MURI2 - BACSU - GREMLIN Contacts

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MURI2 - Glutamate racemase 2

UniProt:	O05412	Sequences: MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSKGKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINKCTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKIIKYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLADRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	265 (244)
Sequences:	3741 (2533)
Seq/√Len:	162.1

ECOLI - MURI
BACSU - MURI2 MURI1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
5_F	19_A	3.662	1.00
31_Y	235_S	3.403	1.00
160_I	194_K	3.368	1.00
65_A	213_L	3.171	1.00
52_F	84_N	2.880	1.00
18_E	21_K	2.795	1.00
36_N	50_Y	2.684	1.00
16_L	28_Y	2.678	1.00
63_I	66_L	2.602	1.00
57_F	233_F	2.528	1.00
109_R	136_L	2.425	1.00
27_D	228_G	2.408	1.00
26_E	64_K	2.386	1.00
212_Q	215_K	2.362	1.00
189_K	193_E	2.310	1.00
125_H	139_C	2.286	1.00
55_A	66_L	2.257	1.00
149_A	188_F	2.220	1.00
61_Q	231_T	2.180	1.00
109_R	138_D	2.155	1.00
2_K	64_K	2.137	1.00
145_L	163_L	2.116	1.00
19_A	28_Y	2.053	1.00
22_V	214_K	2.028	1.00
57_F	61_Q	1.971	1.00
114_A	119_L	1.921	1.00
119_L	139_C	1.825	1.00
19_A	213_L	1.803	1.00
56_E	84_N	1.797	1.00
67_V	213_L	1.768	1.00
116_N	120_K	1.763	1.00
78_I	91_G	1.721	1.00
113_V	178_I	1.709	1.00
108_K	132_D	1.655	1.00
153_D	156_E	1.649	1.00
160_I	191_S	1.642	1.00
68_I	78_I	1.638	1.00
2_K	26_E	1.611	1.00
178_I	196_F	1.601	1.00
140_L	166_E	1.597	1.00
36_N	53_N	1.572	1.00
48_K	80_D	1.566	1.00
111_L	175_Y	1.562	1.00
20_I	230_I	1.556	1.00
18_E	207_V	1.528	1.00
109_R	174_Q	1.524	1.00
85_F	89_I	1.518	1.00
140_L	169_S	1.509	1.00
47_V	117_L	1.506	1.00
111_L	170_F	1.502	1.00
56_E	85_F	1.479	1.00
192_F	202_M	1.469	1.00
59_A	87_F	1.459	1.00
122_E	125_H	1.436	1.00
31_Y	54_A	1.429	1.00
50_Y	53_N	1.425	1.00
49_E	53_N	1.425	1.00
189_K	204_S	1.417	1.00
5_F	16_L	1.409	1.00
186_P	206_S	1.407	1.00
171_D	196_F	1.391	1.00
90_I	216_V	1.391	1.00
97_K	212_Q	1.390	1.00
164_K	168_S	1.385	1.00
52_F	80_D	1.361	1.00
122_E	139_C	1.360	1.00
46_K	50_Y	1.360	1.00
16_L	230_I	1.355	1.00
146_V	185_F	1.350	1.00
112_V	137_V	1.347	1.00
144_G	147_E	1.345	1.00
44_K	76_I	1.344	1.00
19_A	67_V	1.344	1.00
123_K	127_L	1.331	1.00
196_F	200_V	1.329	1.00
163_L	195_L	1.314	1.00
153_D	158_K	1.307	1.00
144_G	165_N	1.294	1.00
125_H	129_K	1.277	1.00
193_E	202_M	1.261	1.00
168_S	172_L	1.252	1.00
55_A	81_L	1.250	1.00
156_E	159_I	1.242	1.00
128_V	137_V	1.231	1.00
42_K	50_Y	1.226	1.00
216_V	220_R	1.205	1.00
4_G	63_I	1.203	1.00
14_T	187_F	1.194	1.00
148_F	159_I	1.189	1.00
96_V	128_V	1.181	1.00
34_T	234_N	1.179	1.00
160_I	195_L	1.174	1.00
207_V	211_K	1.165	1.00
68_I	81_L	1.165	1.00
122_E	126_N	1.153	1.00
65_A	90_I	1.151	1.00
41_E	116_N	1.147	1.00
19_A	210_A	1.142	1.00
64_K	222_Q	1.141	1.00
43_S	46_K	1.136	1.00
189_K	202_M	1.135	1.00
66_L	87_F	1.134	1.00
20_I	28_Y	1.129	1.00
124_F	139_C	1.119	1.00
126_N	130_E	1.119	1.00
119_L	141_A	1.115	1.00
163_L	166_E	1.106	1.00
42_K	46_K	1.104	1.00
16_L	19_A	1.099	1.00
46_K	49_E	1.096	1.00
76_I	117_L	1.093	1.00
242_Q	246_S	1.093	1.00
147_E	185_F	1.091	1.00
3_I	26_E	1.084	0.99
160_I	164_K	1.075	0.99
157_D	161_K	1.074	0.99
15_V	209_T	1.070	0.99
214_K	218_A	1.061	0.99
108_K	134_H	1.060	0.99
107_R	176_G	1.057	0.99
212_Q	216_V	1.051	0.99
164_K	195_L	1.044	0.99
144_G	185_F	1.033	0.99
18_E	206_S	1.031	0.99
98_P	208_G	1.021	0.99
191_S	194_K	1.018	0.99
138_D	173_K	1.013	0.99
111_L	178_I	1.006	0.99
61_Q	233_F	1.004	0.99
22_V	211_K	1.000	0.99
23_L	214_K	0.998	0.99
80_D	84_N	0.998	0.99
156_E	160_I	0.996	0.99
177_T	203_I	0.996	0.99
96_V	127_L	0.995	0.99
177_T	201_D	0.994	0.99
126_N	129_K	0.992	0.99
102_K	201_D	0.987	0.99
78_I	82_R	0.987	0.99
205_G	208_G	0.986	0.99
218_A	223_L	0.983	0.99
81_L	89_I	0.983	0.99
193_E	198_I	0.983	0.99
107_R	177_T	0.981	0.99
98_P	101_N	0.979	0.99
142_L	185_F	0.974	0.99
109_R	175_Y	0.971	0.99
74_T	91_G	0.962	0.99
67_V	90_I	0.955	0.99
50_Y	54_A	0.955	0.99
144_G	162_Y	0.952	0.99
163_L	191_S	0.950	0.99
82_R	127_L	0.946	0.99
27_D	226_G	0.937	0.99
161_K	164_K	0.936	0.99
55_A	89_I	0.933	0.98
51_I	73_A	0.932	0.98
215_K	219_D	0.930	0.98
47_V	51_I	0.923	0.98
26_E	222_Q	0.920	0.98
110_V	135_D	0.912	0.98
163_L	192_F	0.911	0.98
51_I	54_A	0.908	0.98
149_A	159_I	0.906	0.98
27_D	224_G	0.905	0.98
44_K	48_K	0.905	0.98
18_E	210_A	0.894	0.98
192_F	195_L	0.893	0.98
2_K	27_D	0.890	0.98
45_G	49_E	0.887	0.98
128_V	179_V	0.887	0.98
27_D	229_S	0.883	0.98
14_T	186_P	0.882	0.98
149_A	185_F	0.871	0.98
56_E	60_S	0.860	0.97
116_N	141_A	0.859	0.97
241_D	245_I	0.858	0.97
162_Y	166_E	0.858	0.97
197_G	200_V	0.857	0.97
41_E	117_L	0.855	0.97
144_G	166_E	0.854	0.97
74_T	78_I	0.849	0.97
30_F	34_T	0.848	0.97
6_F	54_A	0.845	0.97
41_E	185_F	0.844	0.97
178_I	202_M	0.836	0.97
196_F	202_M	0.835	0.97
59_A	85_F	0.825	0.97
37_V	234_N	0.821	0.97
95_A	205_G	0.820	0.97
64_K	217_L	0.818	0.97
4_G	58_L	0.817	0.96
23_L	26_E	0.817	0.96
55_A	77_A	0.816	0.96
124_F	128_V	0.809	0.96
90_I	213_L	0.807	0.96
74_T	93_E	0.805	0.96
34_T	37_V	0.798	0.96
95_A	99_A	0.795	0.96
22_V	210_A	0.793	0.96
158_K	162_Y	0.785	0.96
112_V	119_L	0.782	0.96
239_I	243_E	0.780	0.95
16_L	20_I	0.777	0.95
17_Y	21_K	0.777	0.95
6_F	55_A	0.770	0.95
127_L	130_E	0.770	0.95
190_N	193_E	0.769	0.95
159_I	191_S	0.767	0.95
79_E	83_R	0.760	0.95
93_E	127_L	0.757	0.95
95_A	98_P	0.757	0.95
146_V	150_E	0.754	0.95
245_I	248_Y	0.742	0.94
36_N	42_K	0.742	0.94
92_I	209_T	0.740	0.94
72_T	115_T	0.734	0.94
10_I	244_V	0.731	0.94
98_P	102_K	0.725	0.93
77_A	81_L	0.724	0.93
81_L	85_F	0.720	0.93
80_D	83_R	0.720	0.93
29_I	233_F	0.718	0.93
113_V	192_F	0.715	0.93
97_K	131_I	0.708	0.92
59_A	89_I	0.707	0.92
36_N	46_K	0.707	0.92
159_I	188_F	0.706	0.92
78_I	93_E	0.705	0.92
187_F	248_Y	0.705	0.92
148_F	162_Y	0.703	0.92
175_Y	196_F	0.703	0.92
96_V	124_F	0.702	0.92
26_E	217_L	0.702	0.92
5_F	210_A	0.701	0.92
208_G	211_K	0.697	0.92
29_I	58_L	0.695	0.92
145_L	188_F	0.689	0.91
148_F	188_F	0.687	0.91
82_R	97_K	0.684	0.91
102_K	203_I	0.684	0.91
59_A	86_D	0.684	0.91
37_V	146_V	0.676	0.91
52_F	55_A	0.675	0.91
167_L	192_F	0.669	0.90
119_L	124_F	0.666	0.90
161_K	165_N	0.664	0.90
27_D	230_I	0.664	0.90
144_G	153_D	0.663	0.90
48_K	52_F	0.662	0.90
100_I	132_D	0.661	0.90
79_E	126_N	0.661	0.90
154_F	159_I	0.658	0.89
232_F	241_D	0.657	0.89
244_V	248_Y	0.655	0.89
155_S	194_K	0.650	0.89
2_K	29_I	0.644	0.88
243_E	246_S	0.643	0.88
175_Y	178_I	0.642	0.88
191_S	195_L	0.641	0.88
142_L	145_L	0.638	0.88
51_I	81_L	0.633	0.88
109_R	176_G	0.632	0.88
163_L	167_L	0.629	0.87
90_I	209_T	0.627	0.87
217_L	223_L	0.626	0.87
52_F	56_E	0.624	0.87
117_L	121_E	0.623	0.87
238_K	242_Q	0.622	0.87
66_L	89_I	0.621	0.87
23_L	64_K	0.619	0.86
18_E	22_V	0.619	0.86
171_D	174_Q	0.619	0.86
157_D	160_I	0.619	0.86
115_T	182_C	0.614	0.86
93_E	97_K	0.609	0.86
108_K	135_D	0.607	0.85
28_Y	230_I	0.607	0.85
231_T	234_N	0.605	0.85
27_D	231_T	0.601	0.85
138_D	175_Y	0.600	0.85
7_D	11_G	0.598	0.85
193_E	201_D	0.598	0.85
100_I	131_I	0.588	0.84
155_S	191_S	0.587	0.83
73_A	94_P	0.586	0.83
143_P	185_F	0.586	0.83
102_K	177_T	0.582	0.83
14_T	206_S	0.581	0.83
106_E	201_D	0.580	0.83
239_I	242_Q	0.578	0.82
55_A	59_A	0.577	0.82
221_N	224_G	0.577	0.82
99_A	176_G	0.577	0.82
27_D	64_K	0.577	0.82
236_G	240_V	0.576	0.82
51_I	68_I	0.575	0.82
82_R	93_E	0.572	0.82
164_K	171_D	0.571	0.82
42_K	51_I	0.568	0.81
65_A	216_V	0.568	0.81
232_F	245_I	0.568	0.81
99_A	110_V	0.566	0.81
71_N	75_S	0.565	0.81
77_A	80_D	0.565	0.81
214_K	223_L	0.565	0.81
66_L	177_T	0.562	0.81
117_L	206_S	0.562	0.81
193_E	197_G	0.562	0.81
216_V	219_D	0.561	0.81
106_E	176_G	0.560	0.80
58_L	66_L	0.560	0.80
237_H	240_V	0.558	0.80
146_V	205_G	0.557	0.80
206_S	248_Y	0.556	0.80
218_A	221_N	0.556	0.80
78_I	127_L	0.555	0.80
70_C	182_C	0.552	0.80
57_F	60_S	0.552	0.80
6_F	51_I	0.552	0.80
10_I	245_I	0.550	0.79
71_N	206_S	0.550	0.79
46_K	236_G	0.550	0.79
37_V	42_K	0.549	0.79
35_L	237_H	0.545	0.79
192_F	197_G	0.542	0.78
226_G	229_S	0.541	0.78
112_V	179_V	0.541	0.78
157_D	164_K	0.540	0.78
91_G	95_A	0.535	0.77
113_V	142_L	0.531	0.77
4_G	62_N	0.531	0.77
242_Q	245_I	0.530	0.77
51_I	77_A	0.529	0.77
190_N	194_K	0.529	0.77
146_V	188_F	0.529	0.77
100_I	135_D	0.529	0.77
171_D	195_L	0.527	0.76
191_S	196_F	0.526	0.76
175_Y	200_V	0.523	0.76
92_I	95_A	0.521	0.76
74_T	234_N	0.521	0.76
75_S	121_E	0.520	0.75
55_A	58_L	0.520	0.75
32_A	236_G	0.519	0.75
65_A	88_P	0.519	0.75
93_E	123_K	0.518	0.75
153_D	159_I	0.518	0.75
128_V	135_D	0.517	0.75
12_G	70_C	0.517	0.75
6_F	30_F	0.517	0.75
51_I	55_A	0.517	0.75
15_V	186_P	0.514	0.75
8_S	12_G	0.513	0.74
234_N	241_D	0.511	0.74
46_K	151_N	0.509	0.74
148_F	153_D	0.508	0.74
95_A	208_G	0.505	0.73
74_T	209_T	0.504	0.73
97_K	208_G	0.504	0.73
92_I	205_G	0.504	0.73
5_F	92_I	0.503	0.73
56_E	59_A	0.502	0.73
8_S	115_T	0.501	0.73
41_E	146_V	0.501	0.73
136_L	173_K	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2dwuA	2	0.9849	100	0.228	Contact Map
1zuwA	2	0.966	100	0.245	Contact Map
2jfqA	2	0.9774	100	0.272	Contact Map
2gzmA	3	0.9774	100	0.272	Contact Map
2vvtA	2	0.9774	100	0.275	Contact Map
2jfnA	1	0.9849	100	0.283	Contact Map
2ohoA	2	0.9698	100	0.288	Contact Map
3istA	2	0.9811	100	0.29	Contact Map
3outA	5	0.966	100	0.299	Contact Map
3uhfA	1	0.9321	100	0.317	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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