GREMLIN Database
SCRK - Putative fructokinase
UniProt: O05510 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (264)
Sequences: 13254 (10077)
Seq/√Len: 620.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_P88_Q3.5121.00
101_S144_Q3.3201.00
26_R274_N3.0781.00
18_R22_T2.9651.00
42_I93_E2.6721.00
224_K267_V2.6321.00
175_F212_A2.5771.00
120_L224_K2.5481.00
147_S221_A2.5431.00
15_A277_I2.5311.00
17_G281_L2.5241.00
108_A135_G2.4351.00
168_C174_C2.4311.00
125_Y228_G2.3991.00
107_A125_Y2.3761.00
87_L91_K2.2941.00
117_A123_C2.2811.00
124_L216_Y2.1711.00
166_G174_C2.1711.00
242_Y246_P2.0631.00
108_A137_I2.0341.00
154_I215_Q2.0121.00
244_Y247_K1.9951.00
101_S106_A1.9891.00
101_S105_N1.9871.00
52_A284_A1.9601.00
114_F282_V1.9591.00
27_I47_Q1.9371.00
138_V143_L1.9321.00
88_Q92_N1.9061.00
122_S223_K1.9021.00
146_L223_K1.8691.00
187_R204_L1.8501.00
84_Y89_T1.8161.00
244_Y248_I1.8091.00
110_G271_L1.7771.00
206_G210_A1.7681.00
89_T92_N1.7651.00
213_L225_I1.7321.00
14_C44_Y1.7151.00
203_E244_Y1.6961.00
165_Q171_H1.6751.00
153_H168_C1.6701.00
224_K265_Y1.6551.00
39_E93_E1.6521.00
53_I94_M1.6231.00
56_G106_A1.6221.00
155_Y215_Q1.6171.00
128_I209_I1.6171.00
121_D139_E1.5801.00
121_D223_K1.5761.00
164_Y186_A1.5311.00
112_F123_C1.5271.00
153_H166_G1.5201.00
120_L223_K1.5171.00
46_S93_E1.5061.00
4_G277_I1.4911.00
3_G45_F1.4751.00
157_R162_D1.4741.00
42_I46_S1.4701.00
207_Y244_Y1.4571.00
123_C137_I1.4481.00
5_I14_C1.4361.00
101_S283_L1.4111.00
53_I96_I1.4021.00
217_I225_I1.4021.00
126_I213_L1.4011.00
11_K28_E1.3931.00
184_I205_E1.3791.00
113_L286_Q1.3681.00
33_M36_E1.3671.00
39_E43_Q1.3571.00
166_G169_P1.3551.00
153_H174_C1.3421.00
211_Q215_Q1.3411.00
108_A123_C1.3341.00
89_T93_E1.3261.00
235_K268_P1.3181.00
112_F137_I1.3091.00
207_Y248_I1.3061.00
113_L282_V1.3021.00
15_A23_I1.2981.00
187_R190_K1.2781.00
42_I94_M1.2751.00
55_I90_V1.2741.00
192_A195_L1.2621.00
105_N142_L1.2411.00
122_S138_V1.2381.00
123_C226_I1.2311.00
158_R163_V1.2251.00
248_I252_Y1.2181.00
188_W201_V1.1961.00
40_K43_Q1.1961.00
4_G280_T1.1941.00
106_A280_T1.1901.00
124_L134_A1.1891.00
120_L123_C1.1841.00
191_K200_Q1.1831.00
72_T85_P1.1811.00
56_G276_G1.1781.00
188_W192_A1.1751.00
158_R211_Q1.1721.00
108_A125_Y1.1591.00
11_K181_G1.1591.00
85_P89_T1.1561.00
17_G23_I1.1511.00
157_R211_Q1.1321.00
145_G221_A1.1301.00
246_P250_N1.1301.00
216_Y219_I1.1241.00
122_S143_L1.1111.00
104_V127_T1.1021.00
188_W198_I1.0911.00
206_G244_Y1.0901.00
187_R201_V1.0801.00
243_Q247_K1.0791.00
38_I89_T1.0741.00
5_I41_V1.0661.00
213_L227_L1.0641.00
29_F40_K1.0521.00
210_A248_I1.0391.00
187_R191_K1.0351.00
50_L96_I1.0351.00
226_I267_V1.0341.00
123_C224_K1.0321.00
164_Y178_L1.0321.00
134_A151_M1.0321.00
44_Y47_Q1.0271.00
107_A276_G1.0271.00
227_L232_M1.0251.00
43_Q47_Q1.0231.00
192_A197_D1.0231.00
102_T150_E1.0191.00
13_V28_E1.0191.00
29_F43_Q1.0151.00
136_A143_L1.0121.00
9_G130_T1.0111.00
27_I44_Y1.0101.00
124_L136_A1.0071.00
29_F47_Q1.0071.00
136_A149_P1.0051.00
4_G54_G1.0031.00
99_G284_A1.0021.00
145_G149_P0.9961.00
46_S94_M0.9951.00
111_E115_G0.9941.00
199_A203_E0.9871.00
4_G281_L0.9851.00
238_F242_Y0.9801.00
91_K98_V0.9771.00
23_I26_R0.9741.00
105_N150_E0.9741.00
124_L225_I0.9691.00
36_E40_K0.9681.00
233_Q273_S0.9621.00
112_F140_G0.9601.00
36_E39_E0.9591.00
174_C177_G0.9581.00
132_I179_A0.9551.00
12_F31_T0.9521.00
62_D74_T0.9511.00
3_G50_L0.9461.00
226_I269_P0.9441.00
118_K270_R0.9371.00
121_D140_G0.9331.00
164_Y177_G0.9311.00
164_Y187_R0.9301.00
14_C48_F0.9281.00
44_Y48_F0.9251.00
35_D89_T0.9241.00
17_G278_I0.9241.00
115_G118_K0.9221.00
243_Q246_P0.9221.00
25_D48_F0.9191.00
29_F44_Y0.9191.00
136_A220_L0.9151.00
164_Y190_K0.9131.00
124_L222_P0.9061.00
188_W193_A0.9031.00
248_I251_S0.9011.00
90_V98_V0.8981.00
14_C27_I0.8971.00
120_L265_Y0.8971.00
72_T83_H0.8951.00
114_F278_I0.8921.00
37_T81_W0.8871.00
233_Q268_P0.8791.00
34_P89_T0.8781.00
207_Y211_Q0.8751.00
157_R178_L0.8651.00
54_G284_A0.8651.00
249_M266_I0.8631.00
18_R24_I0.8601.00
122_S146_L0.8581.00
204_L208_Y0.8561.00
139_E143_L0.8531.00
57_S61_V0.8441.00
182_P186_A0.8411.00
91_K97_P0.8281.00
7_A57_S0.8221.00
238_F268_P0.8161.00
156_I208_Y0.8141.00
15_A26_R0.8131.00
250_N255_F0.8081.00
40_K44_Y0.8061.00
187_R205_E0.8051.00
32_K36_E0.7991.00
267_V270_R0.7971.00
116_E267_V0.7911.00
60_P76_T0.7901.00
122_S139_E0.7891.00
185_E189_G0.7881.00
104_V135_G0.7861.00
13_V26_R0.7861.00
214_A218_L0.7841.00
181_G185_E0.7821.00
109_L112_F0.7781.00
114_F271_L0.7741.00
131_G150_E0.7701.00
75_A82_R0.7681.00
196_S199_A0.7661.00
8_G130_T0.7661.00
129_G230_G0.7651.00
210_A214_A0.7651.00
106_A283_L0.7631.00
227_L266_I0.7631.00
57_S73_I0.7621.00
54_G106_A0.7621.00
43_Q46_S0.7561.00
7_A12_F0.7521.00
116_E226_I0.7521.00
71_G87_L0.7521.00
39_E42_I0.7511.00
116_E270_R0.7491.00
103_D133_G0.7461.00
196_S200_Q0.7451.00
153_H169_P0.7411.00
200_Q204_L0.7401.00
91_K95_K0.7361.00
271_L278_I0.7351.00
175_F205_E0.7351.00
102_T131_G0.7331.00
197_D200_Q0.7321.00
111_E269_P0.7261.00
34_P84_Y0.7251.00
127_T276_G0.7241.00
201_V205_E0.7231.00
7_A41_V0.7231.00
87_L100_F0.7191.00
166_G172_G0.7191.00
155_Y158_R0.7181.00
155_Y211_Q0.7181.00
183_A186_A0.7141.00
183_A187_R0.7141.00
191_K197_D0.7141.00
115_G119_G0.7091.00
5_I45_F0.7081.00
71_G91_K0.7081.00
131_G176_E0.7071.00
126_I134_A0.7031.00
272_G275_A0.7031.00
34_P81_W0.7031.00
247_K251_S0.7031.00
187_R208_Y0.6981.00
156_I212_A0.6961.00
157_R163_V0.6961.00
111_E270_R0.6941.00
178_L208_Y0.6851.00
253_L256_S0.6851.00
125_Y226_I0.6851.00
5_I53_I0.6841.00
157_R164_Y0.6821.00
184_I231_V0.6791.00
99_G283_L0.6781.00
154_I212_A0.6761.00
14_C29_F0.6731.00
110_G282_V0.6711.00
8_G230_G0.6681.00
63_N148_H0.6661.00
166_G170_Y0.6651.00
126_I216_Y0.6631.00
117_A226_I0.6591.00
158_R162_D0.6581.00
95_K98_V0.6521.00
146_L221_A0.6501.00
215_Q218_L0.6501.00
35_D39_E0.6481.00
176_E180_S0.6461.00
7_A37_T0.6451.00
235_K242_Y0.6411.00
63_N144_Q0.6401.00
58_F78_K0.6361.00
149_P221_A0.6351.00
87_L98_V0.6351.00
228_G269_P0.6351.00
76_T79_A0.6331.00
52_A97_P0.6331.00
111_E271_L0.6271.00
88_Q91_K0.6271.00
169_P174_C0.6241.00
210_A244_Y0.6201.00
184_I201_V0.6171.00
217_I245_V0.6171.00
12_F29_F0.6161.00
90_V94_M0.6161.00
166_G177_G0.6111.00
64_D71_G0.6111.00
13_V277_I0.6091.00
38_I93_E0.6071.00
155_Y170_Y0.6061.00
274_N277_I0.6031.00
6_E9_G0.6011.00
16_V50_L0.6001.00
10_T130_T0.6001.00
179_A205_E0.5981.00
202_W206_G0.5971.00
189_G192_A0.5961.00
78_K167_K0.5961.00
143_L220_L0.5921.00
135_G142_L0.5901.00
125_Y129_G0.5901.00
181_G231_V0.5891.00
102_T105_N0.5881.00
158_R207_Y0.5871.00
191_K201_V0.5861.00
186_A190_K0.5851.00
211_Q248_I0.5841.00
170_Y174_C0.5821.00
107_A228_G0.5791.00
282_V286_Q0.5781.00
42_I89_T0.5771.00
9_G127_T0.5761.00
201_V204_L0.5741.00
191_K195_L0.5711.00
154_I218_L0.5701.00
189_G195_L0.5661.00
156_I178_L0.5651.00
107_A127_T0.5651.00
141_R286_Q0.5621.00
6_E276_G0.5621.00
3_G16_V0.5611.00
75_A78_K0.5601.00
208_Y212_A0.5601.00
154_I216_Y0.5591.00
146_L222_P0.5591.00
157_R208_Y0.5581.00
185_E188_W0.5561.00
138_V222_P0.5561.00
60_P74_T0.5551.00
271_L275_A0.5521.00
133_G150_E0.5501.00
137_I142_L0.5501.00
102_T133_G0.5481.00
278_I281_L0.5460.99
113_L285_H0.5450.99
251_S256_S0.5450.99
245_V266_I0.5440.99
274_N278_I0.5430.99
52_A99_G0.5430.99
189_G194_D0.5430.99
92_N95_K0.5420.99
16_V25_D0.5420.99
179_A209_I0.5410.99
168_C172_G0.5390.99
245_V249_M0.5380.99
6_E102_T0.5340.99
61_V73_I0.5330.99
6_E13_V0.5320.99
250_N256_S0.5320.99
282_V285_H0.5320.99
249_M252_Y0.5220.99
16_V48_F0.5220.99
151_M219_I0.5220.99
102_T149_P0.5200.99
35_D93_E0.5190.99
189_G193_A0.5150.99
103_D127_T0.5150.99
200_Q203_E0.5130.99
19_E51_Q0.5110.99
41_V90_V0.5110.99
156_I175_F0.5110.99
212_A217_I0.5100.99
105_N149_P0.5100.99
109_L283_L0.5090.99
131_G152_G0.5090.99
138_V141_R0.5090.99
242_Y245_V0.5080.99
126_I151_M0.5060.99
79_A82_R0.5060.99
128_I231_V0.5050.99
54_G283_L0.5050.99
115_G267_V0.5040.99
85_P91_K0.5040.99
6_E230_G0.5040.99
9_G103_D0.5020.99
237_V242_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ohrA 2 0.9298 100 0.201 Contact Map
1z05A 2 0.9465 100 0.252 Contact Map
1z6rA 3 0.9465 100 0.263 Contact Map
3vglA 3 0.9097 100 0.273 Contact Map
2qm1A 2 0.9197 100 0.277 Contact Map
2yhwA 2 0.893 100 0.279 Contact Map
2ap1A 2 0.913 100 0.282 Contact Map
4htlA 4 0.893 100 0.289 Contact Map
3vovA 3 0.903 100 0.291 Contact Map
2aa4A 2 0.893 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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