GREMLIN Database
YDHK - Uncharacterized protein YdhK
UniProt: O05503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (182)
Sequences: 209 (186)
Seq/√Len: 13.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_V154_L9.0421.00
138_I141_A5.0101.00
88_V105_V4.2541.00
74_L134_I4.2201.00
117_S170_D4.0891.00
139_K155_E3.1130.98
119_T126_R3.0830.98
138_I152_V3.0340.97
138_I146_L2.9740.97
146_L150_D2.8990.97
87_Q102_E2.7040.95
151_Q166_T2.5860.93
90_I202_L2.4680.92
154_L167_A2.4110.91
133_V146_L2.3640.90
83_K86_S2.1910.86
148_P172_A2.1660.85
173_E200_D2.1140.84
74_L179_M2.0620.82
120_P123_G2.0560.82
105_V202_L1.7640.71
31_S40_G1.7610.70
26_G30_L1.7320.69
135_Q144_K1.6900.67
113_A170_D1.6890.67
141_A144_K1.5980.63
115_V129_H1.5560.60
130_H194_H1.5420.60
139_K163_K1.5130.58
117_S198_T1.5050.58
135_Q145_T1.4990.58
65_S88_V1.4970.57
112_T172_A1.4880.57
66_G192_K1.4800.57
90_I180_V1.4350.54
130_H159_M1.4280.54
159_M194_H1.3650.50
134_I172_A1.3500.50
117_S126_R1.3450.49
189_E198_T1.3430.49
108_A176_T1.3420.49
106_T109_Y1.3260.48
70_V74_L1.3160.48
66_G70_V1.3100.47
113_A173_E1.3000.47
96_K180_V1.2410.44
21_S38_A1.2330.43
109_Y179_M1.2020.42
34_F38_A1.2000.42
134_I179_M1.1930.41
59_H70_V1.1920.41
134_I175_T1.1780.40
62_M182_Y1.1690.40
38_A166_T1.1540.39
164_G171_S1.1440.39
88_V103_A1.1370.38
133_V138_I1.1260.38
155_E182_Y1.1220.38
23_Y38_A1.1210.37
96_K153_I1.1030.37
143_D192_K1.1020.37
88_V202_L1.0940.36
113_A175_T1.0860.36
67_S148_P1.0670.35
67_S74_L1.0660.35
59_H113_A1.0640.35
112_T136_E1.0610.35
45_T116_V1.0570.34
77_S110_D1.0570.34
83_K153_I1.0500.34
121_T166_T1.0290.33
75_Q79_N1.0280.33
141_A146_L1.0220.33
23_Y29_M1.0090.32
49_T106_T1.0060.32
49_T157_S0.9980.32
151_Q169_I0.9950.31
138_I190_K0.9950.31
92_T126_R0.9870.31
75_Q81_K0.9800.31
105_V108_A0.9770.31
117_S128_D0.9730.30
173_E189_E0.9730.30
67_S134_I0.9700.30
70_V134_I0.9690.30
125_Q200_D0.9670.30
115_V122_N0.9510.29
24_A34_F0.9510.29
74_L186_T0.9490.29
147_Q187_S0.9400.29
118_Y127_V0.9280.28
79_N157_S0.9270.28
72_E125_Q0.9270.28
146_L152_V0.9250.28
156_A159_M0.9210.28
106_T181_D0.9160.28
62_M161_G0.9150.28
150_D186_T0.9130.28
70_V182_Y0.9100.28
89_I144_K0.9100.28
112_T145_T0.9100.28
67_S191_V0.9090.28
175_T191_V0.9050.27
122_N138_I0.9040.27
82_Y160_K0.9030.27
78_K109_Y0.9010.27
147_Q150_D0.8960.27
175_T200_D0.8800.26
76_E81_K0.8740.26
172_A186_T0.8710.26
74_L185_T0.8670.26
170_D198_T0.8660.26
99_K168_E0.8600.25
164_G167_A0.8530.25
72_E171_S0.8520.25
179_M195_K0.8510.25
66_G195_K0.8460.25
46_K79_N0.8420.25
93_S133_V0.8380.25
173_E191_V0.8370.25
70_V179_M0.8360.24
131_K171_S0.8360.24
40_G112_T0.8340.24
67_S175_T0.8330.24
35_V64_H0.8290.24
86_S128_D0.8280.24
65_S134_I0.8240.24
113_A177_V0.8190.24
96_K151_Q0.8180.24
116_V133_V0.8170.24
63_D168_E0.8160.24
72_E144_K0.8120.24
25_L28_L0.8100.23
106_T173_E0.8090.23
69_D198_T0.8090.23
155_E163_K0.8090.23
92_T182_Y0.8020.23
89_I168_E0.8010.23
175_T189_E0.7980.23
29_M34_F0.7970.23
133_V161_G0.7920.23
93_S99_K0.7820.22
78_K140_D0.7820.22
65_S175_T0.7800.22
57_S60_E0.7780.22
53_H116_V0.7770.22
58_T160_K0.7750.22
24_A50_H0.7700.22
32_L66_G0.7690.22
92_T99_K0.7630.22
66_G134_I0.7560.21
51_D182_Y0.7500.21
90_I115_V0.7450.21
93_S127_V0.7430.21
105_V169_I0.7430.21
113_A134_I0.7310.21
70_V180_V0.7280.20
112_T141_A0.7240.20
137_E192_K0.7180.20
42_N138_I0.7160.20
37_S43_N0.7140.20
115_V155_E0.7130.20
173_E202_L0.7100.20
46_K58_T0.7060.20
115_V171_S0.7020.20
33_V121_T0.6990.19
142_G146_L0.6980.19
133_V163_K0.6920.19
104_T195_K0.6880.19
106_T157_S0.6820.19
27_I38_A0.6820.19
138_I154_L0.6790.19
109_Y140_D0.6700.18
67_S173_E0.6690.18
131_K182_Y0.6680.18
36_L136_E0.6650.18
153_I167_A0.6630.18
26_G40_G0.6520.18
82_Y118_Y0.6480.18
147_Q172_A0.6460.18
73_G168_E0.6400.18
116_V126_R0.6320.17
150_D169_I0.6300.17
29_M52_N0.6240.17
168_E180_V0.6240.17
113_A129_H0.6160.17
59_H169_I0.6100.17
152_V182_Y0.6090.17
33_V192_K0.6070.17
64_H154_L0.6040.16
133_V154_L0.6040.16
157_S192_K0.6010.16
69_D175_T0.6000.16
27_I33_V0.5960.16
143_D174_K0.5920.16
80_P197_V0.5900.16
73_G157_S0.5870.16
113_A150_D0.5870.16
69_D148_P0.5850.16
75_Q106_T0.5840.16
76_E128_D0.5830.16
65_S191_V0.5830.16
136_E145_T0.5810.16
45_T110_D0.5790.16
67_S189_E0.5780.16
79_N170_D0.5760.16
30_L82_Y0.5740.16
28_L82_Y0.5720.16
175_T202_L0.5710.15
83_K163_K0.5710.15
65_S103_A0.5690.15
27_I41_N0.5670.15
31_S38_A0.5660.15
74_L88_V0.5650.15
119_T142_G0.5650.15
106_T185_T0.5630.15
31_S72_E0.5630.15
145_T183_T0.5610.15
61_E144_K0.5600.15
156_A195_K0.5600.15
91_N155_E0.5590.15
89_I103_A0.5580.15
115_V170_D0.5570.15
75_Q122_N0.5550.15
140_D190_K0.5550.15
172_A203_S0.5550.15
111_T124_G0.5540.15
65_S202_L0.5490.15
91_N203_S0.5480.15
128_D160_K0.5420.15
22_K180_V0.5400.15
66_G191_V0.5390.15
47_E58_T0.5360.15
25_L30_L0.5360.15
26_G50_H0.5320.14
22_K109_Y0.5310.14
145_T174_K0.5300.14
69_D171_S0.5290.14
156_A161_G0.5290.14
99_K186_T0.5280.14
128_D163_K0.5280.14
104_T200_D0.5260.14
37_S75_Q0.5260.14
34_F142_G0.5250.14
40_G45_T0.5240.14
119_T140_D0.5230.14
82_Y110_D0.5220.14
60_E91_N0.5210.14
139_K153_I0.5200.14
70_V109_Y0.5200.14
112_T174_K0.5200.14
67_S70_V0.5190.14
137_E156_A0.5180.14
26_G168_E0.5170.14
70_V175_T0.5170.14
29_M40_G0.5130.14
148_P180_V0.5120.14
43_N168_E0.5110.14
70_V169_I0.5110.14
72_E173_E0.5100.14
67_S172_A0.5080.14
148_P189_E0.5070.14
157_S163_K0.5070.14
93_S157_S0.5070.14
92_T119_T0.5070.14
48_S81_K0.5070.14
102_E170_D0.5060.14
130_H156_A0.5060.14
67_S88_V0.5040.14
138_I144_K0.5030.14
103_A108_A0.5010.14
62_M103_A0.5000.14
115_V119_T0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mdwA 1 0.6488 100 0.254 Contact Map
4fibA 1 0.6049 100 0.364 Contact Map
4r2fA 1 0.3902 83.3 0.952 Contact Map
2ltjA 1 0.4 78 0.954 Contact Map
3k6vA 1 0.4732 76.8 0.955 Contact Map
4wzzA 1 0.5268 73.8 0.956 Contact Map
3ucpA 1 0.4878 73.4 0.956 Contact Map
3ombA 1 0.4293 72.5 0.956 Contact Map
4r9fA 1 0.5561 72.4 0.956 Contact Map
3uorA 1 0.3902 70.7 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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