GREMLIN Database
YDHE - Uncharacterized UDP-glucosyltransferase YdhE
UniProt: O05496 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (383)
Sequences: 13098 (10434)
Seq/√Len: 533.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
315_V356_V4.2051.00
365_G368_K3.9801.00
330_L336_G3.7891.00
252_G350_K3.6171.00
299_G316_V3.6081.00
316_V327_A3.2001.00
6_I22_T3.1451.00
370_N374_K2.9791.00
248_D346_A2.9471.00
355_E359_N2.8681.00
350_K354_D2.7811.00
41_K45_E2.7291.00
297_T314_L2.6121.00
337_Y355_E2.5401.00
28_K387_D2.5111.00
189_Y372_S2.4821.00
363_T367_K2.4771.00
218_P222_L2.4381.00
222_L256_K2.3221.00
295_F303_S2.3031.00
354_D358_R2.2871.00
103_Y120_G2.2391.00
24_A27_D2.1741.00
187_S373_F2.1701.00
367_K370_N2.1151.00
152_E155_D2.1101.00
245_L346_A2.1041.00
307_G314_L2.0591.00
304_V330_L1.9651.00
371_Q375_E1.9611.00
331_S338_V1.9491.00
148_E151_Q1.9381.00
315_V352_A1.9371.00
335_A369_I1.9271.00
251_S272_Q1.8881.00
253_F354_D1.8751.00
311_S366_I1.8541.00
147_L151_Q1.8361.00
217_F221_Q1.7871.00
290_E310_F1.7681.00
24_A28_K1.7451.00
252_G346_A1.7421.00
250_F257_V1.7381.00
31_D50_T1.7321.00
113_R120_G1.7311.00
280_A283_V1.7101.00
121_V181_L1.7081.00
337_Y352_A1.7011.00
364_A368_K1.6931.00
258_V288_V1.6431.00
244_N248_D1.6421.00
308_I335_A1.6221.00
294_V353_V1.6211.00
356_V362_Y1.6071.00
4_V100_F1.6001.00
337_Y356_V1.5971.00
76_K80_K1.5961.00
295_F307_G1.5951.00
13_G17_P1.5851.00
28_K383_M1.5591.00
151_Q155_D1.5451.00
368_K372_S1.5441.00
229_Y285_Q1.5401.00
273_A279_I1.5391.00
308_I366_I1.5381.00
82_S85_I1.5341.00
230_I250_F1.5291.00
88_I92_L1.5281.00
5_L35_I1.5181.00
91_D95_S1.5121.00
328_Q332_E1.5101.00
334_H365_G1.5081.00
330_L335_A1.5011.00
114_D178_K1.4951.00
87_Q91_D1.4931.00
329_R332_E1.4921.00
186_T191_Q1.4921.00
41_K51_V1.4861.00
170_N173_Q1.4751.00
22_T49_A1.4711.00
144_G147_L1.4601.00
79_I83_L1.4541.00
90_K115_Y1.4471.00
371_Q374_K1.4461.00
359_N362_Y1.4441.00
161_K166_V1.4381.00
6_I102_Y1.4291.00
38_E53_L1.4281.00
249_A349_L1.4241.00
240_E244_N1.4231.00
351_Q355_E1.4111.00
151_Q154_E1.3951.00
91_D94_K1.3911.00
228_I296_I1.3911.00
340_S343_E1.3861.00
82_S108_A1.3851.00
173_Q176_N1.3841.00
30_Y387_D1.3841.00
337_Y362_Y1.3751.00
364_A367_K1.3691.00
355_E362_Y1.3681.00
88_I91_D1.3651.00
367_K371_Q1.3611.00
334_H361_Q1.3591.00
224_D292_S1.3561.00
79_I82_S1.3551.00
103_Y109_G1.3521.00
216_D222_L1.3471.00
145_A151_Q1.3331.00
360_D364_A1.3311.00
220_E291_Q1.3291.00
33_H52_H1.3251.00
149_L152_E1.3151.00
251_S276_N1.3131.00
159_K163_T1.3051.00
144_G152_E1.2991.00
316_V330_L1.2961.00
384_E388_E1.2901.00
150_D154_E1.2751.00
249_A350_K1.2711.00
151_Q157_L1.2691.00
148_E152_E1.2661.00
161_K165_G1.2651.00
346_A350_K1.2641.00
223_K256_K1.2641.00
202_L385_R1.2591.00
80_K83_L1.2531.00
14_H104_D1.2521.00
147_L152_E1.2501.00
18_T34_Y1.2501.00
377_M380_E1.2491.00
345_N348_I1.2471.00
4_V30_Y1.2331.00
368_K371_Q1.2301.00
309_H374_K1.2211.00
225_E256_K1.2171.00
249_A346_A1.2161.00
28_K384_E1.2141.00
6_I18_T1.2131.00
158_A161_K1.2051.00
169_K172_V1.2051.00
245_L248_D1.2001.00
81_T86_L1.1991.00
26_S49_A1.1981.00
249_A353_V1.1951.00
101_V118_I1.1911.00
148_E155_D1.1901.00
4_V25_F1.1751.00
12_E16_N1.1561.00
42_K46_A1.1551.00
227_V294_V1.1531.00
94_K116_L1.1501.00
295_F312_V1.1401.00
144_G151_Q1.1371.00
381_E385_R1.1351.00
247_I277_F1.1291.00
323_Q326_V1.1281.00
339_I352_A1.1271.00
314_L330_L1.1191.00
158_A162_E1.1191.00
226_K293_D1.1191.00
285_Q306_E1.1151.00
248_D251_S1.1141.00
165_G168_P1.1141.00
379_M383_M1.1121.00
5_L98_F1.1111.00
159_K162_E1.1071.00
376_C381_E1.1021.00
311_S370_N1.0981.00
110_E120_G1.0971.00
229_Y260_A1.0941.00
11_A235_V1.0921.00
24_A383_M1.0911.00
145_A152_E1.0911.00
145_A148_E1.0861.00
161_K164_Y1.0831.00
255_G354_D1.0781.00
101_V113_R1.0761.00
219_I222_L1.0761.00
170_N174_F1.0751.00
229_Y292_S1.0711.00
372_S375_E1.0661.00
146_P154_E1.0661.00
146_P150_D1.0651.00
304_V314_L1.0611.00
8_N18_T1.0571.00
216_D220_E1.0551.00
181_L202_L1.0551.00
147_L155_D1.0551.00
314_L336_G1.0471.00
144_G148_E1.0451.00
361_Q365_G1.0431.00
271_K274_P1.0341.00
236_L319_H1.0341.00
90_K94_K1.0321.00
331_S337_Y1.0311.00
385_R388_E1.0311.00
24_A379_M1.0291.00
142_E145_A1.0281.00
381_E384_E1.0261.00
308_I369_I1.0261.00
335_A366_I1.0221.00
171_L174_F1.0211.00
81_T84_D1.0211.00
77_I80_K1.0211.00
227_V256_K1.0201.00
315_V337_Y1.0191.00
100_F121_V1.0191.00
348_I352_A1.0171.00
143_S151_Q1.0161.00
247_I259_I1.0131.00
143_S152_E1.0131.00
78_H82_S1.0111.00
147_L150_D1.0111.00
43_R46_A1.0071.00
143_S147_L1.0061.00
361_Q364_A1.0041.00
58_L61_T0.9981.00
114_D180_E0.9971.00
87_Q90_K0.9921.00
134_L137_L0.9911.00
299_G327_A0.9891.00
6_I25_F0.9841.00
67_S70_G0.9821.00
229_Y288_V0.9781.00
252_G347_Q0.9721.00
149_L153_C0.9711.00
21_I207_S0.9681.00
85_I88_I0.9681.00
161_K167_A0.9641.00
266_D269_K0.9631.00
112_V116_L0.9621.00
348_I351_Q0.9621.00
22_T32_V0.9581.00
42_K45_E0.9571.00
172_V175_M0.9481.00
23_K27_D0.9481.00
33_H96_I0.9391.00
249_A253_F0.9391.00
26_S32_V0.9391.00
92_L95_S0.9391.00
171_L175_M0.9391.00
143_S154_E0.9381.00
72_L76_K0.9371.00
82_S86_L0.9351.00
142_E146_P0.9351.00
380_E384_E0.9331.00
164_Y167_A0.9321.00
145_A149_L0.9251.00
162_E165_G0.9231.00
286_L310_F0.9221.00
121_V389_L0.9211.00
258_V278_I0.9191.00
152_E156_L0.9171.00
229_Y283_V0.9161.00
328_Q331_S0.9161.00
73_D77_I0.9151.00
52_H92_L0.9101.00
225_E254_N0.9091.00
304_V326_V0.9071.00
329_R333_L0.9021.00
73_D76_K0.8991.00
146_P152_E0.8971.00
383_M387_D0.8971.00
146_P151_Q0.8951.00
90_K93_S0.8931.00
255_G357_L0.8931.00
169_K173_Q0.8931.00
268_T271_K0.8921.00
296_I317_M0.8861.00
289_L295_F0.8761.00
254_N276_N0.8761.00
285_Q289_L0.8751.00
80_K84_D0.8741.00
33_H50_T0.8741.00
83_L86_L0.8691.00
255_G358_R0.8671.00
154_E157_L0.8671.00
297_T304_V0.8621.00
38_E41_K0.8611.00
87_Q115_Y0.8561.00
159_K165_G0.8561.00
40_Y43_R0.8541.00
296_I349_L0.8541.00
145_A154_E0.8541.00
228_I255_G0.8531.00
151_Q156_L0.8531.00
362_Y366_I0.8481.00
24_A380_E0.8471.00
312_V363_T0.8451.00
146_P149_L0.8431.00
344_V349_L0.8431.00
60_T64_H0.8421.00
327_A338_V0.8401.00
243_F261_A0.8361.00
217_F220_E0.8321.00
149_L155_D0.8261.00
183_V204_I0.8251.00
253_F350_K0.8241.00
152_E157_L0.8221.00
32_V49_A0.8161.00
81_T85_I0.8161.00
268_T272_Q0.8141.00
147_L154_E0.8121.00
148_E157_L0.8061.00
43_R47_A0.8041.00
148_E154_E0.8001.00
212_A287_E0.7991.00
147_L153_C0.7991.00
172_V176_N0.7961.00
78_H86_L0.7931.00
274_P277_F0.7931.00
284_P287_E0.7921.00
153_C157_L0.7921.00
133_H136_I0.7851.00
187_S376_C0.7781.00
153_C156_L0.7731.00
67_S71_I0.7711.00
103_Y110_E0.7681.00
369_I372_S0.7671.00
246_C250_F0.7651.00
150_D157_L0.7641.00
84_D87_Q0.7641.00
50_T53_L0.7621.00
213_E287_E0.7601.00
145_A150_D0.7561.00
56_D59_R0.7531.00
160_M164_Y0.7531.00
256_K278_I0.7521.00
214_K217_F0.7511.00
19_L23_K0.7491.00
213_E216_D0.7481.00
204_I207_S0.7481.00
181_L385_R0.7441.00
144_G150_D0.7421.00
89_V93_S0.7411.00
7_L109_G0.7411.00
230_I257_V0.7381.00
163_T168_P0.7371.00
144_G154_E0.7371.00
138_P141_P0.7371.00
225_E255_G0.7331.00
77_I82_S0.7311.00
230_I296_I0.7301.00
30_Y99_D0.7271.00
72_L75_V0.7271.00
110_E114_D0.7271.00
13_G302_N0.7261.00
269_K273_A0.7261.00
283_V288_V0.7231.00
76_K79_I0.7231.00
296_I315_V0.7211.00
79_I85_I0.7171.00
245_L249_A0.7161.00
378_D382_V0.7161.00
158_A168_P0.7161.00
143_S148_E0.7151.00
74_F77_I0.7121.00
234_T282_Y0.7121.00
287_E290_E0.7111.00
214_K218_P0.7091.00
231_S295_F0.7021.00
160_M163_T0.6971.00
162_E168_P0.6971.00
362_Y365_G0.6961.00
78_H85_I0.6961.00
366_I370_N0.6961.00
378_D383_M0.6951.00
182_N201_C0.6941.00
145_A155_D0.6921.00
285_Q295_F0.6921.00
10_P14_H0.6921.00
94_K115_Y0.6911.00
35_I89_V0.6891.00
149_L156_L0.6891.00
335_A365_G0.6881.00
78_H83_L0.6851.00
144_G155_D0.6851.00
85_I89_V0.6831.00
239_T242_F0.6821.00
297_T316_V0.6811.00
135_K138_P0.6811.00
123_S207_S0.6801.00
298_H302_N0.6801.00
150_D153_C0.6771.00
20_G23_K0.6771.00
211_R214_K0.6761.00
232_M317_M0.6741.00
245_L344_V0.6741.00
273_A276_N0.6741.00
231_S303_S0.6731.00
226_K255_G0.6711.00
142_E150_D0.6701.00
75_V78_H0.6661.00
260_A285_Q0.6631.00
347_Q351_Q0.6621.00
142_E156_L0.6601.00
148_E153_C0.6581.00
317_M344_V0.6571.00
87_Q92_L0.6561.00
328_Q338_V0.6561.00
322_D326_V0.6551.00
223_K226_K0.6521.00
59_R62_P0.6521.00
142_E151_Q0.6511.00
158_A165_G0.6511.00
160_M166_V0.6501.00
21_I382_V0.6481.00
36_S51_V0.6471.00
160_M165_G0.6471.00
297_T303_S0.6451.00
228_I353_V0.6451.00
302_N306_E0.6451.00
163_T166_V0.6441.00
20_G24_A0.6411.00
106_F321_K0.6411.00
265_A268_T0.6401.00
218_P278_I0.6391.00
234_T323_Q0.6361.00
286_L306_E0.6361.00
190_F333_L0.6361.00
298_H303_S0.6351.00
213_E217_F0.6341.00
273_A277_F0.6321.00
181_L185_Y0.6321.00
142_E148_E0.6311.00
57_L60_T0.6311.00
384_E387_D0.6301.00
285_Q302_N0.6281.00
386_I390_I0.6281.00
142_E152_E0.6271.00
143_S153_C0.6261.00
11_A14_H0.6261.00
143_S155_D0.6251.00
192_P329_R0.6251.00
144_G149_L0.6251.00
251_S254_N0.6251.00
4_V32_V0.6241.00
270_L273_A0.6231.00
297_T307_G0.6211.00
122_S182_N0.6211.00
48_G52_H0.6191.00
308_I373_F0.6191.00
142_E149_L0.6161.00
169_K174_F0.6161.00
327_A336_G0.6141.00
164_Y168_P0.6141.00
41_K44_L0.6141.00
86_L92_L0.6131.00
267_L270_L0.6131.00
248_D272_Q0.6121.00
61_T64_H0.6111.00
59_R63_I0.6091.00
265_A269_K0.6091.00
70_G73_D0.6091.00
251_S275_E0.6091.00
168_P171_L0.6081.00
92_L96_I0.6071.00
78_H81_T0.6061.00
315_V339_I0.6061.00
77_I81_T0.6051.00
324_P327_A0.6051.00
146_P153_C0.6031.00
355_E361_Q0.6011.00
379_M382_V0.6001.00
269_K272_Q0.5991.00
36_S41_K0.5971.00
245_L349_L0.5961.00
13_G16_N0.5951.00
44_L47_A0.5951.00
143_S146_P0.5910.99
20_G209_P0.5880.99
258_V283_V0.5850.99
212_A218_P0.5850.99
128_L191_Q0.5830.99
217_F222_L0.5820.99
313_P363_T0.5810.99
231_S285_Q0.5810.99
57_L61_T0.5800.99
159_K168_P0.5800.99
114_D161_K0.5780.99
133_H137_L0.5760.99
241_D244_N0.5750.99
150_D155_D0.5750.99
191_Q194_S0.5740.99
149_L154_E0.5740.99
83_L163_T0.5730.99
202_L381_E0.5720.99
233_G300_G0.5710.99
18_T123_S0.5690.99
304_V323_Q0.5690.99
230_I246_C0.5680.99
318_P323_Q0.5660.99
351_Q354_D0.5660.99
86_L90_K0.5650.99
147_L156_L0.5640.99
215_T218_P0.5640.99
93_S116_L0.5630.99
17_P302_N0.5630.99
373_F376_C0.5620.99
236_L320_D0.5620.99
333_L369_I0.5610.99
158_A163_T0.5590.99
143_S149_L0.5590.99
87_Q163_T0.5590.99
13_G19_L0.5570.99
189_Y375_E0.5570.99
294_V312_V0.5570.99
229_Y233_G0.5570.99
238_H262_G0.5540.99
242_F246_C0.5530.99
330_L334_H0.5510.99
250_F353_V0.5510.99
157_L161_K0.5500.99
204_I382_V0.5490.99
84_D88_I0.5480.99
387_D390_I0.5470.99
225_E367_K0.5470.99
146_P155_D0.5450.99
44_L51_V0.5440.99
33_H98_F0.5420.99
81_T87_Q0.5420.99
258_V292_S0.5410.99
288_V295_F0.5410.99
222_L278_I0.5400.99
15_V34_Y0.5400.99
318_P327_A0.5370.99
40_Y44_L0.5370.99
112_V115_Y0.5360.99
161_K168_P0.5360.99
162_E167_A0.5350.99
69_N74_F0.5350.99
298_H323_Q0.5340.99
229_Y295_F0.5340.99
282_Y285_Q0.5340.99
120_G180_E0.5310.99
267_L271_K0.5300.99
68_P71_I0.5290.99
236_L321_K0.5290.99
244_N272_Q0.5280.99
74_F82_S0.5280.99
343_E348_I0.5280.99
379_M384_E0.5270.99
71_I78_H0.5270.99
68_P81_T0.5250.99
25_F32_V0.5240.99
74_F78_H0.5240.99
76_K83_L0.5240.99
125_A323_Q0.5230.99
247_I273_A0.5230.99
38_E55_R0.5230.99
136_I139_L0.5230.99
102_Y183_V0.5230.99
321_K324_P0.5230.99
184_V201_C0.5210.99
221_Q278_I0.5190.99
29_G33_H0.5180.99
340_S348_I0.5180.99
145_A153_C0.5160.99
344_V348_I0.5150.99
215_T220_E0.5110.99
89_V92_L0.5100.99
56_D61_T0.5090.99
85_I93_S0.5090.99
228_I357_L0.5090.99
36_S40_Y0.5090.99
218_P280_A0.5090.99
88_I95_S0.5090.99
170_N176_N0.5090.99
254_N354_D0.5080.98
369_I373_F0.5080.98
244_N346_A0.5040.98
216_D219_I0.5000.98
144_G153_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9696 100 0.333 Contact Map
2pq6A 1 0.9544 100 0.341 Contact Map
3rscA 1 0.9899 100 0.346 Contact Map
1rrvA 1 0.9595 100 0.36 Contact Map
2iyfA 1 0.9848 100 0.36 Contact Map
3ia7A 2 0.9848 100 0.365 Contact Map
2p6pA 2 0.9241 100 0.385 Contact Map
2vchA 1 0.957 100 0.387 Contact Map
3hbfA 1 0.9949 100 0.394 Contact Map
2c1xA 1 0.9848 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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