GREMLIN Database
TATCY - Sec-independent protein translocase protein TatCy
UniProt: O05523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 254 (235)
Sequences: 3442 (2175)
Seq/√Len: 141.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_T233_S4.2491.00
193_R227_E4.0661.00
28_A85_V3.9271.00
20_K24_I3.7801.00
190_A234_K3.6491.00
24_I85_V3.3821.00
88_Y92_A3.1671.00
201_L219_T2.9021.00
186_P237_Y2.7361.00
17_E21_R2.7021.00
33_F78_G2.6211.00
210_P214_S2.3741.00
196_A226_Y2.1451.00
25_V86_I2.1101.00
34_I38_F2.1081.00
43_I77_I2.0981.00
57_T146_N2.0801.00
36_G77_I2.0491.00
185_T188_F1.9971.00
197_Y223_L1.9521.00
178_L183_I1.9451.00
122_S126_Y1.9331.00
186_P233_S1.9321.00
23_L27_L1.9091.00
24_I89_Q1.9011.00
61_F150_G1.8801.00
32_F78_G1.8701.00
78_G82_T1.8511.00
98_L102_E1.8441.00
175_L189_L1.8291.00
140_S147_Q1.8171.00
195_Y199_T1.8081.00
226_Y230_I1.8011.00
110_I114_I1.7901.00
59_N148_V1.7751.00
117_F166_G1.7741.00
65_D150_G1.7461.00
29_F75_F1.7231.00
62_N65_D1.7221.00
39_L42_P1.7081.00
22_L26_A1.7071.00
201_L215_H1.6651.00
200_L222_L1.6611.00
21_R89_Q1.6441.00
113_S170_Q1.6341.00
190_A193_R1.6261.00
192_I195_Y1.6051.00
10_S13_E1.5961.00
187_M191_K1.5861.00
21_R92_A1.5741.00
82_T86_I1.5691.00
212_L215_H1.5601.00
203_I207_I1.5561.00
188_F192_I1.5551.00
184_V189_L1.5541.00
95_S103_R1.5331.00
32_F81_L1.5211.00
63_L133_V1.5061.00
186_P234_K1.4831.00
118_L122_S1.4771.00
186_P190_A1.4641.00
179_T186_P1.4471.00
35_A38_F1.4451.00
236_A240_A1.4371.00
190_A227_E1.4221.00
24_I27_L1.3931.00
9_M13_E1.3701.00
32_F82_T1.3611.00
63_L66_P1.3351.00
60_A66_P1.3251.00
25_V82_T1.3201.00
28_A82_T1.3171.00
198_F202_V1.2881.00
83_S87_L1.2831.00
29_F82_T1.2701.00
70_F139_I1.2691.00
205_A215_H1.2661.00
63_L157_F1.2591.00
115_L119_A1.2541.00
150_G153_E1.2541.00
176_M236_A1.2531.00
210_P215_H1.2451.00
46_Y126_Y1.2281.00
62_N153_E1.2151.00
180_R236_A1.2121.00
137_K147_Q1.2081.00
60_A145_V1.2081.00
231_L235_A1.1841.00
175_L233_S1.1831.00
93_F96_P1.1831.00
121_L162_T1.1821.00
61_F148_V1.1761.00
216_M220_V1.1671.00
187_M190_A1.1661.00
31_V35_A1.1631.00
29_F86_I1.1400.99
207_I218_V1.1370.99
16_A20_K1.1330.99
64_T136_M1.1290.99
129_F158_L1.1240.99
35_A39_L1.1120.99
97_G102_E1.1050.99
227_E231_L1.0980.99
40_A70_F1.0950.99
239_K242_K1.0870.99
175_L229_S1.0820.99
25_V28_A1.0780.99
189_L226_Y1.0740.99
200_L223_L1.0730.99
100_E104_K1.0680.99
24_I88_Y1.0500.99
192_I196_A1.0440.99
89_Q92_A1.0260.99
238_R241_Q1.0250.99
14_H102_E1.0130.99
121_L166_G1.0000.98
36_G81_L0.9900.98
171_M200_L0.9900.98
186_P230_I0.9770.98
93_F97_G0.9770.98
37_F70_F0.9750.98
79_I86_I0.9710.98
17_E89_Q0.9710.98
27_L30_V0.9640.98
30_V34_I0.9550.98
210_P216_M0.9530.98
27_L31_V0.9480.98
204_A208_T0.9480.98
132_V214_S0.9410.98
26_A30_V0.9380.98
60_A151_I0.9230.97
14_H93_F0.9190.97
171_M229_S0.9180.97
190_A230_I0.9090.97
44_I73_F0.9080.97
164_P207_I0.9070.97
132_V136_M0.9040.97
63_L149_I0.9000.97
37_F71_M0.8980.97
133_V157_F0.8840.97
194_K215_H0.8830.97
60_A65_D0.8830.97
193_R197_Y0.8820.97
147_Q150_G0.8790.97
93_F102_E0.8770.97
185_T241_Q0.8760.97
129_F133_V0.8760.97
215_H219_T0.8730.96
29_F79_I0.8720.96
14_H17_E0.8660.96
60_A147_Q0.8600.96
79_I83_S0.8600.96
204_A207_I0.8570.96
197_Y227_E0.8530.96
14_H18_L0.8530.96
45_V48_Q0.8520.96
21_R97_G0.8490.96
184_V188_F0.8450.96
208_T218_V0.8430.96
131_F134_D0.8410.96
200_L204_A0.8370.95
189_L230_I0.8370.95
44_I48_Q0.8360.95
136_M171_M0.8340.95
91_W106_T0.8290.95
60_A140_S0.8290.95
33_F75_F0.8240.95
106_T110_I0.8230.95
233_S237_Y0.8220.95
120_G166_G0.8180.95
193_R231_L0.8130.95
197_Y219_T0.8100.95
168_L222_L0.8090.95
208_T215_H0.8060.94
50_T154_Y0.8060.94
72_Q156_H0.8010.94
113_S173_V0.8000.94
11_L20_K0.7980.94
32_F36_G0.7980.94
14_H96_P0.7970.94
107_L111_P0.7940.94
17_E93_F0.7910.94
19_R23_L0.7890.94
131_F217_M0.7840.94
171_M222_L0.7720.93
80_V121_L0.7690.93
83_S86_I0.7670.93
62_N152_N0.7610.93
187_M234_K0.7590.93
137_K149_I0.7580.92
145_V151_I0.7570.92
205_A208_T0.7460.92
28_A86_I0.7450.92
32_F35_A0.7440.92
199_T202_V0.7430.92
22_L25_V0.7390.91
99_Y102_E0.7340.91
231_L234_K0.7330.91
175_L184_V0.7300.91
208_T211_E0.7290.91
14_H97_G0.7220.91
41_K70_F0.7210.90
156_H160_Q0.7170.90
238_R242_K0.7130.90
38_F42_P0.7060.90
67_L139_I0.6980.89
66_P139_I0.6940.89
151_I173_V0.6930.89
41_K45_V0.6930.89
201_L223_L0.6920.89
36_G78_G0.6920.89
83_S114_I0.6880.88
95_S99_Y0.6870.88
93_F98_L0.6800.88
66_P145_V0.6760.87
204_A219_T0.6730.87
181_L184_V0.6710.87
37_F74_A0.6710.87
119_A122_S0.6710.87
194_K197_Y0.6690.87
116_L225_L0.6690.87
45_V49_E0.6680.87
106_T114_I0.6640.87
61_F65_D0.6640.87
205_A212_L0.6610.86
161_L165_F0.6580.86
123_F229_S0.6580.86
176_M232_I0.6570.86
85_V89_Q0.6550.86
68_Y72_Q0.6520.86
134_D138_R0.6510.85
39_L43_I0.6510.85
224_I235_A0.6500.85
79_I163_I0.6490.85
211_E215_H0.6470.85
94_V106_T0.6470.85
114_I118_L0.6410.85
105_V108_S0.6370.84
74_A77_I0.6330.84
124_S129_F0.6280.83
66_P147_Q0.6260.83
79_I113_S0.6260.83
36_G39_L0.6250.83
42_P45_V0.6220.83
223_L227_E0.6210.83
47_L158_L0.6200.83
57_T148_V0.6200.83
91_W128_L0.6150.82
64_T68_Y0.6130.82
96_P102_E0.6120.82
105_V177_F0.6090.81
160_Q163_I0.6080.81
65_D69_V0.6040.81
169_F225_L0.6040.81
24_I28_A0.6010.81
58_L74_A0.6010.81
21_R96_P0.6000.80
197_Y201_L0.5990.80
19_R211_E0.5980.80
75_F79_I0.5960.80
87_L91_W0.5960.80
140_S145_V0.5960.80
96_P154_Y0.5950.80
124_S161_L0.5930.80
78_G105_V0.5930.80
133_V139_I0.5910.79
117_F170_Q0.5890.79
52_E133_V0.5880.79
220_V224_I0.5880.79
42_P46_Y0.5840.79
87_L118_L0.5830.79
160_Q214_S0.5830.79
52_E55_Q0.5820.78
211_E214_S0.5790.78
168_L218_V0.5780.78
37_F41_K0.5770.78
36_G43_I0.5750.78
41_K60_A0.5750.78
108_S111_P0.5710.77
186_P193_R0.5660.77
9_M12_L0.5650.76
227_E230_I0.5640.76
76_I80_V0.5630.76
87_L113_S0.5630.76
69_V73_F0.5630.76
206_L212_L0.5600.76
38_F74_A0.5580.76
165_F218_V0.5580.76
214_S218_V0.5570.75
76_I159_L0.5570.75
14_H21_R0.5560.75
117_F120_G0.5540.75
67_L136_M0.5530.75
132_V194_K0.5510.75
103_R107_L0.5490.74
131_F210_P0.5480.74
217_M222_L0.5480.74
131_F215_H0.5480.74
65_D149_I0.5460.74
47_L124_S0.5440.74
26_A173_V0.5440.74
137_K140_S0.5420.73
113_S162_T0.5420.73
140_S144_N0.5390.73
155_F231_L0.5390.73
17_E97_G0.5380.73
120_G169_F0.5370.73
204_A222_L0.5360.73
11_L76_I0.5350.72
84_P120_G0.5340.72
208_T214_S0.5330.72
177_F181_L0.5310.72
36_G74_A0.5300.72
124_S165_F0.5300.72
216_M219_T0.5290.72
12_L15_I0.5280.71
193_R230_I0.5260.71
46_Y50_T0.5260.71
46_Y49_E0.5250.71
204_A213_L0.5250.71
131_F213_L0.5250.71
110_I155_F0.5250.71
180_R232_I0.5250.71
128_L190_A0.5250.71
105_V181_L0.5240.71
9_M73_F0.5220.71
69_V151_I0.5220.71
230_I233_S0.5190.70
192_I199_T0.5190.70
31_V34_I0.5180.70
165_F210_P0.5170.70
44_I145_V0.5170.70
194_K198_F0.5160.70
11_L16_A0.5160.70
12_L16_A0.5150.70
204_A210_P0.5140.69
121_L167_L0.5130.69
72_Q76_I0.5130.69
29_F32_F0.5130.69
50_T218_V0.5100.69
35_A81_L0.5090.69
112_V173_V0.5080.69
25_V78_G0.5080.69
106_T157_F0.5080.69
82_T85_V0.5080.69
125_Y128_L0.5070.68
124_S166_G0.5060.68
113_S165_F0.5050.68
144_N149_I0.5020.68
201_L216_M0.5010.68
37_F66_P0.5000.67
89_Q96_P0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.8701 100 0.103 Contact Map
4b4aA 1 0.8701 100 0.111 Contact Map
1pw4A 1 0.7756 37.1 0.951 Contact Map
4m64A 1 0.8071 31.9 0.953 Contact Map
3zuxA 1 0.748 27.1 0.954 Contact Map
4ikvA 1 0.8268 18.4 0.958 Contact Map
5a63B 1 0.4291 15.8 0.959 Contact Map
2cfqA 1 0.811 14.9 0.96 Contact Map
3o7qA 1 0.7402 13.6 0.96 Contact Map
3giaA 1 0.7953 12.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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