GREMLIN Database
THIL - Thiamine-monophosphate kinase
UniProt: O05514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (275)
Sequences: 14894 (9488)
Seq/√Len: 572.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_I293_K3.4111.00
236_E296_Y2.9791.00
236_E298_R2.8721.00
272_V280_L2.6791.00
276_E279_V2.6471.00
152_P299_E2.5511.00
154_D211_A2.4961.00
155_I277_W2.3871.00
238_V241_M2.3751.00
155_I296_Y2.3651.00
60_E108_E2.3411.00
60_E101_A2.3081.00
101_A104_E2.2961.00
157_F293_K2.2961.00
228_A235_I2.2301.00
156_V271_T2.2191.00
40_I79_G2.2171.00
233_V297_V2.1661.00
157_F281_K2.1311.00
211_A273_S2.1251.00
107_N111_K2.0751.00
277_W293_K2.0031.00
224_L235_I1.9491.00
155_I274_N1.9441.00
234_S298_R1.9221.00
273_S276_E1.9041.00
157_F272_V1.9011.00
157_F291_I1.8611.00
224_L237_I1.8601.00
281_K291_I1.8541.00
60_E104_E1.8451.00
70_N135_V1.8261.00
64_Y109_L1.8191.00
277_W281_K1.8081.00
32_T141_K1.8061.00
59_P129_L1.7981.00
274_N296_Y1.7631.00
74_I79_G1.7511.00
211_A271_T1.7401.00
234_S300_K1.7381.00
157_F277_W1.7351.00
152_P233_V1.7211.00
227_I271_T1.6971.00
42_C135_V1.6961.00
207_I283_E1.6851.00
82_K138_E1.6651.00
209_K276_E1.6291.00
156_V235_I1.6121.00
278_E282_Q1.5881.00
234_S303_S1.5871.00
41_V85_L1.5711.00
108_E111_K1.5521.00
36_G141_K1.5471.00
151_K273_S1.5221.00
235_I297_V1.5091.00
284_C291_I1.5041.00
201_V205_C1.4881.00
279_V282_Q1.4841.00
104_E108_E1.4831.00
150_A212_A1.4791.00
38_Q141_K1.4781.00
293_K296_Y1.4721.00
150_A297_V1.4551.00
154_D273_S1.4521.00
224_L269_T1.4491.00
282_Q286_A1.4411.00
213_L270_G1.4381.00
108_E112_L1.4301.00
154_D297_V1.4051.00
61_D194_R1.4021.00
21_D38_Q1.3981.00
30_L40_I1.3981.00
198_R267_E1.3981.00
85_L119_G1.3871.00
164_S172_L1.3851.00
109_L112_L1.3771.00
143_Q206_S1.3731.00
139_I144_A1.3681.00
150_A271_T1.3621.00
28_A77_M1.3561.00
74_I135_V1.3561.00
212_A227_I1.3521.00
80_I206_S1.3451.00
61_D105_G1.3291.00
145_C213_L1.3281.00
151_K211_A1.3251.00
95_T98_E1.3071.00
61_D64_Y1.3071.00
157_F280_L1.3071.00
216_V269_T1.2881.00
29_A118_I1.2861.00
271_T297_V1.2791.00
86_V106_M1.2771.00
88_L99_I1.2731.00
36_G142_G1.2631.00
43_V87_S1.2621.00
83_F118_I1.2621.00
76_A213_L1.2601.00
278_E281_K1.2561.00
45_T132_T1.2501.00
34_K138_E1.2461.00
202_G206_S1.2451.00
266_F294_I1.2441.00
200_S203_R1.2421.00
67_L106_M1.2301.00
281_K293_K1.2221.00
279_V283_E1.2221.00
283_E287_L1.2201.00
67_L84_Y1.2191.00
66_A131_V1.2111.00
164_S245_H1.2101.00
213_L268_L1.2081.00
41_V136_I1.1941.00
234_S301_T1.1911.00
281_K285_A1.1871.00
239_E255_W1.1641.00
156_V160_G1.1581.00
43_V134_T1.1511.00
216_V223_E1.1341.00
64_Y112_L1.1291.00
68_A109_L1.1241.00
212_A271_T1.1231.00
238_V296_Y1.1211.00
161_E164_S1.1071.00
156_V269_T1.0981.00
30_L144_A1.0891.00
283_E286_A1.0861.00
38_Q144_A1.0811.00
56_Y189_I1.0751.00
45_T87_S1.0661.00
155_I272_V1.0651.00
203_R207_I1.0651.00
84_Y135_V1.0631.00
214_N226_E1.0561.00
110_A117_L1.0541.00
166_A262_G1.0541.00
188_F192_H1.0531.00
85_L134_T1.0531.00
300_K303_S1.0531.00
260_L263_G1.0331.00
28_A40_I1.0291.00
201_V204_L1.0291.00
41_V134_T1.0261.00
37_V138_E1.0211.00
282_Q285_A1.0191.00
146_L150_A1.0151.00
71_I135_V1.0151.00
272_V277_W1.0041.00
189_I192_H1.0011.00
186_D194_R0.9971.00
154_D271_T0.9971.00
37_V140_E0.9851.00
38_Q139_I0.9841.00
90_V99_I0.9841.00
280_L283_E0.9831.00
113_Y198_R0.9801.00
146_L149_L0.9731.00
71_I115_M0.9711.00
89_A126_A0.9661.00
149_L211_A0.9531.00
99_I124_S0.9521.00
58_S61_D0.9431.00
83_F116_D0.9431.00
200_S204_L0.9331.00
58_S190_H0.9321.00
202_G205_C0.9301.00
140_E206_S0.9301.00
19_S31_Y0.9231.00
270_G280_L0.9211.00
64_Y108_E0.9201.00
150_A227_I0.9191.00
67_L71_I0.9141.00
67_L110_A0.9111.00
203_R206_S0.9091.00
208_F283_E0.9081.00
33_A138_E0.9071.00
140_E143_Q0.9061.00
159_T284_C0.9041.00
170_S173_L0.9031.00
26_D77_M0.9031.00
203_R287_L0.9031.00
84_Y133_V0.9011.00
54_L128_K0.9011.00
59_P98_E0.8971.00
214_N269_T0.8921.00
64_Y68_A0.8921.00
186_D191_R0.8921.00
63_G105_G0.8861.00
191_R194_R0.8811.00
258_W262_G0.8801.00
159_T201_V0.8741.00
220_L269_T0.8741.00
152_P155_I0.8721.00
259_A264_E0.8711.00
176_T179_Q0.8691.00
186_D190_H0.8601.00
201_V284_C0.8581.00
20_V23_G0.8571.00
110_A115_M0.8571.00
208_F280_L0.8521.00
152_P298_R0.8501.00
71_I109_L0.8491.00
83_F136_I0.8491.00
65_K265_D0.8461.00
32_T38_Q0.8461.00
126_A130_V0.8451.00
190_H193_K0.8381.00
236_E239_E0.8371.00
159_T270_G0.8281.00
192_H195_P0.8281.00
66_A133_V0.8241.00
27_D214_N0.8221.00
106_M133_V0.8201.00
22_V146_L0.8201.00
20_V116_D0.8191.00
207_I279_V0.8151.00
94_W98_E0.8151.00
153_N296_Y0.8131.00
243_P292_T0.8131.00
223_E269_T0.8121.00
204_L208_F0.8121.00
216_V267_E0.8121.00
280_L284_C0.8041.00
224_L228_A0.8021.00
34_K37_V0.8011.00
159_T268_L0.8011.00
63_G102_M0.7931.00
175_E253_P0.7911.00
40_I74_I0.7911.00
145_C210_R0.7901.00
191_R195_P0.7881.00
21_D32_T0.7861.00
161_E290_P0.7801.00
151_K154_D0.7791.00
228_A297_V0.7761.00
80_I202_G0.7741.00
40_I139_I0.7741.00
187_Y190_H0.7741.00
30_L77_M0.7711.00
84_Y106_M0.7691.00
169_L173_L0.7691.00
102_M131_V0.7671.00
285_A290_P0.7621.00
32_T36_G0.7621.00
239_E259_A0.7591.00
100_K104_E0.7531.00
97_S101_A0.7521.00
199_V203_R0.7511.00
42_C74_I0.7501.00
200_S284_C0.7491.00
222_S226_E0.7441.00
190_H194_R0.7431.00
76_A268_L0.7421.00
26_D147_R0.7411.00
156_V297_V0.7401.00
20_V118_I0.7391.00
187_Y191_R0.7361.00
80_I114_H0.7351.00
98_E102_M0.7341.00
84_Y110_A0.7341.00
67_L109_L0.7331.00
46_M69_V0.7331.00
87_S132_T0.7311.00
200_S287_L0.7311.00
45_T89_A0.7291.00
165_S264_E0.7271.00
234_S302_K0.7251.00
164_S169_L0.7241.00
80_I138_E0.7211.00
75_A202_G0.7171.00
216_V220_L0.7091.00
80_I203_R0.7071.00
96_E100_K0.7061.00
220_L224_L0.7061.00
165_S192_H0.7051.00
188_F191_R0.6981.00
102_M106_M0.6981.00
201_V268_L0.6951.00
60_E105_G0.6931.00
158_V266_F0.6931.00
169_L172_L0.6921.00
150_A231_S0.6911.00
195_P199_V0.6911.00
31_Y83_F0.6891.00
43_V132_T0.6891.00
63_G106_M0.6891.00
88_L131_V0.6791.00
52_F56_Y0.6791.00
19_S24_I0.6771.00
232_C300_K0.6741.00
208_F279_V0.6731.00
228_A303_S0.6731.00
19_S32_T0.6711.00
30_L38_Q0.6711.00
89_A130_V0.6701.00
155_I160_G0.6671.00
259_A262_G0.6621.00
197_P289_L0.6581.00
189_I193_K0.6571.00
86_V91_P0.6531.00
162_I194_R0.6511.00
94_W99_I0.6501.00
46_M66_A0.6471.00
38_Q142_G0.6431.00
166_A258_W0.6431.00
149_L156_V0.6411.00
222_S261_F0.6411.00
201_V270_G0.6391.00
274_N277_W0.6371.00
253_P258_W0.6351.00
204_L280_L0.6321.00
79_G139_I0.6311.00
89_A123_V0.6271.00
209_K279_V0.6241.00
145_C205_C0.6221.00
172_L177_N0.6211.00
88_L102_M0.6201.00
31_Y41_V0.6191.00
85_L118_I0.6191.00
221_A260_L0.6181.00
184_E191_R0.6181.00
41_V83_F0.6131.00
157_F270_G0.6111.00
147_R230_A0.6101.00
71_I113_Y0.6101.00
215_D226_E0.6091.00
86_V103_Y0.6081.00
241_M292_T0.6061.00
298_R301_T0.6051.00
72_S265_D0.6021.00
84_Y117_L0.6011.00
70_N133_V0.5991.00
112_L196_E0.5991.00
54_L65_K0.5961.00
214_N227_I0.5951.00
42_C70_N0.5941.00
75_A199_V0.5941.00
19_S22_V0.5931.00
18_S23_G0.5921.00
106_M131_V0.5921.00
205_C213_L0.5901.00
36_G140_E0.5881.00
143_Q208_F0.5881.00
38_Q44_D0.5831.00
258_W261_F0.5831.00
203_R283_E0.5801.00
264_E267_E0.5781.00
160_G290_P0.5761.00
58_S101_A0.5741.00
166_A170_S0.5690.99
98_E101_A0.5670.99
280_L291_I0.5660.99
20_V24_I0.5650.99
278_E293_K0.5640.99
208_F276_E0.5640.99
166_A169_L0.5600.99
73_D215_D0.5590.99
258_W263_G0.5550.99
173_L176_T0.5520.99
105_G109_L0.5520.99
106_M109_L0.5490.99
64_Y194_R0.5490.99
160_G292_T0.5470.99
162_I267_E0.5470.99
228_A231_S0.5460.99
155_I275_E0.5460.99
90_V98_E0.5440.99
41_V44_D0.5440.99
44_D73_D0.5410.99
158_V216_V0.5400.99
104_E107_N0.5400.99
91_P129_L0.5390.99
200_S289_L0.5380.99
150_A211_A0.5380.99
278_E285_A0.5380.99
158_V162_I0.5370.99
204_L284_C0.5340.99
19_S80_I0.5340.99
32_T35_H0.5290.99
22_V30_L0.5240.99
222_S225_N0.5230.99
19_S23_G0.5230.99
257_E262_G0.5220.99
203_R286_A0.5200.99
221_A261_F0.5190.99
158_V243_P0.5190.99
185_T188_F0.5190.99
223_E226_E0.5190.99
106_M117_L0.5170.99
220_L294_I0.5160.99
148_S230_A0.5140.99
74_I137_G0.5140.99
65_K192_H0.5130.99
157_F160_G0.5130.99
20_V25_G0.5120.99
254_N257_E0.5120.99
299_E302_K0.5110.99
148_S231_S0.5110.99
150_A233_V0.5100.99
62_I102_M0.5090.99
35_H140_E0.5090.99
197_P200_S0.5080.99
43_V85_L0.5080.99
72_S266_F0.5070.99
168_G171_L0.5070.99
97_S100_K0.5050.99
73_D217_S0.5030.99
35_H142_G0.5030.99
85_L136_I0.5010.99
153_N297_V0.5010.99
183_V186_D0.5000.99
162_I220_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcqA 2 0.9231 100 0.156 Contact Map
2yxzA 2 0.9108 100 0.212 Contact Map
3c9uA 2 0.9138 100 0.225 Contact Map
2z01A 2 0.9077 100 0.275 Contact Map
3m84A 2 0.9323 100 0.284 Contact Map
3vtiC 2 0.9138 100 0.29 Contact Map
2btuA 2 0.9292 100 0.294 Contact Map
2zodA 2 0.8831 100 0.294 Contact Map
3p4eA 2 0.9169 100 0.3 Contact Map
2rb9A 2 0.9415 100 0.307 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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