MANA2 - BACSU - GREMLIN Contacts

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MANA2 - Probable mannose-6-phosphate isomerase GmuF

UniProt:	O05511	Sequences: MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHAHGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDYAKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKPGDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVITIPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSGRIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	315 (290)
Sequences:	3151 (2369)
Seq/√Len:	139.1

ECOLI - MANA
BACSU - MANA2 MANA1 MANA3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
127_E	155_R	4.494	1.00
6_F	291_S	3.727	1.00
121_D	160_P	3.206	1.00
58_K	66_D	3.132	1.00
142_Q	146_S	2.927	1.00
125_D	157_K	2.917	1.00
158_I	178_T	2.870	1.00
14_R	35_G	2.655	1.00
117_W	179_L	2.568	1.00
277_R	284_Q	2.542	1.00
171_L	193_V	2.523	1.00
102_Y	216_V	2.501	1.00
277_R	305_E	2.485	1.00
50_V	63_V	2.460	1.00
141_K	145_E	2.429	1.00
127_E	157_K	2.405	1.00
101_D	105_L	2.382	1.00
19_T	23_D	2.321	1.00
165_Y	244_S	2.274	1.00
58_K	62_Q	2.258	1.00
59_T	62_Q	2.234	1.00
275_S	288_N	2.194	1.00
148_D	151_G	2.162	1.00
43_H	46_G	2.141	1.00
19_T	22_R	2.133	1.00
171_L	217_I	2.124	1.00
276_G	308_C	2.121	1.00
277_R	286_E	2.077	1.00
136_T	139_E	2.061	1.00
279_I	284_Q	2.036	1.00
125_D	159_K	2.014	1.00
107_E	212_K	1.986	1.00
102_Y	106_H	1.972	1.00
8_E	51_K	1.959	1.00
287_C	293_F	1.950	1.00
100_D	111_L	1.925	1.00
110_D	189_T	1.923	1.00
47_S	61_D	1.896	1.00
288_N	291_S	1.874	1.00
285_Y	293_F	1.868	1.00
52_N	56_A	1.858	1.00
273_S	289_A	1.851	1.00
181_L	270_S	1.805	1.00
45_H	188_D	1.794	1.00
15_L	205_K	1.793	1.00
62_Q	66_D	1.757	1.00
270_S	292_H	1.729	1.00
212_K	215_E	1.720	1.00
93_S	192_R	1.717	1.00
100_D	104_K	1.704	1.00
275_S	286_E	1.701	1.00
99_D	102_Y	1.690	1.00
8_E	49_S	1.673	1.00
279_I	305_E	1.629	1.00
191_Y	216_V	1.616	1.00
19_T	32_Q	1.615	1.00
280_N	283_I	1.611	1.00
83_V	183_I	1.604	1.00
271_V	274_G	1.596	1.00
133_H	154_R	1.589	1.00
63_V	70_I	1.584	1.00
61_D	65_K	1.565	1.00
279_I	303_T	1.564	1.00
304_I	308_C	1.547	1.00
20_K	23_D	1.534	1.00
100_D	112_G	1.526	1.00
39_A	292_H	1.503	1.00
49_S	59_T	1.495	1.00
276_G	293_F	1.466	1.00
6_F	285_Y	1.461	1.00
267_L	302_F	1.457	1.00
296_P	299_F	1.450	1.00
96_V	216_V	1.439	1.00
257_R	305_E	1.437	1.00
9_P	292_H	1.406	1.00
12_K	46_G	1.394	1.00
83_V	181_L	1.379	1.00
64_W	71_F	1.371	1.00
74_P	264_Q	1.368	1.00
255_S	307_T	1.355	1.00
95_Q	190_T	1.354	1.00
62_Q	65_K	1.351	1.00
55_L	63_V	1.349	1.00
159_K	162_D	1.336	1.00
22_R	34_T	1.303	1.00
96_V	217_I	1.302	1.00
121_D	179_L	1.297	1.00
118_Y	249_V	1.296	1.00
78_V	110_D	1.291	1.00
114_T	168_S	1.291	1.00
141_K	214_M	1.287	1.00
101_D	104_K	1.279	1.00
39_A	268_L	1.272	1.00
36_E	84_K	1.271	1.00
128_L	164_F	1.270	1.00
259_A	301_E	1.269	1.00
114_T	165_Y	1.259	1.00
85_L	181_L	1.258	1.00
102_Y	215_E	1.246	1.00
137_K	215_E	1.241	1.00
43_H	186_N	1.237	1.00
140_F	219_I	1.219	1.00
18_G	87_D	1.218	1.00
93_S	206_R	1.214	1.00
195_D	206_R	1.203	1.00
20_K	179_L	1.203	1.00
120_I	272_L	1.200	1.00
29_I	34_T	1.198	1.00
43_H	47_S	1.191	1.00
280_N	299_F	1.190	1.00
134_A	139_E	1.186	1.00
112_G	185_Q	1.181	1.00
78_V	111_L	1.174	1.00
37_C	292_H	1.173	0.99
129_I	155_R	1.156	0.99
15_L	90_M	1.154	0.99
162_D	228_P	1.146	0.99
10_V	46_G	1.144	0.99
90_M	176_K	1.118	0.99
8_E	57_G	1.114	0.99
237_E	250_Y	1.114	0.99
193_V	217_I	1.111	0.99
261_P	301_E	1.110	0.99
183_I	249_V	1.109	0.99
9_P	37_C	1.107	0.99
132_H	217_I	1.104	0.99
116_C	249_V	1.101	0.99
193_V	213_A	1.098	0.99
271_V	287_C	1.097	0.99
104_K	110_D	1.095	0.99
53_G	57_G	1.093	0.99
52_N	55_L	1.092	0.99
82_L	184_Q	1.092	0.99
119_I	178_T	1.083	0.99
239_I	251_K	1.078	0.99
22_R	25_F	1.076	0.99
257_R	303_T	1.072	0.99
87_D	179_L	1.067	0.99
16_W	93_S	1.066	0.99
184_Q	190_T	1.065	0.99
279_I	282_G	1.064	0.99
5_L	63_V	1.056	0.99
275_S	307_T	1.055	0.99
158_I	164_F	1.050	0.99
140_F	193_V	1.050	0.99
269_G	293_F	1.040	0.99
86_L	174_L	1.035	0.99
20_K	178_T	1.033	0.99
132_H	219_I	1.031	0.99
167_P	170_T	1.030	0.99
22_R	30_P	1.029	0.99
83_V	249_V	1.020	0.99
295_L	302_F	1.018	0.99
170_T	218_T	1.014	0.99
114_T	185_Q	1.009	0.98
276_G	287_C	1.009	0.98
93_S	195_D	0.999	0.98
276_G	286_E	0.990	0.98
137_K	141_K	0.981	0.98
22_R	32_Q	0.978	0.98
7_L	294_I	0.977	0.98
165_Y	247_F	0.977	0.98
106_H	212_K	0.974	0.98
116_C	183_I	0.965	0.98
8_E	56_A	0.956	0.98
31_S	34_T	0.953	0.98
41_S	47_S	0.952	0.98
116_C	163_F	0.948	0.98
85_L	120_I	0.943	0.98
22_R	28_A	0.943	0.98
18_G	178_T	0.934	0.97
129_I	175_C	0.930	0.97
9_P	39_A	0.930	0.97
107_E	191_Y	0.925	0.97
192_R	206_R	0.915	0.97
191_Y	212_K	0.915	0.97
273_S	307_T	0.914	0.97
23_D	28_A	0.914	0.97
130_L	153_L	0.910	0.97
278_I	293_F	0.909	0.97
13_E	33_K	0.900	0.97
106_H	215_E	0.891	0.97
20_K	87_D	0.889	0.97
19_T	31_S	0.888	0.97
36_E	82_L	0.883	0.96
287_C	308_C	0.879	0.96
88_A	174_L	0.877	0.96
58_K	63_V	0.870	0.96
47_S	59_T	0.861	0.96
38_W	84_K	0.860	0.96
22_R	29_I	0.852	0.96
142_Q	145_E	0.851	0.96
20_K	24_A	0.849	0.96
53_G	56_A	0.848	0.96
70_I	294_I	0.847	0.96
100_D	185_Q	0.847	0.96
139_E	143_R	0.846	0.96
70_I	296_P	0.836	0.95
112_G	246_Y	0.835	0.95
27_Y	39_A	0.832	0.95
259_A	303_T	0.831	0.95
121_D	125_D	0.828	0.95
138_E	142_Q	0.824	0.95
64_W	67_H	0.824	0.95
240_V	243_Q	0.822	0.95
240_V	250_Y	0.819	0.95
14_R	188_D	0.819	0.95
211_E	215_E	0.816	0.95
13_E	31_S	0.816	0.95
30_P	34_T	0.814	0.94
130_L	166_V	0.813	0.94
145_E	214_M	0.809	0.94
27_Y	34_T	0.809	0.94
84_K	184_Q	0.809	0.94
118_Y	163_F	0.805	0.94
24_A	289_A	0.805	0.94
294_I	297_A	0.804	0.94
38_W	48_S	0.803	0.94
190_T	195_D	0.800	0.94
25_F	289_A	0.800	0.94
233_V	236_A	0.798	0.94
91_D	176_K	0.796	0.94
226_H	229_E	0.795	0.94
21_L	25_F	0.795	0.94
55_L	58_K	0.794	0.94
99_D	218_T	0.783	0.93
42_A	78_V	0.780	0.93
68_P	74_P	0.771	0.93
16_W	192_R	0.764	0.92
102_Y	105_L	0.763	0.92
128_L	158_I	0.762	0.92
271_V	276_G	0.760	0.92
12_K	45_H	0.755	0.92
65_K	77_K	0.751	0.92
286_E	291_S	0.748	0.92
52_N	57_G	0.743	0.91
206_R	209_H	0.742	0.91
92_L	115_E	0.741	0.91
25_F	28_A	0.739	0.91
86_L	189_T	0.733	0.91
114_T	244_S	0.730	0.91
14_R	86_L	0.728	0.90
127_E	176_K	0.727	0.90
83_V	270_S	0.724	0.90
130_L	168_S	0.723	0.90
238_I	250_Y	0.721	0.90
128_L	175_C	0.719	0.90
109_G	189_T	0.717	0.90
64_W	79_F	0.714	0.90
89_N	176_K	0.713	0.90
84_K	187_S	0.709	0.89
27_Y	292_H	0.707	0.89
112_G	184_Q	0.706	0.89
38_W	41_S	0.704	0.89
94_V	153_L	0.701	0.89
25_F	34_T	0.699	0.89
96_V	191_Y	0.698	0.89
55_L	67_H	0.696	0.88
141_K	211_E	0.695	0.88
38_W	43_H	0.693	0.88
273_S	277_R	0.693	0.88
135_S	221_H	0.692	0.88
142_Q	279_I	0.692	0.88
254_I	308_C	0.691	0.88
166_V	170_T	0.691	0.88
96_V	193_V	0.690	0.88
5_L	294_I	0.690	0.88
194_Y	206_R	0.688	0.88
27_Y	37_C	0.687	0.88
6_F	51_K	0.684	0.88
132_H	220_P	0.683	0.87
6_F	293_F	0.683	0.87
160_P	273_S	0.682	0.87
109_G	187_S	0.680	0.87
96_V	170_T	0.678	0.87
93_S	190_T	0.677	0.87
129_I	153_L	0.675	0.87
252_W	269_G	0.675	0.87
163_F	249_V	0.673	0.87
24_A	179_L	0.667	0.86
140_F	144_I	0.665	0.86
143_R	152_L	0.665	0.86
64_W	68_P	0.664	0.86
163_F	242_V	0.662	0.86
69_E	298_H	0.658	0.85
11_F	37_C	0.657	0.85
14_R	33_K	0.657	0.85
254_I	306_G	0.656	0.85
97_H	115_E	0.656	0.85
87_D	178_T	0.653	0.85
7_L	10_V	0.652	0.85
150_N	155_R	0.651	0.85
192_R	195_D	0.651	0.85
278_I	304_I	0.651	0.85
277_R	280_N	0.650	0.85
184_Q	209_H	0.649	0.85
41_S	48_S	0.646	0.84
133_H	137_K	0.646	0.84
105_L	215_E	0.646	0.84
102_Y	107_E	0.645	0.84
102_Y	212_K	0.636	0.83
93_S	204_Q	0.635	0.83
135_S	220_P	0.635	0.83
68_P	72_G	0.635	0.83
42_A	61_D	0.634	0.83
63_V	67_H	0.633	0.83
299_F	302_F	0.633	0.83
243_Q	248_S	0.632	0.83
116_C	270_S	0.632	0.83
85_L	270_S	0.631	0.83
146_S	151_G	0.630	0.83
155_R	175_C	0.630	0.83
5_L	52_N	0.629	0.83
190_T	206_R	0.628	0.83
44_A	78_V	0.626	0.83
113_K	188_D	0.612	0.81
143_R	146_S	0.612	0.81
149_W	152_L	0.611	0.81
11_F	34_T	0.610	0.81
5_L	50_V	0.610	0.81
256_G	306_G	0.609	0.81
175_C	178_T	0.608	0.81
237_E	252_W	0.606	0.80
143_R	148_D	0.606	0.80
99_D	169_G	0.605	0.80
21_L	29_I	0.602	0.80
22_R	31_S	0.601	0.80
269_G	295_L	0.600	0.80
143_R	151_G	0.600	0.80
82_L	187_S	0.599	0.80
191_Y	195_D	0.599	0.80
191_Y	206_R	0.598	0.80
132_H	149_W	0.596	0.79
114_T	246_Y	0.594	0.79
16_W	206_R	0.591	0.79
142_Q	261_P	0.590	0.79
73_F	264_Q	0.589	0.79
116_C	181_L	0.589	0.79
298_H	302_F	0.586	0.78
144_I	151_G	0.586	0.78
19_T	30_P	0.583	0.78
238_I	251_K	0.581	0.78
118_Y	181_L	0.578	0.77
61_D	78_V	0.576	0.77
38_W	82_L	0.576	0.77
111_L	185_Q	0.576	0.77
39_A	83_V	0.573	0.77
130_L	164_F	0.571	0.76
103_A	189_T	0.571	0.76
261_P	303_T	0.571	0.76
99_D	110_D	0.571	0.76
16_W	195_D	0.570	0.76
278_I	285_Y	0.569	0.76
93_S	209_H	0.569	0.76
220_P	223_D	0.568	0.76
23_D	26_G	0.567	0.76
298_H	303_T	0.566	0.76
96_V	118_Y	0.564	0.76
92_L	173_A	0.562	0.75
21_L	179_L	0.562	0.75
22_R	27_Y	0.560	0.75
206_R	213_A	0.560	0.75
11_F	39_A	0.560	0.75
181_L	249_V	0.559	0.75
13_E	32_Q	0.559	0.75
263_Y	267_L	0.559	0.75
138_E	141_K	0.558	0.75
174_L	184_Q	0.557	0.75
35_G	188_D	0.556	0.74
43_H	187_S	0.556	0.74
158_I	175_C	0.556	0.74
112_G	244_S	0.555	0.74
46_G	61_D	0.555	0.74
68_P	71_F	0.554	0.74
95_Q	192_R	0.554	0.74
80_P	187_S	0.554	0.74
88_A	175_C	0.552	0.74
236_A	252_W	0.551	0.74
39_A	85_L	0.550	0.74
108_N	190_T	0.549	0.74
5_L	60_L	0.548	0.73
118_Y	251_K	0.545	0.73
296_P	300_G	0.542	0.73
117_W	164_F	0.540	0.72
39_A	120_I	0.540	0.72
210_I	214_M	0.540	0.72
103_A	109_G	0.538	0.72
20_K	26_G	0.537	0.72
20_K	25_F	0.537	0.72
41_S	186_N	0.537	0.72
272_L	289_A	0.536	0.72
239_I	242_V	0.536	0.72
19_T	26_G	0.535	0.72
129_I	173_A	0.534	0.72
133_H	153_L	0.534	0.72
224_K	228_P	0.532	0.71
287_C	291_S	0.531	0.71
88_A	178_T	0.529	0.71
99_D	168_S	0.528	0.71
68_P	77_K	0.526	0.70
20_K	27_Y	0.523	0.70
118_Y	170_T	0.523	0.70
238_I	252_W	0.520	0.70
236_A	255_S	0.519	0.69
82_L	188_D	0.518	0.69
261_P	277_R	0.518	0.69
170_T	224_K	0.518	0.69
191_Y	209_H	0.515	0.69
96_V	169_G	0.515	0.69
20_K	121_D	0.514	0.69
92_L	95_Q	0.514	0.69
21_L	87_D	0.513	0.69
11_F	14_R	0.512	0.68
10_V	48_S	0.511	0.68
204_Q	207_T	0.511	0.68
262_S	301_E	0.509	0.68
16_W	35_G	0.509	0.68
13_E	34_T	0.509	0.68
50_V	53_G	0.508	0.68
222_I	225_V	0.507	0.68
278_I	284_Q	0.507	0.68
255_S	286_E	0.504	0.67
24_A	28_A	0.504	0.67
282_G	301_E	0.504	0.67
91_D	271_V	0.504	0.67
84_K	113_K	0.503	0.67
51_K	291_S	0.503	0.67
254_I	258_A	0.503	0.67
9_P	48_S	0.503	0.67
11_F	29_I	0.502	0.67
25_F	290_G	0.502	0.67
269_G	304_I	0.501	0.67
232_E	277_R	0.500	0.67
19_T	34_T	0.500	0.67
192_R	209_H	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qwrA	1	0.9968	100	0.119	Contact Map
2wfpA	1	0.9397	100	0.194	Contact Map
1zx5A	1	0.9111	100	0.194	Contact Map
1pmiA	1	0.9492	100	0.235	Contact Map
3rnsA	1	0.6317	99.7	0.814	Contact Map
3bu7A	3	0.8381	99.5	0.839	Contact Map
1y3tA	2	0.7619	98.7	0.882	Contact Map
3myxA	1	0.7143	98.7	0.883	Contact Map
3nw4A	3	0.8667	98.6	0.886	Contact Map
3h7jA	1	0.6571	98.6	0.888	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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