GREMLIN Database
REX - Redox-sensing transcriptional repressor Rex
UniProt: O05521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 215 (203)
Sequences: 1257 (789)
Seq/√Len: 55.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_E164_R5.4371.00
124_I135_N4.4691.00
140_E167_A3.9791.00
149_A165_L3.7951.00
120_N123_K3.6761.00
101_L116_A3.3911.00
138_D141_Q3.2201.00
159_Q163_D2.9701.00
127_E130_G2.8331.00
93_V116_A2.6551.00
91_I165_L2.6531.00
9_P56_Y2.6471.00
141_Q145_D2.3371.00
115_M142_H2.2751.00
134_Y138_D2.2271.00
174_L197_E2.2221.00
142_H146_E2.1161.00
171_K186_H2.0291.00
89_I149_A2.0231.00
175_N191_H2.0141.00
20_Y77_R2.0001.00
87_D112_K1.9851.00
27_H70_D1.9711.00
78_K83_D1.9511.00
161_I164_R1.8811.00
136_L161_I1.8680.99
57_F60_L1.8190.99
89_I115_M1.8050.99
166_V184_P1.7760.99
20_Y73_L1.7760.99
149_A168_L1.7170.99
127_E132_P1.7090.99
139_L165_L1.7040.99
90_L101_L1.6830.99
163_D183_V1.6640.99
40_S50_I1.6570.99
143_V168_L1.6480.99
87_D114_S1.6140.98
163_D167_A1.5980.98
90_L113_I1.5980.98
26_L34_V1.5460.98
164_R168_L1.5450.98
192_I197_E1.5300.98
183_V189_I1.5050.98
162_T181_L1.4930.97
17_P199_Q1.4750.97
95_N98_T1.4710.97
106_T110_N1.4710.97
33_R65_Y1.4640.97
149_A170_I1.4560.97
57_F79_T1.3920.96
166_V187_I1.3910.96
142_H145_D1.3800.96
190_H197_E1.3790.96
157_A160_S1.3780.96
90_L93_V1.3730.96
160_S164_R1.3670.96
24_K77_R1.3660.96
172_G205_L1.3140.95
153_V178_P1.3120.95
89_I142_H1.2910.94
162_T173_I1.2690.94
164_R167_A1.2270.92
134_Y142_H1.2220.92
156_V170_I1.2120.92
85_M112_K1.2090.92
116_A131_V1.2090.92
159_Q184_P1.2060.92
89_I146_E1.2030.92
113_I150_I1.1830.91
63_K192_I1.1800.91
115_M134_Y1.1690.90
52_R65_Y1.1510.90
48_A174_L1.1460.89
151_L177_T1.1440.89
60_L64_G1.1400.89
98_T126_T1.1300.89
58_G64_G1.1290.89
176_F194_L1.1030.88
68_N71_Y1.1010.87
40_S43_V1.1010.87
29_S42_A1.0820.87
140_E168_L1.0810.87
116_A153_V1.0780.86
87_D146_E1.0760.86
60_L79_T1.0680.86
31_K69_V1.0520.85
184_P189_I1.0490.85
9_P45_V1.0440.85
138_D142_H1.0410.84
166_V169_G1.0390.84
88_V113_I1.0350.84
158_A177_T1.0310.84
50_I65_Y1.0300.84
39_L50_I1.0230.83
49_T60_L1.0210.83
119_I157_A1.0010.82
144_K164_R0.9980.82
88_V150_I0.9970.82
27_H73_L0.9950.82
90_L116_A0.9910.81
81_D110_N0.9880.81
87_D147_S0.9760.80
91_I139_L0.9700.80
21_R193_D0.9690.80
162_T183_V0.9650.80
122_S138_D0.9570.79
7_K144_K0.9550.79
123_K133_V0.9520.79
48_A197_E0.9510.79
174_L199_Q0.9450.78
151_L161_I0.9420.78
38_E42_A0.9400.78
125_G128_V0.9220.76
151_L162_T0.9210.76
117_F134_Y0.9150.76
138_D156_V0.9140.76
165_L170_I0.9140.76
24_K73_L0.9130.76
89_I93_V0.9070.75
8_I76_F0.9020.75
117_F142_H0.8900.74
87_D171_K0.8850.73
11_A194_L0.8820.73
122_S164_R0.8810.73
121_E137_D0.8790.73
124_I132_P0.8750.72
152_T182_N0.8560.71
55_S68_N0.8540.71
133_V146_E0.8480.70
149_A162_T0.8480.70
43_V46_D0.8440.70
114_S146_E0.8430.70
114_S142_H0.8360.69
188_R208_Y0.8320.69
63_K111_T0.8320.69
174_L192_I0.8310.69
64_G203_Y0.8260.68
154_P177_T0.8240.68
32_Q70_D0.8210.68
193_D199_Q0.8160.67
70_D74_S0.8070.66
166_V183_V0.8010.66
159_Q183_V0.7970.65
55_S59_A0.7920.65
91_I168_L0.7920.65
122_S126_T0.7810.64
138_D144_K0.7770.63
149_A169_G0.7630.62
200_S204_F0.7630.62
70_D167_A0.7600.62
154_P176_F0.7600.62
119_I136_L0.7590.62
157_A166_V0.7560.61
25_N42_A0.7510.61
119_I124_I0.7480.60
105_F113_I0.7460.60
17_P62_K0.7460.60
13_A60_L0.7350.59
135_N184_P0.7350.59
20_Y199_Q0.7300.59
139_L143_V0.7210.58
84_E206_K0.7170.57
90_L189_I0.7140.57
29_S156_V0.7130.57
141_Q144_K0.7120.57
89_I170_I0.7100.56
197_E201_L0.7060.56
11_A65_Y0.7040.56
52_R193_D0.7030.56
52_R55_S0.7000.55
128_V133_V0.6980.55
43_V50_I0.6970.55
139_L168_L0.6940.55
57_F64_G0.6850.54
133_V186_H0.6840.54
24_K76_F0.6840.54
12_T63_K0.6820.53
158_A175_N0.6810.53
91_I136_L0.6780.53
21_R58_G0.6770.53
81_D206_K0.6730.52
125_G133_V0.6660.52
49_T79_T0.6650.52
46_D49_T0.6640.51
89_I117_F0.6630.51
159_Q166_V0.6620.51
14_K200_S0.6560.51
79_T203_Y0.6550.50
25_N155_A0.6550.50
48_A190_H0.6500.50
17_P174_L0.6500.50
50_I194_L0.6460.50
29_S32_Q0.6410.49
103_Y176_F0.6400.49
59_A64_G0.6370.49
86_T202_V0.6370.49
153_V199_Q0.6350.48
39_L203_Y0.6330.48
23_L76_F0.6320.48
115_M148_V0.6310.48
9_P193_D0.6300.48
23_L111_T0.6300.48
12_T56_Y0.6290.48
50_I63_K0.6240.47
172_G191_H0.6210.47
136_L164_R0.6210.47
63_K197_E0.6210.47
186_H189_I0.6150.46
11_A193_D0.6140.46
174_L194_L0.6140.46
59_A194_L0.6140.46
11_A33_R0.6130.46
119_I135_N0.6100.46
106_T195_A0.6090.46
134_Y187_I0.6080.45
100_F176_F0.6070.45
94_G154_P0.6060.45
110_N174_L0.6010.45
40_S86_T0.6000.45
41_D119_I0.5990.44
174_L203_Y0.5980.44
98_T123_K0.5970.44
127_E164_R0.5970.44
27_H69_V0.5940.44
124_I134_Y0.5930.44
54_F60_L0.5930.44
64_G192_I0.5920.44
52_R63_K0.5920.44
48_A95_N0.5900.44
98_T102_H0.5890.43
174_L193_D0.5870.43
93_V101_L0.5860.43
171_K205_L0.5820.43
17_P65_Y0.5820.43
48_A199_Q0.5780.42
138_D185_E0.5780.42
121_E135_N0.5770.42
137_D164_R0.5730.42
93_V113_I0.5730.42
198_L201_L0.5720.42
17_P20_Y0.5720.42
134_Y141_Q0.5680.41
64_G201_L0.5670.41
30_G122_S0.5650.41
30_G149_A0.5650.41
163_D166_V0.5640.41
202_V206_K0.5630.41
174_L198_L0.5630.41
46_D143_V0.5610.40
185_E208_Y0.5550.40
12_T193_D0.5530.40
36_S64_G0.5530.40
111_T195_A0.5510.39
21_R64_G0.5470.39
105_F178_P0.5470.39
116_A134_Y0.5450.39
43_V47_S0.5440.39
100_F105_F0.5430.39
47_S55_S0.5400.38
24_K115_M0.5400.38
146_E179_A0.5380.38
51_R201_L0.5380.38
39_L202_V0.5360.38
108_N161_I0.5340.38
110_N195_A0.5330.38
104_N178_P0.5320.37
34_V117_F0.5320.37
52_R196_V0.5320.37
17_P22_F0.5320.37
163_D189_I0.5310.37
95_N128_V0.5310.37
58_G203_Y0.5310.37
64_G111_T0.5290.37
143_V151_L0.5280.37
91_I149_A0.5270.37
40_S192_I0.5260.37
183_V187_I0.5260.37
175_N194_L0.5240.37
76_F80_L0.5230.37
9_P43_V0.5220.36
52_R62_K0.5220.36
62_K65_Y0.5220.36
74_S205_L0.5210.36
9_P86_T0.5200.36
117_F143_V0.5160.36
176_F197_E0.5140.36
37_A47_S0.5140.36
36_S57_F0.5140.36
38_E41_D0.5140.36
34_V102_H0.5120.35
102_H129_G0.5110.35
40_S52_R0.5090.35
26_L31_K0.5090.35
85_M152_T0.5090.35
55_S197_E0.5080.35
8_I57_F0.5080.35
29_S160_S0.5070.35
95_N176_F0.5050.35
77_R191_H0.5050.35
17_P50_I0.5040.35
45_V50_I0.5030.35
48_A63_K0.5030.35
46_D62_K0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3keoA 2 0.9442 100 0.343 Contact Map
2vt3A 2 0.9674 100 0.348 Contact Map
3wg9A 2 0.9721 100 0.362 Contact Map
2dt5A 3 0.9721 100 0.366 Contact Map
2py6A 4 0.7395 100 0.635 Contact Map
4e2xA 1 0.8047 99.8 0.759 Contact Map
1gr0A 3 0.6093 99.8 0.762 Contact Map
3ff4A 1 0.4698 99.2 0.831 Contact Map
4rv9A 1 0.8372 99.2 0.839 Contact Map
2fp4A 1 0.6372 98.9 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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