GREMLIN Database
MOAC - Cyclic pyranopterin monophosphate synthase accessory protein
UniProt: O05520 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (154)
Sequences: 2921 (1745)
Seq/√Len: 140.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_Q71_N5.1951.00
101_I125_A2.9341.00
103_A120_S2.8021.00
43_K135_L2.6401.00
31_V147_L2.5371.00
32_S144_T2.4341.00
8_N12_R2.3821.00
148_E156_D2.3371.00
31_V100_H2.2931.00
148_E158_K2.2091.00
35_H142_G2.2071.00
32_S121_A2.1621.00
42_E46_S2.0651.00
23_S110_S2.0101.00
62_G124_C1.8941.00
33_S98_I1.8801.00
25_V106_K1.8721.00
150_T156_D1.8321.00
29_A104_Q1.6881.00
31_V145_F1.6851.00
72_I123_V1.6731.00
33_S100_H1.6351.00
27_T104_Q1.6321.00
122_S144_T1.6291.00
129_Y146_L1.6051.00
34_V125_A1.5921.00
138_G157_F1.5751.00
37_K40_V1.5501.00
23_S108_K1.5381.00
41_Y90_W1.5361.00
91_K100_H1.5341.00
66_A120_S1.4861.00
145_F159_R1.4791.00
35_H140_V1.4701.00
91_K96_E1.4611.00
137_K154_N1.4551.00
44_I132_C1.4551.00
27_T150_T1.4361.00
88_F99_L1.4261.00
36_M40_V1.4241.00
132_C139_M1.4181.00
38_N42_E1.4161.00
45_Q90_W1.3981.00
33_S143_P1.3791.00
90_W99_L1.3781.00
32_S125_A1.3531.00
80_S109_G1.3521.00
27_T106_K1.3331.00
31_V102_K1.3111.00
53_D56_A1.3061.00
81_L105_V1.2551.00
62_G86_I1.2431.00
72_I119_T1.2371.00
56_A59_Q1.2361.00
60_V75_M1.2231.00
34_V139_M1.2121.00
80_S107_T1.2101.00
103_A121_A1.1831.00
19_S82_S1.1761.00
49_I54_V1.1741.00
83_G106_K1.1711.00
7_F57_V1.1450.99
121_A144_T1.1420.99
89_D100_H1.1420.99
89_D102_K1.1340.99
17_D106_K1.1270.99
29_A102_K1.1240.99
13_A56_A1.1230.99
41_Y97_V1.1230.99
43_K48_D1.1220.99
118_L126_L1.1220.99
140_V143_P1.1020.99
125_A141_I1.0970.99
62_G103_A1.0860.99
37_K136_D1.0830.99
43_K49_I1.0800.99
82_S110_S1.0700.99
66_A81_L1.0640.99
122_S141_I1.0390.99
99_L128_V1.0380.99
29_A148_E1.0370.99
49_I132_C1.0020.98
57_V60_V0.9950.98
91_K95_A0.9940.98
12_R59_Q0.9920.98
81_L113_V0.9920.98
35_H98_I0.9880.98
49_I135_L0.9860.98
87_S102_K0.9630.98
19_S25_V0.9570.98
66_A84_V0.9560.98
34_V128_V0.9520.98
141_I144_T0.9410.98
60_V64_M0.9360.98
29_A103_A0.9250.97
79_L107_T0.9250.97
54_V128_V0.9200.97
59_Q87_S0.9180.97
147_L159_R0.9130.97
27_T148_E0.9040.97
38_N97_V0.9010.97
23_S109_G0.8900.97
36_M41_Y0.8870.97
13_A59_Q0.8780.96
19_S106_K0.8760.96
91_K98_I0.8730.96
31_V143_P0.8690.96
70_S78_P0.8680.96
80_S110_S0.8440.96
105_V113_V0.8410.95
102_K147_L0.8370.95
65_A123_V0.8300.95
140_V145_F0.8250.95
86_I124_C0.8190.95
8_N14_Q0.8190.95
122_S125_A0.8120.95
39_E42_E0.8120.95
58_A127_T0.8090.94
24_T151_G0.8040.94
55_L99_L0.8020.94
73_I127_T0.7990.94
79_L105_V0.7930.94
25_V108_K0.7920.94
53_D57_V0.7910.94
8_N85_D0.7870.94
136_D139_M0.7840.93
36_M139_M0.7800.93
34_V101_I0.7790.93
61_A127_T0.7780.93
91_K97_V0.7630.93
101_I124_C0.7630.93
33_S142_G0.7590.92
13_A53_D0.7570.92
98_I142_G0.7520.92
42_E45_Q0.7500.92
137_K153_K0.7500.92
20_E25_V0.7490.92
44_I54_V0.7470.92
84_V105_V0.7370.91
41_Y45_Q0.7340.91
63_I75_M0.7300.91
40_V136_D0.7290.91
14_Q75_M0.7280.91
88_F128_V0.7270.91
82_S108_K0.7260.91
129_Y132_C0.7230.90
88_F101_I0.7130.90
7_F50_G0.7120.90
14_Q83_G0.7080.89
87_S104_Q0.7010.89
7_F47_H0.6880.88
44_I99_L0.6840.88
47_H53_D0.6820.88
3_G9_E0.6740.87
59_Q85_D0.6690.87
101_I121_A0.6590.86
22_S110_S0.6580.86
57_V75_M0.6570.86
55_L88_F0.6520.85
14_Q85_D0.6510.85
129_Y139_M0.6500.85
119_T123_V0.6420.84
70_S80_S0.6400.84
44_I49_I0.6370.84
81_L84_V0.6360.84
17_D83_G0.6350.84
140_V159_R0.6300.83
73_I134_A0.6290.83
129_Y137_K0.6200.82
85_D104_Q0.6190.82
30_A121_A0.6160.82
139_M146_L0.6150.82
50_G135_L0.6080.81
4_F132_C0.6070.81
19_S108_K0.6050.81
37_K41_Y0.6020.80
18_I110_S0.5920.79
10_Q87_S0.5920.79
50_G128_V0.5850.78
33_S91_K0.5850.78
105_V117_A0.5830.78
37_K138_G0.5820.78
41_Y44_I0.5810.78
40_V135_L0.5800.78
138_G146_L0.5800.78
11_G53_D0.5780.78
70_S79_L0.5780.78
13_A88_F0.5740.77
65_A70_S0.5730.77
41_Y98_I0.5710.77
82_S107_T0.5700.77
16_V134_A0.5680.76
40_V44_I0.5660.76
40_V132_C0.5650.76
66_A103_A0.5610.76
15_M18_I0.5590.75
65_A119_T0.5570.75
53_D59_Q0.5550.75
47_H56_A0.5550.75
7_F56_A0.5530.75
33_S96_E0.5510.74
150_T158_K0.5510.74
54_V109_G0.5500.74
64_M69_T0.5490.74
137_K150_T0.5480.74
86_I103_A0.5480.74
119_T126_L0.5480.74
45_Q96_E0.5450.73
61_A113_V0.5450.73
59_Q81_L0.5450.73
105_V146_L0.5450.73
4_F134_A0.5410.73
13_A57_V0.5400.73
68_Q72_I0.5350.72
20_E23_S0.5340.72
63_I84_V0.5330.72
4_F43_K0.5290.71
82_S109_G0.5280.71
36_M136_D0.5260.71
74_P127_T0.5190.70
3_G158_K0.5140.69
64_M70_S0.5140.69
57_V64_M0.5120.69
66_A105_V0.5110.69
137_K155_G0.5070.68
3_G43_K0.5060.68
78_P81_L0.5040.68
62_G66_A0.5030.67
36_M132_C0.5020.67
59_Q88_F0.5000.67
20_E108_K0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eeyA 5 0.9412 100 0.041 Contact Map
4pyaA 3 0.7294 100 0.041 Contact Map
2iihA 4 0.8588 100 0.069 Contact Map
4fdfA 5 0.8294 100 0.085 Contact Map
2eknA 5 0.8176 100 0.105 Contact Map
2ohdA 5 0.8059 100 0.152 Contact Map
3bkrA 1 0.3941 5.9 0.967 Contact Map
1ccwB 2 0.3471 4.2 0.969 Contact Map
1at0A 2 0.4941 3 0.971 Contact Map
2ia9A 2 0.3529 3 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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