GREMLIN Database
MANB1 - Mannan endo-1,4-beta-mannosidase
UniProt: O05512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (302)
Sequences: 688 (546)
Seq/√Len: 31.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_N235_D8.0021.00
187_L240_V5.3811.00
226_H230_D4.6831.00
264_G291_T4.3281.00
91_G127_Q3.9161.00
170_S232_R3.5981.00
60_S345_T3.5261.00
170_S227_Y3.4581.00
222_K259_Y3.3521.00
227_Y232_R3.3411.00
242_S264_G3.3021.00
85_Q349_G3.2291.00
43_V125_I3.2101.00
33_N36_A3.0801.00
287_P319_I3.0581.00
116_L128_I2.7131.00
31_P238_I2.7011.00
169_L227_Y2.6771.00
188_F224_I2.6171.00
224_I228_M2.5971.00
166_N223_K2.5521.00
169_L224_I2.5030.99
37_Q235_D2.3610.99
255_P260_V2.2970.99
59_L89_I2.2550.99
63_F91_G2.2550.99
176_L237_L2.2410.99
165_L191_L2.2340.99
59_L88_A2.2220.99
44_M238_I2.1830.99
169_L228_M2.1580.98
227_Y231_T2.1570.98
254_Y257_A2.1350.98
31_P44_M2.1340.98
36_A41_K2.0140.98
32_V225_Y1.9630.97
33_N225_Y1.9570.97
166_N227_Y1.9320.97
340_Y345_T1.9060.97
196_G199_F1.8630.96
39_T183_G1.8400.96
89_I322_L1.8220.96
119_Y124_G1.8130.95
188_F237_L1.8100.95
174_D232_R1.7640.95
150_Q204_T1.7610.95
217_Y221_Y1.7570.95
242_S291_T1.7430.94
153_K161_E1.7320.94
340_Y347_N1.7300.94
194_M253_F1.7160.94
347_N350_E1.6840.93
131_H192_H1.6800.93
195_N244_D1.6780.93
225_Y239_W1.6580.93
131_H199_F1.6470.92
337_S341_H1.6390.92
91_G322_L1.6270.92
176_L234_L1.6010.91
113_N178_E1.5650.90
127_Q320_Y1.5530.90
240_V291_T1.5470.90
289_A320_Y1.5400.90
117_M184_V1.5340.89
175_G178_E1.5100.89
162_G223_K1.5070.89
180_E235_D1.4760.87
37_Q183_G1.4670.87
309_N338_A1.4540.87
80_R86_S1.4370.86
46_W346_L1.4260.86
177_Q180_E1.4190.85
274_S335_G1.4170.85
312_K342_D1.4160.85
37_Q180_E1.3890.84
177_Q234_L1.3840.84
256_G260_V1.3770.84
234_L239_W1.3770.84
38_Q42_T1.3770.84
254_Y260_V1.3700.83
37_Q40_T1.3660.83
132_L168_M1.3630.83
50_L319_I1.3530.82
177_Q232_R1.3370.82
188_F228_M1.3280.81
162_G166_N1.3210.81
189_R292_E1.3160.81
43_V185_P1.3070.80
90_Y119_Y1.2950.79
58_V311_I1.2900.79
346_L350_E1.2860.79
63_F322_L1.2700.78
117_M121_K1.2570.77
140_G143_K1.2480.77
257_A260_V1.2290.76
154_I165_L1.2270.76
152_K216_L1.2000.74
132_L191_L1.1850.73
222_K258_S1.1830.73
222_K226_H1.1800.73
60_S323_A1.1800.73
40_T43_V1.1660.72
27_H31_P1.1600.71
158_S162_G1.1490.71
122_N348_K1.1420.70
124_G347_N1.1340.70
40_T265_L1.1270.69
33_N234_L1.1220.69
33_N41_K1.1210.69
117_M182_Q1.1090.68
121_K182_Q1.0970.67
169_L223_K1.0950.67
193_E292_E1.0860.66
192_H199_F1.0860.66
266_D292_E1.0720.65
225_Y229_T1.0700.65
33_N37_Q1.0590.64
156_D159_T1.0440.63
199_F268_Y1.0360.63
91_G129_S1.0310.62
129_S264_G1.0250.62
153_K159_T1.0230.62
64_G325_N1.0200.61
85_Q347_N1.0190.61
221_Y296_Q1.0170.61
223_K227_Y1.0070.60
321_F345_T1.0050.60
179_L186_V0.9980.60
262_I311_I0.9870.59
115_D119_Y0.9810.58
321_F339_L0.9720.58
256_G259_Y0.9720.58
106_D112_C0.9660.57
96_R133_A0.9650.57
189_R193_E0.9640.57
73_M76_A0.9580.56
60_S321_F0.9580.56
41_K45_N0.9560.56
104_I110_V0.9510.56
33_N229_T0.9440.55
67_S92_C0.9360.55
119_Y126_P0.9340.55
104_I108_I0.9340.55
218_K222_K0.9330.54
92_C126_P0.9280.54
150_Q153_K0.9240.54
46_W59_L0.9240.54
120_W125_I0.9230.54
190_P200_W0.9200.53
189_R266_D0.9190.53
293_V321_F0.9150.53
263_V284_L0.9140.53
58_V344_W0.9130.53
92_C128_I0.9090.53
312_K344_W0.9070.52
263_V281_L0.9030.52
279_D282_T0.9020.52
60_S347_N0.9020.52
51_P319_I0.9000.52
280_Q283_A0.8930.51
138_Q164_R0.8930.51
174_D177_Q0.8830.50
309_N342_D0.8800.50
308_I339_L0.8770.50
118_S122_N0.8760.50
176_L188_F0.8710.49
345_T350_E0.8680.49
149_D154_I0.8670.49
68_H325_N0.8640.49
40_T44_M0.8600.49
106_D110_V0.8600.49
311_I344_W0.8570.48
106_D109_D0.8550.48
254_Y263_V0.8530.48
44_M48_A0.8500.48
339_L345_T0.8470.47
334_K338_A0.8460.47
293_V323_A0.8450.47
31_P36_A0.8390.47
125_I185_P0.8370.47
165_L168_M0.8340.46
151_Y165_L0.8340.46
78_R82_A0.8330.46
52_N350_E0.8320.46
278_Y282_T0.8280.46
92_C170_S0.8270.46
138_Q141_H0.8250.46
62_A65_G0.8240.46
76_A81_S0.8200.45
103_N107_S0.8180.45
144_T203_L0.8120.45
191_L202_G0.8090.44
89_I127_Q0.8080.44
165_L169_L0.8080.44
194_M243_P0.8060.44
135_P190_P0.7980.44
30_S34_P0.7970.43
229_T239_W0.7940.43
95_A221_Y0.7930.43
93_D128_I0.7920.43
151_Y154_I0.7910.43
90_Y115_D0.7850.42
47_L287_P0.7830.42
94_Y113_N0.7820.42
151_Y216_L0.7800.42
163_K334_K0.7800.42
241_Y286_K0.7760.42
192_H196_G0.7700.41
179_L184_V0.7690.41
64_G68_H0.7610.41
258_S343_S0.7570.40
244_D250_K0.7570.40
183_G276_N0.7560.40
100_E133_A0.7490.40
166_N170_S0.7450.39
98_W110_V0.7440.39
49_H287_P0.7410.39
35_N285_N0.7400.39
298_A338_A0.7380.39
129_S265_L0.7310.38
311_I315_Y0.7310.38
36_A235_D0.7310.38
193_E266_D0.7280.38
260_V264_G0.7260.38
95_A100_E0.7220.38
36_A225_Y0.7160.37
82_A333_N0.7120.37
227_Y259_Y0.7110.37
73_M113_N0.7100.37
86_S122_N0.7100.37
129_S238_I0.7100.37
91_G196_G0.7100.37
142_F145_P0.6990.36
61_G89_I0.6980.36
32_V38_Q0.6960.36
96_R108_I0.6960.36
77_D86_S0.6960.36
140_G144_T0.6960.36
134_N164_R0.6950.36
155_L159_T0.6940.35
193_E198_W0.6910.35
30_S38_Q0.6890.35
217_Y264_G0.6860.35
244_D269_F0.6830.35
157_S162_G0.6820.35
45_N121_K0.6810.34
64_G95_A0.6810.34
225_Y230_D0.6800.34
131_H266_D0.6800.34
335_G345_T0.6780.34
83_T333_N0.6760.34
131_H200_W0.6740.34
230_D258_S0.6730.34
43_V120_W0.6730.34
153_K343_S0.6720.34
43_V89_I0.6720.34
79_I124_G0.6710.34
176_L186_V0.6660.33
46_W49_H0.6650.33
198_W294_G0.6640.33
169_L231_T0.6640.33
172_I228_M0.6610.33
136_A139_S0.6610.33
59_L347_N0.6600.33
297_T318_T0.6590.33
241_Y331_A0.6590.33
88_A351_I0.6580.33
68_H108_I0.6560.33
57_R350_E0.6560.33
127_Q196_G0.6550.33
257_A285_N0.6540.33
121_K233_G0.6530.32
42_T351_I0.6530.32
135_P150_Q0.6520.32
113_N128_I0.6520.32
276_N313_Q0.6520.32
288_F321_F0.6500.32
246_N249_F0.6500.32
99_L105_E0.6480.32
33_N239_W0.6480.32
280_Q284_L0.6480.32
173_A185_P0.6470.32
219_Q230_D0.6470.32
297_T331_A0.6450.32
226_H229_T0.6440.32
158_S322_L0.6410.32
189_R198_W0.6380.31
195_N316_P0.6370.31
234_L237_L0.6340.31
33_N233_G0.6330.31
117_M180_E0.6320.31
222_K257_A0.6310.31
52_N220_L0.6300.31
169_L191_L0.6300.31
173_A232_R0.6290.31
173_A228_M0.6280.31
56_N219_Q0.6270.31
195_N267_A0.6270.31
104_I109_D0.6270.31
113_N175_G0.6260.31
151_Y191_L0.6240.30
31_P48_A0.6230.30
134_N138_Q0.6220.30
193_E196_G0.6220.30
34_P258_S0.6210.30
217_Y286_K0.6200.30
125_I265_L0.6200.30
189_R196_G0.6190.30
191_L224_I0.6180.30
134_N137_F0.6180.30
156_D162_G0.6170.30
156_D219_Q0.6170.30
121_K338_A0.6140.30
203_L221_Y0.6140.30
229_T234_L0.6110.30
199_F292_E0.6090.29
140_G146_I0.6090.29
91_G320_Y0.6080.29
93_D107_S0.6080.29
189_R199_F0.6080.29
79_I326_D0.6070.29
194_M241_Y0.6070.29
169_L225_Y0.6060.29
86_S348_K0.6050.29
250_K263_V0.6050.29
35_N230_D0.6050.29
89_I217_Y0.6030.29
37_Q184_V0.6010.29
105_E108_I0.6000.29
288_F318_T0.6000.29
36_A40_T0.5990.29
155_L263_V0.5980.29
63_F129_S0.5970.29
192_H266_D0.5960.29
289_A319_I0.5960.29
91_G285_N0.5960.29
226_H259_Y0.5950.28
158_S263_V0.5940.28
222_K256_G0.5940.28
121_K236_H0.5940.28
78_R243_P0.5940.28
29_V48_A0.5930.28
51_P287_P0.5930.28
37_Q185_P0.5920.28
170_S231_T0.5920.28
193_E199_F0.5910.28
98_W168_M0.5900.28
35_N235_D0.5900.28
260_V263_V0.5900.28
279_D342_D0.5890.28
46_W50_L0.5890.28
28_T283_A0.5870.28
35_N338_A0.5830.28
335_G339_L0.5830.28
195_N265_L0.5790.27
78_R336_A0.5780.27
59_L120_W0.5780.27
198_W292_E0.5770.27
214_I252_D0.5750.27
129_S155_L0.5740.27
95_A133_A0.5740.27
269_F274_S0.5720.27
115_D118_S0.5710.27
202_G294_G0.5700.27
170_S174_D0.5690.27
217_Y241_Y0.5690.27
214_I218_K0.5670.27
79_I311_I0.5660.27
269_F311_I0.5650.27
196_G268_Y0.5640.26
94_Y264_G0.5630.26
219_Q323_A0.5620.26
198_W202_G0.5620.26
196_G292_E0.5620.26
52_N56_N0.5600.26
95_A105_E0.5570.26
147_T220_L0.5560.26
293_V335_G0.5540.26
290_F295_P0.5540.26
190_P236_H0.5530.26
40_T277_G0.5530.26
26_A30_S0.5530.26
259_Y319_I0.5530.26
142_F168_M0.5520.26
243_P281_L0.5520.26
91_G131_H0.5500.26
97_G340_Y0.5500.26
151_Y159_T0.5500.26
197_E253_F0.5500.26
75_E79_I0.5490.26
218_K259_Y0.5470.25
66_Y90_Y0.5460.25
192_H292_E0.5460.25
228_M260_V0.5420.25
199_F266_D0.5420.25
121_K283_A0.5420.25
179_L287_P0.5420.25
157_S184_V0.5410.25
278_Y281_L0.5400.25
119_Y348_K0.5380.25
230_D239_W0.5380.25
184_V218_K0.5380.25
94_Y172_I0.5350.25
117_M178_E0.5340.25
308_I311_I0.5320.24
158_S163_K0.5310.24
113_N117_M0.5310.24
38_Q41_K0.5300.24
349_G352_W0.5300.24
132_L224_I0.5290.24
62_A336_A0.5280.24
282_T288_F0.5270.24
80_R184_V0.5270.24
58_V350_E0.5260.24
176_L239_W0.5260.24
26_A186_V0.5250.24
283_A342_D0.5250.24
46_W351_I0.5230.24
26_A121_K0.5230.24
278_Y321_F0.5230.24
179_L236_H0.5220.24
295_P330_A0.5210.24
132_L194_M0.5210.24
91_G242_S0.5210.24
127_Q322_L0.5210.24
93_D96_R0.5200.24
126_P284_L0.5200.24
343_S353_N0.5200.24
181_N215_S0.5190.24
127_Q199_F0.5190.24
192_H198_W0.5160.24
322_L325_N0.5160.24
285_N338_A0.5140.23
243_P264_G0.5140.23
128_I348_K0.5140.23
172_I247_R0.5130.23
181_N252_D0.5120.23
240_V289_A0.5120.23
138_Q155_L0.5100.23
94_Y128_I0.5100.23
59_L285_N0.5100.23
92_C119_Y0.5100.23
27_H32_V0.5090.23
162_G227_Y0.5070.23
281_L284_L0.5070.23
187_L237_L0.5060.23
64_G90_Y0.5060.23
190_P324_W0.5060.23
65_G68_H0.5050.23
272_A281_L0.5040.23
233_G350_E0.5010.23
131_H255_P0.5000.23
113_N116_L0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cbwA 1 0.9282 100 0.268 Contact Map
3wdqA 1 0.8453 100 0.276 Contact Map
3zm8A 1 0.8867 100 0.276 Contact Map
1odzA 1 0.8867 100 0.277 Contact Map
4cd5A 1 0.8702 100 0.285 Contact Map
3tp4A 2 0.8895 100 0.297 Contact Map
2v3gA 1 0.6906 100 0.588 Contact Map
2ddxA 1 0.7459 100 0.657 Contact Map
1xyzA 1 0.7514 96.5 0.94 Contact Map
3wugA 1 0.7624 96.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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