SCRK - BACSU - GREMLIN Contacts

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SCRK - Putative fructokinase

UniProt:	O05510	Sequences: MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQYFSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFSTDVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHPDDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYILILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAGIIGTLVLAHQALQAEAASGEVRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (264)
Sequences:	13254 (10077)
Seq/√Len:	620.2

ECOLI - NAGK MAK MLC NANK ALSK YPHH NAGC
BACSU - SCRK GLK XYLR
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_P	88_Q	3.512	1.00
101_S	144_Q	3.320	1.00
26_R	274_N	3.078	1.00
18_R	22_T	2.965	1.00
42_I	93_E	2.672	1.00
224_K	267_V	2.632	1.00
175_F	212_A	2.577	1.00
120_L	224_K	2.548	1.00
147_S	221_A	2.543	1.00
15_A	277_I	2.531	1.00
17_G	281_L	2.524	1.00
108_A	135_G	2.435	1.00
168_C	174_C	2.431	1.00
125_Y	228_G	2.399	1.00
107_A	125_Y	2.376	1.00
87_L	91_K	2.294	1.00
117_A	123_C	2.281	1.00
124_L	216_Y	2.171	1.00
166_G	174_C	2.171	1.00
242_Y	246_P	2.063	1.00
108_A	137_I	2.034	1.00
154_I	215_Q	2.012	1.00
244_Y	247_K	1.995	1.00
101_S	106_A	1.989	1.00
101_S	105_N	1.987	1.00
52_A	284_A	1.960	1.00
114_F	282_V	1.959	1.00
27_I	47_Q	1.937	1.00
138_V	143_L	1.932	1.00
88_Q	92_N	1.906	1.00
122_S	223_K	1.902	1.00
146_L	223_K	1.869	1.00
187_R	204_L	1.850	1.00
84_Y	89_T	1.816	1.00
244_Y	248_I	1.809	1.00
110_G	271_L	1.777	1.00
206_G	210_A	1.768	1.00
89_T	92_N	1.765	1.00
213_L	225_I	1.732	1.00
14_C	44_Y	1.715	1.00
203_E	244_Y	1.696	1.00
165_Q	171_H	1.675	1.00
153_H	168_C	1.670	1.00
224_K	265_Y	1.655	1.00
39_E	93_E	1.652	1.00
53_I	94_M	1.623	1.00
56_G	106_A	1.622	1.00
155_Y	215_Q	1.617	1.00
128_I	209_I	1.617	1.00
121_D	139_E	1.580	1.00
121_D	223_K	1.576	1.00
164_Y	186_A	1.531	1.00
112_F	123_C	1.527	1.00
153_H	166_G	1.520	1.00
120_L	223_K	1.517	1.00
46_S	93_E	1.506	1.00
4_G	277_I	1.491	1.00
3_G	45_F	1.475	1.00
157_R	162_D	1.474	1.00
42_I	46_S	1.470	1.00
207_Y	244_Y	1.457	1.00
123_C	137_I	1.448	1.00
5_I	14_C	1.436	1.00
101_S	283_L	1.411	1.00
53_I	96_I	1.402	1.00
217_I	225_I	1.402	1.00
126_I	213_L	1.401	1.00
11_K	28_E	1.393	1.00
184_I	205_E	1.379	1.00
113_L	286_Q	1.368	1.00
33_M	36_E	1.367	1.00
39_E	43_Q	1.357	1.00
166_G	169_P	1.355	1.00
153_H	174_C	1.342	1.00
211_Q	215_Q	1.341	1.00
108_A	123_C	1.334	1.00
89_T	93_E	1.326	1.00
235_K	268_P	1.318	1.00
112_F	137_I	1.309	1.00
207_Y	248_I	1.306	1.00
113_L	282_V	1.302	1.00
15_A	23_I	1.298	1.00
187_R	190_K	1.278	1.00
42_I	94_M	1.275	1.00
55_I	90_V	1.274	1.00
192_A	195_L	1.262	1.00
105_N	142_L	1.241	1.00
122_S	138_V	1.238	1.00
123_C	226_I	1.231	1.00
158_R	163_V	1.225	1.00
248_I	252_Y	1.218	1.00
188_W	201_V	1.196	1.00
40_K	43_Q	1.196	1.00
4_G	280_T	1.194	1.00
106_A	280_T	1.190	1.00
124_L	134_A	1.189	1.00
120_L	123_C	1.184	1.00
191_K	200_Q	1.183	1.00
72_T	85_P	1.181	1.00
56_G	276_G	1.178	1.00
188_W	192_A	1.175	1.00
158_R	211_Q	1.172	1.00
108_A	125_Y	1.159	1.00
11_K	181_G	1.159	1.00
85_P	89_T	1.156	1.00
17_G	23_I	1.151	1.00
157_R	211_Q	1.132	1.00
145_G	221_A	1.130	1.00
246_P	250_N	1.130	1.00
216_Y	219_I	1.124	1.00
122_S	143_L	1.111	1.00
104_V	127_T	1.102	1.00
188_W	198_I	1.091	1.00
206_G	244_Y	1.090	1.00
187_R	201_V	1.080	1.00
243_Q	247_K	1.079	1.00
38_I	89_T	1.074	1.00
5_I	41_V	1.066	1.00
213_L	227_L	1.064	1.00
29_F	40_K	1.052	1.00
210_A	248_I	1.039	1.00
187_R	191_K	1.035	1.00
50_L	96_I	1.035	1.00
226_I	267_V	1.034	1.00
123_C	224_K	1.032	1.00
164_Y	178_L	1.032	1.00
134_A	151_M	1.032	1.00
44_Y	47_Q	1.027	1.00
107_A	276_G	1.027	1.00
227_L	232_M	1.025	1.00
43_Q	47_Q	1.023	1.00
192_A	197_D	1.023	1.00
102_T	150_E	1.019	1.00
13_V	28_E	1.019	1.00
29_F	43_Q	1.015	1.00
136_A	143_L	1.012	1.00
9_G	130_T	1.011	1.00
27_I	44_Y	1.010	1.00
124_L	136_A	1.007	1.00
29_F	47_Q	1.007	1.00
136_A	149_P	1.005	1.00
4_G	54_G	1.003	1.00
99_G	284_A	1.002	1.00
145_G	149_P	0.996	1.00
46_S	94_M	0.995	1.00
111_E	115_G	0.994	1.00
199_A	203_E	0.987	1.00
4_G	281_L	0.985	1.00
238_F	242_Y	0.980	1.00
91_K	98_V	0.977	1.00
23_I	26_R	0.974	1.00
105_N	150_E	0.974	1.00
124_L	225_I	0.969	1.00
36_E	40_K	0.968	1.00
233_Q	273_S	0.962	1.00
112_F	140_G	0.960	1.00
36_E	39_E	0.959	1.00
174_C	177_G	0.958	1.00
132_I	179_A	0.955	1.00
12_F	31_T	0.952	1.00
62_D	74_T	0.951	1.00
3_G	50_L	0.946	1.00
226_I	269_P	0.944	1.00
118_K	270_R	0.937	1.00
121_D	140_G	0.933	1.00
164_Y	177_G	0.931	1.00
164_Y	187_R	0.930	1.00
14_C	48_F	0.928	1.00
44_Y	48_F	0.925	1.00
35_D	89_T	0.924	1.00
17_G	278_I	0.924	1.00
115_G	118_K	0.922	1.00
243_Q	246_P	0.922	1.00
25_D	48_F	0.919	1.00
29_F	44_Y	0.919	1.00
136_A	220_L	0.915	1.00
164_Y	190_K	0.913	1.00
124_L	222_P	0.906	1.00
188_W	193_A	0.903	1.00
248_I	251_S	0.901	1.00
90_V	98_V	0.898	1.00
14_C	27_I	0.897	1.00
120_L	265_Y	0.897	1.00
72_T	83_H	0.895	1.00
114_F	278_I	0.892	1.00
37_T	81_W	0.887	1.00
233_Q	268_P	0.879	1.00
34_P	89_T	0.878	1.00
207_Y	211_Q	0.875	1.00
157_R	178_L	0.865	1.00
54_G	284_A	0.865	1.00
249_M	266_I	0.863	1.00
18_R	24_I	0.860	1.00
122_S	146_L	0.858	1.00
204_L	208_Y	0.856	1.00
139_E	143_L	0.853	1.00
57_S	61_V	0.844	1.00
182_P	186_A	0.841	1.00
91_K	97_P	0.828	1.00
7_A	57_S	0.822	1.00
238_F	268_P	0.816	1.00
156_I	208_Y	0.814	1.00
15_A	26_R	0.813	1.00
250_N	255_F	0.808	1.00
40_K	44_Y	0.806	1.00
187_R	205_E	0.805	1.00
32_K	36_E	0.799	1.00
267_V	270_R	0.797	1.00
116_E	267_V	0.791	1.00
60_P	76_T	0.790	1.00
122_S	139_E	0.789	1.00
185_E	189_G	0.788	1.00
104_V	135_G	0.786	1.00
13_V	26_R	0.786	1.00
214_A	218_L	0.784	1.00
181_G	185_E	0.782	1.00
109_L	112_F	0.778	1.00
114_F	271_L	0.774	1.00
131_G	150_E	0.770	1.00
75_A	82_R	0.768	1.00
196_S	199_A	0.766	1.00
8_G	130_T	0.766	1.00
129_G	230_G	0.765	1.00
210_A	214_A	0.765	1.00
106_A	283_L	0.763	1.00
227_L	266_I	0.763	1.00
57_S	73_I	0.762	1.00
54_G	106_A	0.762	1.00
43_Q	46_S	0.756	1.00
7_A	12_F	0.752	1.00
116_E	226_I	0.752	1.00
71_G	87_L	0.752	1.00
39_E	42_I	0.751	1.00
116_E	270_R	0.749	1.00
103_D	133_G	0.746	1.00
196_S	200_Q	0.745	1.00
153_H	169_P	0.741	1.00
200_Q	204_L	0.740	1.00
91_K	95_K	0.736	1.00
271_L	278_I	0.735	1.00
175_F	205_E	0.735	1.00
102_T	131_G	0.733	1.00
197_D	200_Q	0.732	1.00
111_E	269_P	0.726	1.00
34_P	84_Y	0.725	1.00
127_T	276_G	0.724	1.00
201_V	205_E	0.723	1.00
7_A	41_V	0.723	1.00
87_L	100_F	0.719	1.00
166_G	172_G	0.719	1.00
155_Y	158_R	0.718	1.00
155_Y	211_Q	0.718	1.00
183_A	186_A	0.714	1.00
183_A	187_R	0.714	1.00
191_K	197_D	0.714	1.00
115_G	119_G	0.709	1.00
5_I	45_F	0.708	1.00
71_G	91_K	0.708	1.00
131_G	176_E	0.707	1.00
126_I	134_A	0.703	1.00
272_G	275_A	0.703	1.00
34_P	81_W	0.703	1.00
247_K	251_S	0.703	1.00
187_R	208_Y	0.698	1.00
156_I	212_A	0.696	1.00
157_R	163_V	0.696	1.00
111_E	270_R	0.694	1.00
178_L	208_Y	0.685	1.00
253_L	256_S	0.685	1.00
125_Y	226_I	0.685	1.00
5_I	53_I	0.684	1.00
157_R	164_Y	0.682	1.00
184_I	231_V	0.679	1.00
99_G	283_L	0.678	1.00
154_I	212_A	0.676	1.00
14_C	29_F	0.673	1.00
110_G	282_V	0.671	1.00
8_G	230_G	0.668	1.00
63_N	148_H	0.666	1.00
166_G	170_Y	0.665	1.00
126_I	216_Y	0.663	1.00
117_A	226_I	0.659	1.00
158_R	162_D	0.658	1.00
95_K	98_V	0.652	1.00
146_L	221_A	0.650	1.00
215_Q	218_L	0.650	1.00
35_D	39_E	0.648	1.00
176_E	180_S	0.646	1.00
7_A	37_T	0.645	1.00
235_K	242_Y	0.641	1.00
63_N	144_Q	0.640	1.00
58_F	78_K	0.636	1.00
149_P	221_A	0.635	1.00
87_L	98_V	0.635	1.00
228_G	269_P	0.635	1.00
76_T	79_A	0.633	1.00
52_A	97_P	0.633	1.00
111_E	271_L	0.627	1.00
88_Q	91_K	0.627	1.00
169_P	174_C	0.624	1.00
210_A	244_Y	0.620	1.00
184_I	201_V	0.617	1.00
217_I	245_V	0.617	1.00
12_F	29_F	0.616	1.00
90_V	94_M	0.616	1.00
166_G	177_G	0.611	1.00
64_D	71_G	0.611	1.00
13_V	277_I	0.609	1.00
38_I	93_E	0.607	1.00
155_Y	170_Y	0.606	1.00
274_N	277_I	0.603	1.00
6_E	9_G	0.601	1.00
16_V	50_L	0.600	1.00
10_T	130_T	0.600	1.00
179_A	205_E	0.598	1.00
202_W	206_G	0.597	1.00
189_G	192_A	0.596	1.00
78_K	167_K	0.596	1.00
143_L	220_L	0.592	1.00
135_G	142_L	0.590	1.00
125_Y	129_G	0.590	1.00
181_G	231_V	0.589	1.00
102_T	105_N	0.588	1.00
158_R	207_Y	0.587	1.00
191_K	201_V	0.586	1.00
186_A	190_K	0.585	1.00
211_Q	248_I	0.584	1.00
170_Y	174_C	0.582	1.00
107_A	228_G	0.579	1.00
282_V	286_Q	0.578	1.00
42_I	89_T	0.577	1.00
9_G	127_T	0.576	1.00
201_V	204_L	0.574	1.00
191_K	195_L	0.571	1.00
154_I	218_L	0.570	1.00
189_G	195_L	0.566	1.00
156_I	178_L	0.565	1.00
107_A	127_T	0.565	1.00
141_R	286_Q	0.562	1.00
6_E	276_G	0.562	1.00
3_G	16_V	0.561	1.00
75_A	78_K	0.560	1.00
208_Y	212_A	0.560	1.00
154_I	216_Y	0.559	1.00
146_L	222_P	0.559	1.00
157_R	208_Y	0.558	1.00
185_E	188_W	0.556	1.00
138_V	222_P	0.556	1.00
60_P	74_T	0.555	1.00
271_L	275_A	0.552	1.00
133_G	150_E	0.550	1.00
137_I	142_L	0.550	1.00
102_T	133_G	0.548	1.00
278_I	281_L	0.546	0.99
113_L	285_H	0.545	0.99
251_S	256_S	0.545	0.99
245_V	266_I	0.544	0.99
274_N	278_I	0.543	0.99
52_A	99_G	0.543	0.99
189_G	194_D	0.543	0.99
92_N	95_K	0.542	0.99
16_V	25_D	0.542	0.99
179_A	209_I	0.541	0.99
168_C	172_G	0.539	0.99
245_V	249_M	0.538	0.99
6_E	102_T	0.534	0.99
61_V	73_I	0.533	0.99
6_E	13_V	0.532	0.99
250_N	256_S	0.532	0.99
282_V	285_H	0.532	0.99
249_M	252_Y	0.522	0.99
16_V	48_F	0.522	0.99
151_M	219_I	0.522	0.99
102_T	149_P	0.520	0.99
35_D	93_E	0.519	0.99
189_G	193_A	0.515	0.99
103_D	127_T	0.515	0.99
200_Q	203_E	0.513	0.99
19_E	51_Q	0.511	0.99
41_V	90_V	0.511	0.99
156_I	175_F	0.511	0.99
212_A	217_I	0.510	0.99
105_N	149_P	0.510	0.99
109_L	283_L	0.509	0.99
131_G	152_G	0.509	0.99
138_V	141_R	0.509	0.99
242_Y	245_V	0.508	0.99
126_I	151_M	0.506	0.99
79_A	82_R	0.506	0.99
128_I	231_V	0.505	0.99
54_G	283_L	0.505	0.99
115_G	267_V	0.504	0.99
85_P	91_K	0.504	0.99
6_E	230_G	0.504	0.99
9_G	103_D	0.502	0.99
237_V	242_Y	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ohrA	2	0.9298	100	0.201	Contact Map
1z05A	2	0.9465	100	0.252	Contact Map
1z6rA	3	0.9465	100	0.263	Contact Map
3vglA	3	0.9097	100	0.273	Contact Map
2qm1A	2	0.9197	100	0.277	Contact Map
2yhwA	2	0.893	100	0.279	Contact Map
2ap1A	2	0.913	100	0.282	Contact Map
4htlA	4	0.893	100	0.289	Contact Map
3vovA	3	0.903	100	0.291	Contact Map
2aa4A	2	0.893	100	0.294	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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