GREMLIN Database
TSAD - tRNA N6-adenosine threonylcarbamoyltransferase
UniProt: O05518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (328)
Sequences: 4332 (2458)
Seq/√Len: 135.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_K155_S3.9011.00
11_G313_A3.3411.00
25_K29_E3.3371.00
67_E71_K3.2531.00
128_V301_P3.2091.00
211_Y263_E3.1101.00
120_G312_I3.0111.00
83_A316_G2.9691.00
195_G240_D2.7421.00
149_Y266_V2.6111.00
175_A184_G2.5741.00
8_Y74_M2.5611.00
82_I104_L2.5281.00
65_I100_A2.4831.00
151_K157_E2.4401.00
181_P187_Q2.4101.00
84_V112_L2.3811.00
8_Y25_K2.3371.00
247_N280_G2.3131.00
189_D279_R2.2851.00
79_I110_I2.2201.00
201_L225_T2.2091.00
268_Q296_T2.2031.00
76_Y108_Y2.1361.00
286_E291_Q2.1311.00
21_A64_V2.0501.00
223_I227_H2.0351.00
34_V67_E2.0031.00
15_S85_T2.0001.00
193_E279_R1.9951.00
261_A269_V1.9691.00
245_F249_V1.9591.00
203_R251_D1.9531.00
174_V222_V1.9471.00
188_I242_S1.9361.00
257_T269_V1.8951.00
317_T321_E1.8921.00
199_I225_T1.8861.00
21_A65_I1.8551.00
34_V71_K1.8381.00
56_H59_E1.8321.00
66_E70_R1.8021.00
84_V98_V1.7931.00
105_S112_L1.7821.00
120_G315_A1.7621.00
262_K293_E1.7291.00
9_V81_A1.7281.00
40_E43_K1.7181.00
174_V245_F1.7091.00
11_G316_G1.7081.00
135_A150_M1.7011.00
76_Y104_L1.6891.00
187_Q190_K1.6861.00
149_Y157_E1.6861.00
167_A249_V1.6811.00
224_N227_H1.6741.00
118_I139_V1.6571.00
7_M26_N1.6351.00
69_F76_Y1.6021.00
80_D110_I1.5961.00
81_A320_F1.5741.00
201_L241_L1.5681.00
290_A297_L1.5671.00
194_K239_E1.5651.00
261_A295_I1.5611.00
76_Y79_I1.5571.00
203_R248_S1.5481.00
119_A156_F1.5391.00
202_P221_A1.5381.00
191_L239_E1.5191.00
163_L212_N1.5151.00
191_L238_P1.5101.00
34_V64_V1.5031.00
243_A247_N1.5021.00
149_Y264_Y1.4931.00
254_V284_A1.4911.00
33_N303_A1.4901.00
201_L221_A1.4801.00
101_A112_L1.4791.00
32_S68_A1.4471.00
189_D246_Q1.4421.00
280_G284_A1.4421.00
152_E155_S1.4271.00
271_L299_I1.4251.00
36_A60_Q1.4121.00
284_A288_E1.3991.00
234_Q237_A1.3981.00
30_I304_L1.3891.00
20_A309_A1.3811.00
177_T223_I1.3691.00
140_V281_L1.3661.00
186_P190_K1.3501.00
319_A324_I1.3321.00
147_L257_T1.3291.00
26_N317_T1.3271.00
247_N284_A1.3201.00
33_N68_A1.3101.00
12_I97_G1.3091.00
222_V245_F1.3091.00
11_G309_A1.3061.00
75_T78_D1.3001.00
23_I32_S1.2961.00
103_A107_A1.2751.00
9_V83_A1.2691.00
250_I284_A1.2671.00
114_G326_G1.2601.00
250_I281_L1.2581.00
23_I68_A1.2511.00
218_L249_V1.2411.00
8_Y23_I1.2401.00
25_K31_I1.2351.00
227_H231_Q1.2351.00
133_F153_H1.2341.00
280_G283_A1.2231.00
289_F293_E1.2211.00
314_A318_I1.2161.00
196_N240_D1.2151.00
9_V320_F1.2111.00
20_A35_V1.2091.00
159_I264_Y1.2091.00
191_L194_K1.2031.00
18_E39_I1.1981.00
152_E322_K1.1981.00
196_N243_A1.1971.00
190_K194_K1.1891.00
277_A302_L1.1770.99
32_S72_A1.1720.99
190_K193_E1.1690.99
258_A289_F1.1560.99
268_Q298_V1.1330.99
165_D219_K1.1310.99
125_N270_L1.1280.99
84_V101_A1.1250.99
8_Y80_D1.1250.99
82_I105_S1.1240.99
74_M78_D1.1220.99
229_A234_Q1.1190.99
246_Q280_G1.1140.99
34_V68_A1.1120.99
257_T285_L1.1090.99
226_L241_L1.1070.99
283_A288_E1.1050.99
126_R318_I1.1020.99
135_A270_L1.1000.99
198_N247_N1.1000.99
147_L213_F1.0990.99
222_V241_L1.0980.99
68_A72_A1.0910.99
7_M80_D1.0910.99
289_F292_H1.0820.99
69_F74_M1.0770.99
81_A113_V1.0690.99
91_V332_G1.0680.99
160_G260_A1.0670.99
209_G259_R1.0640.99
258_A293_E1.0630.99
177_T226_L1.0600.99
12_I65_I1.0560.99
86_E114_G1.0560.99
288_E292_H1.0550.99
23_I79_I1.0550.99
122_I137_A1.0300.99
189_D193_E1.0300.99
233_G236_I1.0300.99
91_V334_P1.0260.99
100_A103_A1.0170.98
187_Q191_L1.0170.98
104_L108_Y1.0150.98
224_N228_N1.0130.98
199_I240_D1.0100.98
243_A246_Q1.0060.98
113_V325_R1.0020.98
318_I321_E0.9950.98
203_R252_V0.9920.98
33_N310_A0.9900.98
98_V332_G0.9830.98
132_V268_Q0.9810.98
195_G243_A0.9790.98
79_I108_Y0.9790.98
23_I74_M0.9780.98
158_V161_E0.9770.98
207_E210_S0.9710.98
174_V177_T0.9690.98
228_N231_Q0.9660.98
41_S56_H0.9660.98
225_T229_A0.9640.98
61_I100_A0.9640.98
203_R255_T0.9590.98
22_A309_A0.9560.98
251_D284_A0.9550.98
136_L264_Y0.9530.98
119_A154_G0.9510.98
320_F325_R0.9470.98
191_L242_S0.9460.97
112_L330_M0.9460.97
238_P242_S0.9430.97
87_G116_H0.9430.97
21_A68_A0.9330.97
146_E161_E0.9310.97
178_M226_L0.9280.97
301_P304_L0.9270.97
77_S108_Y0.9260.97
24_V314_A0.9230.97
271_L285_L0.9200.97
255_T259_R0.9190.97
31_I74_M0.9180.97
326_G330_M0.9180.97
189_D280_G0.9070.97
123_Y153_H0.9050.97
290_A295_I0.9000.97
269_V290_A0.8980.97
321_E324_I0.8960.97
333_Q336_L0.8950.96
82_I110_I0.8930.96
26_N321_E0.8890.96
20_A33_N0.8850.96
125_N272_A0.8830.96
248_S252_V0.8800.96
167_A253_L0.8800.96
258_A262_K0.8800.96
99_N103_A0.8800.96
171_Y189_D0.8750.96
286_E297_L0.8720.96
21_A34_V0.8710.96
210_S263_E0.8700.96
27_G317_T0.8650.96
86_E333_Q0.8640.96
258_A292_H0.8630.96
247_N251_D0.8570.96
178_M242_S0.8540.95
98_V102_K0.8540.95
119_A319_A0.8500.95
197_D247_N0.8430.95
167_A215_F0.8420.95
229_A237_A0.8390.95
113_V320_F0.8390.95
123_Y314_A0.8390.95
24_V30_I0.8380.95
114_G330_M0.8370.95
240_D244_S0.8360.95
283_A286_E0.8330.95
104_L110_I0.8310.95
205_W210_S0.8280.95
211_Y259_R0.8270.95
70_R73_G0.8260.95
126_R314_A0.8220.94
129_E296_T0.8150.94
62_T100_A0.8110.94
82_I108_Y0.8060.94
51_E55_R0.8020.94
21_A309_A0.8010.94
148_V158_V0.8000.94
131_I135_A0.8000.94
175_A181_P0.7990.93
258_A261_A0.7980.93
169_E219_K0.7950.93
254_V289_F0.7940.93
176_R242_S0.7930.93
221_A225_T0.7920.93
7_M25_K0.7910.93
203_R247_N0.7910.93
193_E283_A0.7890.93
215_F249_V0.7870.93
18_E93_A0.7770.93
171_Y246_Q0.7730.92
170_A245_F0.7710.92
31_I68_A0.7700.92
267_K296_T0.7650.92
54_S92_G0.7650.92
127_L310_A0.7650.92
286_E299_I0.7640.92
227_H230_S0.7640.92
277_A306_T0.7640.92
180_L191_L0.7590.92
51_E92_G0.7570.92
123_Y315_A0.7550.91
105_S110_I0.7510.91
240_D243_A0.7500.91
254_V257_T0.7500.91
210_S259_R0.7470.91
98_V330_M0.7470.91
276_A305_C0.7460.91
174_V178_M0.7450.91
148_V156_F0.7430.91
137_A272_A0.7420.91
230_S233_G0.7420.91
136_L266_V0.7410.91
24_V313_A0.7380.90
18_E182_Y0.7360.90
261_A264_Y0.7330.90
122_I139_V0.7330.90
284_A289_F0.7320.90
199_I237_A0.7300.90
146_E158_V0.7300.90
140_V253_L0.7280.90
30_I310_A0.7240.90
123_Y135_A0.7240.90
252_V256_K0.7240.90
40_E44_R0.7200.89
74_M79_I0.7200.89
33_N304_L0.7190.89
319_A325_R0.7190.89
195_G244_S0.7160.89
61_I96_I0.7160.89
171_Y245_F0.7150.89
123_Y156_F0.7150.89
82_I101_A0.7050.88
32_S71_K0.7040.88
36_A64_V0.7020.88
199_I229_A0.7000.88
81_A114_G0.7000.88
102_K112_L0.6990.88
98_V112_L0.6950.88
316_G320_F0.6940.88
14_T19_T0.6930.88
67_E70_R0.6920.87
235_E238_P0.6920.87
237_A240_D0.6900.87
229_A233_G0.6890.87
12_I21_A0.6870.87
285_L297_L0.6870.87
91_V94_L0.6830.87
136_L261_A0.6830.87
261_A289_F0.6820.87
86_E330_M0.6760.86
201_L218_L0.6750.86
124_A272_A0.6750.86
200_P244_S0.6740.86
133_F150_M0.6720.86
38_Q42_H0.6720.86
95_L332_G0.6710.86
197_D243_A0.6710.86
254_V285_L0.6690.86
138_L257_T0.6680.86
16_C48_V0.6640.85
18_E37_S0.6630.85
8_Y79_I0.6620.85
30_I313_A0.6600.85
139_V146_E0.6600.85
178_M238_P0.6580.85
211_Y264_Y0.6560.85
288_E291_Q0.6560.85
8_Y11_G0.6560.85
236_I239_E0.6510.84
165_D169_E0.6510.84
198_N244_S0.6480.84
65_I104_L0.6480.84
84_V330_M0.6480.84
290_A293_E0.6460.84
86_E336_L0.6450.84
32_S69_F0.6430.83
14_T97_G0.6430.83
171_Y188_I0.6420.83
160_G212_N0.6420.83
24_V81_A0.6420.83
46_G173_K0.6400.83
157_E264_Y0.6390.83
167_A218_L0.6340.82
174_V249_V0.6340.82
77_S110_I0.6300.82
62_T309_A0.6270.82
76_Y110_I0.6250.82
21_A32_S0.6240.82
258_A295_I0.6240.82
189_D250_I0.6240.82
7_M81_A0.6230.81
137_A270_L0.6210.81
221_A224_N0.6190.81
45_F52_I0.6180.81
12_I61_I0.6180.81
8_Y78_D0.6160.81
18_E35_V0.6160.81
276_A301_P0.6150.81
87_G336_L0.6150.81
115_V315_A0.6140.80
250_I280_G0.6130.80
7_M317_T0.6120.80
224_N231_Q0.6090.80
159_I263_E0.6090.80
81_A316_G0.6080.80
14_T61_I0.6080.80
36_A67_E0.6080.80
205_W208_E0.6060.80
229_A236_I0.6050.79
169_E173_K0.6030.79
131_I298_V0.6020.79
205_W256_K0.6020.79
248_S251_D0.6010.79
179_G238_P0.5990.79
30_I33_N0.5960.78
314_A317_T0.5960.78
123_Y126_R0.5940.78
9_V316_G0.5930.78
24_V29_E0.5930.78
54_S96_I0.5920.78
251_D255_T0.5920.78
333_Q337_E0.5890.78
170_A219_K0.5870.77
325_R329_D0.5860.77
164_D214_S0.5850.77
51_E54_S0.5820.77
90_L219_K0.5820.77
84_V97_G0.5820.77
246_Q278_N0.5800.77
136_L257_T0.5800.77
123_Y133_F0.5780.76
60_Q63_L0.5780.76
35_V303_A0.5780.76
126_R133_F0.5770.76
14_T36_A0.5700.75
86_E98_V0.5680.75
129_E298_V0.5680.75
118_I146_E0.5650.75
103_A108_Y0.5650.75
69_F108_Y0.5650.75
153_H318_I0.5640.75
235_E239_E0.5640.75
10_L21_A0.5640.75
163_L205_W0.5630.74
257_T261_A0.5620.74
259_R263_E0.5620.74
195_G199_I0.5620.74
258_A290_A0.5610.74
82_I112_L0.5580.74
283_A291_Q0.5570.74
205_W252_V0.5570.74
123_Y150_M0.5570.74
125_N271_L0.5560.74
37_S40_E0.5540.73
93_A116_H0.5530.73
135_A153_H0.5520.73
129_E301_P0.5510.73
118_I148_V0.5510.73
269_V297_L0.5510.73
160_G211_Y0.5500.73
135_A268_Q0.5470.72
127_L270_L0.5450.72
175_A306_T0.5440.72
319_A326_G0.5440.72
7_M320_F0.5430.72
136_L289_F0.5430.72
225_T228_N0.5410.72
25_K317_T0.5410.72
32_S35_V0.5400.71
313_A316_G0.5390.71
8_Y31_I0.5380.71
90_L169_E0.5370.71
106_F328_Y0.5370.71
95_L99_N0.5370.71
116_H119_A0.5360.71
282_R299_I0.5360.71
11_G118_I0.5350.71
177_T227_H0.5330.70
100_A104_L0.5320.70
23_I69_F0.5310.70
244_S247_N0.5300.70
219_K223_I0.5300.70
132_V296_T0.5270.70
319_A323_G0.5260.69
189_D278_N0.5260.69
128_V304_L0.5260.69
199_I244_S0.5250.69
139_V144_H0.5240.69
133_F152_E0.5240.69
202_P248_S0.5230.69
202_P305_C0.5170.68
136_L269_V0.5170.68
39_I48_V0.5170.68
220_S224_N0.5160.68
165_D170_A0.5150.68
197_D240_D0.5150.68
326_G331_N0.5130.68
23_I72_A0.5130.68
31_I72_A0.5130.68
18_E58_V0.5120.67
126_R153_H0.5120.67
30_I127_L0.5100.67
156_F319_A0.5080.67
147_L260_A0.5060.66
139_V335_G0.5060.66
12_I104_L0.5050.66
183_P186_P0.5040.66
72_A78_D0.5030.66
312_I315_A0.5030.66
225_T241_L0.5030.66
321_E325_R0.5030.66
56_H276_A0.5030.66
222_V244_S0.5030.66
122_I148_V0.5030.66
10_L23_I0.5020.66
15_S309_A0.5020.66
90_L183_P0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3en9A 1 0.9422 100 0.342 Contact Map
4k25A 2 0.9277 100 0.371 Contact Map
3zeuB 1 0.9682 100 0.424 Contact Map
2ivnA 1 0.9364 100 0.447 Contact Map
3enoA 1 0.9451 100 0.457 Contact Map
3venA 1 0.9249 100 0.489 Contact Map
3vthA 1 0.8353 100 0.596 Contact Map
4g9iA 1 0.8555 100 0.624 Contact Map
3ttcA 1 0.815 100 0.631 Contact Map
4m7xA 2 0.7514 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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