Y22_R0.6971.00
46_W68_T0.6961.00
17_L21_E0.6941.00
103_K107_T0.6921.00
30_K43_D0.6831.00
77_V80_R0.6731.00
78_E82_N0.6731.00
49_F53_M0.6611.00
83_I87_E0.6461.00
54_R87_E0.6461.00
86_D90_R0.6431.00
31_R37_R0.6401.00
45_K48_E0.6391.00
12_L16_T0.6381.00
111_D114_G0.6311.00
82_N85_A0.6301.00
88_R91_L0.6201.00
4_A36_I0.6191.00
48_E52_C0.6141.00
87_E94_K0.6121.00
80_R84_L0.6121.00
24_G27_P0.6111.00
57_G87_E0.6111.00
83_I86_D0.6061.00
107_T110_K0.6031.00
53_M58_L0.6011.00
4_A7_A0.5891.00
73_G80_R0.5861.00
97_E100_E0.5861.00
100_E103_K0.5831.00
91_L105_L0.5801.00
58_L76_T0.5801.00
48_E51_K0.5791.00
23_V60_I0.5761.00
91_L98_I0.5711.00
6_V26_I0.5711.00
52_C97_E0.5681.00
3_I14_A0.5631.00
54_R59_S0.5621.00
13_T19_Y0.5581.00
21_E29_V0.5511.00
70_F73_G0.5511.00
108_K112_Y0.5501.00
32_K35_G0.5481.00
10_F51_K0.5471.00
31_R34_S0.5451.00
21_E28_P0.5411.00
100_E104_R0.5321.00
88_R95_R0.5301.00
42_E45_K0.5291.00
78_E81_K0.5281.00
79_A83_I0.5271.00
2_N14_A0.5271.00
62_A86_D0.5261.00
74_D77_V0.5131.00
66_Y69_L0.5121.00
101_T104_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gpvA 2 0.8214 100 0.215 Contact Map
3gp4A 4 0.9214 100 0.22 Contact Map
1q06A 2 0.9071 99.9 0.244 Contact Map
3qaoA 2 0.8214 99.9 0.255 Contact Map
3hh0A 4 0.9429 99.9 0.262 Contact Map
2dg6A 2 0.9357 99.9 0.264 Contact Map
4ua1A 2 0.8929 99.9 0.281 Contact Map
1r8dA 2 0.7643 99.9 0.287 Contact Map
2vz4A 2 0.7071 99.9 0.293 Contact Map
2zhgA 2 0.8429 99.9 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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