GREMLIN Database
PTEC - Oligo-beta-mannoside permease IIC component
UniProt: O05507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (412)
Sequences: 2129 (1537)
Seq/√Len: 75.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_F102_G4.7321.00
366_V396_M4.3181.00
295_T327_N4.2421.00
356_V403_I3.8871.00
297_A404_V3.8101.00
299_V330_I3.0321.00
266_A274_P2.9581.00
367_P390_S2.8881.00
239_F343_I2.8791.00
391_I395_V2.8201.00
86_I143_M2.8081.00
353_V404_V2.8011.00
352_V407_I2.7711.00
306_M416_D2.7091.00
262_E275_H2.5441.00
79_S142_G2.4761.00
353_V400_N2.4171.00
197_V208_V2.3911.00
356_V396_M2.3901.00
349_A352_V2.3571.00
417_K421_A2.3011.00
94_Y154_R2.2921.00
402_L406_V2.2361.00
192_L196_M2.1781.00
156_I185_I2.1751.00
21_Y90_L2.1421.00
349_A407_I2.1361.00
352_V403_I2.1221.00
83_V105_A2.1041.00
224_I355_L2.0941.00
305_F409_F2.0621.00
91_S101_G2.0431.00
20_R94_Y2.0201.00
421_A425_E2.0061.00
357_T361_M1.9871.00
300_F401_L1.9681.00
419_N422_K1.9651.00
94_Y151_E1.9391.00
242_L247_I1.9301.00
367_P392_M1.8991.00
385_I394_G1.8901.00
396_M400_N1.8861.00
228_L351_M1.8821.00
232_F351_M1.8801.00
399_I403_I1.8791.00
384_G397_Q1.8481.00
308_S416_D1.8331.00
87_G101_G1.8141.00
21_Y151_E1.8121.00
342_I415_M1.7951.00
267_Y273_I1.7911.00
359_L363_A1.7861.00
306_M412_L1.7861.00
420_L424_K1.7831.00
360_A365_L1.7791.00
266_A273_I1.7661.00
357_T400_N1.7651.00
360_A396_M1.7641.00
222_S275_H1.7641.00
301_T304_I1.7641.00
295_T322_G1.7391.00
59_M63_F1.7241.00
388_T393_G1.7181.00
384_G393_G1.7111.00
336_I342_I1.6871.00
6_S11_P1.6851.00
265_S269_A1.6811.00
151_E154_R1.6761.00
297_A405_F1.6581.00
360_A366_V1.6391.00
297_A401_L1.6331.00
349_A404_V1.6291.00
278_S369_P1.6281.00
254_P258_T1.6231.00
236_I240_F1.6051.00
365_L392_M1.6051.00
20_R93_S1.5730.99
381_F394_G1.5730.99
357_T396_M1.5610.99
224_I228_L1.5450.99
415_M419_N1.5430.99
311_M415_M1.5430.99
112_L145_T1.5400.99
97_E175_K1.5390.99
301_T412_L1.5370.99
146_A150_G1.5360.99
154_R158_Q1.5310.99
87_G102_G1.5250.99
228_L355_L1.5250.99
301_T405_F1.5240.99
274_P368_P1.5180.99
392_M395_V1.5170.99
383_N397_Q1.5080.99
406_V409_F1.4930.99
238_W244_G1.4890.99
166_P169_V1.4890.99
365_L396_M1.4800.99
294_M353_V1.4780.99
88_Y99_V1.4760.99
84_F106_L1.4540.99
41_I45_L1.4500.99
51_L55_M1.4380.99
155_R159_K1.4220.99
90_L151_E1.4180.99
87_G105_A1.4040.99
55_M63_F1.4030.99
60_L63_F1.4010.99
4_K8_F1.3990.99
232_F236_I1.3970.99
204_N207_D1.3960.99
245_Q292_T1.3960.99
310_Q419_N1.3950.99
261_V265_S1.3930.99
108_S190_F1.3920.99
25_L147_F1.3750.98
108_S186_T1.3730.98
308_S423_E1.3610.98
156_I161_L1.3360.98
161_L185_I1.3160.98
107_V187_L1.3150.98
381_F398_L1.3150.98
285_Y361_M1.3140.98
312_K316_K1.3130.98
343_I347_V1.3110.98
19_N151_E1.3090.98
358_Y362_S1.3070.98
398_L402_L1.3070.98
356_V360_A1.3010.98
148_L189_V1.2950.98
90_L94_Y1.2920.98
28_A85_G1.2920.98
21_Y147_F1.2830.98
231_V354_T1.2750.97
380_L401_L1.2720.97
355_L359_L1.2680.97
302_I315_S1.2660.97
83_V146_A1.2590.97
331_I346_W1.2510.97
28_A89_Y1.2510.97
296_L401_L1.2500.97
266_A272_E1.2480.97
279_K283_E1.2480.97
390_S393_G1.2440.97
162_T178_A1.2430.97
421_A424_K1.2280.97
301_T305_F1.2260.97
35_L81_F1.2180.97
311_M419_N1.2170.97
132_D137_K1.2150.97
322_G327_N1.2120.97
259_L275_H1.2070.96
341_I414_A1.2060.96
82_V139_M1.2050.96
211_H215_A1.2020.96
267_Y371_G1.1960.96
42_F70_A1.1920.96
356_V400_N1.1900.96
308_S420_L1.1830.96
152_I186_T1.1790.96
309_R313_Q1.1710.96
113_T206_H1.1670.96
83_V142_G1.1670.96
71_S76_G1.1660.96
31_L85_G1.1660.96
47_N68_G1.1580.96
32_A85_G1.1560.95
63_F67_F1.1510.95
301_T315_S1.1480.95
83_V87_G1.1400.95
313_Q316_K1.1390.95
291_G295_T1.1370.95
314_V318_G1.1160.95
83_V102_G1.1140.94
5_I11_P1.1130.94
301_T409_F1.1130.94
37_I180_L1.1120.94
165_M169_V1.0990.94
300_F405_F1.0980.94
39_G74_T1.0970.94
70_A191_L1.0960.94
287_V354_T1.0940.94
266_A271_K1.0870.94
378_V386_M1.0860.94
142_G146_A1.0860.94
381_F397_Q1.0850.94
273_I371_G1.0840.94
413_K416_D1.0820.94
291_G327_N1.0720.93
141_L206_H1.0720.93
165_M168_G1.0710.93
20_R151_E1.0570.93
348_L352_V1.0540.93
380_L397_Q1.0460.92
273_I368_P1.0350.92
264_L268_T1.0350.92
361_M368_P1.0340.92
315_S412_L1.0290.92
265_S268_T1.0280.92
225_I229_I1.0230.92
293_G327_N1.0230.92
290_G296_L1.0210.91
4_K11_P1.0210.91
261_V264_L1.0140.91
250_S254_P1.0140.91
305_F405_F1.0140.91
346_W408_W1.0130.91
104_I183_A1.0060.91
327_N331_I1.0060.91
72_T76_G1.0030.91
51_L54_I1.0030.91
299_V315_S1.0020.91
262_E266_A1.0000.91
5_I414_A1.0000.91
90_L150_G0.9970.90
303_L315_S0.9970.90
28_A146_A0.9950.90
29_F82_V0.9940.90
92_K98_A0.9940.90
145_T190_F0.9920.90
80_V110_L0.9920.90
289_M294_M0.9910.90
148_L190_F0.9880.90
297_A300_F0.9870.90
381_F384_G0.9860.90
89_Y92_K0.9820.90
150_G154_R0.9820.90
28_A86_I0.9810.90
285_Y388_T0.9750.89
264_L371_G0.9730.89
304_I409_F0.9730.89
266_A269_A0.9720.89
96_V154_R0.9700.89
200_F203_T0.9680.89
303_L319_L0.9680.89
253_D279_K0.9670.89
77_I81_F0.9640.89
84_F99_V0.9640.89
196_M199_L0.9620.89
148_L152_I0.9570.89
222_S259_L0.9570.89
294_M297_A0.9550.88
418_L421_A0.9540.88
225_I228_L0.9530.88
231_V287_V0.9520.88
88_Y98_A0.9520.88
400_N404_V0.9480.88
361_M369_P0.9410.88
28_A147_F0.9300.87
290_G294_M0.9300.87
24_V93_S0.9220.87
349_A353_V0.9220.87
230_A252_M0.9200.87
356_V399_I0.9190.86
305_F412_L0.9190.86
46_T68_G0.9190.86
80_V134_L0.9180.86
21_Y94_Y0.9170.86
196_M200_F0.9150.86
360_A363_A0.9140.86
416_D423_E0.9110.86
54_I57_A0.9060.86
181_I185_I0.9030.86
104_I186_T0.9020.85
359_L362_S0.9000.85
366_V390_S0.8950.85
207_D211_H0.8940.85
96_V158_Q0.8840.84
5_I74_T0.8840.84
109_F142_G0.8830.84
304_I416_D0.8830.84
47_N377_T0.8810.84
108_S149_S0.8810.84
330_I336_I0.8800.84
194_N198_T0.8800.84
331_I336_I0.8790.84
360_A364_G0.8790.84
402_L405_F0.8770.84
32_A82_V0.8750.84
7_Q11_P0.8740.84
129_I134_L0.8710.83
43_V75_M0.8670.83
46_T67_F0.8650.83
366_V392_M0.8640.83
54_I58_S0.8600.83
170_P216_P0.8590.83
230_A248_I0.8590.83
290_G293_G0.8580.82
33_F36_T0.8570.82
216_P329_P0.8510.82
412_L416_D0.8460.82
299_V302_I0.8430.81
266_A270_G0.8400.81
395_V399_I0.8390.81
416_D420_L0.8390.81
82_V86_I0.8380.81
391_I394_G0.8370.81
298_I408_W0.8360.81
92_K95_Q0.8350.81
220_L229_I0.8340.81
109_F134_L0.8310.80
322_G330_I0.8300.80
144_I209_I0.8260.80
152_I189_V0.8250.80
174_A178_A0.8210.80
238_W243_H0.8190.79
243_H328_E0.8160.79
285_Y357_T0.8150.79
170_P329_P0.8140.79
79_S83_V0.8140.79
396_M399_I0.8120.79
394_G397_Q0.8120.79
27_D93_S0.8120.79
101_G153_Y0.8100.79
27_D172_A0.8080.79
325_N376_W0.8050.78
145_T149_S0.8050.78
96_V157_V0.8020.78
6_S10_V0.8010.78
98_A102_G0.8010.78
227_T354_T0.8010.78
298_I412_L0.8010.78
55_M60_L0.7980.78
163_I166_P0.7930.77
228_L232_F0.7910.77
374_V387_A0.7890.77
260_Q280_P0.7880.77
152_I185_I0.7870.77
117_I128_V0.7840.76
366_V393_G0.7840.76
289_M296_L0.7820.76
328_E332_F0.7810.76
409_F412_L0.7760.76
297_A406_V0.7760.76
11_P14_G0.7760.76
235_Q292_T0.7730.75
349_A403_I0.7720.75
305_F312_K0.7710.75
163_I169_V0.7710.75
276_I361_M0.7690.75
252_M256_W0.7670.75
203_T208_V0.7670.75
341_I418_L0.7650.75
110_L134_L0.7650.75
161_L181_I0.7610.74
16_L22_L0.7600.74
414_A418_L0.7590.74
420_L423_E0.7580.74
369_P388_T0.7580.74
151_E155_R0.7550.74
364_G368_P0.7540.74
304_I315_S0.7530.73
22_L338_M0.7530.73
12_I16_L0.7480.73
189_V192_L0.7470.73
400_N403_I0.7470.73
22_L26_R0.7400.72
46_T70_A0.7380.72
57_A60_L0.7380.72
293_G346_W0.7350.72
149_S190_F0.7330.71
303_L316_K0.7300.71
360_A399_I0.7300.71
401_L405_F0.7270.71
73_A110_L0.7260.71
213_I237_L0.7230.70
18_N103_A0.7200.70
259_L262_E0.7200.70
133_R207_D0.7200.70
20_R24_V0.7190.70
47_N50_F0.7150.70
157_V162_T0.7150.70
306_M311_M0.7150.70
302_I412_L0.7120.69
165_M177_F0.7120.69
276_I281_F0.7120.69
43_V71_S0.7110.69
350_P408_W0.7110.69
294_M404_V0.7100.69
149_S186_T0.7080.69
220_L322_G0.7070.69
399_I402_L0.7070.69
14_G18_N0.7050.68
422_K425_E0.7040.68
293_G408_W0.7000.68
109_F113_T0.7000.68
170_P177_F0.6990.68
19_N94_Y0.6980.68
267_Y274_P0.6960.68
266_A368_P0.6950.67
311_M342_I0.6930.67
27_D89_Y0.6910.67
178_A181_I0.6900.67
235_Q288_G0.6890.67
302_I334_L0.6880.67
291_G408_W0.6870.66
257_N261_V0.6850.66
305_F316_K0.6840.66
28_A82_V0.6840.66
81_F107_V0.6840.66
30_M355_L0.6830.66
106_L134_L0.6820.66
80_V106_L0.6800.66
285_Y366_V0.6790.66
362_S367_P0.6780.65
5_I9_L0.6770.65
96_V150_G0.6760.65
55_M58_S0.6700.65
299_V322_G0.6700.65
16_L355_L0.6700.65
318_G330_I0.6680.64
348_L407_I0.6670.64
53_K57_A0.6650.64
101_G150_G0.6630.64
285_Y387_A0.6630.64
227_T282_M0.6620.64
195_V199_L0.6610.64
24_V90_L0.6610.64
69_I194_N0.6590.63
405_F409_F0.6580.63
29_F44_V0.6580.63
226_P240_F0.6560.63
384_G394_G0.6550.63
310_Q416_D0.6530.63
403_I407_I0.6520.62
224_I359_L0.6520.62
24_V28_A0.6510.62
299_V412_L0.6490.62
170_P173_V0.6480.62
77_I80_V0.6480.62
58_S62_S0.6460.62
413_K417_K0.6460.62
205_M208_V0.6460.62
281_F357_T0.6450.62
235_Q346_W0.6420.61
22_L256_W0.6420.61
84_F87_G0.6400.61
353_V357_T0.6390.61
157_V160_N0.6370.61
345_P411_F0.6360.61
228_L354_T0.6350.60
53_K56_N0.6340.60
7_Q232_F0.6340.60
238_W338_M0.6320.60
160_N164_K0.6300.60
290_G327_N0.6300.60
314_V330_I0.6300.60
8_F11_P0.6290.60
43_V46_T0.6290.60
166_P170_P0.6290.60
167_A171_P0.6290.60
308_S311_M0.6290.60
141_L145_T0.6280.60
260_Q373_T0.6280.60
308_S315_S0.6270.59
243_H332_F0.6270.59
303_L334_L0.6260.59
381_F401_L0.6250.59
183_A187_L0.6250.59
86_I147_F0.6240.59
55_M59_M0.6230.59
87_G91_S0.6230.59
267_Y270_G0.6220.59
91_S150_G0.6210.59
73_A111_L0.6210.59
303_L416_D0.6190.58
367_P393_G0.6180.58
277_I358_Y0.6170.58
296_L323_I0.6170.58
409_F413_K0.6160.58
117_I126_T0.6150.58
292_T346_W0.6150.58
331_I337_V0.6110.57
23_Q26_R0.6110.57
259_L278_S0.6110.57
290_G298_I0.6100.57
175_K178_A0.6080.57
319_L323_I0.6080.57
101_G149_S0.6070.57
218_V258_T0.6070.57
13_A19_N0.6070.57
68_G71_S0.6070.57
295_T318_G0.6070.57
112_L190_F0.6070.57
37_I375_P0.6050.57
77_I110_L0.6050.57
176_S180_L0.6020.56
403_I406_V0.6020.56
297_A408_W0.6010.56
296_L322_G0.6010.56
311_M315_S0.5990.56
212_A395_V0.5980.56
19_N90_L0.5980.56
51_L60_L0.5960.56
51_L63_F0.5960.56
348_L351_M0.5950.56
315_S318_G0.5950.56
365_L399_I0.5940.55
226_P239_F0.5920.55
300_F344_V0.5910.55
307_K413_K0.5850.54
276_I358_Y0.5840.54
299_V319_L0.5830.54
5_I8_F0.5810.54
238_W328_E0.5810.54
269_A272_E0.5810.54
146_A149_S0.5800.54
369_P393_G0.5750.53
336_I346_W0.5740.53
414_A417_K0.5700.52
413_K420_L0.5690.52
304_I316_K0.5670.52
366_V400_N0.5670.52
78_M257_N0.5660.52
394_G398_L0.5660.52
156_I160_N0.5650.52
4_K7_Q0.5640.52
367_P394_G0.5610.51
238_W292_T0.5600.51
85_G89_Y0.5600.51
26_R97_E0.5590.51
244_G350_P0.5580.51
351_M355_L0.5570.51
173_V375_P0.5550.50
71_S75_M0.5550.50
244_G346_W0.5540.50
234_I288_G0.5540.50
374_V378_V0.5520.50
180_L375_P0.5510.50
109_F135_G0.5510.50
327_N346_W0.5500.50
67_F191_L0.5500.50
208_V213_I0.5480.50
19_N24_V0.5470.49
258_T262_E0.5460.49
231_V282_M0.5460.49
197_V205_M0.5460.49
87_G150_G0.5450.49
306_M310_Q0.5440.49
293_G350_P0.5440.49
311_M412_L0.5420.49
64_Q68_G0.5420.49
318_G322_G0.5420.49
133_R206_H0.5420.49
199_L202_K0.5410.49
258_T261_V0.5400.49
378_V384_G0.5380.48
17_N22_L0.5380.48
90_L154_R0.5360.48
164_K167_A0.5360.48
45_L189_V0.5350.48
106_L181_I0.5350.48
342_I408_W0.5340.48
5_I128_V0.5340.48
309_R312_K0.5340.48
350_P401_L0.5340.48
25_L139_M0.5340.48
111_L187_L0.5340.48
18_N23_Q0.5340.48
280_P284_I0.5340.48
238_W332_F0.5330.48
372_V375_P0.5330.48
311_M334_L0.5330.48
4_K363_A0.5320.48
184_F188_T0.5320.48
280_P369_P0.5310.47
173_V176_S0.5310.47
376_W380_L0.5300.47
191_L194_N0.5290.47
168_G309_R0.5290.47
66_H191_L0.5270.47
8_F398_L0.5270.47
220_L226_P0.5270.47
346_W350_P0.5270.47
320_A343_I0.5260.47
51_L59_M0.5250.47
105_A108_S0.5250.47
218_V226_P0.5250.47
39_G179_A0.5240.47
281_F396_M0.5240.47
374_V386_M0.5240.47
264_L372_V0.5240.47
61_T64_Q0.5230.46
170_P254_P0.5220.46
22_L27_D0.5210.46
95_Q271_K0.5210.46
8_F307_K0.5200.46
22_L305_F0.5190.46
53_K58_S0.5190.46
26_R30_M0.5180.46
186_T189_V0.5180.46
352_V356_V0.5170.46
20_R37_I0.5170.46
152_I190_F0.5150.45
215_A219_G0.5150.45
147_F151_E0.5140.45
285_Y393_G0.5140.45
281_F361_M0.5130.45
56_N60_L0.5120.45
143_M254_P0.5120.45
168_G320_A0.5120.45
304_I405_F0.5120.45
96_V101_G0.5090.45
227_T277_I0.5090.45
271_K274_P0.5090.45
7_Q348_L0.5080.45
5_I323_I0.5060.44
47_N408_W0.5050.44
38_F187_L0.5040.44
20_R154_R0.5040.44
296_L405_F0.5040.44
92_K97_E0.5040.44
375_P378_V0.5030.44
243_H337_V0.5030.44
109_F165_M0.5020.44
366_V375_P0.5020.44
208_V356_V0.5010.44
162_T175_K0.5000.44
37_I280_P0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9683 100 0.302 Contact Map
3mktA 1 0.3733 28.6 0.972 Contact Map
4humA 1 0.3665 23.6 0.973 Contact Map
4lz6A 1 0.3439 20.7 0.974 Contact Map
3w4tA 1 0.3348 18.1 0.975 Contact Map
1pw4A 1 0.4548 9.3 0.978 Contact Map
2rddB 1 0.0837 8.1 0.978 Contact Map
2kluA 1 0.1267 7.5 0.979 Contact Map
4twkA 2 0.1403 7.3 0.979 Contact Map
2kncA 1 0.1176 6.8 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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