GREMLIN Database
MURI2 - Glutamate racemase 2
UniProt: O05412 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (244)
Sequences: 3741 (2533)
Seq/√Len: 162.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_F19_A3.6621.00
31_Y235_S3.4031.00
160_I194_K3.3681.00
65_A213_L3.1711.00
52_F84_N2.8801.00
18_E21_K2.7951.00
36_N50_Y2.6841.00
16_L28_Y2.6781.00
63_I66_L2.6021.00
57_F233_F2.5281.00
109_R136_L2.4251.00
27_D228_G2.4081.00
26_E64_K2.3861.00
212_Q215_K2.3621.00
189_K193_E2.3101.00
125_H139_C2.2861.00
55_A66_L2.2571.00
149_A188_F2.2201.00
61_Q231_T2.1801.00
109_R138_D2.1551.00
2_K64_K2.1371.00
145_L163_L2.1161.00
19_A28_Y2.0531.00
22_V214_K2.0281.00
57_F61_Q1.9711.00
114_A119_L1.9211.00
119_L139_C1.8251.00
19_A213_L1.8031.00
56_E84_N1.7971.00
67_V213_L1.7681.00
116_N120_K1.7631.00
78_I91_G1.7211.00
113_V178_I1.7091.00
108_K132_D1.6551.00
153_D156_E1.6491.00
160_I191_S1.6421.00
68_I78_I1.6381.00
2_K26_E1.6111.00
178_I196_F1.6011.00
140_L166_E1.5971.00
36_N53_N1.5721.00
48_K80_D1.5661.00
111_L175_Y1.5621.00
20_I230_I1.5561.00
18_E207_V1.5281.00
109_R174_Q1.5241.00
85_F89_I1.5181.00
140_L169_S1.5091.00
47_V117_L1.5061.00
111_L170_F1.5021.00
56_E85_F1.4791.00
192_F202_M1.4691.00
59_A87_F1.4591.00
122_E125_H1.4361.00
31_Y54_A1.4291.00
50_Y53_N1.4251.00
49_E53_N1.4251.00
189_K204_S1.4171.00
5_F16_L1.4091.00
186_P206_S1.4071.00
171_D196_F1.3911.00
90_I216_V1.3911.00
97_K212_Q1.3901.00
164_K168_S1.3851.00
52_F80_D1.3611.00
122_E139_C1.3601.00
46_K50_Y1.3601.00
16_L230_I1.3551.00
146_V185_F1.3501.00
112_V137_V1.3471.00
144_G147_E1.3451.00
44_K76_I1.3441.00
19_A67_V1.3441.00
123_K127_L1.3311.00
196_F200_V1.3291.00
163_L195_L1.3141.00
153_D158_K1.3071.00
144_G165_N1.2941.00
125_H129_K1.2771.00
193_E202_M1.2611.00
168_S172_L1.2521.00
55_A81_L1.2501.00
156_E159_I1.2421.00
128_V137_V1.2311.00
42_K50_Y1.2261.00
216_V220_R1.2051.00
4_G63_I1.2031.00
14_T187_F1.1941.00
148_F159_I1.1891.00
96_V128_V1.1811.00
34_T234_N1.1791.00
160_I195_L1.1741.00
207_V211_K1.1651.00
68_I81_L1.1651.00
122_E126_N1.1531.00
65_A90_I1.1511.00
41_E116_N1.1471.00
19_A210_A1.1421.00
64_K222_Q1.1411.00
43_S46_K1.1361.00
189_K202_M1.1351.00
66_L87_F1.1341.00
20_I28_Y1.1291.00
124_F139_C1.1191.00
126_N130_E1.1191.00
119_L141_A1.1151.00
163_L166_E1.1061.00
42_K46_K1.1041.00
16_L19_A1.0991.00
46_K49_E1.0961.00
76_I117_L1.0931.00
242_Q246_S1.0931.00
147_E185_F1.0911.00
3_I26_E1.0840.99
160_I164_K1.0750.99
157_D161_K1.0740.99
15_V209_T1.0700.99
214_K218_A1.0610.99
108_K134_H1.0600.99
107_R176_G1.0570.99
212_Q216_V1.0510.99
164_K195_L1.0440.99
144_G185_F1.0330.99
18_E206_S1.0310.99
98_P208_G1.0210.99
191_S194_K1.0180.99
138_D173_K1.0130.99
111_L178_I1.0060.99
61_Q233_F1.0040.99
22_V211_K1.0000.99
23_L214_K0.9980.99
80_D84_N0.9980.99
156_E160_I0.9960.99
177_T203_I0.9960.99
96_V127_L0.9950.99
177_T201_D0.9940.99
126_N129_K0.9920.99
102_K201_D0.9870.99
78_I82_R0.9870.99
205_G208_G0.9860.99
218_A223_L0.9830.99
81_L89_I0.9830.99
193_E198_I0.9830.99
107_R177_T0.9810.99
98_P101_N0.9790.99
142_L185_F0.9740.99
109_R175_Y0.9710.99
74_T91_G0.9620.99
67_V90_I0.9550.99
50_Y54_A0.9550.99
144_G162_Y0.9520.99
163_L191_S0.9500.99
82_R127_L0.9460.99
27_D226_G0.9370.99
161_K164_K0.9360.99
55_A89_I0.9330.98
51_I73_A0.9320.98
215_K219_D0.9300.98
47_V51_I0.9230.98
26_E222_Q0.9200.98
110_V135_D0.9120.98
163_L192_F0.9110.98
51_I54_A0.9080.98
149_A159_I0.9060.98
27_D224_G0.9050.98
44_K48_K0.9050.98
18_E210_A0.8940.98
192_F195_L0.8930.98
2_K27_D0.8900.98
45_G49_E0.8870.98
128_V179_V0.8870.98
27_D229_S0.8830.98
14_T186_P0.8820.98
149_A185_F0.8710.98
56_E60_S0.8600.97
116_N141_A0.8590.97
241_D245_I0.8580.97
162_Y166_E0.8580.97
197_G200_V0.8570.97
41_E117_L0.8550.97
144_G166_E0.8540.97
74_T78_I0.8490.97
30_F34_T0.8480.97
6_F54_A0.8450.97
41_E185_F0.8440.97
178_I202_M0.8360.97
196_F202_M0.8350.97
59_A85_F0.8250.97
37_V234_N0.8210.97
95_A205_G0.8200.97
64_K217_L0.8180.97
4_G58_L0.8170.96
23_L26_E0.8170.96
55_A77_A0.8160.96
124_F128_V0.8090.96
90_I213_L0.8070.96
74_T93_E0.8050.96
34_T37_V0.7980.96
95_A99_A0.7950.96
22_V210_A0.7930.96
158_K162_Y0.7850.96
112_V119_L0.7820.96
239_I243_E0.7800.95
16_L20_I0.7770.95
17_Y21_K0.7770.95
6_F55_A0.7700.95
127_L130_E0.7700.95
190_N193_E0.7690.95
159_I191_S0.7670.95
79_E83_R0.7600.95
93_E127_L0.7570.95
95_A98_P0.7570.95
146_V150_E0.7540.95
245_I248_Y0.7420.94
36_N42_K0.7420.94
92_I209_T0.7400.94
72_T115_T0.7340.94
10_I244_V0.7310.94
98_P102_K0.7250.93
77_A81_L0.7240.93
81_L85_F0.7200.93
80_D83_R0.7200.93
29_I233_F0.7180.93
113_V192_F0.7150.93
97_K131_I0.7080.92
59_A89_I0.7070.92
36_N46_K0.7070.92
159_I188_F0.7060.92
78_I93_E0.7050.92
187_F248_Y0.7050.92
148_F162_Y0.7030.92
175_Y196_F0.7030.92
96_V124_F0.7020.92
26_E217_L0.7020.92
5_F210_A0.7010.92
208_G211_K0.6970.92
29_I58_L0.6950.92
145_L188_F0.6890.91
148_F188_F0.6870.91
82_R97_K0.6840.91
102_K203_I0.6840.91
59_A86_D0.6840.91
37_V146_V0.6760.91
52_F55_A0.6750.91
167_L192_F0.6690.90
119_L124_F0.6660.90
161_K165_N0.6640.90
27_D230_I0.6640.90
144_G153_D0.6630.90
48_K52_F0.6620.90
100_I132_D0.6610.90
79_E126_N0.6610.90
154_F159_I0.6580.89
232_F241_D0.6570.89
244_V248_Y0.6550.89
155_S194_K0.6500.89
2_K29_I0.6440.88
243_E246_S0.6430.88
175_Y178_I0.6420.88
191_S195_L0.6410.88
142_L145_L0.6380.88
51_I81_L0.6330.88
109_R176_G0.6320.88
163_L167_L0.6290.87
90_I209_T0.6270.87
217_L223_L0.6260.87
52_F56_E0.6240.87
117_L121_E0.6230.87
238_K242_Q0.6220.87
66_L89_I0.6210.87
23_L64_K0.6190.86
18_E22_V0.6190.86
171_D174_Q0.6190.86
157_D160_I0.6190.86
115_T182_C0.6140.86
93_E97_K0.6090.86
108_K135_D0.6070.85
28_Y230_I0.6070.85
231_T234_N0.6050.85
27_D231_T0.6010.85
138_D175_Y0.6000.85
7_D11_G0.5980.85
193_E201_D0.5980.85
100_I131_I0.5880.84
155_S191_S0.5870.83
73_A94_P0.5860.83
143_P185_F0.5860.83
102_K177_T0.5820.83
14_T206_S0.5810.83
106_E201_D0.5800.83
239_I242_Q0.5780.82
55_A59_A0.5770.82
221_N224_G0.5770.82
99_A176_G0.5770.82
27_D64_K0.5770.82
236_G240_V0.5760.82
51_I68_I0.5750.82
82_R93_E0.5720.82
164_K171_D0.5710.82
42_K51_I0.5680.81
65_A216_V0.5680.81
232_F245_I0.5680.81
99_A110_V0.5660.81
71_N75_S0.5650.81
77_A80_D0.5650.81
214_K223_L0.5650.81
66_L177_T0.5620.81
117_L206_S0.5620.81
193_E197_G0.5620.81
216_V219_D0.5610.81
106_E176_G0.5600.80
58_L66_L0.5600.80
237_H240_V0.5580.80
146_V205_G0.5570.80
206_S248_Y0.5560.80
218_A221_N0.5560.80
78_I127_L0.5550.80
70_C182_C0.5520.80
57_F60_S0.5520.80
6_F51_I0.5520.80
10_I245_I0.5500.79
71_N206_S0.5500.79
46_K236_G0.5500.79
37_V42_K0.5490.79
35_L237_H0.5450.79
192_F197_G0.5420.78
226_G229_S0.5410.78
112_V179_V0.5410.78
157_D164_K0.5400.78
91_G95_A0.5350.77
113_V142_L0.5310.77
4_G62_N0.5310.77
242_Q245_I0.5300.77
51_I77_A0.5290.77
190_N194_K0.5290.77
146_V188_F0.5290.77
100_I135_D0.5290.77
171_D195_L0.5270.76
191_S196_F0.5260.76
175_Y200_V0.5230.76
92_I95_A0.5210.76
74_T234_N0.5210.76
75_S121_E0.5200.75
55_A58_L0.5200.75
32_A236_G0.5190.75
65_A88_P0.5190.75
93_E123_K0.5180.75
153_D159_I0.5180.75
128_V135_D0.5170.75
12_G70_C0.5170.75
6_F30_F0.5170.75
51_I55_A0.5170.75
15_V186_P0.5140.75
8_S12_G0.5130.74
234_N241_D0.5110.74
46_K151_N0.5090.74
148_F153_D0.5080.74
95_A208_G0.5050.73
74_T209_T0.5040.73
97_K208_G0.5040.73
92_I205_G0.5040.73
5_F92_I0.5030.73
56_E59_A0.5020.73
8_S115_T0.5010.73
41_E146_V0.5010.73
136_L173_K0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dwuA 2 0.9849 100 0.228 Contact Map
1zuwA 2 0.966 100 0.245 Contact Map
2jfqA 2 0.9774 100 0.272 Contact Map
2gzmA 3 0.9774 100 0.272 Contact Map
2vvtA 2 0.9774 100 0.275 Contact Map
2jfnA 1 0.9849 100 0.283 Contact Map
2ohoA 2 0.9698 100 0.288 Contact Map
3istA 2 0.9811 100 0.29 Contact Map
3outA 5 0.966 100 0.299 Contact Map
3uhfA 1 0.9321 100 0.317 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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