MANB1 - BACSU - GREMLIN Contacts

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MANB1 - Mannan endo-1,4-beta-mannosidase

UniProt:	O05512	Sequences: MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVMNWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETANIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTVEGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYKQLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSINGYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNKGASALYHDSWTLNKGEIWNGDSLTPIVE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	362 (302)
Sequences:	688 (546)
Seq/√Len:	31.4

BACSU - MANB1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_N	235_D	8.002	1.00
187_L	240_V	5.381	1.00
226_H	230_D	4.683	1.00
264_G	291_T	4.328	1.00
91_G	127_Q	3.916	1.00
170_S	232_R	3.598	1.00
60_S	345_T	3.526	1.00
170_S	227_Y	3.458	1.00
222_K	259_Y	3.352	1.00
227_Y	232_R	3.341	1.00
242_S	264_G	3.302	1.00
85_Q	349_G	3.229	1.00
43_V	125_I	3.210	1.00
33_N	36_A	3.080	1.00
287_P	319_I	3.058	1.00
116_L	128_I	2.713	1.00
31_P	238_I	2.701	1.00
169_L	227_Y	2.677	1.00
188_F	224_I	2.617	1.00
224_I	228_M	2.597	1.00
166_N	223_K	2.552	1.00
169_L	224_I	2.503	0.99
37_Q	235_D	2.361	0.99
255_P	260_V	2.297	0.99
59_L	89_I	2.255	0.99
63_F	91_G	2.255	0.99
176_L	237_L	2.241	0.99
165_L	191_L	2.234	0.99
59_L	88_A	2.222	0.99
44_M	238_I	2.183	0.99
169_L	228_M	2.158	0.98
227_Y	231_T	2.157	0.98
254_Y	257_A	2.135	0.98
31_P	44_M	2.134	0.98
36_A	41_K	2.014	0.98
32_V	225_Y	1.963	0.97
33_N	225_Y	1.957	0.97
166_N	227_Y	1.932	0.97
340_Y	345_T	1.906	0.97
196_G	199_F	1.863	0.96
39_T	183_G	1.840	0.96
89_I	322_L	1.822	0.96
119_Y	124_G	1.813	0.95
188_F	237_L	1.810	0.95
174_D	232_R	1.764	0.95
150_Q	204_T	1.761	0.95
217_Y	221_Y	1.757	0.95
242_S	291_T	1.743	0.94
153_K	161_E	1.732	0.94
340_Y	347_N	1.730	0.94
194_M	253_F	1.716	0.94
347_N	350_E	1.684	0.93
131_H	192_H	1.680	0.93
195_N	244_D	1.678	0.93
225_Y	239_W	1.658	0.93
131_H	199_F	1.647	0.92
337_S	341_H	1.639	0.92
91_G	322_L	1.627	0.92
176_L	234_L	1.601	0.91
113_N	178_E	1.565	0.90
127_Q	320_Y	1.553	0.90
240_V	291_T	1.547	0.90
289_A	320_Y	1.540	0.90
117_M	184_V	1.534	0.89
175_G	178_E	1.510	0.89
162_G	223_K	1.507	0.89
180_E	235_D	1.476	0.87
37_Q	183_G	1.467	0.87
309_N	338_A	1.454	0.87
80_R	86_S	1.437	0.86
46_W	346_L	1.426	0.86
177_Q	180_E	1.419	0.85
274_S	335_G	1.417	0.85
312_K	342_D	1.416	0.85
37_Q	180_E	1.389	0.84
177_Q	234_L	1.384	0.84
256_G	260_V	1.377	0.84
234_L	239_W	1.377	0.84
38_Q	42_T	1.377	0.84
254_Y	260_V	1.370	0.83
37_Q	40_T	1.366	0.83
132_L	168_M	1.363	0.83
50_L	319_I	1.353	0.82
177_Q	232_R	1.337	0.82
188_F	228_M	1.328	0.81
162_G	166_N	1.321	0.81
189_R	292_E	1.316	0.81
43_V	185_P	1.307	0.80
90_Y	119_Y	1.295	0.79
58_V	311_I	1.290	0.79
346_L	350_E	1.286	0.79
63_F	322_L	1.270	0.78
117_M	121_K	1.257	0.77
140_G	143_K	1.248	0.77
257_A	260_V	1.229	0.76
154_I	165_L	1.227	0.76
152_K	216_L	1.200	0.74
132_L	191_L	1.185	0.73
222_K	258_S	1.183	0.73
222_K	226_H	1.180	0.73
60_S	323_A	1.180	0.73
40_T	43_V	1.166	0.72
27_H	31_P	1.160	0.71
158_S	162_G	1.149	0.71
122_N	348_K	1.142	0.70
124_G	347_N	1.134	0.70
40_T	265_L	1.127	0.69
33_N	234_L	1.122	0.69
33_N	41_K	1.121	0.69
117_M	182_Q	1.109	0.68
121_K	182_Q	1.097	0.67
169_L	223_K	1.095	0.67
193_E	292_E	1.086	0.66
192_H	199_F	1.086	0.66
266_D	292_E	1.072	0.65
225_Y	229_T	1.070	0.65
33_N	37_Q	1.059	0.64
156_D	159_T	1.044	0.63
199_F	268_Y	1.036	0.63
91_G	129_S	1.031	0.62
129_S	264_G	1.025	0.62
153_K	159_T	1.023	0.62
64_G	325_N	1.020	0.61
85_Q	347_N	1.019	0.61
221_Y	296_Q	1.017	0.61
223_K	227_Y	1.007	0.60
321_F	345_T	1.005	0.60
179_L	186_V	0.998	0.60
262_I	311_I	0.987	0.59
115_D	119_Y	0.981	0.58
321_F	339_L	0.972	0.58
256_G	259_Y	0.972	0.58
106_D	112_C	0.966	0.57
96_R	133_A	0.965	0.57
189_R	193_E	0.964	0.57
73_M	76_A	0.958	0.56
60_S	321_F	0.958	0.56
41_K	45_N	0.956	0.56
104_I	110_V	0.951	0.56
33_N	229_T	0.944	0.55
67_S	92_C	0.936	0.55
119_Y	126_P	0.934	0.55
104_I	108_I	0.934	0.55
218_K	222_K	0.933	0.54
92_C	126_P	0.928	0.54
150_Q	153_K	0.924	0.54
46_W	59_L	0.924	0.54
120_W	125_I	0.923	0.54
190_P	200_W	0.920	0.53
189_R	266_D	0.919	0.53
293_V	321_F	0.915	0.53
263_V	284_L	0.914	0.53
58_V	344_W	0.913	0.53
92_C	128_I	0.909	0.53
312_K	344_W	0.907	0.52
263_V	281_L	0.903	0.52
279_D	282_T	0.902	0.52
60_S	347_N	0.902	0.52
51_P	319_I	0.900	0.52
280_Q	283_A	0.893	0.51
138_Q	164_R	0.893	0.51
174_D	177_Q	0.883	0.50
309_N	342_D	0.880	0.50
308_I	339_L	0.877	0.50
118_S	122_N	0.876	0.50
176_L	188_F	0.871	0.49
345_T	350_E	0.868	0.49
149_D	154_I	0.867	0.49
68_H	325_N	0.864	0.49
40_T	44_M	0.860	0.49
106_D	110_V	0.860	0.49
311_I	344_W	0.857	0.48
106_D	109_D	0.855	0.48
254_Y	263_V	0.853	0.48
44_M	48_A	0.850	0.48
339_L	345_T	0.847	0.47
334_K	338_A	0.846	0.47
293_V	323_A	0.845	0.47
31_P	36_A	0.839	0.47
125_I	185_P	0.837	0.47
165_L	168_M	0.834	0.46
151_Y	165_L	0.834	0.46
78_R	82_A	0.833	0.46
52_N	350_E	0.832	0.46
278_Y	282_T	0.828	0.46
92_C	170_S	0.827	0.46
138_Q	141_H	0.825	0.46
62_A	65_G	0.824	0.46
76_A	81_S	0.820	0.45
103_N	107_S	0.818	0.45
144_T	203_L	0.812	0.45
191_L	202_G	0.809	0.44
89_I	127_Q	0.808	0.44
165_L	169_L	0.808	0.44
194_M	243_P	0.806	0.44
135_P	190_P	0.798	0.44
30_S	34_P	0.797	0.43
229_T	239_W	0.794	0.43
95_A	221_Y	0.793	0.43
93_D	128_I	0.792	0.43
151_Y	154_I	0.791	0.43
90_Y	115_D	0.785	0.42
47_L	287_P	0.783	0.42
94_Y	113_N	0.782	0.42
151_Y	216_L	0.780	0.42
163_K	334_K	0.780	0.42
241_Y	286_K	0.776	0.42
192_H	196_G	0.770	0.41
179_L	184_V	0.769	0.41
64_G	68_H	0.761	0.41
258_S	343_S	0.757	0.40
244_D	250_K	0.757	0.40
183_G	276_N	0.756	0.40
100_E	133_A	0.749	0.40
166_N	170_S	0.745	0.39
98_W	110_V	0.744	0.39
49_H	287_P	0.741	0.39
35_N	285_N	0.740	0.39
298_A	338_A	0.738	0.39
129_S	265_L	0.731	0.38
311_I	315_Y	0.731	0.38
36_A	235_D	0.731	0.38
193_E	266_D	0.728	0.38
260_V	264_G	0.726	0.38
95_A	100_E	0.722	0.38
36_A	225_Y	0.716	0.37
82_A	333_N	0.712	0.37
227_Y	259_Y	0.711	0.37
73_M	113_N	0.710	0.37
86_S	122_N	0.710	0.37
129_S	238_I	0.710	0.37
91_G	196_G	0.710	0.37
142_F	145_P	0.699	0.36
61_G	89_I	0.698	0.36
32_V	38_Q	0.696	0.36
96_R	108_I	0.696	0.36
77_D	86_S	0.696	0.36
140_G	144_T	0.696	0.36
134_N	164_R	0.695	0.36
155_L	159_T	0.694	0.35
193_E	198_W	0.691	0.35
30_S	38_Q	0.689	0.35
217_Y	264_G	0.686	0.35
244_D	269_F	0.683	0.35
157_S	162_G	0.682	0.35
45_N	121_K	0.681	0.34
64_G	95_A	0.681	0.34
225_Y	230_D	0.680	0.34
131_H	266_D	0.680	0.34
335_G	345_T	0.678	0.34
83_T	333_N	0.676	0.34
131_H	200_W	0.674	0.34
230_D	258_S	0.673	0.34
43_V	120_W	0.673	0.34
153_K	343_S	0.672	0.34
43_V	89_I	0.672	0.34
79_I	124_G	0.671	0.34
176_L	186_V	0.666	0.33
46_W	49_H	0.665	0.33
198_W	294_G	0.664	0.33
169_L	231_T	0.664	0.33
172_I	228_M	0.661	0.33
136_A	139_S	0.661	0.33
59_L	347_N	0.660	0.33
297_T	318_T	0.659	0.33
241_Y	331_A	0.659	0.33
88_A	351_I	0.658	0.33
68_H	108_I	0.656	0.33
57_R	350_E	0.656	0.33
127_Q	196_G	0.655	0.33
257_A	285_N	0.654	0.33
121_K	233_G	0.653	0.32
42_T	351_I	0.653	0.32
135_P	150_Q	0.652	0.32
113_N	128_I	0.652	0.32
276_N	313_Q	0.652	0.32
288_F	321_F	0.650	0.32
246_N	249_F	0.650	0.32
99_L	105_E	0.648	0.32
33_N	239_W	0.648	0.32
280_Q	284_L	0.648	0.32
173_A	185_P	0.647	0.32
219_Q	230_D	0.647	0.32
297_T	331_A	0.645	0.32
226_H	229_T	0.644	0.32
158_S	322_L	0.641	0.32
189_R	198_W	0.638	0.31
195_N	316_P	0.637	0.31
234_L	237_L	0.634	0.31
33_N	233_G	0.633	0.31
117_M	180_E	0.632	0.31
222_K	257_A	0.631	0.31
52_N	220_L	0.630	0.31
169_L	191_L	0.630	0.31
173_A	232_R	0.629	0.31
173_A	228_M	0.628	0.31
56_N	219_Q	0.627	0.31
195_N	267_A	0.627	0.31
104_I	109_D	0.627	0.31
113_N	175_G	0.626	0.31
151_Y	191_L	0.624	0.30
31_P	48_A	0.623	0.30
134_N	138_Q	0.622	0.30
193_E	196_G	0.622	0.30
34_P	258_S	0.621	0.30
217_Y	286_K	0.620	0.30
125_I	265_L	0.620	0.30
189_R	196_G	0.619	0.30
191_L	224_I	0.618	0.30
134_N	137_F	0.618	0.30
156_D	162_G	0.617	0.30
156_D	219_Q	0.617	0.30
121_K	338_A	0.614	0.30
203_L	221_Y	0.614	0.30
229_T	234_L	0.611	0.30
199_F	292_E	0.609	0.29
140_G	146_I	0.609	0.29
91_G	320_Y	0.608	0.29
93_D	107_S	0.608	0.29
189_R	199_F	0.608	0.29
79_I	326_D	0.607	0.29
194_M	241_Y	0.607	0.29
169_L	225_Y	0.606	0.29
86_S	348_K	0.605	0.29
250_K	263_V	0.605	0.29
35_N	230_D	0.605	0.29
89_I	217_Y	0.603	0.29
37_Q	184_V	0.601	0.29
105_E	108_I	0.600	0.29
288_F	318_T	0.600	0.29
36_A	40_T	0.599	0.29
155_L	263_V	0.598	0.29
63_F	129_S	0.597	0.29
192_H	266_D	0.596	0.29
289_A	319_I	0.596	0.29
91_G	285_N	0.596	0.29
226_H	259_Y	0.595	0.28
158_S	263_V	0.594	0.28
222_K	256_G	0.594	0.28
121_K	236_H	0.594	0.28
78_R	243_P	0.594	0.28
29_V	48_A	0.593	0.28
51_P	287_P	0.593	0.28
37_Q	185_P	0.592	0.28
170_S	231_T	0.592	0.28
193_E	199_F	0.591	0.28
98_W	168_M	0.590	0.28
35_N	235_D	0.590	0.28
260_V	263_V	0.590	0.28
279_D	342_D	0.589	0.28
46_W	50_L	0.589	0.28
28_T	283_A	0.587	0.28
35_N	338_A	0.583	0.28
335_G	339_L	0.583	0.28
195_N	265_L	0.579	0.27
78_R	336_A	0.578	0.27
59_L	120_W	0.578	0.27
198_W	292_E	0.577	0.27
214_I	252_D	0.575	0.27
129_S	155_L	0.574	0.27
95_A	133_A	0.574	0.27
269_F	274_S	0.572	0.27
115_D	118_S	0.571	0.27
202_G	294_G	0.570	0.27
170_S	174_D	0.569	0.27
217_Y	241_Y	0.569	0.27
214_I	218_K	0.567	0.27
79_I	311_I	0.566	0.27
269_F	311_I	0.565	0.27
196_G	268_Y	0.564	0.26
94_Y	264_G	0.563	0.26
219_Q	323_A	0.562	0.26
198_W	202_G	0.562	0.26
196_G	292_E	0.562	0.26
52_N	56_N	0.560	0.26
95_A	105_E	0.557	0.26
147_T	220_L	0.556	0.26
293_V	335_G	0.554	0.26
290_F	295_P	0.554	0.26
190_P	236_H	0.553	0.26
40_T	277_G	0.553	0.26
26_A	30_S	0.553	0.26
259_Y	319_I	0.553	0.26
142_F	168_M	0.552	0.26
243_P	281_L	0.552	0.26
91_G	131_H	0.550	0.26
97_G	340_Y	0.550	0.26
151_Y	159_T	0.550	0.26
197_E	253_F	0.550	0.26
75_E	79_I	0.549	0.26
218_K	259_Y	0.547	0.25
66_Y	90_Y	0.546	0.25
192_H	292_E	0.546	0.25
228_M	260_V	0.542	0.25
199_F	266_D	0.542	0.25
121_K	283_A	0.542	0.25
179_L	287_P	0.542	0.25
157_S	184_V	0.541	0.25
278_Y	281_L	0.540	0.25
119_Y	348_K	0.538	0.25
230_D	239_W	0.538	0.25
184_V	218_K	0.538	0.25
94_Y	172_I	0.535	0.25
117_M	178_E	0.534	0.25
308_I	311_I	0.532	0.24
158_S	163_K	0.531	0.24
113_N	117_M	0.531	0.24
38_Q	41_K	0.530	0.24
349_G	352_W	0.530	0.24
132_L	224_I	0.529	0.24
62_A	336_A	0.528	0.24
282_T	288_F	0.527	0.24
80_R	184_V	0.527	0.24
58_V	350_E	0.526	0.24
176_L	239_W	0.526	0.24
26_A	186_V	0.525	0.24
283_A	342_D	0.525	0.24
46_W	351_I	0.523	0.24
26_A	121_K	0.523	0.24
278_Y	321_F	0.523	0.24
179_L	236_H	0.522	0.24
295_P	330_A	0.521	0.24
132_L	194_M	0.521	0.24
91_G	242_S	0.521	0.24
127_Q	322_L	0.521	0.24
93_D	96_R	0.520	0.24
126_P	284_L	0.520	0.24
343_S	353_N	0.520	0.24
181_N	215_S	0.519	0.24
127_Q	199_F	0.519	0.24
192_H	198_W	0.516	0.24
322_L	325_N	0.516	0.24
285_N	338_A	0.514	0.23
243_P	264_G	0.514	0.23
128_I	348_K	0.514	0.23
172_I	247_R	0.513	0.23
181_N	252_D	0.512	0.23
240_V	289_A	0.512	0.23
138_Q	155_L	0.510	0.23
94_Y	128_I	0.510	0.23
59_L	285_N	0.510	0.23
92_C	119_Y	0.510	0.23
27_H	32_V	0.509	0.23
162_G	227_Y	0.507	0.23
281_L	284_L	0.507	0.23
187_L	237_L	0.506	0.23
64_G	90_Y	0.506	0.23
190_P	324_W	0.506	0.23
65_G	68_H	0.505	0.23
272_A	281_L	0.504	0.23
233_G	350_E	0.501	0.23
131_H	255_P	0.500	0.23
113_N	116_L	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cbwA	1	0.9282	100	0.268	Contact Map
3wdqA	1	0.8453	100	0.276	Contact Map
3zm8A	1	0.8867	100	0.276	Contact Map
1odzA	1	0.8867	100	0.277	Contact Map
4cd5A	1	0.8702	100	0.285	Contact Map
3tp4A	2	0.8895	100	0.297	Contact Map
2v3gA	1	0.6906	100	0.588	Contact Map
2ddxA	1	0.7459	100	0.657	Contact Map
1xyzA	1	0.7514	96.5	0.94	Contact Map
3wugA	1	0.7624	96.5	0.94	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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