GREMLIN Database
YRPG - Uncharacterized oxidoreductase YrpG
UniProt: O05408 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (269)
Sequences: 32227 (20421)
Seq/√Len: 1245.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E291_R3.2001.00
113_E153_K3.0501.00
29_E68_K2.8251.00
259_L305_I2.7921.00
112_L148_Q2.6281.00
71_A120_Q2.5161.00
302_D305_I2.4781.00
109_R151_S2.4521.00
5_Y12_R2.4421.00
109_R147_T2.3521.00
38_E42_N2.3501.00
258_E308_M2.3121.00
258_E305_I2.1441.00
253_S257_K2.0951.00
33_F72_Q2.0231.00
273_A306_L2.0171.00
82_L121_T1.9841.00
303_K307_R1.9841.00
146_E150_R1.9811.00
114_G118_R1.9201.00
203_A207_L1.9141.00
76_R79_K1.9071.00
123_H155_D1.9051.00
33_F68_K1.9041.00
254_D308_M1.8971.00
147_T151_S1.8891.00
84_T124_I1.8621.00
128_Q184_T1.8571.00
168_V172_A1.8221.00
204_A211_V1.8161.00
105_L147_T1.7991.00
17_C46_F1.7941.00
287_V291_R1.7941.00
147_T150_R1.7621.00
269_A299_I1.7571.00
274_N310_N1.7471.00
261_E299_I1.7441.00
42_N291_R1.7091.00
28_D31_T1.6821.00
84_T115_S1.6741.00
42_N294_I1.6741.00
38_E287_V1.6561.00
105_L109_R1.6471.00
251_K254_D1.6461.00
86_V108_I1.6361.00
262_K292_D1.6361.00
112_L127_Y1.6311.00
210_G279_A1.6091.00
61_L64_S1.6051.00
39_A44_I1.6041.00
295_K298_E1.5991.00
83_A128_Q1.5951.00
33_F37_D1.5841.00
307_R311_D1.5771.00
86_V127_Y1.5601.00
124_I154_V1.5581.00
20_T47_F1.5511.00
109_R113_E1.5421.00
128_Q212_V1.5301.00
168_V203_A1.5211.00
38_E41_D1.5101.00
11_L156_Y1.5061.00
33_F69_W1.5061.00
146_E180_M1.5031.00
144_A147_T1.4911.00
51_N111_H1.4761.00
199_E202_P1.4651.00
31_T34_R1.4621.00
40_L80_V1.4151.00
261_E265_N1.4021.00
110_R114_G1.4011.00
63_E67_G1.3831.00
113_E117_K1.3691.00
205_R275_P1.3681.00
109_R144_A1.3611.00
29_E33_F1.3571.00
202_P206_D1.3541.00
149_V180_M1.3541.00
291_R295_K1.3531.00
11_L81_V1.3481.00
171_Q203_A1.3451.00
148_Q154_V1.3411.00
64_S118_R1.3301.00
308_M311_D1.3231.00
37_D41_D1.3211.00
112_L124_I1.3091.00
163_A166_H1.2991.00
105_L143_E1.2971.00
261_E266_V1.2961.00
36_M69_W1.2961.00
114_G117_K1.2901.00
156_Y183_V1.2881.00
37_D72_Q1.2871.00
269_A273_A1.2831.00
187_H211_V1.2791.00
105_L144_A1.2741.00
154_V157_I1.2651.00
171_Q207_L1.2621.00
262_K265_N1.2561.00
168_V206_D1.2531.00
255_L266_V1.2511.00
284_P289_Q1.2471.00
284_P290_L1.2401.00
67_G120_Q1.2371.00
81_V126_L1.2361.00
47_F66_I1.2251.00
77_R123_H1.2151.00
288_E291_R1.2131.00
251_K308_M1.2051.00
126_L184_T1.2021.00
254_D258_E1.2011.00
34_R38_E1.1931.00
77_R121_T1.1921.00
139_D173_E1.1791.00
9_T156_Y1.1711.00
164_G203_A1.1711.00
191_L309_L1.1701.00
119_L124_I1.1601.00
35_I290_L1.1451.00
30_K34_R1.1421.00
46_F212_V1.1081.00
64_S68_K1.1061.00
37_D69_W1.1021.00
106_Y110_R1.1011.00
132_I166_H1.1001.00
68_K72_Q1.0961.00
271_V280_P1.0931.00
290_L294_I1.0851.00
201_L205_R1.0821.00
146_E149_V1.0811.00
145_F157_I1.0801.00
192_L249_L1.0741.00
113_E151_S1.0711.00
140_E143_E1.0651.00
149_V183_V1.0621.00
107_K110_R1.0611.00
105_L140_E1.0561.00
254_D257_K1.0541.00
189_Y274_N1.0541.00
139_D169_K1.0511.00
168_V207_L1.0501.00
194_R313_F1.0471.00
250_E254_D1.0451.00
252_F263_E1.0421.00
129_M145_F1.0401.00
188_K193_E1.0381.00
46_F83_A1.0321.00
8_R183_V1.0311.00
191_L267_A1.0281.00
45_Q81_V1.0271.00
253_S263_E1.0211.00
272_L296_A1.0161.00
265_N295_K1.0091.00
14_S45_Q1.0081.00
250_E253_S1.0011.00
169_K173_E0.9991.00
148_Q153_K0.9911.00
63_E115_S0.9861.00
159_S182_L0.9811.00
68_K120_Q0.9751.00
5_Y10_G0.9711.00
34_R287_V0.9691.00
14_S44_I0.9671.00
268_L296_A0.9621.00
184_T212_V0.9611.00
164_G168_V0.9591.00
9_T183_V0.9551.00
104_S107_K0.9531.00
36_M47_F0.9511.00
265_N292_D0.9491.00
70_F80_V0.9431.00
148_Q151_S0.9431.00
15_R272_L0.9421.00
125_E155_D0.9391.00
64_S117_K0.9371.00
205_R277_L0.9241.00
143_E147_T0.9221.00
159_S167_L0.9201.00
288_E292_D0.9191.00
292_D295_K0.9101.00
202_P205_R0.9091.00
212_V279_A0.9061.00
109_R112_L0.9031.00
258_E302_D0.8991.00
51_N107_K0.8981.00
198_M202_P0.8971.00
255_L259_L0.8971.00
67_G71_A0.8841.00
83_A212_V0.8811.00
29_E65_I0.8811.00
9_T149_V0.8781.00
274_N306_L0.8751.00
116_L153_K0.8721.00
161_N214_W0.8721.00
304_E307_R0.8681.00
259_L302_D0.8671.00
146_E157_I0.8611.00
307_R310_N0.8571.00
110_R113_E0.8531.00
144_A148_Q0.8531.00
157_I182_L0.8481.00
20_T66_I0.8451.00
15_R297_V0.8421.00
201_L211_V0.8411.00
51_N90_I0.8401.00
304_E308_M0.8391.00
18_L23_F0.8381.00
143_E146_E0.8381.00
20_T62_T0.8371.00
169_K172_A0.8321.00
273_A300_S0.8251.00
243_E247_L0.8211.00
109_R148_Q0.8201.00
185_E204_A0.8201.00
266_V299_I0.8191.00
83_A126_L0.8161.00
194_R310_N0.8141.00
29_E61_L0.8111.00
286_T289_Q0.8101.00
89_P102_G0.8041.00
40_L76_R0.8001.00
167_L209_L0.7981.00
17_C282_I0.7901.00
18_L39_A0.7851.00
261_E298_E0.7791.00
34_R37_D0.7751.00
273_A303_K0.7701.00
216_P282_I0.7691.00
269_A296_A0.7681.00
56_G63_E0.7621.00
142_W182_L0.7531.00
213_A280_P0.7531.00
164_G200_V0.7521.00
35_I287_V0.7471.00
204_A209_L0.7471.00
267_A271_V0.7451.00
131_H161_N0.7421.00
197_E202_P0.7391.00
159_S185_E0.7381.00
189_Y201_L0.7361.00
210_G278_T0.7361.00
213_A216_P0.7361.00
261_E269_A0.7351.00
203_A206_D0.7331.00
261_E295_K0.7271.00
142_W170_A0.7271.00
36_M40_L0.7251.00
227_L253_S0.7241.00
78_E123_H0.7221.00
42_N295_K0.7221.00
112_L153_K0.7201.00
38_E290_L0.7161.00
252_F309_L0.7161.00
66_I70_F0.7151.00
194_R197_E0.7141.00
266_V301_L0.7101.00
84_T127_Y0.7091.00
138_W173_E0.7061.00
259_L266_V0.7041.00
141_I144_A0.7041.00
116_L121_T0.7031.00
171_Q181_G0.7031.00
51_N118_R0.7021.00
149_V156_Y0.7001.00
30_K33_F0.6991.00
270_W310_N0.6951.00
142_W157_I0.6921.00
200_V204_A0.6901.00
257_K260_G0.6881.00
145_F149_V0.6861.00
285_R289_Q0.6851.00
108_I141_I0.6841.00
16_L272_L0.6791.00
115_S127_Y0.6781.00
11_L155_D0.6781.00
159_S162_F0.6771.00
252_F267_A0.6771.00
247_L250_E0.6761.00
108_I148_Q0.6751.00
42_N290_L0.6751.00
255_L305_I0.6741.00
301_L306_L0.6711.00
51_N114_G0.6711.00
111_H114_G0.6661.00
40_L47_F0.6611.00
289_Q292_D0.6581.00
21_M215_S0.6571.00
23_F35_I0.6571.00
44_I294_I0.6551.00
228_K250_E0.6541.00
49_T66_I0.6521.00
249_L253_S0.6511.00
201_L274_N0.6491.00
251_K312_I0.6481.00
76_R80_V0.6481.00
112_L116_L0.6451.00
255_L308_M0.6441.00
246_R250_E0.6431.00
301_L305_I0.6431.00
168_V171_Q0.6421.00
271_V278_T0.6381.00
164_G199_E0.6371.00
31_T287_V0.6371.00
40_L69_W0.6351.00
88_E91_S0.6341.00
45_Q79_K0.6321.00
6_L210_G0.6311.00
63_E118_R0.6291.00
86_V103_L0.6281.00
216_P271_V0.6271.00
22_N219_G0.6271.00
256_C266_V0.6261.00
138_W141_I0.6261.00
35_I284_P0.6231.00
191_L270_W0.6221.00
264_A292_D0.6211.00
72_Q76_R0.6181.00
37_D76_R0.6131.00
124_I127_Y0.6121.00
13_V46_F0.6111.00
256_C263_E0.6101.00
108_I144_A0.6081.00
33_F65_I0.6071.00
104_S141_I0.6031.00
109_R153_K0.5991.00
189_Y271_V0.5991.00
6_L9_T0.5951.00
75_Q80_V0.5941.00
189_Y194_R0.5941.00
32_A65_I0.5931.00
127_Y154_V0.5931.00
128_Q158_G0.5931.00
103_L129_M0.5931.00
52_I87_Y0.5911.00
149_V154_V0.5911.00
116_L122_D0.5901.00
8_R181_G0.5881.00
17_C281_I0.5881.00
13_V279_A0.5871.00
194_R198_M0.5831.00
287_V290_L0.5801.00
116_L124_I0.5801.00
116_L123_H0.5781.00
255_L312_I0.5761.00
224_G227_L0.5731.00
246_R249_L0.5721.00
305_I308_M0.5711.00
62_T67_G0.5671.00
159_S170_A0.5651.00
269_A297_V0.5631.00
266_V305_I0.5611.00
247_L251_K0.5611.00
86_V111_H0.5561.00
23_F32_A0.5561.00
48_D186_Q0.5551.00
189_Y211_V0.5531.00
17_C279_A0.5491.00
61_L65_I0.5481.00
170_A182_L0.5481.00
51_N87_Y0.5471.00
213_A277_L0.5461.00
115_S118_R0.5451.00
269_A300_S0.5441.00
77_R125_E0.5441.00
259_L299_I0.5391.00
255_L258_E0.5381.00
40_L45_Q0.5361.00
256_C259_L0.5351.00
16_L297_V0.5321.00
166_H169_K0.5281.00
165_W168_V0.5271.00
167_L204_A0.5271.00
35_I285_R0.5261.00
227_L250_E0.5261.00
41_D287_V0.5261.00
228_K243_E0.5251.00
127_Y145_F0.5211.00
266_V309_L0.5211.00
171_Q209_L0.5171.00
46_F81_V0.5171.00
56_G61_L0.5151.00
189_Y278_T0.5141.00
272_L280_P0.5141.00
151_S154_V0.5121.00
129_M141_I0.5121.00
50_A130_H0.5111.00
139_D143_E0.5101.00
112_L144_A0.5101.00
252_F256_C0.5101.00
40_L79_K0.5091.00
85_K130_H0.5091.00
68_K71_A0.5091.00
72_Q75_Q0.5071.00
132_I162_F0.5071.00
90_I107_K0.5071.00
113_E148_Q0.5051.00
88_E131_H0.5041.00
49_T62_T0.5041.00
187_H200_V0.5041.00
70_F76_R0.5021.00
223_G226_A0.5021.00
157_I180_M0.5021.00
18_L35_I0.5001.00
91_S129_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lqaA 2 0.9663 100 0.109 Contact Map
3lutA 3 0.9417 100 0.113 Contact Map
4xk2A 5 0.911 100 0.113 Contact Map
1pyfA 1 0.9172 100 0.118 Contact Map
3eauA 3 0.9448 100 0.118 Contact Map
1pz1A 1 0.9509 100 0.119 Contact Map
2bp1A 2 0.9202 100 0.128 Contact Map
3erpA 6 0.908 100 0.128 Contact Map
3n2tA 1 0.954 100 0.13 Contact Map
3v0sA 1 0.8344 100 0.13 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.