GREMLIN Database
2NPD - Probable nitronate monooxygenase
UniProt: O05413 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (305)
Sequences: 5733 (3512)
Seq/√Len: 201.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_C336_L4.9561.00
251_Q255_E3.2291.00
27_R57_E3.0591.00
247_P251_Q3.0141.00
241_H332_S2.9431.00
220_V340_L2.9181.00
15_I209_I2.8801.00
52_E119_K2.8131.00
331_I339_Q2.7811.00
56_K120_Y2.7651.00
276_V281_E2.6891.00
52_E120_Y2.6501.00
170_L200_A2.6451.00
30_S61_L2.4111.00
40_S67_Q2.4061.00
115_D119_K2.3921.00
32_V37_A2.3511.00
237_F337_L2.3141.00
134_E138_K2.2831.00
37_A337_L2.2691.00
331_I336_L2.2531.00
138_K142_T2.1671.00
220_V231_V2.1481.00
216_D219_G2.1291.00
334_K338_N2.1111.00
202_D218_R2.0721.00
217_H343_E2.0611.00
161_E205_S2.0531.00
26_P54_Q1.9941.00
201_A208_V1.9621.00
148_I167_I1.9471.00
193_L197_I1.9221.00
239_I254_L1.8911.00
217_H221_K1.8851.00
29_A58_I1.8741.00
52_E56_K1.8711.00
312_N315_Q1.8341.00
238_L245_A1.8031.00
262_K280_M1.7811.00
167_I209_I1.7801.00
278_K282_E1.7671.00
50_L53_Q1.7631.00
254_L330_E1.7541.00
38_L124_A1.7441.00
223_A231_V1.7351.00
125_C140_L1.7331.00
28_L333_V1.7281.00
335_Q338_N1.6831.00
215_I323_G1.6651.00
116_L120_Y1.6621.00
221_K225_T1.6481.00
57_E61_L1.6261.00
115_D139_E1.6181.00
239_I327_L1.6151.00
16_Q32_V1.5921.00
30_S58_I1.5791.00
209_I230_G1.5741.00
201_A229_Q1.5741.00
158_L203_A1.5621.00
214_M223_A1.5551.00
256_A324_I1.5521.00
55_I120_Y1.4911.00
11_T341_C1.4881.00
30_S34_N1.4871.00
241_H331_I1.4851.00
339_Q343_E1.4791.00
158_L162_E1.4581.00
233_I340_L1.4461.00
11_T64_A1.4451.00
12_K341_C1.4441.00
161_E206_V1.4311.00
158_L161_E1.4301.00
151_A160_M1.4241.00
151_A168_V1.4051.00
332_S335_Q1.4041.00
338_N342_Q1.4031.00
192_G195_A1.3971.00
34_N61_L1.3941.00
220_V233_I1.3881.00
25_K244_N1.3831.00
329_E339_Q1.3641.00
118_L139_E1.3591.00
23_I245_A1.3541.00
262_K276_V1.3331.00
159_L162_E1.3301.00
48_P116_L1.3241.00
149_G165_M1.3201.00
118_L143_A1.3131.00
117_I125_C1.3031.00
49_D53_Q1.3011.00
157_A200_A1.2991.00
257_N260_D1.2721.00
112_Q115_D1.2721.00
194_M222_A1.2721.00
54_Q57_E1.2681.00
23_I238_L1.2631.00
256_A275_I1.2621.00
200_A204_L1.2511.00
141_K147_L1.2501.00
15_I40_S1.2401.00
47_T50_L1.2371.00
219_G326_S1.2351.00
278_K314_D1.2291.00
116_L119_K1.2271.00
53_Q57_E1.2261.00
34_N62_T1.2241.00
214_M231_V1.2191.00
139_E142_T1.2091.00
241_H330_E1.2021.00
241_H335_Q1.1951.00
245_A250_K1.1901.00
147_L165_M1.1891.00
233_I237_F1.1841.00
210_A223_A1.1801.00
154_V158_L1.1801.00
31_A35_Q1.1801.00
154_V203_A1.1701.00
14_I337_L1.1681.00
155_E158_L1.1631.00
59_F120_Y1.1511.00
46_L54_Q1.1471.00
43_S51_L1.1471.00
297_N301_K1.1341.00
192_G322_Q1.1241.00
214_M220_V1.1211.00
331_I335_Q1.1181.00
198_P201_A1.1171.00
198_P226_L1.1061.00
24_T29_A1.1061.00
17_A171_Q1.1031.00
248_V251_Q1.1031.00
109_D112_Q1.0781.00
256_A260_D1.0771.00
146_C167_I1.0741.00
278_K281_E1.0731.00
320_A324_I1.0711.00
195_A198_P1.0701.00
31_A34_N1.0691.00
16_Q237_F1.0681.00
10_L38_L1.0681.00
56_K60_E1.0581.00
32_V333_V1.0581.00
137_V141_K1.0551.00
154_V200_A1.0481.00
168_V204_L1.0401.00
138_K141_K1.0391.00
200_A203_A1.0371.00
198_P203_A1.0251.00
140_L145_C1.0211.00
160_M165_M1.0211.00
66_F123_K1.0181.00
124_A148_I1.0161.00
242_E332_S1.0091.00
297_N300_T1.0091.00
148_I169_V1.0081.00
34_N64_A1.0071.00
240_C332_S1.0011.00
26_P30_S0.9971.00
152_S156_E0.9951.00
219_G222_A0.9931.00
16_Q24_T0.9931.00
198_P216_D0.9901.00
215_I233_I0.9841.00
276_V280_M0.9791.00
153_T156_E0.9781.00
11_T338_N0.9761.00
131_L163_R0.9721.00
29_A41_L0.9710.99
141_K166_D0.9690.99
233_I236_A0.9690.99
193_L200_A0.9680.99
26_P58_I0.9680.99
33_S64_A0.9670.99
238_L253_I0.9600.99
154_V199_Q0.9570.99
52_E116_L0.9530.99
135_D138_K0.9520.99
19_M23_I0.9490.99
114_I136_A0.9490.99
161_E203_A0.9480.99
28_L237_F0.9370.99
276_V284_E0.9360.99
198_P218_R0.9340.99
302_A306_K0.9320.99
149_G160_M0.9310.99
306_K310_Q0.9280.99
58_I61_L0.9280.99
111_Y115_D0.9280.99
195_A322_Q0.9270.99
262_K284_E0.9210.99
27_R241_H0.9110.99
55_I59_F0.9110.99
196_L200_A0.9100.99
102_S105_E0.9100.99
209_I232_Q0.9080.99
15_I38_L0.9080.99
293_Y297_N0.9070.99
114_I118_L0.9070.99
170_L208_V0.9040.99
14_I341_C0.9040.99
111_Y139_E0.9030.99
274_G280_M0.9010.99
335_Q339_Q0.9010.99
258_E325_R0.9000.99
291_L295_Y0.8980.99
69_N73_P0.8960.99
137_V147_L0.8940.99
170_L210_A0.8940.99
293_Y299_L0.8940.99
34_N334_K0.8880.99
267_F279_W0.8860.99
76_L79_P0.8860.99
221_K224_L0.8840.99
199_Q203_A0.8840.99
51_L68_I0.8790.99
233_I336_L0.8760.99
236_A331_I0.8720.99
161_E204_L0.8680.99
220_V336_L0.8680.99
194_M223_A0.8650.99
193_L196_L0.8640.99
57_E60_E0.8620.99
197_I201_A0.8620.99
263_L271_E0.8600.99
27_R61_L0.8570.99
267_F277_N0.8520.99
193_L210_A0.8510.99
296_Q300_T0.8510.99
29_A33_S0.8490.99
148_I209_I0.8480.99
53_Q56_K0.8460.99
200_A208_V0.8420.99
134_E163_R0.8370.98
26_P57_E0.8370.98
252_K255_E0.8300.98
101_T104_Q0.8260.98
282_E285_Q0.8260.98
287_E290_T0.8220.98
124_A167_I0.8210.98
170_L197_I0.8190.98
121_K145_C0.8170.98
169_V230_G0.8100.98
40_S101_T0.8080.98
280_M284_E0.8030.98
245_A249_H0.8030.98
272_A319_W0.8030.98
222_A226_L0.8010.98
239_I330_E0.8010.98
252_K275_I0.7990.98
174_E322_Q0.7970.98
279_W283_N0.7930.98
115_D118_L0.7920.98
197_I208_V0.7910.98
235_S320_A0.7900.98
51_L55_I0.7880.98
150_T180_G0.7870.98
215_I219_G0.7800.98
40_S126_S0.7780.98
268_S297_N0.7760.98
114_I140_L0.7750.98
33_S39_G0.7730.97
59_F66_F0.7690.97
264_T268_S0.7670.97
139_E143_A0.7620.97
252_K256_A0.7590.97
18_P40_S0.7580.97
255_E258_E0.7550.97
154_V204_L0.7550.97
294_P297_N0.7530.97
336_L339_Q0.7500.97
298_T301_K0.7450.97
204_L208_V0.7440.97
157_A197_I0.7400.97
195_A222_A0.7380.97
34_N63_D0.7280.96
292_P295_Y0.7260.96
110_F114_I0.7260.96
215_I326_S0.7260.96
35_Q334_K0.7210.96
131_L149_G0.7190.96
18_P42_A0.7160.96
117_I140_L0.7160.96
136_A140_L0.7130.96
44_G71_F0.7100.96
55_I68_I0.7050.96
216_D326_S0.7040.96
236_A336_L0.7040.96
117_I121_K0.7020.96
58_I66_F0.6980.95
137_V165_M0.6960.95
239_I250_K0.6940.95
173_S263_L0.6930.95
201_A226_L0.6930.95
160_M168_V0.6920.95
111_Y135_D0.6910.95
33_S62_T0.6900.95
106_E109_D0.6860.95
128_T150_T0.6830.95
41_L54_Q0.6830.95
261_T273_R0.6820.95
31_A334_K0.6810.95
118_L122_V0.6810.95
101_T108_D0.6800.95
333_V337_L0.6730.94
240_C331_I0.6720.94
72_V76_L0.6660.94
214_M219_G0.6660.94
293_Y296_Q0.6660.94
58_I62_T0.6650.94
15_I230_G0.6650.94
112_Q116_L0.6640.94
337_L341_C0.6620.94
33_S38_L0.6580.94
248_V313_H0.6580.94
292_P296_Q0.6560.94
28_L32_V0.6550.94
8_F167_I0.6540.94
201_A204_L0.6530.94
30_S57_E0.6490.93
113_K116_L0.6460.93
202_D216_D0.6410.93
118_L140_L0.6400.93
198_P202_D0.6390.93
55_I66_F0.6380.93
74_L78_M0.6380.93
281_E285_Q0.6360.93
67_Q124_A0.6340.93
29_A66_F0.6330.92
168_V206_V0.6320.92
308_S311_N0.6300.92
14_I37_A0.6260.92
201_A205_S0.6250.92
102_S107_W0.6240.92
50_L54_Q0.6210.92
296_Q299_L0.6210.92
159_L163_R0.6200.92
219_G226_L0.6190.92
123_K145_C0.6180.92
103_V107_W0.6170.91
323_G326_S0.6160.91
286_F291_L0.6160.91
33_S58_I0.6130.91
20_A319_W0.6130.91
8_F146_C0.6120.91
106_E110_F0.6120.91
198_P219_G0.6110.91
157_A168_V0.6100.91
247_P250_K0.6080.91
268_S272_A0.6070.91
247_P330_E0.6050.91
101_T105_E0.6010.90
15_I232_Q0.5990.90
102_S106_E0.5980.90
70_V117_I0.5980.90
293_Y298_T0.5970.90
329_E335_Q0.5970.90
158_L204_L0.5960.90
70_V73_P0.5950.90
104_Q107_W0.5940.90
173_S190_A0.5940.90
246_H249_H0.5900.90
123_K146_C0.5900.90
211_A232_Q0.5900.90
291_L296_Q0.5900.90
201_A223_A0.5900.90
155_E159_L0.5890.90
16_Q37_A0.5850.89
291_L294_P0.5830.89
129_F171_Q0.5830.89
101_T107_W0.5810.89
222_A322_Q0.5790.89
110_F113_K0.5780.89
275_I320_A0.5770.89
46_L50_L0.5770.89
290_T296_Q0.5760.88
278_K315_Q0.5750.88
10_L146_C0.5750.88
131_L134_E0.5750.88
306_K309_L0.5740.88
284_E287_E0.5730.88
255_E260_D0.5720.88
41_L46_L0.5710.88
195_A199_Q0.5700.88
16_Q39_G0.5700.88
108_D112_Q0.5690.88
156_E159_L0.5690.88
43_S46_L0.5640.87
217_H220_V0.5630.87
20_A42_A0.5630.87
171_Q175_A0.5630.87
30_S62_T0.5610.87
35_Q337_L0.5600.87
193_L199_Q0.5600.87
194_M226_L0.5590.87
191_V195_A0.5570.87
265_T271_E0.5560.87
192_G219_G0.5540.86
193_L203_A0.5540.86
192_G196_L0.5540.86
151_A156_E0.5530.86
220_V224_L0.5530.86
197_I210_A0.5520.86
62_T66_F0.5510.86
196_L199_Q0.5500.86
300_T304_R0.5470.86
161_E165_M0.5470.86
128_T149_G0.5460.86
15_I126_S0.5440.85
199_Q202_D0.5430.85
313_H318_L0.5400.85
260_D276_V0.5390.85
20_A44_G0.5390.85
21_G319_W0.5390.85
252_K277_N0.5380.85
33_S40_S0.5370.85
274_G317_S0.5370.85
31_A332_S0.5370.85
263_L266_L0.5370.85
293_Y300_T0.5360.85
10_L37_A0.5360.85
295_Y298_T0.5360.85
191_V196_L0.5360.85
107_W113_K0.5330.84
170_L193_L0.5320.84
195_A323_G0.5310.84
73_P76_L0.5300.84
249_H324_I0.5300.84
126_S232_Q0.5300.84
10_L124_A0.5280.84
313_H316_M0.5260.84
52_E59_F0.5260.84
241_H329_E0.5210.83
140_L143_A0.5200.83
249_H318_L0.5190.83
103_V106_E0.5180.83
333_V338_N0.5180.83
290_T293_Y0.5160.82
216_D236_A0.5160.82
102_S108_D0.5150.82
49_D52_E0.5150.82
59_F123_K0.5140.82
174_E192_G0.5140.82
175_A180_G0.5130.82
136_A139_E0.5120.82
339_Q342_Q0.5120.82
277_N318_L0.5100.82
44_G293_Y0.5080.81
27_R244_N0.5070.81
14_I224_L0.5060.81
26_P41_L0.5060.81
274_G319_W0.5040.81
240_C250_K0.5040.81
191_V322_Q0.5030.81
105_E109_D0.5030.81
264_T267_F0.5030.81
45_Y300_T0.5030.81
338_N341_C0.5020.81
132_P136_A0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2uvaG 3 0.8934 100 0.323 Contact Map
2uv8G 3 0.8963 100 0.328 Contact Map
4qitA 2 0.9856 100 0.333 Contact Map
3bw2A 2 0.9712 100 0.337 Contact Map
2gjlA 2 0.8905 100 0.361 Contact Map
4iqlA 2 0.8732 100 0.368 Contact Map
3bo9A 2 0.8674 100 0.37 Contact Map
4cw5A 2 0.9135 100 0.374 Contact Map
2z6iA 2 0.8732 100 0.392 Contact Map
3zenD 6 0.8674 100 0.415 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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