GREMLIN Database
GMUR - HTH-type transcriptional regulator GmuR
UniProt: O05509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (187)
Sequences: 21460 (16075)
Seq/√Len: 1175.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_P24_Q3.8051.00
14_R19_V3.7521.00
12_R53_E3.1371.00
8_A49_N3.0461.00
14_R35_E2.9661.00
57_F67_I2.8771.00
101_Q189_D2.6581.00
116_S181_R2.6191.00
7_I38_S2.4711.00
10_E14_R2.4681.00
59_K62_H2.4041.00
184_K187_H2.4001.00
29_E40_R2.3921.00
58_R64_T2.2951.00
108_T111_V2.1711.00
8_A53_E2.1681.00
7_I36_F2.0571.00
25_P65_F2.0571.00
13_N17_N2.0521.00
10_E36_F1.9481.00
111_V153_N1.9311.00
62_H65_F1.8971.00
128_R174_A1.8821.00
8_A12_R1.8521.00
51_V58_R1.7671.00
187_H191_Q1.7531.00
107_P112_A1.7291.00
105_Q185_S1.7221.00
12_R16_K1.7031.00
45_R48_D1.6841.00
94_K98_K1.6781.00
12_R55_L1.5921.00
96_K131_I1.5521.00
186_D189_D1.5441.00
32_L43_M1.5391.00
31_S35_E1.5291.00
125_Y141_K1.5211.00
14_R20_Y1.5101.00
6_I10_E1.5071.00
189_D193_L1.5071.00
51_V56_L1.4861.00
48_D58_R1.4671.00
30_V34_K1.4651.00
47_L56_L1.4551.00
28_D31_S1.4451.00
111_V143_Y1.4151.00
22_I68_Q1.3971.00
127_V141_K1.3771.00
56_L64_T1.3711.00
10_E13_N1.3651.00
15_I66_I1.3611.00
107_P111_V1.3471.00
38_S43_M1.3471.00
112_A181_R1.3411.00
14_R18_N1.3171.00
48_D52_A1.3171.00
179_K187_H1.3051.00
184_K200_P1.2891.00
20_Y66_I1.2771.00
31_S34_K1.2691.00
147_H150_P1.2681.00
114_H147_H1.2661.00
57_F65_F1.2561.00
178_R182_A1.2551.00
104_V122_P1.2271.00
29_E44_K1.2191.00
98_K131_I1.1861.00
116_S177_H1.1841.00
101_Q185_S1.1831.00
100_I192_H1.1741.00
107_P183_C1.1541.00
49_N52_A1.1461.00
25_P63_G1.1441.00
16_K55_L1.1441.00
59_K65_F1.1401.00
97_S189_D1.1381.00
48_D51_V1.1381.00
133_E136_P1.1301.00
3_K6_I1.1251.00
139_L189_D1.0911.00
104_V146_T1.0881.00
185_S195_C1.0811.00
146_T150_P1.0791.00
4_Y49_N1.0671.00
93_K193_L1.0671.00
156_V160_S1.0621.00
93_K197_Q1.0581.00
49_N53_E1.0571.00
20_Y24_Q1.0401.00
182_A187_H1.0331.00
47_L64_T1.0201.00
14_R36_F1.0181.00
93_K97_S1.0151.00
174_A178_R1.0131.00
59_K63_G1.0101.00
127_V188_I1.0091.00
112_A177_H1.0041.00
177_H181_R0.9971.00
145_P148_L0.9821.00
190_Q194_G0.9741.00
106_F122_P0.9571.00
103_E125_Y0.9531.00
23_D57_F0.9531.00
97_S193_L0.9391.00
11_M32_L0.9381.00
91_K102_F0.9361.00
45_R49_N0.9321.00
109_E113_A0.9281.00
163_N167_N0.9201.00
196_K199_D0.9191.00
100_I104_V0.9161.00
160_S163_N0.9051.00
9_N12_R0.9051.00
101_Q186_D0.9031.00
5_E9_N0.8961.00
187_H190_Q0.8961.00
186_D190_Q0.8931.00
143_Y147_H0.8891.00
126_V143_Y0.8811.00
172_K198_D0.8771.00
123_V143_Y0.8761.00
99_V149_I0.8681.00
123_V140_E0.8581.00
33_A43_M0.8581.00
110_E114_H0.8571.00
112_A183_C0.8401.00
111_V151_G0.8371.00
136_P139_L0.8281.00
159_D163_N0.8241.00
107_P151_G0.8241.00
105_Q125_Y0.8211.00
122_P126_V0.8171.00
85_G88_N0.8141.00
130_R140_E0.8081.00
25_P28_D0.8051.00
162_Y165_I0.8001.00
27_P35_E0.7991.00
112_A116_S0.7981.00
107_P115_L0.7981.00
141_K145_P0.7941.00
185_S189_D0.7931.00
39_S42_T0.7901.00
98_K101_Q0.7891.00
10_E35_E0.7871.00
7_I43_M0.7861.00
5_E49_N0.7851.00
102_F153_N0.7801.00
101_Q105_Q0.7681.00
29_E58_R0.7641.00
26_I56_L0.7561.00
47_L51_V0.7551.00
111_V114_H0.7551.00
125_Y128_R0.7551.00
22_I67_I0.7531.00
147_H151_G0.7491.00
160_S165_I0.7481.00
104_V180_I0.7481.00
144_M177_H0.7471.00
88_N91_K0.7451.00
36_F43_M0.7431.00
125_Y129_L0.7411.00
114_H150_P0.7401.00
11_M20_Y0.7361.00
156_V164_H0.7361.00
23_D68_Q0.7351.00
171_L175_G0.7331.00
155_D158_H0.7311.00
160_S164_H0.7291.00
34_K37_N0.7271.00
88_N155_D0.7271.00
86_L90_L0.7221.00
125_Y143_Y0.7211.00
98_K102_F0.7211.00
139_L143_Y0.7151.00
195_C199_D0.7091.00
126_V130_R0.7081.00
9_N13_N0.7061.00
61_G64_T0.7051.00
184_K199_D0.7021.00
32_L47_L0.7011.00
115_L123_V0.6971.00
124_Y127_V0.6951.00
8_A46_A0.6941.00
156_V159_D0.6921.00
91_K106_F0.6921.00
158_H162_Y0.6901.00
96_K134_G0.6901.00
7_I10_E0.6881.00
145_P173_I0.6861.00
193_L197_Q0.6761.00
92_D96_K0.6751.00
115_L147_H0.6651.00
124_Y128_R0.6641.00
14_R17_N0.6641.00
19_V35_E0.6591.00
129_L136_P0.6591.00
20_Y26_I0.6561.00
107_P180_I0.6561.00
146_T162_Y0.6541.00
188_I192_H0.6501.00
131_I134_G0.6481.00
176_T191_Q0.6421.00
190_Q193_L0.6401.00
92_D95_I0.6391.00
126_V129_L0.6361.00
136_P140_E0.6351.00
4_Y8_A0.6341.00
47_L58_R0.6271.00
33_A36_F0.6191.00
116_S125_Y0.6171.00
97_S100_I0.6171.00
123_V126_V0.6161.00
102_F106_F0.6161.00
164_H167_N0.6151.00
87_T91_K0.6111.00
166_T170_Q0.6071.00
178_R181_R0.6001.00
164_H169_L0.5911.00
97_S101_Q0.5911.00
175_G191_Q0.5861.00
4_Y45_R0.5831.00
183_C189_D0.5811.00
101_Q125_Y0.5791.00
116_S174_A0.5781.00
167_N170_Q0.5781.00
100_I129_L0.5771.00
42_T46_A0.5771.00
51_V64_T0.5771.00
126_V140_E0.5771.00
25_P62_H0.5741.00
172_K195_C0.5701.00
93_K200_P0.5701.00
111_V150_P0.5681.00
42_T45_R0.5671.00
113_A116_S0.5671.00
101_Q127_V0.5671.00
84_L88_N0.5661.00
20_Y27_P0.5651.00
104_V185_S0.5621.00
91_K95_I0.5601.00
140_E143_Y0.5591.00
124_Y174_A0.5581.00
191_Q194_G0.5561.00
108_T143_Y0.5551.00
32_L36_F0.5501.00
127_V139_L0.5481.00
105_Q143_Y0.5481.00
41_M45_R0.5471.00
149_I165_I0.5471.00
175_G187_H0.5461.00
107_P123_V0.5451.00
99_V152_I0.5451.00
33_A40_R0.5401.00
7_I11_M0.5401.00
30_V40_R0.5391.00
30_V33_A0.5391.00
13_N16_K0.5381.00
114_H143_Y0.5371.00
179_K184_K0.5351.00
143_Y146_T0.5341.00
112_A115_L0.5341.00
28_D43_M0.5321.00
91_K154_D0.5291.00
123_V147_H0.5261.00
175_G178_R0.5251.00
157_L160_S0.5251.00
98_K189_D0.5241.00
122_P146_T0.5231.00
176_T192_H0.5221.00
131_I136_P0.5211.00
111_V115_L0.5211.00
5_E8_A0.5201.00
43_M56_L0.5191.00
158_H165_I0.5141.00
115_L151_G0.5111.00
115_L177_H0.5081.00
124_Y177_H0.5061.00
155_D159_D0.5041.00
166_T172_K0.5031.00
3_K42_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0wA 2 0.9789 100 0.13 Contact Map
3bwgA 2 0.9705 100 0.153 Contact Map
3f8mA 2 0.9536 100 0.156 Contact Map
2ra5A 2 0.6203 100 0.16 Contact Map
3edpA 2 0.9241 100 0.163 Contact Map
3eetA 2 0.9747 100 0.185 Contact Map
3f8lA 2 0.6751 100 0.443 Contact Map
2di3A 2 0.8523 99.9 0.534 Contact Map
3c7jA 4 0.8312 99.9 0.543 Contact Map
1hw1A 2 0.8228 99.9 0.544 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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