GREMLIN Database
YDIL - Putative membrane peptidase YdiL
UniProt: O05525 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (207)
Sequences: 3888 (3469)
Seq/√Len: 241.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_G193_A4.2871.00
173_G186_T4.1121.00
136_S214_T3.9621.00
152_F197_A3.7371.00
201_R204_V3.1491.00
147_F175_V3.0701.00
195_L208_A2.9911.00
212_M216_V2.9441.00
173_G185_Y2.8601.00
170_V186_T2.8291.00
139_G210_L2.8071.00
156_Y197_A2.7881.00
152_F193_A2.7421.00
161_F197_A2.7321.00
140_P210_L2.6811.00
194_F198_R2.6511.00
196_Y205_P2.6381.00
169_S190_F2.4861.00
178_D181_H2.3031.00
173_G189_G2.2181.00
152_F168_S2.2151.00
181_H185_Y1.9481.00
161_F165_G1.9461.00
203_W206_I1.9331.00
141_I206_I1.9031.00
169_S193_A1.8861.00
165_G197_A1.8421.00
196_Y199_T1.8331.00
169_S186_T1.8181.00
168_S193_A1.7521.00
153_G156_Y1.7481.00
165_G190_F1.7301.00
189_G193_A1.7301.00
160_N163_F1.6961.00
12_Y15_M1.6411.00
195_L204_V1.6321.00
87_A91_F1.6001.00
149_K202_I1.5511.00
152_F165_G1.5441.00
136_S139_G1.5261.00
152_F156_Y1.5261.00
188_M192_F1.5121.00
16_Q19_A1.4651.00
15_M19_A1.4421.00
169_S173_G1.3981.00
164_A168_S1.3921.00
162_F166_L1.3711.00
140_P213_N1.3701.00
159_T163_F1.3681.00
82_L85_L1.3651.00
149_K153_G1.3601.00
136_S217_V1.3531.00
19_A22_A1.3311.00
166_L190_F1.3271.00
192_F205_P1.3251.00
193_A197_A1.3241.00
66_T69_K1.3211.00
168_S196_Y1.2891.00
168_S189_G1.2701.00
61_L65_R1.2621.00
196_Y201_R1.2611.00
20_L24_P1.2511.00
16_Q20_L1.2451.00
201_R205_P1.2281.00
58_V62_L1.2161.00
202_I206_I1.2071.00
212_M215_F1.2031.00
152_F196_Y1.2021.00
132_I217_V1.2011.00
12_Y19_A1.1891.00
159_T164_A1.1891.00
169_S189_G1.1851.00
165_G194_F1.1441.00
120_A123_D1.1411.00
84_I88_I1.1401.00
210_L214_T1.1241.00
156_Y161_F1.1221.00
163_F167_I1.1181.00
182_L186_T1.1121.00
151_I168_S1.1031.00
192_F208_A1.1011.00
139_G206_I1.0991.00
186_T190_F1.0951.00
156_Y164_A1.0921.00
64_L68_P1.0901.00
152_F164_A1.0891.00
149_K201_R1.0881.00
195_L205_P1.0871.00
135_S139_G1.0821.00
160_N164_A1.0791.00
100_I104_I1.0711.00
204_V207_F1.0691.00
153_G196_Y1.0531.00
79_S82_L1.0171.00
141_I210_L1.0051.00
86_W90_G0.9921.00
182_L185_Y0.9911.00
202_I205_P0.9821.00
190_F193_A0.9791.00
119_Q123_D0.9721.00
80_I83_S0.9671.00
206_I210_L0.9531.00
131_M135_S0.9531.00
92_F96_F0.9431.00
85_L89_A0.9391.00
102_G106_Y0.9381.00
81_G85_L0.9381.00
155_L159_T0.9371.00
137_I141_I0.9331.00
151_I171_I0.9321.00
91_F211_M0.9321.00
12_Y16_Q0.9301.00
24_P28_K0.9191.00
101_A105_E0.9131.00
108_V111_I0.9111.00
132_I136_S0.9061.00
185_Y189_G0.8961.00
13_I16_Q0.8921.00
66_T70_E0.8891.00
78_D82_L0.8881.00
200_K205_P0.8871.00
20_L27_F0.8810.99
91_F94_A0.8780.99
178_D185_Y0.8750.99
38_D41_M0.8680.99
19_A23_I0.8670.99
154_A157_E0.8660.99
39_E48_W0.8640.99
145_I206_I0.8590.99
147_F172_F0.8530.99
128_V131_M0.8510.99
136_S140_P0.8400.99
94_A98_Q0.8390.99
183_L187_A0.8340.99
53_F57_L0.8320.99
135_S217_V0.8320.99
178_D182_L0.8280.99
117_N121_I0.8210.99
83_S86_W0.8150.99
207_F211_M0.8140.99
180_K183_L0.8110.99
176_H209_H0.8110.99
118_T122_L0.8100.99
41_M44_A0.8070.99
181_H184_L0.8050.99
173_G181_H0.8020.99
207_F210_L0.7990.99
46_G49_S0.7990.99
155_L167_I0.7960.99
173_G182_L0.7950.99
139_G142_L0.7930.99
82_L86_W0.7920.99
172_F176_H0.7900.99
184_L212_M0.7810.99
90_G191_T0.7800.99
199_T204_V0.7790.99
45_Q49_S0.7720.99
79_S83_S0.7710.99
25_L29_F0.7710.99
14_I19_A0.7710.99
180_K184_L0.7690.99
185_Y188_M0.7630.99
76_Q80_I0.7620.98
116_E119_Q0.7570.98
54_I57_L0.7570.98
89_A93_I0.7560.98
150_I154_A0.7510.98
60_V64_L0.7490.98
95_L98_Q0.7440.98
177_A182_L0.7420.98
154_A179_L0.7380.98
117_N185_Y0.7370.98
95_L99_G0.7340.98
117_N120_A0.7280.98
156_Y200_K0.7240.98
130_L134_V0.7230.98
32_A36_P0.7190.98
52_S56_C0.7190.98
149_K156_Y0.7180.98
136_S210_L0.7170.98
129_P133_I0.7130.98
162_F190_F0.7110.98
62_L66_T0.7090.98
54_I58_V0.7080.98
89_A96_F0.7030.97
125_I129_P0.7000.97
190_F194_F0.6990.97
22_A26_L0.6950.97
99_G103_S0.6940.97
156_Y160_N0.6930.97
184_L187_A0.6910.97
192_F195_L0.6910.97
60_V63_I0.6860.97
45_Q48_W0.6850.97
161_F164_A0.6800.97
88_I92_F0.6780.97
15_M18_S0.6770.97
164_A185_Y0.6770.97
211_M214_T0.6760.97
194_F204_V0.6740.97
78_D83_S0.6710.97
196_Y200_K0.6700.97
14_I17_F0.6690.97
137_I140_P0.6690.97
115_S118_T0.6540.96
61_L64_L0.6520.96
14_I18_S0.6510.96
76_Q84_I0.6500.96
24_P27_F0.6490.96
74_N77_K0.6490.96
196_Y204_V0.6480.96
18_S22_A0.6440.96
49_S52_S0.6430.96
42_L45_Q0.6420.96
17_F20_L0.6400.96
93_I96_F0.6370.95
165_G169_S0.6360.95
94_A104_I0.6350.95
205_P213_N0.6330.95
49_S53_F0.6330.95
162_F194_F0.6310.95
140_P206_I0.6270.95
93_I106_Y0.6230.95
87_A208_A0.6180.95
14_I30_G0.6070.94
92_F103_S0.6060.94
152_F161_F0.6040.94
67_V70_E0.6010.94
17_F41_M0.5980.94
44_A47_L0.5960.94
172_F209_H0.5960.94
103_S106_Y0.5960.94
143_E176_H0.5930.93
97_S187_A0.5920.93
48_W55_A0.5910.93
67_V71_T0.5910.93
188_M212_M0.5900.93
214_T218_I0.5890.93
39_E42_L0.5880.93
162_F165_G0.5870.93
81_G218_I0.5840.93
12_Y24_P0.5840.93
57_L60_V0.5830.93
28_K191_T0.5830.93
53_F61_L0.5810.93
142_L145_I0.5800.93
140_P221_L0.5730.92
29_F39_E0.5710.92
155_L201_R0.5700.92
93_I97_S0.5680.92
168_S182_L0.5660.92
57_L61_L0.5650.92
45_Q50_V0.5630.92
65_R69_K0.5630.92
18_S33_G0.5620.91
62_L65_R0.5590.91
154_A164_A0.5580.91
174_I177_A0.5570.91
84_I87_A0.5510.91
27_F32_A0.5500.91
138_V213_N0.5480.90
13_I70_E0.5480.90
20_L30_G0.5470.90
164_A203_W0.5440.90
101_A104_I0.5440.90
23_I27_F0.5430.90
217_V221_L0.5420.90
17_F27_F0.5410.90
184_L216_V0.5400.90
68_P71_T0.5400.90
115_S122_L0.5360.89
133_I137_I0.5360.89
90_G195_L0.5350.89
136_S216_V0.5350.89
137_I210_L0.5340.89
83_S87_A0.5330.89
143_E209_H0.5320.89
150_I161_F0.5320.89
183_L186_T0.5310.89
96_F103_S0.5310.89
43_H47_L0.5300.89
197_A212_M0.5270.89
42_L47_L0.5250.89
14_I26_L0.5240.88
46_G62_L0.5230.88
28_K32_A0.5220.88
185_Y196_Y0.5220.88
197_A201_R0.5200.88
146_I150_I0.5190.88
50_V54_I0.5180.88
82_L89_A0.5180.88
55_A58_V0.5170.88
162_F169_S0.5170.88
175_V180_K0.5160.88
65_R70_E0.5140.87
14_I31_Y0.5140.87
17_F21_I0.5120.87
196_Y203_W0.5090.87
181_H188_M0.5090.87
43_H46_G0.5090.87
198_R204_V0.5080.87
103_S108_V0.5080.87
161_F193_A0.5070.87
192_F196_Y0.5070.87
98_Q101_A0.5060.87
116_E122_L0.5060.87
42_L56_C0.5050.87
163_F166_L0.5040.86
91_F208_A0.5040.86
90_G208_A0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cadC 1 0.8975 99.9 0.482 Contact Map
4c7rA 3 0.7992 12.3 0.938 Contact Map
4ev6A 3 0.25 5.1 0.948 Contact Map
4i0uA 4 0.2418 5 0.948 Contact Map
1afoA 2 0.1639 3.8 0.951 Contact Map
2wswA 3 0.8115 3.6 0.952 Contact Map
3aqpA 1 0.2541 2.8 0.954 Contact Map
3o7qA 1 0.6393 2.4 0.956 Contact Map
3rkoK 1 0.3156 2.2 0.957 Contact Map
2mofA 1 0.1721 1.9 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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