GREMLIN Database
MANA2 - Probable mannose-6-phosphate isomerase GmuF
UniProt: O05511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (290)
Sequences: 3151 (2369)
Seq/√Len: 139.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_E155_R4.4941.00
6_F291_S3.7271.00
121_D160_P3.2061.00
58_K66_D3.1321.00
142_Q146_S2.9271.00
125_D157_K2.9171.00
158_I178_T2.8701.00
14_R35_G2.6551.00
117_W179_L2.5681.00
277_R284_Q2.5421.00
171_L193_V2.5231.00
102_Y216_V2.5011.00
277_R305_E2.4851.00
50_V63_V2.4601.00
141_K145_E2.4291.00
127_E157_K2.4051.00
101_D105_L2.3821.00
19_T23_D2.3211.00
165_Y244_S2.2741.00
58_K62_Q2.2581.00
59_T62_Q2.2341.00
275_S288_N2.1941.00
148_D151_G2.1621.00
43_H46_G2.1411.00
19_T22_R2.1331.00
171_L217_I2.1241.00
276_G308_C2.1211.00
277_R286_E2.0771.00
136_T139_E2.0611.00
279_I284_Q2.0361.00
125_D159_K2.0141.00
107_E212_K1.9861.00
102_Y106_H1.9721.00
8_E51_K1.9591.00
287_C293_F1.9501.00
100_D111_L1.9251.00
110_D189_T1.9231.00
47_S61_D1.8961.00
288_N291_S1.8741.00
285_Y293_F1.8681.00
52_N56_A1.8581.00
273_S289_A1.8511.00
181_L270_S1.8051.00
45_H188_D1.7941.00
15_L205_K1.7931.00
62_Q66_D1.7571.00
270_S292_H1.7291.00
212_K215_E1.7201.00
93_S192_R1.7171.00
100_D104_K1.7041.00
275_S286_E1.7011.00
99_D102_Y1.6901.00
8_E49_S1.6731.00
279_I305_E1.6291.00
191_Y216_V1.6161.00
19_T32_Q1.6151.00
280_N283_I1.6111.00
83_V183_I1.6041.00
271_V274_G1.5961.00
133_H154_R1.5891.00
63_V70_I1.5841.00
61_D65_K1.5651.00
279_I303_T1.5641.00
304_I308_C1.5471.00
20_K23_D1.5341.00
100_D112_G1.5261.00
39_A292_H1.5031.00
49_S59_T1.4951.00
276_G293_F1.4661.00
6_F285_Y1.4611.00
267_L302_F1.4571.00
296_P299_F1.4501.00
96_V216_V1.4391.00
257_R305_E1.4371.00
9_P292_H1.4061.00
12_K46_G1.3941.00
83_V181_L1.3791.00
64_W71_F1.3711.00
74_P264_Q1.3681.00
255_S307_T1.3551.00
95_Q190_T1.3541.00
62_Q65_K1.3511.00
55_L63_V1.3491.00
159_K162_D1.3361.00
22_R34_T1.3031.00
96_V217_I1.3021.00
121_D179_L1.2971.00
118_Y249_V1.2961.00
78_V110_D1.2911.00
114_T168_S1.2911.00
141_K214_M1.2871.00
101_D104_K1.2791.00
39_A268_L1.2721.00
36_E84_K1.2711.00
128_L164_F1.2701.00
259_A301_E1.2691.00
114_T165_Y1.2591.00
85_L181_L1.2581.00
102_Y215_E1.2461.00
137_K215_E1.2411.00
43_H186_N1.2371.00
140_F219_I1.2191.00
18_G87_D1.2181.00
93_S206_R1.2141.00
195_D206_R1.2031.00
20_K179_L1.2031.00
120_I272_L1.2001.00
29_I34_T1.1981.00
43_H47_S1.1911.00
280_N299_F1.1901.00
134_A139_E1.1861.00
112_G185_Q1.1811.00
78_V111_L1.1741.00
37_C292_H1.1730.99
129_I155_R1.1560.99
15_L90_M1.1540.99
162_D228_P1.1460.99
10_V46_G1.1440.99
90_M176_K1.1180.99
8_E57_G1.1140.99
237_E250_Y1.1140.99
193_V217_I1.1110.99
261_P301_E1.1100.99
183_I249_V1.1090.99
9_P37_C1.1070.99
132_H217_I1.1040.99
116_C249_V1.1010.99
193_V213_A1.0980.99
271_V287_C1.0970.99
104_K110_D1.0950.99
53_G57_G1.0930.99
52_N55_L1.0920.99
82_L184_Q1.0920.99
119_I178_T1.0830.99
239_I251_K1.0780.99
22_R25_F1.0760.99
257_R303_T1.0720.99
87_D179_L1.0670.99
16_W93_S1.0660.99
184_Q190_T1.0650.99
279_I282_G1.0640.99
5_L63_V1.0560.99
275_S307_T1.0550.99
158_I164_F1.0500.99
140_F193_V1.0500.99
269_G293_F1.0400.99
86_L174_L1.0350.99
20_K178_T1.0330.99
132_H219_I1.0310.99
167_P170_T1.0300.99
22_R30_P1.0290.99
83_V249_V1.0200.99
295_L302_F1.0180.99
170_T218_T1.0140.99
114_T185_Q1.0090.98
276_G287_C1.0090.98
93_S195_D0.9990.98
276_G286_E0.9900.98
137_K141_K0.9810.98
22_R32_Q0.9780.98
7_L294_I0.9770.98
165_Y247_F0.9770.98
106_H212_K0.9740.98
116_C183_I0.9650.98
8_E56_A0.9560.98
31_S34_T0.9530.98
41_S47_S0.9520.98
116_C163_F0.9480.98
85_L120_I0.9430.98
22_R28_A0.9430.98
18_G178_T0.9340.97
129_I175_C0.9300.97
9_P39_A0.9300.97
107_E191_Y0.9250.97
192_R206_R0.9150.97
191_Y212_K0.9150.97
273_S307_T0.9140.97
23_D28_A0.9140.97
130_L153_L0.9100.97
278_I293_F0.9090.97
13_E33_K0.9000.97
106_H215_E0.8910.97
20_K87_D0.8890.97
19_T31_S0.8880.97
36_E82_L0.8830.96
287_C308_C0.8790.96
88_A174_L0.8770.96
58_K63_V0.8700.96
47_S59_T0.8610.96
38_W84_K0.8600.96
22_R29_I0.8520.96
142_Q145_E0.8510.96
20_K24_A0.8490.96
53_G56_A0.8480.96
70_I294_I0.8470.96
100_D185_Q0.8470.96
139_E143_R0.8460.96
70_I296_P0.8360.95
112_G246_Y0.8350.95
27_Y39_A0.8320.95
259_A303_T0.8310.95
121_D125_D0.8280.95
138_E142_Q0.8240.95
64_W67_H0.8240.95
240_V243_Q0.8220.95
240_V250_Y0.8190.95
14_R188_D0.8190.95
211_E215_E0.8160.95
13_E31_S0.8160.95
30_P34_T0.8140.94
130_L166_V0.8130.94
145_E214_M0.8090.94
27_Y34_T0.8090.94
84_K184_Q0.8090.94
118_Y163_F0.8050.94
24_A289_A0.8050.94
294_I297_A0.8040.94
38_W48_S0.8030.94
190_T195_D0.8000.94
25_F289_A0.8000.94
233_V236_A0.7980.94
91_D176_K0.7960.94
226_H229_E0.7950.94
21_L25_F0.7950.94
55_L58_K0.7940.94
99_D218_T0.7830.93
42_A78_V0.7800.93
68_P74_P0.7710.93
16_W192_R0.7640.92
102_Y105_L0.7630.92
128_L158_I0.7620.92
271_V276_G0.7600.92
12_K45_H0.7550.92
65_K77_K0.7510.92
286_E291_S0.7480.92
52_N57_G0.7430.91
206_R209_H0.7420.91
92_L115_E0.7410.91
25_F28_A0.7390.91
86_L189_T0.7330.91
114_T244_S0.7300.91
14_R86_L0.7280.90
127_E176_K0.7270.90
83_V270_S0.7240.90
130_L168_S0.7230.90
238_I250_Y0.7210.90
128_L175_C0.7190.90
109_G189_T0.7170.90
64_W79_F0.7140.90
89_N176_K0.7130.90
84_K187_S0.7090.89
27_Y292_H0.7070.89
112_G184_Q0.7060.89
38_W41_S0.7040.89
94_V153_L0.7010.89
25_F34_T0.6990.89
96_V191_Y0.6980.89
55_L67_H0.6960.88
141_K211_E0.6950.88
38_W43_H0.6930.88
273_S277_R0.6930.88
135_S221_H0.6920.88
142_Q279_I0.6920.88
254_I308_C0.6910.88
166_V170_T0.6910.88
96_V193_V0.6900.88
5_L294_I0.6900.88
194_Y206_R0.6880.88
27_Y37_C0.6870.88
6_F51_K0.6840.88
132_H220_P0.6830.87
6_F293_F0.6830.87
160_P273_S0.6820.87
109_G187_S0.6800.87
96_V170_T0.6780.87
93_S190_T0.6770.87
129_I153_L0.6750.87
252_W269_G0.6750.87
163_F249_V0.6730.87
24_A179_L0.6670.86
140_F144_I0.6650.86
143_R152_L0.6650.86
64_W68_P0.6640.86
163_F242_V0.6620.86
69_E298_H0.6580.85
11_F37_C0.6570.85
14_R33_K0.6570.85
254_I306_G0.6560.85
97_H115_E0.6560.85
87_D178_T0.6530.85
7_L10_V0.6520.85
150_N155_R0.6510.85
192_R195_D0.6510.85
278_I304_I0.6510.85
277_R280_N0.6500.85
184_Q209_H0.6490.85
41_S48_S0.6460.84
133_H137_K0.6460.84
105_L215_E0.6460.84
102_Y107_E0.6450.84
102_Y212_K0.6360.83
93_S204_Q0.6350.83
135_S220_P0.6350.83
68_P72_G0.6350.83
42_A61_D0.6340.83
63_V67_H0.6330.83
299_F302_F0.6330.83
243_Q248_S0.6320.83
116_C270_S0.6320.83
85_L270_S0.6310.83
146_S151_G0.6300.83
155_R175_C0.6300.83
5_L52_N0.6290.83
190_T206_R0.6280.83
44_A78_V0.6260.83
113_K188_D0.6120.81
143_R146_S0.6120.81
149_W152_L0.6110.81
11_F34_T0.6100.81
5_L50_V0.6100.81
256_G306_G0.6090.81
175_C178_T0.6080.81
237_E252_W0.6060.80
143_R148_D0.6060.80
99_D169_G0.6050.80
21_L29_I0.6020.80
22_R31_S0.6010.80
269_G295_L0.6000.80
143_R151_G0.6000.80
82_L187_S0.5990.80
191_Y195_D0.5990.80
191_Y206_R0.5980.80
132_H149_W0.5960.79
114_T246_Y0.5940.79
16_W206_R0.5910.79
142_Q261_P0.5900.79
73_F264_Q0.5890.79
116_C181_L0.5890.79
298_H302_F0.5860.78
144_I151_G0.5860.78
19_T30_P0.5830.78
238_I251_K0.5810.78
118_Y181_L0.5780.77
61_D78_V0.5760.77
38_W82_L0.5760.77
111_L185_Q0.5760.77
39_A83_V0.5730.77
130_L164_F0.5710.76
103_A189_T0.5710.76
261_P303_T0.5710.76
99_D110_D0.5710.76
16_W195_D0.5700.76
278_I285_Y0.5690.76
93_S209_H0.5690.76
220_P223_D0.5680.76
23_D26_G0.5670.76
298_H303_T0.5660.76
96_V118_Y0.5640.76
92_L173_A0.5620.75
21_L179_L0.5620.75
22_R27_Y0.5600.75
206_R213_A0.5600.75
11_F39_A0.5600.75
181_L249_V0.5590.75
13_E32_Q0.5590.75
263_Y267_L0.5590.75
138_E141_K0.5580.75
174_L184_Q0.5570.75
35_G188_D0.5560.74
43_H187_S0.5560.74
158_I175_C0.5560.74
112_G244_S0.5550.74
46_G61_D0.5550.74
68_P71_F0.5540.74
95_Q192_R0.5540.74
80_P187_S0.5540.74
88_A175_C0.5520.74
236_A252_W0.5510.74
39_A85_L0.5500.74
108_N190_T0.5490.74
5_L60_L0.5480.73
118_Y251_K0.5450.73
296_P300_G0.5420.73
117_W164_F0.5400.72
39_A120_I0.5400.72
210_I214_M0.5400.72
103_A109_G0.5380.72
20_K26_G0.5370.72
20_K25_F0.5370.72
41_S186_N0.5370.72
272_L289_A0.5360.72
239_I242_V0.5360.72
19_T26_G0.5350.72
129_I173_A0.5340.72
133_H153_L0.5340.72
224_K228_P0.5320.71
287_C291_S0.5310.71
88_A178_T0.5290.71
99_D168_S0.5280.71
68_P77_K0.5260.70
20_K27_Y0.5230.70
118_Y170_T0.5230.70
238_I252_W0.5200.70
236_A255_S0.5190.69
82_L188_D0.5180.69
261_P277_R0.5180.69
170_T224_K0.5180.69
191_Y209_H0.5150.69
96_V169_G0.5150.69
20_K121_D0.5140.69
92_L95_Q0.5140.69
21_L87_D0.5130.69
11_F14_R0.5120.68
10_V48_S0.5110.68
204_Q207_T0.5110.68
262_S301_E0.5090.68
16_W35_G0.5090.68
13_E34_T0.5090.68
50_V53_G0.5080.68
222_I225_V0.5070.68
278_I284_Q0.5070.68
255_S286_E0.5040.67
24_A28_A0.5040.67
282_G301_E0.5040.67
91_D271_V0.5040.67
84_K113_K0.5030.67
51_K291_S0.5030.67
254_I258_A0.5030.67
9_P48_S0.5030.67
11_F29_I0.5020.67
25_F290_G0.5020.67
269_G304_I0.5010.67
232_E277_R0.5000.67
19_T34_T0.5000.67
192_R209_H0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qwrA 1 0.9968 100 0.119 Contact Map
2wfpA 1 0.9397 100 0.194 Contact Map
1zx5A 1 0.9111 100 0.194 Contact Map
1pmiA 1 0.9492 100 0.235 Contact Map
3rnsA 1 0.6317 99.7 0.814 Contact Map
3bu7A 3 0.8381 99.5 0.839 Contact Map
1y3tA 2 0.7619 98.7 0.882 Contact Map
3myxA 1 0.7143 98.7 0.883 Contact Map
3nw4A 3 0.8667 98.6 0.886 Contact Map
3h7jA 1 0.6571 98.6 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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