GREMLIN Database
YRPE - Probable metal-binding protein YrpE
UniProt: O05410 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (197)
Sequences: 292 (199)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_V171_I5.4051.00
88_D166_Y4.2211.00
109_T241_G3.9041.00
151_V198_I3.7070.99
235_Y247_E3.3600.99
104_Y244_I3.2460.98
198_I215_L3.1850.98
145_V154_F2.5360.93
149_D163_K2.5280.93
176_A179_R2.4960.93
184_I221_R2.4550.92
204_S208_T2.3870.91
157_G243_D2.3820.91
84_S104_Y2.3620.90
97_D143_R2.3540.90
240_D243_D2.3260.90
114_F130_K2.2480.88
162_G187_L2.0800.84
162_G219_D2.0760.83
175_D243_D2.0750.83
61_H65_H2.0390.82
224_L228_V2.0300.82
216_Y228_V2.0220.82
77_Y135_K2.0070.81
165_T188_A1.9960.81
75_K78_E1.9840.80
167_D186_K1.9390.79
235_Y248_M1.8650.76
80_Y176_A1.8160.74
114_F126_A1.8120.74
184_I228_V1.7840.73
194_L219_D1.7720.72
245_A249_M1.7530.71
104_Y241_G1.7200.70
187_L194_L1.7040.69
80_Y178_N1.6360.66
131_E222_E1.6350.66
216_Y224_L1.6270.65
142_D156_N1.6060.64
107_D241_G1.6010.64
174_Y199_Q1.5930.64
152_T159_E1.5880.63
143_R237_S1.5660.62
55_D58_T1.5580.62
63_H66_S1.5290.60
94_W216_Y1.5030.59
170_E216_Y1.4870.58
77_Y216_Y1.4740.57
243_D246_H1.4720.57
167_D221_R1.4500.56
198_I217_W1.4310.55
220_D223_A1.4190.54
112_E242_H1.3990.53
151_V215_L1.3950.53
239_M247_E1.3810.52
80_Y179_R1.3720.52
76_I85_Q1.3570.51
186_K221_R1.3280.49
116_Y119_E1.3080.48
143_R154_F1.2630.46
55_D59_H1.2600.46
162_G194_L1.2370.44
174_Y201_S1.1960.42
55_D62_S1.1830.42
88_D130_K1.1740.41
167_D220_D1.1680.41
169_Y226_D1.1640.41
216_Y229_K1.1500.40
160_Y193_G1.1490.40
141_V234_Y1.1400.39
130_K134_K1.1280.39
64_D67_H1.1200.38
183_Y230_N1.1020.37
71_E239_M1.0920.37
113_V201_S1.0800.36
79_G172_L1.0660.36
116_Y195_P1.0660.36
73_T156_N1.0570.35
204_S210_A1.0550.35
87_K206_Y1.0520.35
113_V174_Y1.0290.34
104_Y107_D1.0250.34
183_Y206_Y1.0200.33
95_E147_Q1.0090.33
57_H61_H1.0060.33
204_S211_S0.9690.31
195_P246_H0.9680.31
130_K208_T0.9620.31
80_Y244_I0.9570.30
56_S62_S0.9560.30
151_V217_W0.9500.30
142_D155_K0.9460.30
113_V199_Q0.9440.30
126_A130_K0.9400.30
208_T223_A0.9350.29
82_K128_E0.9330.29
62_S65_H0.9240.29
102_Y234_Y0.9170.28
63_H68_A0.9160.28
63_H67_H0.9120.28
60_E67_H0.9070.28
112_E194_L0.9050.28
63_H94_W0.8970.28
95_E156_N0.8950.28
56_S59_H0.8710.26
87_K207_P0.8700.26
82_K85_Q0.8670.26
56_S66_S0.8640.26
180_G201_S0.8590.26
187_L190_K0.8580.26
99_Q103_P0.8490.26
90_L131_E0.8440.25
101_V235_Y0.8440.25
239_M243_D0.8420.25
160_Y222_E0.8420.25
84_S87_K0.8400.25
92_S148_K0.8370.25
138_Q209_K0.8370.25
155_K183_Y0.8350.25
80_Y83_N0.8350.25
148_K215_L0.8340.25
59_H63_H0.8320.25
136_G199_Q0.8140.24
131_E134_K0.8130.24
97_D237_S0.8110.24
114_F190_K0.8060.24
162_G192_E0.8040.24
56_S60_E0.8020.24
223_A228_V0.8000.24
181_V201_S0.8000.24
100_S103_P0.7920.23
182_R201_S0.7900.23
97_D102_Y0.7840.23
178_N250_A0.7830.23
68_A104_Y0.7820.23
150_T163_K0.7810.23
142_D148_K0.7790.23
148_K175_D0.7710.22
196_Q229_K0.7710.22
190_K220_D0.7680.22
99_Q109_T0.7630.22
108_G168_G0.7620.22
174_Y180_G0.7610.22
140_D160_Y0.7560.22
93_D207_P0.7560.22
226_D241_G0.7560.22
86_V132_Y0.7510.22
199_Q227_E0.7490.22
215_L221_R0.7480.22
170_E221_R0.7470.22
104_Y240_D0.7450.21
180_G199_Q0.7450.21
174_Y181_V0.7410.21
112_E115_S0.7380.21
184_I229_K0.7370.21
187_L192_E0.7370.21
224_L249_M0.7370.21
89_R108_G0.7360.21
151_V220_D0.7360.21
85_Q186_K0.7300.21
71_E75_K0.7300.21
94_W208_T0.7280.21
94_W215_L0.7280.21
175_D219_D0.7270.21
174_Y182_R0.7240.21
84_S246_H0.7240.21
183_Y239_M0.7240.21
108_G202_D0.7240.21
181_V199_Q0.7200.21
172_L180_G0.7190.21
165_T170_E0.7190.21
64_D193_G0.7190.21
76_I80_Y0.7170.20
123_G130_K0.7170.20
119_E246_H0.7170.20
94_W210_A0.7150.20
140_D155_K0.7130.20
71_E186_K0.7120.20
101_V141_V0.7080.20
62_S66_S0.7070.20
147_Q249_M0.7050.20
113_V180_G0.7040.20
140_D211_S0.7020.20
113_V181_V0.6990.20
163_K206_Y0.6980.20
155_K158_K0.6980.20
123_G129_Y0.6930.20
182_R199_Q0.6890.19
159_E240_D0.6870.19
90_L149_D0.6810.19
116_Y167_D0.6790.19
158_K240_D0.6770.19
97_D145_V0.6740.19
56_S61_H0.6730.19
105_L110_L0.6720.19
85_Q213_Y0.6700.19
82_K158_K0.6690.19
162_G195_P0.6690.19
130_K145_V0.6660.19
57_H63_H0.6660.19
219_D242_H0.6650.19
145_V159_E0.6610.19
113_V182_R0.6590.18
79_G180_G0.6570.18
68_A175_D0.6560.18
68_A73_T0.6510.18
235_Y239_M0.6500.18
239_M248_M0.6490.18
78_E247_E0.6480.18
82_K246_H0.6470.18
55_D61_H0.6460.18
82_K130_K0.6370.18
216_Y230_N0.6360.18
95_E189_K0.6360.18
186_K246_H0.6350.18
176_A250_A0.6320.18
137_Y200_F0.6280.17
152_T237_S0.6260.17
74_E223_A0.6260.17
116_Y246_H0.6250.17
175_D238_K0.6220.17
189_K192_E0.6210.17
149_D238_K0.6210.17
55_D219_D0.6190.17
121_E220_D0.6180.17
196_Q209_K0.6160.17
149_D165_T0.6140.17
111_D171_I0.6130.17
238_K242_H0.6130.17
138_Q176_A0.6080.17
135_K223_A0.6060.17
174_Y227_E0.6050.17
94_W176_A0.6050.17
74_E165_T0.5990.17
108_G164_Y0.5970.17
84_S90_L0.5940.16
188_A243_D0.5930.16
126_A129_Y0.5920.16
67_H72_E0.5910.16
55_D71_E0.5900.16
145_V165_T0.5900.16
62_S72_E0.5900.16
175_D226_D0.5880.16
104_Y238_K0.5860.16
142_D208_T0.5810.16
66_S243_D0.5790.16
114_F189_K0.5770.16
71_E222_E0.5760.16
149_D241_G0.5750.16
172_L181_V0.5750.16
132_Y171_I0.5700.16
170_E228_V0.5650.16
165_T175_D0.5650.16
141_V215_L0.5630.16
136_G174_Y0.5600.15
127_E192_E0.5590.15
172_L182_R0.5590.15
89_R168_G0.5570.15
64_D226_D0.5570.15
59_H145_V0.5560.15
159_E222_E0.5560.15
188_A206_Y0.5550.15
111_D130_K0.5550.15
65_H112_E0.5540.15
234_Y250_A0.5540.15
222_E237_S0.5520.15
115_S192_E0.5520.15
108_G132_Y0.5520.15
168_G202_D0.5490.15
94_W106_Q0.5480.15
87_K138_Q0.5410.15
84_S158_K0.5360.15
89_R202_D0.5350.15
59_H243_D0.5330.15
125_T156_N0.5310.15
184_I225_L0.5300.15
55_D76_I0.5300.15
59_H66_S0.5300.15
213_Y241_G0.5260.14
81_F235_Y0.5230.14
150_T223_A0.5220.14
147_Q157_G0.5200.14
187_L197_Y0.5190.14
213_Y228_V0.5180.14
148_K211_S0.5170.14
151_V213_Y0.5150.14
125_T128_E0.5150.14
150_T204_S0.5150.14
94_W204_S0.5130.14
60_E65_H0.5120.14
172_L201_S0.5100.14
59_H65_H0.5070.14
179_R250_A0.5070.14
172_L199_Q0.5050.14
132_Y164_Y0.5030.14
201_S230_N0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1txlA 1 0.745 100 0.277 Contact Map
2o1eA 1 0.247 98.4 0.911 Contact Map
2prsA 1 0.239 97.1 0.933 Contact Map
4cl2A 1 0.239 96.5 0.937 Contact Map
4xrvA 1 0.239 96.4 0.938 Contact Map
3ujpA 4 0.243 96.3 0.938 Contact Map
1toaA 1 0.243 96.1 0.94 Contact Map
3mfqA 1 0.239 96.1 0.94 Contact Map
4utoA 1 0.243 95.5 0.942 Contact Map
4oxrA 2 0.239 95.3 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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