GREMLIN Database
PTEA - Oligo-beta-mannoside-specific phosphotransferase enzyme IIA component
UniProt: O05506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (98)
Sequences: 1382 (1005)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D106_K4.4291.00
35_A40_K3.1831.00
40_K43_E3.0671.00
37_K103_D2.9921.00
37_K100_E2.9861.00
29_I51_A2.7091.00
68_K73_E2.5721.00
35_A47_L2.2461.00
28_C50_K2.2381.00
21_H54_D2.1851.00
33_L98_V2.1431.00
101_M104_L1.9531.00
52_E95_K1.8821.00
35_A43_E1.7981.00
24_N54_D1.7901.00
34_R100_E1.5661.00
43_E47_L1.5271.00
62_H85_E1.5191.00
52_E99_K1.5141.00
43_E46_A1.4871.00
77_F82_M1.4871.00
48_I102_L1.4801.00
20_L24_N1.4661.00
16_F20_L1.4401.00
28_C47_L1.4041.00
31_Q47_L1.3750.99
46_A50_K1.3510.99
47_L50_K1.3180.99
49_A53_Q1.3180.99
101_M105_F1.3000.99
64_Q68_K1.2710.99
69_E72_G1.2390.99
57_A60_D1.2160.99
46_A49_A1.2050.99
95_K99_K1.1460.98
33_L101_M1.1380.98
65_M81_L1.1200.98
45_D49_A1.1140.98
41_K106_K1.1030.98
39_G107_T1.0970.97
36_Y102_L1.0930.97
49_A52_E1.0920.97
53_Q57_A1.0770.97
63_F85_E1.0770.97
15_S81_L1.0690.97
35_A38_E1.0460.97
67_Q71_G1.0380.96
22_S58_A1.0220.96
56_S60_D1.0210.96
30_I96_E0.9860.95
81_L84_A0.9820.95
62_H92_L0.9760.95
27_S31_Q0.9560.94
10_T13_Q0.9420.94
30_I94_M0.9380.94
50_K53_Q0.9260.93
19_I84_A0.9070.93
26_R96_E0.8970.92
90_S94_M0.8880.92
68_K75_T0.8860.92
54_D57_A0.8440.90
87_H92_L0.8360.89
36_Y105_F0.8300.89
29_I91_T0.8290.89
36_Y41_K0.8260.89
15_S79_L0.8220.89
89_M93_S0.8210.88
33_L97_L0.8150.88
15_S80_L0.8110.88
29_I48_I0.8100.88
12_E80_L0.8020.87
87_H96_E0.7740.85
29_I95_K0.7710.85
68_K71_G0.7700.85
37_K107_T0.7470.83
61_I64_Q0.7440.83
17_Q21_H0.7380.83
30_I98_V0.7370.82
37_K105_F0.7300.82
85_E90_S0.7280.82
85_E92_L0.7260.82
21_H57_A0.7210.81
27_S30_I0.7160.81
62_H90_S0.6920.78
65_M79_L0.6870.78
22_S91_T0.6850.78
46_A53_Q0.6840.78
94_M98_V0.6820.77
62_H87_H0.6810.77
51_A95_K0.6810.77
82_M85_E0.6800.77
13_Q17_Q0.6730.76
66_I70_S0.6720.76
11_D81_L0.6690.76
42_D46_A0.6680.76
29_I98_V0.6630.75
28_C54_D0.6630.75
24_N28_C0.6630.75
45_D99_K0.6550.74
26_R93_S0.6520.74
15_S20_L0.6420.73
22_S87_H0.6410.73
66_I79_L0.6370.72
93_S96_E0.6330.72
30_I93_S0.6310.72
82_M87_H0.6280.71
38_E42_D0.6280.71
69_E78_S0.6170.70
94_M97_L0.6060.69
69_E80_L0.6010.68
53_Q56_S0.5960.67
40_K46_A0.5940.67
78_S81_L0.5910.67
51_A55_L0.5840.66
21_H24_N0.5820.66
26_R90_S0.5810.65
66_I82_M0.5800.65
44_A98_V0.5760.65
50_K54_D0.5730.64
42_D49_A0.5670.64
48_I99_K0.5650.63
60_D99_K0.5630.63
57_A61_I0.5610.63
14_I64_Q0.5570.62
18_L22_S0.5570.62
22_S93_S0.5550.62
49_A103_D0.5480.61
36_Y44_A0.5480.61
55_L92_L0.5420.60
37_K104_L0.5390.60
12_E15_S0.5360.59
32_S36_Y0.5350.59
90_S93_S0.5350.59
16_F72_G0.5290.58
93_S98_V0.5280.58
34_R37_K0.5250.58
42_D45_D0.5250.58
91_T94_M0.5160.56
92_L95_K0.5160.56
39_G105_F0.5140.56
11_D61_I0.5110.56
30_I33_L0.5070.55
33_L37_K0.5050.55
15_S82_M0.5020.54
51_A96_E0.5010.54
24_N87_H0.5010.54
66_I84_A0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l8rA 3 0.9273 100 0.059 Contact Map
2e2aA 3 0.9455 100 0.078 Contact Map
1wcrA 3 0.9364 100 0.089 Contact Map
3k1sA 6 0.9636 100 0.091 Contact Map
3ieeA 1 0.9818 7.9 0.933 Contact Map
4udxX 2 0.9364 6.2 0.936 Contact Map
4lpzC 2 0.1818 5.2 0.939 Contact Map
2j7aA 5 0.9545 5.2 0.939 Contact Map
1oahA 2 0.9364 4.8 0.94 Contact Map
4mgeA 3 0.8182 4.1 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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