TATCY - BACSU - GREMLIN Contacts

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TATCY - Sec-independent protein translocase protein TatCy

UniProt:	O05523	Sequences: MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPIIVYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKERKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQLTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMVTVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	254 (235)
Sequences:	3442 (2175)
Seq/√Len:	141.9

ECOLI - TATC
BACSU - TATCY TATCD
HALSA - Q9HN36 Q9HN37
SULSO - Q97ZU3 Q97UB0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
179_T	233_S	4.249	1.00
193_R	227_E	4.066	1.00
28_A	85_V	3.927	1.00
20_K	24_I	3.780	1.00
190_A	234_K	3.649	1.00
24_I	85_V	3.382	1.00
88_Y	92_A	3.167	1.00
201_L	219_T	2.902	1.00
186_P	237_Y	2.736	1.00
17_E	21_R	2.702	1.00
33_F	78_G	2.621	1.00
210_P	214_S	2.374	1.00
196_A	226_Y	2.145	1.00
25_V	86_I	2.110	1.00
34_I	38_F	2.108	1.00
43_I	77_I	2.098	1.00
57_T	146_N	2.080	1.00
36_G	77_I	2.049	1.00
185_T	188_F	1.997	1.00
197_Y	223_L	1.952	1.00
178_L	183_I	1.945	1.00
122_S	126_Y	1.933	1.00
186_P	233_S	1.932	1.00
23_L	27_L	1.909	1.00
24_I	89_Q	1.901	1.00
61_F	150_G	1.880	1.00
32_F	78_G	1.870	1.00
78_G	82_T	1.851	1.00
98_L	102_E	1.844	1.00
175_L	189_L	1.829	1.00
140_S	147_Q	1.817	1.00
195_Y	199_T	1.808	1.00
226_Y	230_I	1.801	1.00
110_I	114_I	1.790	1.00
59_N	148_V	1.775	1.00
117_F	166_G	1.774	1.00
65_D	150_G	1.746	1.00
29_F	75_F	1.723	1.00
62_N	65_D	1.722	1.00
39_L	42_P	1.708	1.00
22_L	26_A	1.707	1.00
201_L	215_H	1.665	1.00
200_L	222_L	1.661	1.00
21_R	89_Q	1.644	1.00
113_S	170_Q	1.634	1.00
190_A	193_R	1.626	1.00
192_I	195_Y	1.605	1.00
10_S	13_E	1.596	1.00
187_M	191_K	1.586	1.00
21_R	92_A	1.574	1.00
82_T	86_I	1.569	1.00
212_L	215_H	1.560	1.00
203_I	207_I	1.556	1.00
188_F	192_I	1.555	1.00
184_V	189_L	1.554	1.00
95_S	103_R	1.533	1.00
32_F	81_L	1.521	1.00
63_L	133_V	1.506	1.00
186_P	234_K	1.483	1.00
118_L	122_S	1.477	1.00
186_P	190_A	1.464	1.00
179_T	186_P	1.447	1.00
35_A	38_F	1.445	1.00
236_A	240_A	1.437	1.00
190_A	227_E	1.422	1.00
24_I	27_L	1.393	1.00
9_M	13_E	1.370	1.00
32_F	82_T	1.361	1.00
63_L	66_P	1.335	1.00
60_A	66_P	1.325	1.00
25_V	82_T	1.320	1.00
28_A	82_T	1.317	1.00
198_F	202_V	1.288	1.00
83_S	87_L	1.283	1.00
29_F	82_T	1.270	1.00
70_F	139_I	1.269	1.00
205_A	215_H	1.266	1.00
63_L	157_F	1.259	1.00
115_L	119_A	1.254	1.00
150_G	153_E	1.254	1.00
176_M	236_A	1.253	1.00
210_P	215_H	1.245	1.00
46_Y	126_Y	1.228	1.00
62_N	153_E	1.215	1.00
180_R	236_A	1.212	1.00
137_K	147_Q	1.208	1.00
60_A	145_V	1.208	1.00
231_L	235_A	1.184	1.00
175_L	233_S	1.183	1.00
93_F	96_P	1.183	1.00
121_L	162_T	1.182	1.00
61_F	148_V	1.176	1.00
216_M	220_V	1.167	1.00
187_M	190_A	1.166	1.00
31_V	35_A	1.163	1.00
29_F	86_I	1.140	0.99
207_I	218_V	1.137	0.99
16_A	20_K	1.133	0.99
64_T	136_M	1.129	0.99
129_F	158_L	1.124	0.99
35_A	39_L	1.112	0.99
97_G	102_E	1.105	0.99
227_E	231_L	1.098	0.99
40_A	70_F	1.095	0.99
239_K	242_K	1.087	0.99
175_L	229_S	1.082	0.99
25_V	28_A	1.078	0.99
189_L	226_Y	1.074	0.99
200_L	223_L	1.073	0.99
100_E	104_K	1.068	0.99
24_I	88_Y	1.050	0.99
192_I	196_A	1.044	0.99
89_Q	92_A	1.026	0.99
238_R	241_Q	1.025	0.99
14_H	102_E	1.013	0.99
121_L	166_G	1.000	0.98
36_G	81_L	0.990	0.98
171_M	200_L	0.990	0.98
186_P	230_I	0.977	0.98
93_F	97_G	0.977	0.98
37_F	70_F	0.975	0.98
79_I	86_I	0.971	0.98
17_E	89_Q	0.971	0.98
27_L	30_V	0.964	0.98
30_V	34_I	0.955	0.98
210_P	216_M	0.953	0.98
27_L	31_V	0.948	0.98
204_A	208_T	0.948	0.98
132_V	214_S	0.941	0.98
26_A	30_V	0.938	0.98
60_A	151_I	0.923	0.97
14_H	93_F	0.919	0.97
171_M	229_S	0.918	0.97
190_A	230_I	0.909	0.97
44_I	73_F	0.908	0.97
164_P	207_I	0.907	0.97
132_V	136_M	0.904	0.97
63_L	149_I	0.900	0.97
37_F	71_M	0.898	0.97
133_V	157_F	0.884	0.97
194_K	215_H	0.883	0.97
60_A	65_D	0.883	0.97
193_R	197_Y	0.882	0.97
147_Q	150_G	0.879	0.97
93_F	102_E	0.877	0.97
185_T	241_Q	0.876	0.97
129_F	133_V	0.876	0.97
215_H	219_T	0.873	0.96
29_F	79_I	0.872	0.96
14_H	17_E	0.866	0.96
60_A	147_Q	0.860	0.96
79_I	83_S	0.860	0.96
204_A	207_I	0.857	0.96
197_Y	227_E	0.853	0.96
14_H	18_L	0.853	0.96
45_V	48_Q	0.852	0.96
21_R	97_G	0.849	0.96
184_V	188_F	0.845	0.96
208_T	218_V	0.843	0.96
131_F	134_D	0.841	0.96
200_L	204_A	0.837	0.95
189_L	230_I	0.837	0.95
44_I	48_Q	0.836	0.95
136_M	171_M	0.834	0.95
91_W	106_T	0.829	0.95
60_A	140_S	0.829	0.95
33_F	75_F	0.824	0.95
106_T	110_I	0.823	0.95
233_S	237_Y	0.822	0.95
120_G	166_G	0.818	0.95
193_R	231_L	0.813	0.95
197_Y	219_T	0.810	0.95
168_L	222_L	0.809	0.95
208_T	215_H	0.806	0.94
50_T	154_Y	0.806	0.94
72_Q	156_H	0.801	0.94
113_S	173_V	0.800	0.94
11_L	20_K	0.798	0.94
32_F	36_G	0.798	0.94
14_H	96_P	0.797	0.94
107_L	111_P	0.794	0.94
17_E	93_F	0.791	0.94
19_R	23_L	0.789	0.94
131_F	217_M	0.784	0.94
171_M	222_L	0.772	0.93
80_V	121_L	0.769	0.93
83_S	86_I	0.767	0.93
62_N	152_N	0.761	0.93
187_M	234_K	0.759	0.93
137_K	149_I	0.758	0.92
145_V	151_I	0.757	0.92
205_A	208_T	0.746	0.92
28_A	86_I	0.745	0.92
32_F	35_A	0.744	0.92
199_T	202_V	0.743	0.92
22_L	25_V	0.739	0.91
99_Y	102_E	0.734	0.91
231_L	234_K	0.733	0.91
175_L	184_V	0.730	0.91
208_T	211_E	0.729	0.91
14_H	97_G	0.722	0.91
41_K	70_F	0.721	0.90
156_H	160_Q	0.717	0.90
238_R	242_K	0.713	0.90
38_F	42_P	0.706	0.90
67_L	139_I	0.698	0.89
66_P	139_I	0.694	0.89
151_I	173_V	0.693	0.89
41_K	45_V	0.693	0.89
201_L	223_L	0.692	0.89
36_G	78_G	0.692	0.89
83_S	114_I	0.688	0.88
95_S	99_Y	0.687	0.88
93_F	98_L	0.680	0.88
66_P	145_V	0.676	0.87
204_A	219_T	0.673	0.87
181_L	184_V	0.671	0.87
37_F	74_A	0.671	0.87
119_A	122_S	0.671	0.87
194_K	197_Y	0.669	0.87
116_L	225_L	0.669	0.87
45_V	49_E	0.668	0.87
106_T	114_I	0.664	0.87
61_F	65_D	0.664	0.87
205_A	212_L	0.661	0.86
161_L	165_F	0.658	0.86
123_F	229_S	0.658	0.86
176_M	232_I	0.657	0.86
85_V	89_Q	0.655	0.86
68_Y	72_Q	0.652	0.86
134_D	138_R	0.651	0.85
39_L	43_I	0.651	0.85
224_I	235_A	0.650	0.85
79_I	163_I	0.649	0.85
211_E	215_H	0.647	0.85
94_V	106_T	0.647	0.85
114_I	118_L	0.641	0.85
105_V	108_S	0.637	0.84
74_A	77_I	0.633	0.84
124_S	129_F	0.628	0.83
66_P	147_Q	0.626	0.83
79_I	113_S	0.626	0.83
36_G	39_L	0.625	0.83
42_P	45_V	0.622	0.83
223_L	227_E	0.621	0.83
47_L	158_L	0.620	0.83
57_T	148_V	0.620	0.83
91_W	128_L	0.615	0.82
64_T	68_Y	0.613	0.82
96_P	102_E	0.612	0.82
105_V	177_F	0.609	0.81
160_Q	163_I	0.608	0.81
65_D	69_V	0.604	0.81
169_F	225_L	0.604	0.81
24_I	28_A	0.601	0.81
58_L	74_A	0.601	0.81
21_R	96_P	0.600	0.80
197_Y	201_L	0.599	0.80
19_R	211_E	0.598	0.80
75_F	79_I	0.596	0.80
87_L	91_W	0.596	0.80
140_S	145_V	0.596	0.80
96_P	154_Y	0.595	0.80
124_S	161_L	0.593	0.80
78_G	105_V	0.593	0.80
133_V	139_I	0.591	0.79
117_F	170_Q	0.589	0.79
52_E	133_V	0.588	0.79
220_V	224_I	0.588	0.79
42_P	46_Y	0.584	0.79
87_L	118_L	0.583	0.79
160_Q	214_S	0.583	0.79
52_E	55_Q	0.582	0.78
211_E	214_S	0.579	0.78
168_L	218_V	0.578	0.78
37_F	41_K	0.577	0.78
36_G	43_I	0.575	0.78
41_K	60_A	0.575	0.78
108_S	111_P	0.571	0.77
186_P	193_R	0.566	0.77
9_M	12_L	0.565	0.76
227_E	230_I	0.564	0.76
76_I	80_V	0.563	0.76
87_L	113_S	0.563	0.76
69_V	73_F	0.563	0.76
206_L	212_L	0.560	0.76
38_F	74_A	0.558	0.76
165_F	218_V	0.558	0.76
214_S	218_V	0.557	0.75
76_I	159_L	0.557	0.75
14_H	21_R	0.556	0.75
117_F	120_G	0.554	0.75
67_L	136_M	0.553	0.75
132_V	194_K	0.551	0.75
103_R	107_L	0.549	0.74
131_F	210_P	0.548	0.74
217_M	222_L	0.548	0.74
131_F	215_H	0.548	0.74
65_D	149_I	0.546	0.74
47_L	124_S	0.544	0.74
26_A	173_V	0.544	0.74
137_K	140_S	0.542	0.73
113_S	162_T	0.542	0.73
140_S	144_N	0.539	0.73
155_F	231_L	0.539	0.73
17_E	97_G	0.538	0.73
120_G	169_F	0.537	0.73
204_A	222_L	0.536	0.73
11_L	76_I	0.535	0.72
84_P	120_G	0.534	0.72
208_T	214_S	0.533	0.72
177_F	181_L	0.531	0.72
36_G	74_A	0.530	0.72
124_S	165_F	0.530	0.72
216_M	219_T	0.529	0.72
12_L	15_I	0.528	0.71
193_R	230_I	0.526	0.71
46_Y	50_T	0.526	0.71
46_Y	49_E	0.525	0.71
204_A	213_L	0.525	0.71
131_F	213_L	0.525	0.71
110_I	155_F	0.525	0.71
180_R	232_I	0.525	0.71
128_L	190_A	0.525	0.71
105_V	181_L	0.524	0.71
9_M	73_F	0.522	0.71
69_V	151_I	0.522	0.71
230_I	233_S	0.519	0.70
192_I	199_T	0.519	0.70
31_V	34_I	0.518	0.70
165_F	210_P	0.517	0.70
44_I	145_V	0.517	0.70
194_K	198_F	0.516	0.70
11_L	16_A	0.516	0.70
12_L	16_A	0.515	0.70
204_A	210_P	0.514	0.69
121_L	167_L	0.513	0.69
72_Q	76_I	0.513	0.69
29_F	32_F	0.513	0.69
50_T	218_V	0.510	0.69
35_A	81_L	0.509	0.69
112_V	173_V	0.508	0.69
25_V	78_G	0.508	0.69
106_T	157_F	0.508	0.69
82_T	85_V	0.508	0.69
125_Y	128_L	0.507	0.68
124_S	166_G	0.506	0.68
113_S	165_F	0.505	0.68
144_N	149_I	0.502	0.68
201_L	216_M	0.501	0.68
37_F	66_P	0.500	0.67
89_Q	96_P	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4httA	1	0.8701	100	0.103	Contact Map
4b4aA	1	0.8701	100	0.111	Contact Map
1pw4A	1	0.7756	37.1	0.951	Contact Map
4m64A	1	0.8071	31.9	0.953	Contact Map
3zuxA	1	0.748	27.1	0.954	Contact Map
4ikvA	1	0.8268	18.4	0.958	Contact Map
5a63B	1	0.4291	15.8	0.959	Contact Map
2cfqA	1	0.811	14.9	0.96	Contact Map
3o7qA	1	0.7402	13.6	0.96	Contact Map
3giaA	1	0.7953	12.9	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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