GREMLIN Database
YDHD - Putative sporulation-specific glycosylase YdhD
UniProt: O05495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (329)
Sequences: 1136 (928)
Seq/√Len: 51.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_R228_Q4.2691.00
230_R240_L3.9191.00
230_R234_Q3.3271.00
294_R389_E3.3121.00
197_D201_T3.0311.00
199_V207_V2.9511.00
200_S236_G2.9181.00
179_H218_D2.8261.00
105_F109_R2.8031.00
297_I311_I2.7831.00
358_P376_D2.7401.00
226_L263_I2.6511.00
272_I297_I2.6181.00
387_V395_I2.6021.00
172_G175_T2.5241.00
218_D221_L2.4761.00
242_I267_V2.4601.00
259_D262_G2.4351.00
192_V229_L2.4261.00
375_E383_K2.3391.00
297_I392_L2.2601.00
294_R298_E2.2561.00
242_I263_I2.1971.00
105_F110_N2.1961.00
288_A314_P2.1901.00
301_I306_S2.1801.00
209_I226_L2.1701.00
358_P379_S2.1241.00
331_S341_R2.1161.00
195_I207_V2.1061.00
193_N232_R2.1001.00
199_V238_Y2.0901.00
306_S391_R2.0771.00
210_D273_M2.0641.00
271_F396_G2.0061.00
136_A140_D1.9891.00
163_A167_N1.9841.00
352_S355_Y1.9711.00
319_D370_H1.9380.99
161_P166_T1.9220.99
171_G175_T1.9020.99
189_T232_R1.8940.99
261_G265_A1.8850.99
227_R266_V1.8740.99
381_S385_Q1.8690.99
209_I229_L1.8640.99
189_T228_Q1.8610.99
171_G174_S1.8590.99
285_G288_A1.8260.99
294_R386_I1.7940.99
382_R385_Q1.7720.99
273_M316_Y1.7680.99
244_V300_T1.7610.99
192_V232_R1.7260.99
341_R360_F1.7220.99
161_P167_N1.7100.99
226_L267_V1.6940.99
210_D316_Y1.6890.99
243_A273_M1.6830.98
223_T263_I1.6700.98
264_G270_M1.6700.98
288_A293_I1.6620.98
186_T190_N1.6520.98
223_T262_G1.6350.98
179_H183_N1.6130.98
191_L195_I1.6050.98
275_Y312_G1.5970.98
350_Q359_F1.5940.98
189_T193_N1.5900.98
192_V228_Q1.5790.98
212_E273_M1.5530.97
212_E243_A1.5490.97
102_T105_F1.5460.97
101_G393_Q1.5360.97
240_L267_V1.5260.97
162_L166_T1.5190.97
215_S218_D1.4990.97
133_Y166_T1.4920.97
163_A166_T1.4820.97
164_T167_N1.4790.97
349_I374_F1.4780.97
269_Y393_Q1.4630.96
147_D150_A1.4520.96
321_I370_H1.4410.96
106_Y110_N1.4340.96
350_Q360_F1.4330.96
103_L106_Y1.4150.96
361_R371_E1.4120.95
224_G227_R1.3970.95
175_T218_D1.3910.95
341_R345_Y1.3880.95
106_Y109_R1.3820.95
349_I376_D1.3740.95
317_G372_V1.3720.95
207_V233_L1.3630.94
356_Q382_R1.3560.94
104_S109_R1.3540.94
212_E316_Y1.3410.94
219_R259_D1.3350.94
133_Y202_R1.3280.94
353_A356_Q1.3250.94
181_V191_L1.3190.93
156_Q160_T1.3170.93
351_Y379_S1.3050.93
228_Q232_R1.2930.93
264_G305_P1.2920.93
337_N340_E1.2780.92
159_V162_L1.2770.92
157_R161_P1.2680.92
263_I267_V1.2580.92
212_E275_Y1.2390.91
336_Q339_I1.2370.91
294_R390_Y1.2350.91
243_A275_Y1.2290.91
244_V270_M1.2270.91
286_P357_S1.1880.89
161_P165_I1.1850.89
161_P164_T1.1830.89
182_L225_F1.1710.89
317_G374_F1.1670.88
104_S107_V1.1640.88
301_I392_L1.1580.88
165_I168_L1.1560.88
180_Q187_A1.1560.88
298_E390_Y1.1480.88
220_D262_G1.1450.87
160_T165_I1.1400.87
305_P308_K1.1400.87
183_N221_L1.1380.87
297_I301_I1.1340.87
193_N197_D1.1340.87
163_A205_G1.1340.87
376_D379_S1.1340.87
321_I368_R1.1320.87
105_F108_L1.1300.87
188_R221_L1.1290.87
311_I392_L1.1250.86
157_R162_L1.1250.86
126_S269_Y1.1170.86
351_Y356_Q1.1160.86
380_M397_A1.1120.86
223_T242_I1.1040.85
140_D194_N1.0920.85
277_W289_P1.0910.85
227_R231_D1.0900.85
220_D223_T1.0880.85
310_I393_Q1.0780.84
145_L151_I1.0750.84
245_P258_Y1.0700.84
234_Q268_N1.0660.83
156_Q159_V1.0650.83
157_R160_T1.0550.83
135_I181_V1.0470.82
188_R224_G1.0460.82
225_F229_L1.0440.82
175_T213_Q1.0420.82
226_L242_I1.0400.82
245_P255_L1.0370.82
207_V261_G1.0270.81
147_D151_I1.0260.81
206_G313_V1.0200.81
200_S238_Y1.0170.80
207_V229_L1.0150.80
311_I387_V1.0100.80
340_E343_M1.0070.80
148_A152_E1.0020.79
131_F167_N0.9970.79
226_L266_V0.9950.79
230_R266_V0.9940.79
185_P228_Q0.9900.78
286_P289_P0.9890.78
210_D243_A0.9830.78
315_L397_A0.9790.78
220_D224_G0.9690.77
210_D275_Y0.9680.77
292_E295_R0.9540.76
178_V214_V0.9490.75
227_R265_A0.9450.75
100_A388_R0.9410.75
385_Q388_R0.9390.75
397_A407_G0.9370.75
300_T309_I0.9350.74
276_D316_Y0.9350.74
163_A169_T0.9340.74
260_Y304_V0.9320.74
162_L168_L0.9310.74
190_N194_N0.9290.74
184_N187_A0.9270.74
399_Q402_L0.9260.74
162_L167_N0.9230.73
85_Q88_A0.9220.73
313_V380_M0.9190.73
108_L111_P0.9130.73
159_V167_N0.9100.72
100_A105_F0.9090.72
241_T269_Y0.9090.72
127_S165_I0.9060.72
112_D128_I0.8980.71
278_H282_S0.8960.71
195_I225_F0.8940.71
94_S307_R0.8920.71
160_T167_N0.8870.70
208_T271_F0.8860.70
319_D372_V0.8850.70
150_A153_T0.8810.70
358_P362_Y0.8780.70
183_N224_G0.8770.70
287_V318_Y0.8590.68
327_G332_A0.8530.67
262_G266_V0.8510.67
317_G338_A0.8490.67
142_A145_L0.8460.67
195_I229_L0.8450.67
155_W160_T0.8450.67
357_S383_K0.8400.66
245_P296_T0.8370.66
278_H285_G0.8330.66
183_N218_D0.8320.65
254_W280_A0.8320.65
284_P289_P0.8320.65
262_G265_A0.8310.65
73_R80_S0.8310.65
223_T259_D0.8300.65
75_A79_I0.8290.65
327_G331_S0.8280.65
171_G213_Q0.8250.65
208_T243_A0.8240.65
157_R203_G0.8210.64
310_I363_S0.8180.64
122_A162_L0.8130.64
179_H221_L0.8120.64
227_R262_G0.8080.63
73_R81_P0.8060.63
375_E379_S0.8050.63
101_G105_F0.8050.63
306_S392_L0.8040.63
351_Y358_P0.8040.63
140_D190_N0.8030.63
313_V387_V0.8010.62
284_P288_A0.8010.62
288_A313_V0.7970.62
73_R79_I0.7950.62
206_G317_G0.7940.62
149_A153_T0.7930.62
84_L89_K0.7890.61
244_V260_Y0.7850.61
132_E167_N0.7810.61
333_I372_V0.7790.60
125_S339_I0.7700.59
74_A77_P0.7690.59
226_L268_N0.7670.59
213_Q273_M0.7650.59
176_E240_L0.7630.59
351_Y382_R0.7630.59
160_T164_T0.7610.59
104_S110_N0.7600.58
129_S271_F0.7590.58
110_N113_L0.7590.58
272_I309_I0.7590.58
193_N228_Q0.7560.58
161_P168_L0.7550.58
158_R164_T0.7550.58
349_I378_R0.7510.57
260_Y264_G0.7500.57
338_A342_A0.7490.57
215_S238_Y0.7470.57
155_W161_P0.7460.57
159_V164_T0.7460.57
327_G335_N0.7440.57
203_G346_Q0.7380.56
285_G289_P0.7370.56
196_Y199_V0.7370.56
362_Y370_H0.7370.56
272_I311_I0.7360.56
375_E380_M0.7350.56
162_L165_I0.7350.56
243_A312_G0.7330.56
176_E215_S0.7330.56
208_T214_V0.7300.55
157_R166_T0.7290.55
87_G92_I0.7270.55
331_S337_N0.7270.55
181_V192_V0.7260.55
136_A184_N0.7250.55
165_I317_G0.7250.55
135_I211_F0.7240.55
255_L276_D0.7210.54
297_I304_V0.7210.54
133_Y204_Y0.7170.54
208_T241_T0.7150.54
349_I360_F0.7150.54
159_V166_T0.7150.54
83_A88_A0.7140.54
301_I390_Y0.7130.54
155_W159_V0.7120.54
129_S167_N0.7110.53
254_W258_Y0.7100.53
163_A168_L0.7100.53
260_Y300_T0.7050.53
243_A255_L0.7030.53
363_S370_H0.7030.53
275_Y398_W0.6980.52
360_F372_V0.6980.52
213_Q243_A0.6980.52
265_A307_R0.6930.52
301_I304_V0.6930.52
213_Q254_W0.6930.52
82_N85_Q0.6910.51
334_S402_L0.6890.51
195_I209_I0.6890.51
164_T169_T0.6850.51
342_A345_Y0.6840.51
80_S85_Q0.6830.50
361_R369_T0.6780.50
208_T212_E0.6780.50
191_L209_I0.6780.50
164_T168_L0.6780.50
222_F258_Y0.6750.50
196_Y232_R0.6730.49
145_L148_A0.6730.49
246_A276_D0.6720.49
213_Q255_L0.6690.49
313_V384_M0.6670.49
106_Y128_I0.6660.49
168_L402_L0.6640.49
342_A349_I0.6630.48
192_V196_Y0.6630.48
178_V182_L0.6620.48
267_V270_M0.6620.48
299_F302_A0.6610.48
335_N338_A0.6600.48
342_A346_Q0.6600.48
162_L169_T0.6600.48
158_R161_P0.6600.48
102_T395_I0.6590.48
73_R83_A0.6570.48
312_G316_Y0.6560.48
180_Q184_N0.6540.47
77_P80_S0.6500.47
337_N403_G0.6480.47
139_G181_V0.6470.47
235_A306_S0.6460.47
343_M346_Q0.6450.47
319_D322_I0.6440.46
181_V187_A0.6430.46
264_G308_K0.6430.46
148_A151_I0.6410.46
275_Y316_Y0.6390.46
254_W274_A0.6390.46
86_A89_K0.6380.46
384_M388_R0.6380.46
339_I404_F0.6360.46
97_N391_R0.6360.46
342_A360_F0.6350.46
178_V211_F0.6340.45
351_Y378_R0.6330.45
102_T106_Y0.6310.45
175_T215_S0.6310.45
75_A81_P0.6310.45
118_I202_R0.6290.45
285_G292_E0.6260.45
273_M398_W0.6250.45
189_T192_V0.6240.44
206_G394_A0.6240.44
191_L196_Y0.6240.44
77_P83_A0.6230.44
175_T279_H0.6220.44
288_A395_I0.6200.44
109_R233_L0.6200.44
289_P293_I0.6170.44
86_A90_I0.6140.43
107_V111_P0.6130.43
77_P85_Q0.6120.43
222_F309_I0.6090.43
348_P353_A0.6090.43
208_T213_Q0.6090.43
277_W293_I0.6090.43
355_Y359_F0.6070.43
216_A257_G0.6060.43
129_S132_E0.6040.42
326_P329_V0.6000.42
325_Q368_R0.5980.42
140_D221_L0.5960.42
231_D235_A0.5950.41
254_W277_W0.5940.41
83_A86_A0.5900.41
181_V184_N0.5860.41
258_Y263_I0.5850.40
158_R165_I0.5840.40
242_I270_M0.5840.40
196_Y238_Y0.5840.40
169_T172_G0.5840.40
220_D227_R0.5840.40
332_A337_N0.5820.40
333_I345_Y0.5810.40
233_L238_Y0.5810.40
146_N152_E0.5810.40
77_P89_K0.5810.40
135_I381_S0.5790.40
109_R113_L0.5790.40
356_Q386_I0.5770.40
115_R400_L0.5770.40
309_I377_V0.5770.40
171_G208_T0.5760.40
286_P291_T0.5750.39
107_V110_N0.5730.39
104_S108_L0.5710.39
339_I342_A0.5680.39
137_P169_T0.5660.39
331_S345_Y0.5650.38
287_V373_W0.5650.38
334_S338_A0.5630.38
125_S355_Y0.5630.38
193_N196_Y0.5620.38
219_R223_T0.5620.38
196_Y240_L0.5620.38
213_Q245_P0.5620.38
291_T294_R0.5610.38
350_Q361_R0.5600.38
221_L224_G0.5600.38
132_E276_D0.5590.38
195_I240_L0.5570.38
330_A334_S0.5570.38
106_Y243_A0.5560.38
287_V314_P0.5560.38
223_T261_G0.5550.37
318_Y332_A0.5550.37
105_F111_P0.5540.37
381_S388_R0.5530.37
241_T393_Q0.5530.37
329_V334_S0.5520.37
285_G355_Y0.5510.37
73_R82_N0.5510.37
285_G291_T0.5500.37
314_P396_G0.5490.37
106_Y113_L0.5480.37
327_G346_Q0.5480.37
117_L120_D0.5480.37
123_P267_V0.5460.37
126_S393_Q0.5460.37
197_D200_S0.5450.37
212_E398_W0.5450.37
213_Q253_P0.5450.37
256_R278_H0.5450.37
307_R393_Q0.5440.36
315_L380_M0.5430.36
160_T163_A0.5430.36
166_T314_P0.5420.36
199_V246_A0.5400.36
135_I191_L0.5380.36
193_N306_S0.5370.36
87_G90_I0.5330.35
284_P324_Y0.5330.35
77_P307_R0.5320.35
293_I311_I0.5320.35
299_F303_Q0.5300.35
196_Y233_L0.5300.35
304_V398_W0.5290.35
332_A402_L0.5290.35
289_P317_G0.5290.35
386_I390_Y0.5290.35
211_F225_F0.5280.35
297_I306_S0.5270.35
171_G234_Q0.5270.35
75_A93_P0.5270.35
377_V380_M0.5250.35
75_A88_A0.5240.35
217_A265_A0.5240.35
81_P91_T0.5230.34
139_G142_A0.5200.34
258_Y278_H0.5200.34
263_I266_V0.5200.34
117_L131_F0.5200.34
223_T266_V0.5190.34
230_R396_G0.5180.34
128_I400_L0.5170.34
196_Y215_S0.5150.34
119_N185_P0.5140.34
157_R164_T0.5130.34
219_R257_G0.5130.34
166_T169_T0.5120.33
98_Y102_T0.5120.33
184_N353_A0.5120.33
213_Q256_R0.5110.33
189_T297_I0.5090.33
293_I298_E0.5090.33
141_I144_Q0.5080.33
248_T254_W0.5060.33
298_E353_A0.5060.33
297_I309_I0.5020.32
181_V223_T0.5010.32
126_S321_I0.5010.32
234_Q240_L0.5010.32
116_E119_N0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cz8A 2 0.719 100 0.428 Contact Map
3w4rA 1 0.7452 100 0.435 Contact Map
1wb0A 2 0.731 100 0.447 Contact Map
3fy1A 1 0.7405 100 0.447 Contact Map
1itxA 1 0.7595 100 0.448 Contact Map
4wkaA 1 0.7357 100 0.45 Contact Map
1vf8A 1 0.7381 100 0.45 Contact Map
4q6tA 1 0.731 100 0.451 Contact Map
4wiwA 1 0.7476 100 0.453 Contact Map
1goiA 2 0.75 100 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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