GREMLIN Database
PTEB - Oligo-beta-mannoside-specific phosphotransferase enzyme IIB component
UniProt: O05505 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 103 (97)
Sequences: 1217 (873)
Seq/√Len: 88.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_K66_Q3.4801.00
28_I94_E3.4491.00
3_K33_E2.3561.00
80_D95_Q2.3261.00
51_A99_L2.0421.00
83_A88_D2.0101.00
90_K94_E2.0061.00
42_A65_L2.0001.00
19_T22_K1.9781.00
43_K68_E1.9401.00
17_L92_A1.8511.00
19_T23_E1.8121.00
77_E99_L1.8041.00
80_D83_A1.7871.00
18_V34_I1.7571.00
83_A91_K1.6971.00
30_E97_L1.6811.00
66_Q70_D1.6231.00
5_L49_A1.6141.00
5_L37_V1.5341.00
24_Y28_I1.4971.00
28_I90_K1.4791.00
23_E27_S1.4630.99
63_S66_Q1.4510.99
21_M34_I1.4360.99
95_Q98_S1.4200.99
23_E26_Q1.3730.99
24_Y27_S1.3200.99
32_A97_L1.3200.99
16_L19_T1.2720.98
94_E98_S1.2660.98
88_D91_K1.2380.98
61_L64_E1.2280.98
53_L77_E1.2250.98
12_M15_S1.2120.98
24_Y90_K1.1830.98
24_Y89_G1.1760.97
7_A42_A1.1510.97
16_L87_A1.1470.97
67_K70_D1.1400.97
83_A92_A1.1280.97
25_A34_I1.1240.97
77_E95_Q1.1220.97
22_K26_Q1.1110.96
91_K94_E1.1110.96
83_A95_Q1.1020.96
39_Q61_L1.0700.96
46_M69_A1.0700.96
6_L14_T1.0570.95
65_L76_V1.0220.94
70_D73_N1.0140.94
64_E67_K1.0120.94
35_W49_A1.0040.94
5_L35_W1.0020.94
28_I97_L1.0010.94
93_Y97_L0.9810.93
17_L79_I0.9680.93
62_K77_E0.9640.92
4_I32_A0.9620.92
27_S90_K0.9620.92
30_E93_Y0.9560.92
69_A72_Y0.9490.92
51_A100_M0.9430.92
52_V74_I0.9420.91
25_A32_A0.9400.91
10_S38_G0.9370.91
54_I58_M0.9300.91
62_K76_V0.9270.91
65_L69_A0.9240.91
21_M96_A0.9210.91
42_A49_A0.9150.90
4_I96_A0.9150.90
7_A37_V0.9130.90
22_K33_E0.9130.90
52_V69_A0.8840.89
24_Y93_Y0.8740.88
14_T55_G0.8480.87
62_K78_V0.8450.86
47_R72_Y0.8250.85
51_A96_A0.8090.84
52_V65_L0.8070.84
3_K49_A0.7690.81
3_K35_W0.7680.81
37_V49_A0.7650.80
54_I78_V0.7640.80
35_W45_D0.7540.79
86_M91_K0.7540.79
96_A99_L0.7530.79
7_A52_V0.7430.78
54_I62_K0.7400.78
20_K23_E0.7320.77
45_D48_K0.7270.77
25_A93_Y0.7040.75
79_I92_A0.6860.73
89_G92_A0.6740.71
39_Q65_L0.6680.71
19_T26_Q0.6680.71
41_K44_E0.6670.71
42_A52_V0.6580.70
8_C11_G0.6520.69
53_L95_Q0.6470.68
95_Q99_L0.6420.68
13_S84_Y0.6400.67
40_D61_L0.6370.67
94_E97_L0.6240.65
69_A73_N0.6090.64
58_M61_L0.6060.63
63_S67_K0.5980.62
9_S38_G0.5920.61
12_M16_L0.5920.61
37_V45_D0.5900.61
82_M88_D0.5880.61
18_V21_M0.5850.60
9_S39_Q0.5840.60
7_A41_K0.5810.60
16_L20_K0.5800.60
26_Q31_E0.5780.60
87_A92_A0.5770.59
5_L69_A0.5770.59
40_D58_M0.5760.59
6_L21_M0.5700.59
14_T21_M0.5690.58
55_G76_V0.5670.58
82_M86_M0.5630.58
13_S85_G0.5590.57
33_E48_K0.5580.57
7_A58_M0.5560.57
21_M92_A0.5550.57
30_E100_M0.5430.55
39_Q45_D0.5390.54
70_D76_V0.5390.54
37_V41_K0.5380.54
39_Q58_M0.5350.54
46_M70_D0.5330.54
8_C36_A0.5310.53
5_L52_V0.5290.53
46_M68_E0.5290.53
9_S57_Q0.5290.53
77_E80_D0.5190.52
25_A30_E0.5130.51
7_A65_L0.5100.50
8_C14_T0.5090.50
21_M93_Y0.5090.50
9_S61_L0.5030.49
32_A60_F0.5020.49
9_S58_M0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nbmA 1 0.9515 100 0.294 Contact Map
4mgeA 3 0.9903 99.9 0.34 Contact Map
1e2bA 1 0.9806 99.9 0.361 Contact Map
2l2qA 1 1 99.9 0.365 Contact Map
2kyrA 1 0.932 99.9 0.403 Contact Map
4tn5A 2 0.932 99.9 0.414 Contact Map
2m1zA 1 0.932 99.9 0.425 Contact Map
2r4qA 1 0.9126 99.9 0.444 Contact Map
1tvmA 1 0.8932 99.7 0.557 Contact Map
3czcA 1 0.8835 99.4 0.625 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0056 seconds.