GREMLIN Database
TSAB - tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
UniProt: O05516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (201)
Sequences: 7587 (5123)
Seq/√Len: 361.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_T19_R3.8021.00
61_V199_G3.0921.00
5_A196_A2.9081.00
44_H48_N2.8781.00
54_P86_L2.7921.00
43_V78_L2.6441.00
45_S49_D2.6371.00
98_T195_L2.5631.00
19_R22_T2.4961.00
2_T52_M2.4791.00
127_Q132_L2.4621.00
27_Y45_S2.4511.00
34_N37_V2.4271.00
27_Y49_D2.3611.00
39_A78_L2.2361.00
62_V76_V2.2271.00
57_L88_I2.0841.00
60_I79_A2.0771.00
77_T81_T2.0751.00
106_F184_T2.0591.00
53_A56_D2.0561.00
58_S88_I2.0521.00
3_I59_K2.0451.00
83_A90_I2.0301.00
62_V90_I2.0171.00
54_P57_L2.0111.00
60_I82_L2.0041.00
59_K91_S1.9861.00
9_S63_A1.9791.00
17_L46_L1.9341.00
79_A90_I1.9291.00
127_Q134_E1.9171.00
125_L156_R1.8681.00
81_T85_S1.8661.00
47_L54_P1.8351.00
25_A46_L1.8051.00
15_I43_V1.6881.00
158_V179_K1.6371.00
173_E177_G1.6161.00
135_Q138_P1.6071.00
60_I88_I1.5881.00
2_T58_S1.5861.00
46_L50_C1.5351.00
40_M78_L1.5301.00
64_K92_A1.4801.00
29_T38_R1.4131.00
16_A192_P1.4131.00
26_E191_R1.4061.00
97_E133_L1.3971.00
3_I61_V1.3841.00
23_V26_E1.3701.00
96_L115_D1.3651.00
17_L50_C1.3261.00
15_I42_A1.3051.00
170_Q173_E1.2981.00
57_L86_L1.2971.00
172_I175_V1.2961.00
124_G135_Q1.2931.00
43_V82_L1.2491.00
171_M174_D1.2471.00
171_M175_V1.2371.00
146_D149_E1.2371.00
176_L180_G1.2321.00
143_M146_D1.2221.00
82_L86_L1.2211.00
52_M56_D1.2201.00
18_L196_A1.2201.00
111_S126_Y1.2201.00
6_I75_G1.2191.00
14_G192_P1.1941.00
17_L52_M1.1831.00
8_T75_G1.1641.00
26_E30_Y1.1581.00
15_I46_L1.1571.00
142_V147_W1.1541.00
194_E198_L1.1351.00
6_I43_V1.1331.00
13_L42_A1.1291.00
94_S139_D1.1201.00
27_Y42_A1.1111.00
125_L134_E1.1091.00
94_S97_E1.1041.00
191_R194_E1.1021.00
17_L57_L1.0941.00
125_L154_K1.0861.00
5_A199_G1.0741.00
165_T168_H1.0581.00
189_N192_P1.0481.00
7_D63_A1.0441.00
190_P194_E1.0411.00
45_S48_N1.0361.00
54_P82_L1.0291.00
127_Q156_R1.0251.00
47_L52_M1.0241.00
72_V76_V1.0221.00
25_A50_C1.0211.00
184_T187_Q1.0161.00
34_N38_R1.0101.00
170_Q174_D1.0091.00
137_V150_M1.0091.00
108_G157_P1.0081.00
81_T84_W1.0041.00
60_I86_L0.9931.00
169_K173_E0.9911.00
55_Q86_L0.9911.00
128_Y133_L0.9771.00
59_K89_P0.9741.00
130_N133_L0.9701.00
19_R24_I0.9681.00
6_I79_A0.9631.00
25_A29_T0.9631.00
135_Q139_D0.9581.00
26_E193_S0.9491.00
164_D168_H0.9491.00
111_S125_L0.9421.00
192_P195_L0.9351.00
109_L125_L0.9271.00
158_V162_G0.9251.00
137_V140_Q0.9201.00
99_L161_L0.9091.00
101_A104_R0.9091.00
62_V75_G0.9081.00
5_A61_V0.9041.00
73_R77_T0.8991.00
128_Y132_L0.8951.00
11_Y163_H0.8951.00
14_G28_I0.8941.00
120_Q141_N0.8941.00
192_P199_G0.8861.00
10_N114_F0.8861.00
60_I83_A0.8831.00
93_V98_T0.8811.00
12_T30_Y0.8761.00
109_L127_Q0.8731.00
120_Q143_M0.8691.00
111_S160_F0.8681.00
122_Y138_P0.8671.00
123_T142_V0.8631.00
5_A192_P0.8591.00
78_L81_T0.8591.00
146_D150_M0.8521.00
140_Q150_M0.8511.00
27_Y46_L0.8451.00
98_T198_L0.8391.00
65_G94_S0.8341.00
129_K134_E0.8311.00
38_R41_P0.8271.00
18_L197_F0.8241.00
69_Y73_R0.8211.00
194_E199_G0.8111.00
2_T56_D0.8081.00
174_D178_T0.8071.00
196_A199_G0.8061.00
200_K203_E0.7931.00
123_T147_W0.7901.00
113_I162_G0.7881.00
76_V80_K0.7831.00
63_A95_S0.7801.00
145_A149_E0.7691.00
164_D167_L0.7671.00
110_I161_L0.7641.00
172_I180_G0.7631.00
27_Y30_Y0.7621.00
108_G159_L0.7601.00
100_A113_I0.7541.00
175_V178_T0.7491.00
101_A197_F0.7461.00
189_N198_L0.7391.00
109_L129_K0.7371.00
80_K90_I0.7341.00
48_N51_D0.7331.00
9_S95_S0.7331.00
40_M44_H0.7261.00
192_P198_L0.7261.00
26_E29_T0.7251.00
174_D177_G0.7241.00
158_V181_F0.7211.00
5_A18_L0.7211.00
103_G162_G0.7200.99
112_P123_T0.7190.99
97_E135_Q0.7180.99
173_E176_L0.7160.99
26_E46_L0.7150.99
17_L47_L0.7140.99
190_P195_L0.7120.99
2_T17_L0.7120.99
96_L124_G0.7100.99
190_P199_G0.7060.99
47_L86_L0.7010.99
10_N63_A0.7010.99
52_M57_L0.6990.99
12_T28_I0.6980.99
59_K199_G0.6860.99
70_T73_R0.6840.99
2_T57_L0.6830.99
116_A122_Y0.6830.99
47_L57_L0.6750.99
115_D122_Y0.6740.99
157_P179_K0.6720.99
19_R52_M0.6710.99
167_L185_A0.6660.99
141_N145_A0.6660.99
101_A133_L0.6650.99
47_L50_C0.6640.99
195_L199_G0.6610.99
136_V139_D0.6600.99
119_G143_M0.6580.99
141_N144_L0.6570.99
119_G171_M0.6550.99
99_L112_P0.6530.99
172_I176_L0.6530.99
2_T5_A0.6480.99
61_V195_L0.6480.99
36_S70_T0.6470.99
78_L82_L0.6460.99
190_P198_L0.6460.99
10_N95_S0.6360.99
141_N149_E0.6350.99
97_E126_Y0.6320.99
108_G158_V0.6320.99
39_A43_V0.6300.99
35_H75_G0.6290.99
25_A30_Y0.6280.99
194_E197_F0.6260.99
77_T80_K0.6240.99
61_V196_A0.6240.99
190_P193_S0.6220.99
124_G133_L0.6180.98
193_S196_A0.6170.98
20_E58_S0.6150.98
148_L152_K0.6130.98
103_G161_L0.6120.98
76_V92_A0.6110.98
93_V195_L0.6080.98
109_L112_P0.6050.98
97_E101_A0.6020.98
4_L60_I0.5990.98
109_L136_V0.5990.98
112_P161_L0.5960.98
59_K92_A0.5960.98
25_A28_I0.5950.98
75_G79_A0.5950.98
148_L172_I0.5950.98
13_L38_R0.5920.98
62_V79_A0.5900.98
93_V198_L0.5900.98
101_A198_L0.5890.98
136_V154_K0.5870.98
102_N194_E0.5840.98
24_I27_Y0.5810.98
64_K76_V0.5810.98
20_E200_K0.5800.98
32_K70_T0.5780.98
81_T86_L0.5780.98
112_P154_K0.5770.98
57_L60_I0.5760.98
91_S199_G0.5750.98
145_A171_M0.5750.98
69_Y77_T0.5730.98
99_L114_F0.5730.98
115_D120_Q0.5660.97
187_Q190_P0.5640.97
154_K158_V0.5590.97
148_L151_L0.5580.97
97_E124_G0.5530.97
142_V150_M0.5510.97
109_L158_V0.5500.97
97_E100_A0.5500.97
113_I121_V0.5500.97
61_V91_S0.5490.97
41_P44_H0.5490.97
108_G181_F0.5440.97
7_D14_G0.5420.97
161_L182_I0.5390.96
115_D167_L0.5370.96
13_L39_A0.5370.96
189_N195_L0.5370.96
18_L23_V0.5340.96
35_H68_S0.5300.96
23_V27_Y0.5280.96
5_A16_A0.5270.96
166_S169_K0.5260.96
166_S184_T0.5220.96
71_G100_A0.5220.96
9_S72_V0.5220.96
155_D158_V0.5200.96
110_I133_L0.5200.96
160_F165_T0.5160.95
96_L112_P0.5150.95
18_L21_D0.5140.95
100_A124_G0.5140.95
10_N190_P0.5120.95
187_Q192_P0.5100.95
113_I160_F0.5080.95
103_G160_F0.5070.95
62_V80_K0.5050.95
25_A49_D0.5040.95
121_V147_W0.5020.95
101_A129_K0.5010.95
124_G139_D0.5010.95
68_S80_K0.5010.95
139_D143_M0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zeuA 1 0.9694 100 0.234 Contact Map
2a6aA 3 0.8428 100 0.241 Contact Map
5br9A 2 0.9127 100 0.267 Contact Map
3r6mA 2 0.8952 100 0.303 Contact Map
3en9A 1 0.952 100 0.534 Contact Map
3venA 1 0.9694 99.9 0.597 Contact Map
4k25A 2 0.9083 99.9 0.599 Contact Map
3enoA 1 0.9651 99.9 0.611 Contact Map
2ivnA 1 0.9782 99.9 0.611 Contact Map
3zeuB 1 0.9083 99.9 0.62 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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