GREMLIN Database
GMUD - 6-phospho-beta-glucosidase GmuD
UniProt: O05508 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (439)
Sequences: 6755 (4288)
Seq/√Len: 204.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_D100_K4.3681.00
387_Q451_K4.1011.00
110_D161_R3.5951.00
402_I412_V3.1671.00
106_N161_R3.1621.00
73_K115_N3.0961.00
66_K111_E3.0181.00
106_N157_L2.9361.00
123_L154_C2.9291.00
449_V453_G2.8691.00
111_E114_A2.8511.00
99_D103_D2.8101.00
60_Q63_D2.7791.00
103_D107_N2.7391.00
99_D157_L2.7391.00
90_I153_T2.6891.00
401_W404_R2.6531.00
300_Y398_H2.6471.00
234_S239_D2.5941.00
30_R63_D2.5931.00
152_R156_R2.5781.00
17_S77_H2.4731.00
395_I417_L2.3461.00
349_Y408_E2.3351.00
70_R115_N2.3111.00
393_E397_E2.2811.00
353_I408_E2.2741.00
212_Y221_I2.2551.00
141_R284_D2.2481.00
145_D207_R2.2321.00
210_Q214_E2.1861.00
389_D451_K2.1851.00
43_E56_A2.1811.00
438_S448_T2.1801.00
109_I158_F2.1441.00
61_F104_F2.1091.00
66_K107_N2.0981.00
79_S416_H2.0811.00
381_D385_I2.0601.00
118_E163_K2.0601.00
61_F80_F2.0541.00
69_I108_V2.0511.00
457_K461_E2.0401.00
84_I121_V1.9581.00
40_Y130_M1.9331.00
113_I161_R1.9141.00
148_E211_A1.9091.00
100_K103_D1.9001.00
69_I115_N1.8921.00
82_M109_I1.8901.00
152_R211_A1.8821.00
36_N87_S1.8681.00
28_A35_Q1.8551.00
283_E286_D1.8391.00
199_F263_F1.8341.00
265_K269_D1.8311.00
152_R215_M1.8271.00
212_Y219_G1.7941.00
106_N110_D1.7851.00
349_Y404_R1.7821.00
35_Q40_Y1.7601.00
231_Y350_D1.7441.00
207_R287_I1.7401.00
19_A24_M1.7391.00
27_A30_R1.7381.00
111_E115_N1.7261.00
220_K363_E1.6801.00
45_E48_R1.6751.00
110_D113_I1.6691.00
82_M108_V1.6651.00
216_K219_G1.6631.00
118_E164_K1.6501.00
280_Y285_L1.6401.00
109_I113_I1.6391.00
131_A134_K1.6361.00
135_I146_A1.6321.00
112_L117_I1.6201.00
346_K401_W1.6071.00
70_R111_E1.5931.00
262_E289_K1.5921.00
352_L410_S1.5911.00
106_N158_F1.5681.00
356_K361_N1.5681.00
148_E207_R1.5661.00
300_Y347_G1.5641.00
458_E461_E1.5581.00
65_Y107_N1.5561.00
349_Y353_I1.5481.00
69_I111_E1.5471.00
365_F413_K1.5411.00
14_W79_S1.5291.00
143_T146_A1.5281.00
354_N358_N1.5261.00
79_S120_F1.5041.00
22_T55_P1.5021.00
198_G254_F1.4981.00
34_G93_G1.4921.00
166_F224_I1.4911.00
155_F212_Y1.4791.00
64_N67_E1.4631.00
188_K193_E1.4601.00
19_A80_F1.4531.00
248_A266_E1.4521.00
139_V193_E1.4471.00
69_I112_L1.4441.00
253_S267_L1.4371.00
160_G216_K1.4311.00
338_H374_E1.4261.00
136_G140_N1.4231.00
255_L296_L1.4021.00
166_F295_L1.3991.00
403_H407_Q1.3971.00
72_M77_H1.3891.00
417_L436_F1.3881.00
102_A153_T1.3871.00
74_E453_G1.3741.00
369_N415_Y1.3691.00
90_I97_I1.3671.00
82_M121_V1.3601.00
120_F416_H1.3491.00
348_V402_I1.3481.00
40_Y134_K1.3291.00
211_A214_E1.3261.00
262_E361_N1.3251.00
60_Q64_N1.3251.00
260_K361_N1.3231.00
27_A63_D1.3171.00
455_W459_V1.3121.00
449_V454_K1.3001.00
164_K220_K1.2981.00
163_K218_D1.2981.00
352_L402_I1.2961.00
223_I258_S1.2901.00
190_D193_E1.2881.00
84_I154_C1.2801.00
262_E268_V1.2611.00
94_T135_I1.2521.00
397_E400_K1.2491.00
458_E462_H1.2461.00
141_R200_H1.2341.00
145_D148_E1.2341.00
399_L402_I1.2291.00
454_K457_K1.2231.00
168_H204_S1.2141.00
72_M437_V1.2121.00
70_R74_E1.2121.00
94_T146_A1.2101.00
142_E145_D1.2081.00
174_P201_T1.2081.00
381_D387_Q1.2071.00
353_I410_S1.2031.00
396_K400_K1.2001.00
385_I451_K1.1961.00
168_H201_T1.1891.00
84_I89_L1.1861.00
92_N131_A1.1861.00
123_L147_Y1.1831.00
155_F208_A1.1831.00
102_A157_L1.1761.00
61_F108_V1.1751.00
285_L288_I1.1701.00
331_P334_K1.1691.00
65_Y111_E1.1671.00
256_D358_N1.1531.00
138_W143_T1.1481.00
10_P406_I1.1471.00
148_E208_A1.1431.00
19_A82_M1.1421.00
259_V362_I1.1381.00
384_G448_T1.1381.00
59_S421_M1.1371.00
356_K411_N1.1361.00
34_G131_A1.1301.00
232_P240_V1.1301.00
156_R215_M1.1291.00
330_M333_R1.1231.00
106_N160_G1.1211.00
28_A33_K1.1191.00
256_D260_K1.1191.00
133_Q188_K1.1151.00
281_N284_D1.1101.00
339_R372_G1.1101.00
74_E449_V1.1031.00
456_F460_A1.1021.00
403_H406_I1.0941.00
128_M143_T1.0941.00
232_P243_G1.0931.00
247_D354_N1.0891.00
130_M134_K1.0891.00
27_A31_D1.0881.00
155_F221_I1.0871.00
209_I213_R1.0821.00
227_L351_I1.0791.00
148_E152_R1.0791.00
151_A208_A1.0791.00
230_S246_A1.0771.00
95_G149_N1.0731.00
142_E146_A1.0721.00
64_N446_E1.0721.00
102_A106_N1.0711.00
109_I121_V1.0691.00
57_D441_L1.0681.00
241_K245_I1.0641.00
109_I161_R1.0591.00
330_M334_K1.0571.00
233_R307_K1.0551.00
9_F403_H1.0541.00
238_A346_K1.0531.00
346_K350_D1.0511.00
200_H203_L1.0481.00
97_I153_T1.0471.00
9_F406_I1.0461.00
133_Q179_Y1.0431.00
282_A285_L1.0431.00
237_P240_V1.0361.00
207_R211_A1.0341.00
238_A308_A1.0341.00
237_P241_K1.0341.00
34_G91_P1.0331.00
135_I142_E1.0261.00
336_N342_E1.0211.00
348_V366_I1.0161.00
363_E411_N1.0131.00
106_N113_I1.0131.00
236_H240_V1.0121.00
211_A215_M1.0111.00
337_P371_M1.0101.00
151_A211_A1.0091.00
239_D308_A1.0051.00
440_N446_E1.0021.00
92_N96_E1.0021.00
348_V412_V0.9911.00
159_G219_G0.9891.00
89_L153_T0.9881.00
212_Y217_Q0.9871.00
269_D272_K0.9861.00
153_T157_L0.9841.00
363_E413_K0.9781.00
120_F164_K0.9781.00
392_I455_W0.9711.00
210_Q291_N0.9711.00
393_E396_K0.9701.00
246_A306_V0.9701.00
33_K87_S0.9681.00
146_A149_N0.9651.00
262_E265_K0.9620.99
128_M137_G0.9550.99
248_A267_L0.9540.99
443_K446_E0.9530.99
144_V207_R0.9520.99
17_S72_M0.9520.99
230_S243_G0.9520.99
240_V243_G0.9510.99
120_F365_F0.9500.99
241_K244_E0.9490.99
155_F219_G0.9480.99
24_M61_F0.9470.99
374_E431_K0.9440.99
247_D251_N0.9430.99
431_K443_K0.9430.99
335_M397_E0.9420.99
209_I221_I0.9410.99
248_A252_R0.9380.99
373_V390_Y0.9290.99
376_E381_D0.9270.99
14_W120_F0.9260.99
67_E70_R0.9260.99
244_E248_A0.9250.99
154_C158_F0.9250.99
136_G139_V0.9250.99
103_D106_N0.9200.99
222_G297_G0.9180.99
381_D384_G0.9160.99
12_D413_K0.9100.99
141_R281_N0.9070.99
130_M133_Q0.9030.99
32_G98_N0.9020.99
386_I448_T0.9020.99
15_W399_L0.9000.99
37_I133_Q0.8990.99
107_N110_D0.8960.99
102_A154_C0.8960.99
151_A155_F0.8930.99
139_V188_K0.8910.99
94_T134_K0.8900.99
247_D252_R0.8870.99
106_N109_I0.8870.99
77_H420_F0.8860.99
433_R441_L0.8850.99
339_R432_N0.8830.99
406_I412_V0.8820.99
208_A211_A0.8780.99
157_L161_R0.8780.99
235_S240_V0.8780.99
207_R210_Q0.8770.99
70_R73_K0.8750.99
225_L255_L0.8730.99
256_D359_Y0.8710.99
210_Q287_I0.8700.99
49_F53_V0.8700.99
50_F53_V0.8680.99
175_V197_V0.8670.99
371_M390_Y0.8600.99
269_D273_H0.8600.99
222_G295_L0.8600.99
166_F297_G0.8580.99
160_G219_G0.8550.99
348_V401_W0.8510.99
150_Y154_C0.8480.99
421_M439_V0.8480.99
113_I119_P0.8440.99
283_E287_I0.8430.99
346_K404_R0.8420.99
372_G432_N0.8410.99
454_K458_E0.8410.99
298_V364_C0.8400.99
244_E266_E0.8390.99
124_F128_M0.8390.99
344_Y347_G0.8370.99
72_M117_I0.8360.99
15_W78_N0.8350.99
192_K278_P0.8340.99
196_Q279_D0.8320.99
135_I143_T0.8300.99
212_Y216_K0.8290.98
303_P342_E0.8290.98
389_D393_E0.8290.98
159_G216_K0.8240.98
173_V226_N0.8230.98
168_H174_P0.8200.98
205_S209_I0.8200.98
104_F108_V0.8190.98
140_N146_A0.8180.98
53_V431_K0.8150.98
124_F127_D0.8120.98
144_V203_L0.8050.98
233_R239_D0.8050.98
8_R11_K0.8050.98
302_Q342_E0.8040.98
167_T223_I0.8020.98
303_P347_G0.8000.98
353_I357_E0.7990.98
77_H456_F0.7970.98
400_K404_R0.7960.98
252_R358_N0.7910.98
451_K454_K0.7900.98
167_T205_S0.7870.98
303_P344_Y0.7860.98
24_M59_S0.7860.98
227_L298_V0.7840.98
14_W118_E0.7800.98
65_Y69_I0.7790.98
94_T131_A0.7790.98
335_M390_Y0.7760.98
349_Y401_W0.7740.98
192_K196_Q0.7710.98
329_V333_R0.7710.98
8_R403_H0.7680.98
153_T156_R0.7670.98
230_S306_V0.7670.98
244_E354_N0.7640.97
37_I128_M0.7640.97
10_P411_N0.7630.97
57_D445_G0.7630.97
93_G131_A0.7610.97
74_E457_K0.7610.97
75_L449_V0.7600.97
85_S127_D0.7580.97
57_D60_Q0.7570.97
21_A85_S0.7560.97
265_K268_V0.7530.97
33_K36_N0.7520.97
119_P163_K0.7510.97
121_V162_V0.7470.97
352_L412_V0.7470.97
259_V296_L0.7450.97
356_K410_S0.7430.97
99_D106_N0.7420.97
97_I102_A0.7400.97
89_L154_C0.7380.97
376_E382_E0.7370.97
241_K346_K0.7340.97
384_G446_E0.7330.97
296_L362_I0.7330.97
236_H239_D0.7330.97
353_I356_K0.7320.97
381_D386_I0.7310.97
94_T149_N0.7310.97
113_I118_E0.7300.97
335_M393_E0.7290.97
361_N411_N0.7280.97
364_C410_S0.7280.97
73_K116_G0.7260.97
267_L271_L0.7260.97
147_Y151_A0.7250.96
229_P350_D0.7250.96
68_D447_R0.7240.96
55_P58_T0.7240.96
385_I448_T0.7230.96
343_I373_V0.7230.96
198_G253_S0.7220.96
423_N434_Y0.7220.96
31_D62_Y0.7220.96
167_T221_I0.7210.96
259_V293_V0.7170.96
29_D35_Q0.7150.96
159_G215_M0.7150.96
437_V449_V0.7130.96
405_A410_S0.7120.96
24_M423_N0.7090.96
324_Y328_Y0.7080.96
113_I163_K0.7080.96
28_A56_A0.7060.96
177_G183_F0.7040.96
399_L417_L0.7030.96
90_I96_E0.7000.96
172_I226_N0.6990.96
204_S208_A0.6970.96
202_M288_I0.6970.96
381_D448_T0.6960.96
155_F215_M0.6940.96
192_K277_M0.6930.95
224_I299_N0.6880.95
262_E285_L0.6870.95
92_N95_G0.6860.95
112_L116_G0.6860.95
338_H373_V0.6850.95
112_L115_N0.6840.95
92_N134_K0.6830.95
202_M258_S0.6820.95
101_A104_F0.6810.95
133_Q139_V0.6810.95
139_V197_V0.6800.95
27_A62_Y0.6760.95
392_I451_K0.6760.95
82_M112_L0.6750.95
69_I117_I0.6750.95
42_F45_E0.6720.95
240_V244_E0.6720.95
19_A421_M0.6710.95
120_F166_F0.6680.94
109_I162_V0.6680.94
425_S434_Y0.6680.94
154_C165_W0.6650.94
227_L255_L0.6650.94
78_N118_E0.6640.94
35_Q43_E0.6630.94
225_L254_F0.6610.94
173_V177_G0.6610.94
206_A288_I0.6610.94
346_K349_Y0.6600.94
269_D404_R0.6600.94
145_D149_N0.6590.94
436_F456_F0.6590.94
156_R211_A0.6590.94
66_K70_R0.6580.94
285_L289_K0.6570.94
272_K277_M0.6550.94
399_L459_V0.6550.94
12_D406_I0.6540.94
75_L436_F0.6540.94
113_I116_G0.6530.94
152_R214_E0.6520.94
51_D54_G0.6510.94
231_Y303_P0.6490.94
151_A154_C0.6490.94
51_D431_K0.6480.94
200_H281_N0.6400.93
28_A85_S0.6400.93
339_R428_N0.6390.93
242_A246_A0.6390.93
18_S416_H0.6380.93
309_K312_L0.6360.93
389_D392_I0.6350.93
298_V355_L0.6350.93
236_H308_A0.6350.93
141_R283_E0.6350.93
404_R408_E0.6330.93
182_D189_V0.6320.93
81_R169_N0.6320.93
35_Q130_M0.6300.93
72_M420_F0.6280.92
149_N153_T0.6270.92
261_G289_K0.6260.92
365_F414_G0.6250.92
185_Y190_D0.6250.92
352_L405_A0.6240.92
209_I293_V0.6240.92
195_V271_L0.6230.92
147_Y168_H0.6220.92
299_N367_S0.6220.92
220_K413_K0.6210.92
123_L155_F0.6200.92
141_R203_L0.6190.92
442_E445_G0.6190.92
282_A286_D0.6170.92
252_R354_N0.6160.92
14_W78_N0.6160.92
84_I109_I0.6160.92
132_L146_A0.6160.92
233_R305_R0.6130.92
300_Y348_V0.6130.92
124_F174_P0.6130.92
424_W441_L0.6120.92
287_I291_N0.6110.91
78_N460_A0.6110.91
144_V204_S0.6090.91
323_R328_Y0.6080.91
227_L251_N0.6070.91
139_V196_Q0.6040.91
227_L355_L0.6030.91
107_N111_E0.6030.91
267_L270_I0.6020.91
102_A158_F0.6010.91
338_H432_N0.6000.91
35_Q87_S0.5990.91
90_I149_N0.5990.91
42_F424_W0.5980.91
438_S450_K0.5980.91
162_V165_W0.5970.90
337_P373_V0.5960.90
206_A291_N0.5960.90
9_F15_W0.5950.90
199_F280_Y0.5950.90
215_M219_G0.5950.90
75_L453_G0.5930.90
50_F428_N0.5930.90
206_A292_T0.5920.90
179_Y188_K0.5890.90
123_L151_A0.5890.90
144_V148_E0.5890.90
210_Q292_T0.5880.90
92_N146_A0.5870.90
232_P239_D0.5870.90
337_P372_G0.5870.90
459_V462_H0.5870.90
281_N285_L0.5860.90
438_S446_E0.5860.90
234_S307_K0.5850.90
89_L102_A0.5840.90
110_D160_G0.5840.90
71_L421_M0.5830.89
222_G365_F0.5810.89
73_K114_A0.5810.89
420_F437_V0.5800.89
71_L437_V0.5750.89
186_P189_V0.5750.89
228_T304_R0.5740.89
248_A354_N0.5740.89
255_L355_L0.5740.89
16_G416_H0.5730.89
325_F328_Y0.5720.89
192_K276_F0.5700.88
385_I454_K0.5690.88
229_P247_D0.5680.88
131_A146_A0.5680.88
423_N426_W0.5670.88
47_H52_H0.5670.88
188_K191_F0.5670.88
402_I406_I0.5650.88
252_R256_D0.5650.88
61_F69_I0.5630.88
301_Y368_E0.5620.88
328_Y331_P0.5620.88
355_L364_C0.5620.88
336_N340_G0.5620.88
231_Y344_Y0.5610.88
110_D114_A0.5610.88
365_F416_H0.5600.88
404_R407_Q0.5600.88
27_A33_K0.5600.88
34_G90_I0.5600.88
19_A420_F0.5600.88
80_F112_L0.5600.88
364_C412_V0.5590.87
66_K69_I0.5570.87
200_H279_D0.5560.87
50_F431_K0.5560.87
246_A250_F0.5560.87
196_Q200_H0.5550.87
210_Q213_R0.5550.87
350_D353_I0.5540.87
135_I140_N0.5530.87
24_M80_F0.5530.87
164_K365_F0.5520.87
245_I308_A0.5520.87
42_F55_P0.5500.87
128_M133_Q0.5500.87
253_S271_L0.5500.87
120_F413_K0.5490.86
37_I124_F0.5490.86
271_L276_F0.5480.86
138_W168_H0.5480.86
392_I396_K0.5460.86
185_Y188_K0.5460.86
424_W430_Y0.5440.86
429_A443_K0.5430.86
76_G457_K0.5430.86
386_I438_S0.5420.86
205_S258_S0.5410.86
61_F72_M0.5410.86
183_F186_P0.5390.85
184_H187_N0.5390.85
19_A61_F0.5380.85
77_H117_I0.5380.85
132_L143_T0.5370.85
49_F52_H0.5350.85
29_D56_A0.5340.85
382_E385_I0.5320.85
90_I94_T0.5310.85
297_G367_S0.5300.85
419_T423_N0.5300.85
57_D63_D0.5290.84
179_Y197_V0.5280.84
209_I291_N0.5280.84
442_E446_E0.5280.84
395_I399_L0.5270.84
445_G449_V0.5260.84
383_Q387_Q0.5260.84
179_Y185_Y0.5240.84
61_F65_Y0.5220.84
8_R407_Q0.5220.84
72_M80_F0.5220.84
93_G132_L0.5210.84
249_F267_L0.5200.83
203_L287_I0.5190.83
28_A43_E0.5180.83
324_Y327_P0.5170.83
256_D262_E0.5170.83
14_W164_K0.5150.83
112_L119_P0.5150.83
41_W185_Y0.5150.83
236_H309_K0.5140.83
28_A57_D0.5140.83
19_A423_N0.5140.83
400_K403_H0.5130.83
167_T208_A0.5130.83
179_Y186_P0.5130.83
131_A135_I0.5120.82
307_K326_D0.5110.82
242_A245_I0.5100.82
268_V285_L0.5100.82
22_T42_F0.5070.82
280_Y283_E0.5070.82
255_L259_V0.5070.82
224_I295_L0.5070.82
454_K461_E0.5060.82
45_E49_F0.5060.82
437_V453_G0.5060.82
209_I212_Y0.5050.82
239_D242_A0.5050.82
47_H53_V0.5040.81
367_S413_K0.5040.81
41_W187_N0.5040.81
45_E51_D0.5030.81
59_S72_M0.5020.81
155_F211_A0.5010.81
234_S240_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v02A 2 0.9828 100 0.097 Contact Map
3ptmA 1 0.9806 100 0.097 Contact Map
1v08A 2 0.9871 100 0.099 Contact Map
2dgaA 5 0.9892 100 0.1 Contact Map
1cbgA 2 0.9849 100 0.103 Contact Map
2jf7A 5 0.9677 100 0.103 Contact Map
3wq5A 1 0.9763 100 0.104 Contact Map
3w53A 1 0.9785 100 0.111 Contact Map
3f5lA 2 0.9763 100 0.112 Contact Map
3gnpA 1 0.972 100 0.116 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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