AAPA - BACSU - GREMLIN Contacts

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AAPA - Amino-acid permease AapA

UniProt:	O06005	Sequences: MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGKSIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGWTYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFWFALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVVFAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNESPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKLTSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYRKTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIILYKVQTRRGHKVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	462 (427)
Sequences:	24746 (15941)
Seq/√Len:	771.4

ECOLI - AROP PHEP CYCA PROY YIFK ANSP GABP MMUP LYSP PUUP PLAP POTE FRLA YCAM GADC YGJI ADIC YJEM YBAT YJEH CADB ARCD TNAB
BACSU - AAPA YDGF YBGF YTNA YBXG ROCC HUTM GABP YVBW ROCE YHDG YCGH YFNA ASPP STET YBEC ARCD YECA YDAO GERBB GERAB YNDE GERKB YFKT
HALSA - Q9HHU7 Q9HQB3 Q9HSL5
SULSO - Q97XM0 Q97U05 Q97WS3 Q97X49 Q97ZB5 Q97VA6 Q7LXI7 Q97Z63 Q97U33 Q97VA8 Q97WD4 Q97VR4 Q97Y76 Q97YN3 Q97YX9 Q97U39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_L	348_S	4.426	1.00
330_L	342_N	4.299	1.00
390_K	394_T	3.490	1.00
382_G	417_L	3.298	1.00
61_G	253_L	3.269	1.00
239_K	243_K	3.121	1.00
333_K	342_N	3.085	1.00
21_K	235_E	2.931	1.00
85_V	324_D	2.795	1.00
234_T	240_V	2.775	1.00
101_G	321_L	2.725	1.00
236_N	239_K	2.663	1.00
322_A	332_K	2.561	1.00
137_L	352_L	2.553	1.00
335_T	341_S	2.547	1.00
176_G	262_V	2.533	1.00
26_Q	247_Q	2.475	1.00
232_G	323_K	2.475	1.00
330_L	333_K	2.458	1.00
22_N	247_Q	2.422	1.00
290_V	294_L	2.418	1.00
174_V	178_L	2.357	1.00
73_E	392_R	2.322	1.00
385_V	416_T	2.253	1.00
22_N	240_V	2.238	1.00
233_E	316_R	2.237	1.00
89_R	97_A	2.224	1.00
145_I	149_A	2.212	1.00
345_F	349_I	2.209	1.00
319_Y	323_K	2.161	1.00
152_K	156_E	2.150	1.00
25_I	234_T	2.112	1.00
141_I	352_L	2.110	1.00
442_V	445_V	2.099	1.00
22_N	26_Q	2.090	1.00
281_Q	284_S	2.067	1.00
144_L	344_L	2.065	1.00
414_Y	418_A	2.037	1.00
148_L	341_S	2.028	1.00
449_I	453_V	2.022	1.00
92_L	390_K	2.003	1.00
243_K	247_Q	1.998	1.00
136_G	355_V	1.982	1.00
70_S	385_V	1.972	1.00
448_I	452_K	1.967	1.00
445_V	449_I	1.964	1.00
137_L	355_V	1.946	1.00
89_R	94_N	1.941	1.00
163_L	167_I	1.939	1.00
105_W	347_S	1.933	1.00
21_K	24_H	1.926	1.00
16_L	334_L	1.915	1.00
62_V	66_F	1.906	1.00
331_L	346_F	1.899	1.00
325_H	329_G	1.882	1.00
281_Q	285_A	1.855	1.00
45_S	53_I	1.849	1.00
335_T	339_V	1.836	1.00
386_I	417_L	1.798	1.00
92_L	386_I	1.788	1.00
411_L	415_L	1.783	1.00
447_L	450_L	1.777	1.00
246_N	250_V	1.775	1.00
236_N	240_V	1.771	1.00
24_H	159_F	1.753	1.00
88_V	100_T	1.738	1.00
438_F	442_V	1.734	1.00
147_N	308_N	1.733	1.00
52_S	210_F	1.710	1.00
56_A	213_S	1.693	1.00
141_I	348_S	1.691	1.00
268_P	271_V	1.684	1.00
29_A	248_I	1.682	1.00
100_T	383_I	1.680	1.00
140_L	351_I	1.667	1.00
26_Q	251_R	1.662	1.00
93_G	96_A	1.654	1.00
112_A	351_I	1.651	1.00
20_L	24_H	1.647	1.00
442_V	446_L	1.644	1.00
418_A	422_F	1.642	1.00
148_L	345_F	1.641	1.00
337_S	341_S	1.641	1.00
167_I	171_A	1.627	1.00
116_L	307_A	1.617	1.00
52_S	203_F	1.575	1.00
390_K	393_K	1.561	1.00
250_V	254_L	1.546	1.00
63_F	419_F	1.545	1.00
444_F	448_I	1.536	1.00
446_L	450_L	1.534	1.00
318_V	343_A	1.514	1.00
236_N	243_K	1.495	1.00
123_T	135_P	1.493	1.00
230_T	312_F	1.489	1.00
60_T	217_V	1.482	1.00
81_Y	232_G	1.470	1.00
342_N	346_F	1.467	1.00
271_V	285_A	1.465	1.00
149_A	337_S	1.463	1.00
66_F	415_L	1.460	1.00
177_I	262_V	1.448	1.00
68_M	249_P	1.444	1.00
137_L	141_I	1.443	1.00
166_V	170_L	1.441	1.00
319_Y	334_L	1.432	1.00
284_S	292_A	1.428	1.00
119_V	300_L	1.426	1.00
314_T	347_S	1.426	1.00
116_L	140_L	1.419	1.00
92_L	96_A	1.416	1.00
88_V	383_I	1.416	1.00
441_P	445_V	1.406	1.00
17_S	338_N	1.402	1.00
168_A	298_V	1.390	1.00
329_G	332_K	1.385	1.00
275_N	281_Q	1.383	1.00
333_K	341_S	1.382	1.00
144_L	345_F	1.378	1.00
386_I	390_K	1.376	1.00
16_L	319_Y	1.372	1.00
62_V	415_L	1.371	1.00
315_S	344_L	1.370	1.00
329_G	333_K	1.368	1.00
192_S	196_L	1.361	1.00
440_T	444_F	1.358	1.00
140_L	348_S	1.357	1.00
24_H	155_G	1.345	1.00
95_M	451_Y	1.344	1.00
438_F	449_I	1.318	1.00
443_W	447_L	1.314	1.00
40_L	118_A	1.311	1.00
22_N	243_K	1.308	1.00
119_V	139_A	1.305	1.00
237_P	242_P	1.297	1.00
240_V	243_K	1.296	1.00
78_N	90_D	1.295	1.00
70_S	413_N	1.285	1.00
408_F	412_S	1.282	1.00
67_I	385_V	1.276	1.00
254_L	258_G	1.274	1.00
68_M	245_I	1.274	1.00
173_I	258_G	1.270	1.00
180_I	265_C	1.270	1.00
91_Y	387_C	1.269	1.00
20_L	25_I	1.265	1.00
382_G	421_A	1.254	1.00
77_S	402_N	1.254	1.00
318_V	327_A	1.248	1.00
86_D	90_D	1.246	1.00
20_L	155_G	1.243	1.00
293_S	297_F	1.239	1.00
115_D	306_A	1.238	1.00
69_R	246_N	1.232	1.00
146_M	157_L	1.228	1.00
284_S	289_V	1.223	1.00
33_A	252_I	1.223	1.00
23_R	27_L	1.219	1.00
192_S	195_N	1.216	1.00
143_L	307_A	1.211	1.00
54_L	261_F	1.206	1.00
389_L	414_Y	1.194	1.00
277_S	281_Q	1.191	1.00
105_W	318_V	1.181	1.00
422_F	426_I	1.180	1.00
88_V	96_A	1.169	1.00
176_G	266_I	1.168	1.00
71_L	84_F	1.166	1.00
181_A	184_F	1.163	1.00
393_K	396_Q	1.162	1.00
158_E	308_N	1.160	1.00
193_L	196_L	1.160	1.00
393_K	410_P	1.156	1.00
133_W	137_L	1.145	1.00
46_I	53_I	1.144	1.00
25_I	244_A	1.143	1.00
98_F	102_W	1.142	1.00
178_L	183_G	1.140	1.00
131_P	134_L	1.133	1.00
206_G	209_G	1.133	1.00
410_P	414_Y	1.128	1.00
177_I	181_A	1.127	1.00
342_N	345_F	1.119	1.00
235_E	240_V	1.114	1.00
80_G	86_D	1.112	1.00
396_Q	402_N	1.098	1.00
171_A	175_T	1.098	1.00
334_L	338_N	1.098	1.00
85_V	320_S	1.097	1.00
323_K	332_K	1.095	1.00
388_H	413_N	1.094	1.00
434_R	437_L	1.091	1.00
19_G	235_E	1.088	1.00
134_L	138_L	1.082	1.00
28_M	230_T	1.081	1.00
123_T	127_L	1.078	1.00
30_I	251_R	1.073	1.00
29_A	227_V	1.073	1.00
75_L	87_F	1.073	1.00
172_L	176_G	1.072	1.00
157_L	161_F	1.071	1.00
421_A	425_V	1.071	1.00
442_V	447_L	1.064	1.00
349_I	353_I	1.063	1.00
170_L	174_V	1.057	1.00
156_E	160_W	1.056	1.00
138_L	142_I	1.055	1.00
287_G	291_A	1.054	1.00
438_F	447_L	1.048	1.00
203_F	210_F	1.045	1.00
434_R	438_F	1.041	1.00
90_D	395_R	1.038	1.00
73_E	76_L	1.036	1.00
151_V	312_F	1.035	1.00
435_I	438_F	1.032	1.00
425_V	429_L	1.023	1.00
120_G	135_P	1.021	1.00
141_I	145_I	1.020	1.00
30_I	252_I	1.017	1.00
411_L	414_Y	1.014	1.00
58_L	257_V	1.014	1.00
409_Y	413_N	1.013	1.00
433_T	437_L	1.003	1.00
77_S	400_K	1.002	1.00
195_N	198_S	0.995	1.00
231_A	241_I	0.994	1.00
130_V	134_L	0.987	1.00
385_V	417_L	0.985	1.00
148_L	339_V	0.985	1.00
211_I	422_F	0.976	1.00
144_L	148_L	0.976	1.00
80_G	90_D	0.975	1.00
417_L	421_A	0.971	1.00
408_F	411_L	0.970	1.00
436_A	440_T	0.968	1.00
268_P	285_A	0.962	1.00
66_F	412_S	0.960	1.00
166_V	255_F	0.960	1.00
435_I	442_V	0.957	1.00
382_G	420_L	0.951	1.00
438_F	445_V	0.946	1.00
275_N	278_P	0.943	1.00
225_E	229_L	0.941	1.00
161_F	305_S	0.935	1.00
222_V	377_F	0.932	1.00
114_A	219_F	0.932	1.00
173_I	262_V	0.925	1.00
165_K	302_S	0.917	1.00
82_H	86_D	0.915	1.00
148_L	335_T	0.915	1.00
123_T	300_L	0.914	1.00
191_A	194_N	0.913	1.00
120_G	136_G	0.911	1.00
178_L	182_K	0.911	1.00
397_H	402_N	0.909	1.00
266_I	282_V	0.907	1.00
16_L	316_R	0.903	1.00
19_G	152_K	0.900	1.00
311_L	348_S	0.898	1.00
424_L	427_L	0.897	1.00
61_G	221_F	0.897	1.00
54_L	264_M	0.896	1.00
117_T	369_I	0.888	1.00
447_L	451_Y	0.888	1.00
172_L	283_F	0.887	1.00
331_L	342_N	0.886	1.00
135_P	138_L	0.886	1.00
143_L	308_N	0.883	1.00
27_L	159_F	0.883	1.00
34_I	37_G	0.880	1.00
400_K	403_K	0.880	1.00
382_G	386_I	0.878	1.00
24_H	156_E	0.877	1.00
247_Q	251_R	0.877	1.00
253_L	257_V	0.876	1.00
422_F	425_V	0.875	1.00
89_R	324_D	0.874	1.00
76_L	403_K	0.874	1.00
335_T	338_N	0.872	1.00
142_I	304_A	0.868	1.00
341_S	345_F	0.866	1.00
173_I	177_I	0.865	1.00
193_L	197_W	0.862	1.00
16_L	233_E	0.861	1.00
102_W	327_A	0.857	1.00
432_D	436_A	0.857	1.00
288_I	291_A	0.857	1.00
416_T	420_L	0.852	1.00
96_A	383_I	0.851	1.00
428_A	431_N	0.851	1.00
114_A	370_T	0.851	1.00
22_N	244_A	0.851	1.00
389_L	410_P	0.849	1.00
120_G	132_Q	0.848	1.00
395_R	400_K	0.842	1.00
82_H	85_V	0.839	1.00
55_F	210_F	0.837	1.00
177_I	258_G	0.835	1.00
58_L	62_V	0.833	1.00
445_V	448_I	0.830	1.00
178_L	181_A	0.826	1.00
348_S	352_L	0.826	1.00
389_L	413_N	0.826	1.00
23_R	159_F	0.825	1.00
261_F	265_C	0.824	1.00
95_M	99_I	0.824	1.00
181_A	185_S	0.824	1.00
88_V	387_C	0.820	1.00
289_V	293_S	0.819	1.00
392_R	396_Q	0.818	1.00
65_F	69_R	0.818	1.00
180_I	183_G	0.817	1.00
450_L	453_V	0.817	1.00
119_V	303_A	0.814	1.00
432_D	435_I	0.813	1.00
327_A	331_L	0.809	1.00
192_S	197_W	0.805	1.00
93_G	452_K	0.801	1.00
140_L	355_V	0.799	1.00
156_E	159_F	0.798	1.00
119_V	304_A	0.798	1.00
226_L	313_S	0.797	1.00
439_V	442_V	0.794	1.00
74_L	87_F	0.791	1.00
133_W	355_V	0.788	1.00
222_V	381_W	0.788	1.00
65_F	246_N	0.787	1.00
449_I	452_K	0.783	1.00
438_F	448_I	0.782	1.00
200_G	204_P	0.780	1.00
145_I	148_L	0.772	1.00
212_L	216_M	0.770	1.00
34_I	165_K	0.769	1.00
432_D	437_L	0.767	1.00
109_I	350_A	0.767	1.00
207_W	210_F	0.766	1.00
437_L	441_P	0.760	1.00
448_I	451_Y	0.759	1.00
66_F	70_S	0.758	1.00
438_F	441_P	0.757	1.00
433_T	436_A	0.757	1.00
104_Y	108_W	0.755	1.00
389_L	393_K	0.753	1.00
388_H	392_R	0.752	1.00
124_Q	128_P	0.751	1.00
180_I	184_F	0.749	1.00
143_L	311_L	0.748	1.00
149_A	153_L	0.747	1.00
273_N	278_P	0.745	1.00
444_F	447_L	0.743	1.00
193_L	198_S	0.743	1.00
446_L	452_K	0.742	1.00
26_Q	244_A	0.738	1.00
74_L	388_H	0.737	1.00
372_V	376_C	0.737	1.00
242_P	245_I	0.735	1.00
438_F	443_W	0.735	1.00
148_L	337_S	0.734	1.00
336_S	341_S	0.734	1.00
55_F	58_L	0.731	1.00
93_G	97_A	0.729	1.00
38_L	259_A	0.729	1.00
33_A	248_I	0.728	1.00
69_R	412_S	0.728	1.00
173_I	259_A	0.723	1.00
330_L	346_F	0.723	1.00
349_I	352_L	0.722	1.00
64_C	224_I	0.720	1.00
443_W	450_L	0.719	1.00
111_L	373_S	0.719	1.00
290_V	293_S	0.719	1.00
143_L	304_A	0.718	1.00
318_V	346_F	0.717	1.00
340_P	343_A	0.714	1.00
110_S	372_V	0.712	1.00
45_S	49_A	0.710	1.00
423_I	427_L	0.710	1.00
442_V	449_I	0.708	1.00
420_L	423_I	0.707	1.00
85_V	89_R	0.704	1.00
409_Y	412_S	0.703	1.00
147_N	344_L	0.702	1.00
278_P	283_F	0.701	1.00
124_Q	132_Q	0.700	1.00
440_T	449_I	0.700	1.00
413_N	417_L	0.699	1.00
16_L	19_G	0.699	1.00
67_I	420_L	0.698	1.00
26_Q	29_A	0.697	1.00
23_R	156_E	0.696	1.00
113_M	369_I	0.696	1.00
55_F	59_I	0.695	1.00
180_I	262_V	0.694	1.00
236_N	242_P	0.693	1.00
123_T	139_A	0.692	1.00
111_L	114_A	0.692	1.00
182_K	185_S	0.691	1.00
387_C	391_Y	0.691	1.00
438_F	444_F	0.690	1.00
91_Y	390_K	0.688	1.00
375_I	424_L	0.687	1.00
147_N	312_F	0.686	1.00
19_G	151_V	0.686	1.00
402_N	405_K	0.684	1.00
111_L	115_D	0.682	1.00
436_A	449_I	0.682	1.00
31_G	162_A	0.682	1.00
437_L	447_L	0.682	1.00
42_S	260_L	0.676	1.00
133_W	136_G	0.676	1.00
407_P	411_L	0.675	1.00
34_I	39_F	0.674	1.00
35_G	39_F	0.674	1.00
251_R	255_F	0.671	1.00
311_L	315_S	0.670	1.00
153_L	156_E	0.670	1.00
107_C	377_F	0.669	1.00
34_I	255_F	0.669	1.00
77_S	403_K	0.668	1.00
155_G	159_F	0.668	1.00
315_S	343_A	0.666	1.00
139_A	307_A	0.666	1.00
228_G	245_I	0.666	1.00
393_K	397_H	0.665	1.00
195_N	199_H	0.665	1.00
294_L	298_V	0.665	1.00
194_N	197_W	0.664	1.00
241_I	245_I	0.662	1.00
443_W	446_L	0.662	1.00
232_G	319_Y	0.662	1.00
439_V	443_W	0.662	1.00
137_L	356_S	0.662	1.00
437_L	440_T	0.660	1.00
71_L	384_T	0.659	1.00
164_I	298_V	0.659	1.00
51_P	264_M	0.658	1.00
41_G	370_T	0.657	1.00
331_L	343_A	0.655	1.00
440_T	447_L	0.655	1.00
120_G	123_T	0.654	1.00
222_V	225_E	0.654	1.00
247_Q	250_V	0.651	1.00
148_L	344_L	0.651	1.00
191_A	195_N	0.650	1.00
57_Y	220_A	0.649	1.00
32_G	310_A	0.649	1.00
68_M	224_I	0.648	1.00
316_R	319_Y	0.647	1.00
19_G	23_R	0.647	1.00
410_P	413_N	0.645	1.00
251_R	254_L	0.644	1.00
397_H	401_A	0.643	1.00
196_L	199_H	0.643	1.00
116_L	120_G	0.642	1.00
406_M	409_Y	0.642	1.00
283_F	288_I	0.642	1.00
54_L	58_L	0.641	1.00
435_I	447_L	0.641	1.00
151_V	230_T	0.639	1.00
376_C	380_I	0.639	1.00
435_I	439_V	0.638	1.00
103_T	380_I	0.637	1.00
150_T	153_L	0.636	1.00
322_A	331_L	0.635	1.00
193_L	265_C	0.631	1.00
278_P	286_V	0.631	1.00
283_F	286_V	0.630	1.00
125_Y	296_N	0.629	1.00
85_V	101_G	0.627	1.00
194_N	198_S	0.626	1.00
395_R	402_N	0.625	1.00
437_L	444_F	0.625	1.00
259_A	263_I	0.623	1.00
262_V	265_C	0.621	1.00
211_I	426_I	0.621	1.00
141_I	144_L	0.619	1.00
81_Y	319_Y	0.619	1.00
401_A	405_K	0.618	1.00
91_Y	391_Y	0.617	1.00
92_L	387_C	0.616	1.00
416_T	419_F	0.613	1.00
72_G	76_L	0.612	1.00
238_Q	403_K	0.611	1.00
302_S	305_S	0.610	1.00
314_T	318_V	0.610	1.00
30_I	162_A	0.607	1.00
414_Y	417_L	0.606	1.00
84_F	225_E	0.606	1.00
445_V	451_Y	0.605	1.00
438_F	446_L	0.605	1.00
274_P	278_P	0.604	1.00
69_R	407_P	0.604	1.00
32_G	309_S	0.604	1.00
125_Y	128_P	0.604	1.00
32_G	226_L	0.604	1.00
53_I	260_L	0.603	1.00
259_A	279_F	0.603	1.00
59_I	214_F	0.603	1.00
140_L	352_L	0.602	1.00
175_T	179_L	0.601	1.00
115_D	303_A	0.601	1.00
258_G	262_V	0.601	1.00
77_S	396_Q	0.601	1.00
406_M	412_S	0.600	1.00
144_L	311_L	0.599	1.00
155_G	308_N	0.599	1.00
391_Y	395_R	0.597	1.00
441_P	444_F	0.597	1.00
75_L	228_G	0.594	1.00
60_T	218_V	0.594	1.00
400_K	405_K	0.594	1.00
201_G	204_P	0.593	1.00
70_S	416_T	0.593	1.00
162_A	165_K	0.593	1.00
66_F	416_T	0.591	1.00
108_W	310_A	0.591	1.00
43_G	46_I	0.589	1.00
115_D	307_A	0.587	1.00
408_F	413_N	0.586	1.00
48_F	212_L	0.586	1.00
446_L	449_I	0.585	1.00
44_K	367_T	0.585	1.00
396_Q	400_K	0.583	1.00
436_A	441_P	0.582	1.00
75_L	241_I	0.581	1.00
277_S	280_V	0.580	1.00
85_V	97_A	0.579	1.00
432_D	446_L	0.579	1.00
113_M	354_G	0.579	1.00
446_L	453_V	0.578	1.00
83_S	228_G	0.577	1.00
126_W	297_F	0.577	1.00
88_V	97_A	0.576	1.00
16_L	81_Y	0.574	1.00
438_F	450_L	0.572	1.00
36_T	219_F	0.572	1.00
60_T	221_F	0.571	1.00
40_L	43_G	0.570	1.00
23_R	26_Q	0.569	1.00
181_A	191_A	0.567	1.00
54_L	257_V	0.567	1.00
100_T	380_I	0.566	1.00
103_T	379_F	0.566	1.00
185_S	265_C	0.565	1.00
29_A	33_A	0.565	1.00
68_M	72_G	0.564	1.00
237_P	240_V	0.563	1.00
227_V	241_I	0.563	1.00
74_L	91_Y	0.562	1.00
122_Y	299_V	0.562	1.00
229_L	313_S	0.561	1.00
233_E	334_L	0.561	1.00
70_S	406_M	0.561	1.00
159_F	163_L	0.560	1.00
142_I	146_M	0.560	1.00
440_T	451_Y	0.560	1.00
234_T	241_I	0.559	1.00
164_I	168_A	0.558	1.00
420_L	424_L	0.557	1.00
297_F	301_T	0.556	1.00
356_S	359_Y	0.555	1.00
84_F	229_L	0.555	1.00
103_T	107_C	0.554	1.00
222_V	373_S	0.554	1.00
397_H	400_K	0.552	1.00
199_H	270_N	0.550	1.00
115_D	118_A	0.548	1.00
30_I	33_A	0.548	1.00
160_W	163_L	0.547	1.00
436_A	439_V	0.547	1.00
318_V	322_A	0.547	1.00
392_R	409_Y	0.547	1.00
67_I	225_E	0.546	1.00
139_A	143_L	0.545	1.00
54_L	57_Y	0.543	1.00
122_Y	280_V	0.543	1.00
435_I	446_L	0.542	1.00
153_L	157_L	0.540	1.00
158_E	305_S	0.540	1.00
129_D	132_Q	0.539	1.00
154_F	312_F	0.538	1.00
45_S	217_V	0.537	1.00
273_N	277_S	0.536	1.00
138_L	141_I	0.536	1.00
433_T	446_L	0.536	1.00
346_F	350_A	0.536	1.00
109_I	347_S	0.535	1.00
316_R	334_L	0.535	1.00
334_L	337_S	0.534	1.00
115_D	120_G	0.533	1.00
207_W	211_I	0.533	1.00
434_R	445_V	0.531	1.00
139_A	304_A	0.531	1.00
434_R	448_I	0.530	1.00
251_R	258_G	0.529	1.00
445_V	453_V	0.528	1.00
316_R	340_P	0.528	1.00
432_D	449_I	0.528	1.00
57_Y	260_L	0.528	1.00
225_E	381_W	0.527	1.00
283_F	291_A	0.526	1.00
418_A	421_A	0.526	1.00
34_I	41_G	0.526	1.00
185_S	264_M	0.526	1.00
167_I	170_L	0.524	1.00
413_N	420_L	0.524	1.00
273_N	281_Q	0.523	1.00
80_G	232_G	0.523	1.00
179_L	182_K	0.523	1.00
444_F	449_I	0.522	1.00
389_L	417_L	0.522	1.00
233_E	340_P	0.521	1.00
126_W	296_N	0.520	1.00
209_G	212_L	0.520	1.00
378_I	420_L	0.519	1.00
367_T	370_T	0.519	1.00
49_A	213_S	0.518	1.00
238_Q	401_A	0.518	1.00
191_A	197_W	0.516	1.00
433_T	438_F	0.516	1.00
180_I	266_I	0.516	1.00
239_K	242_P	0.516	1.00
18_R	235_E	0.515	1.00
426_I	430_A	0.515	1.00
119_V	123_T	0.515	1.00
48_F	51_P	0.514	1.00
65_F	250_V	0.513	1.00
274_P	277_S	0.513	1.00
425_V	428_A	0.512	1.00
377_F	380_I	0.511	1.00
38_L	169_I	0.510	1.00
39_F	169_I	0.507	1.00
21_K	152_K	0.505	1.00
25_I	230_T	0.505	1.00
443_W	451_Y	0.503	1.00
315_S	347_S	0.502	1.00
107_C	376_C	0.502	1.00
179_L	184_F	0.502	1.00
127_L	135_P	0.501	1.00
42_S	46_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l1lA	2	0.8918	100	0.3	Contact Map
3giaA	1	0.9069	100	0.354	Contact Map
4djkA	2	0.8874	100	0.356	Contact Map
3dh4A	3	0.9113	99.2	0.839	Contact Map
2xq2A	2	0.9177	99.2	0.842	Contact Map
2jlnA	1	0.881	98.8	0.861	Contact Map
4wgvA	2	0.7987	97.8	0.897	Contact Map
2a65A	2	0.9177	97.7	0.899	Contact Map
4us3A	1	0.8442	97.5	0.903	Contact Map
4xp4A	1	0.9286	96.9	0.912	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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