GREMLIN Database
YRAO - Uncharacterized transporter YraO
UniProt: O05407 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 438 (429)
Sequences: 665 (415)
Seq/√Len: 20.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
240_L273_I11.8751.00
284_R287_E5.5161.00
69_F245_V4.5771.00
5_L39_G4.0451.00
248_I266_G3.8861.00
269_L273_I3.7291.00
234_R237_L3.6791.00
102_A142_L3.6321.00
49_I304_V3.3851.00
184_G428_L3.3101.00
277_N280_M3.2961.00
69_F248_I3.1681.00
36_A45_I3.1050.99
98_A142_L3.0680.99
341_T354_Y3.0480.99
7_F318_I2.9470.99
102_A189_V2.9010.99
73_L245_V2.8460.99
15_I19_T2.7480.99
31_T34_V2.6850.98
234_R275_Y2.6450.98
6_G318_I2.6420.98
183_L187_A2.6280.98
248_I262_L2.5730.98
85_K88_S2.5660.98
130_K136_P2.5510.98
410_F414_A2.4890.97
41_F48_M2.4740.97
51_E311_G2.3930.97
351_N387_H2.3400.96
60_A300_F2.3380.96
49_I261_V2.2870.95
103_V190_I2.2610.95
97_I132_I2.2560.95
86_I100_G2.2390.95
101_S129_Y2.2270.95
72_I267_F2.2210.95
188_C421_T2.1790.94
82_L242_L2.1480.94
78_L242_L2.1140.93
232_L235_P2.0900.93
73_L78_L2.0890.93
423_L427_L2.0700.92
141_T414_A2.0610.92
99_I194_F2.0130.91
29_T264_L1.9940.91
393_V396_T1.9920.91
64_L296_V1.9890.91
3_T321_S1.9530.90
200_E203_R1.9180.89
16_L31_T1.9040.89
98_A134_M1.8890.88
145_L418_A1.8810.88
76_A275_Y1.8570.87
350_S353_A1.8220.86
33_I265_I1.8130.86
118_Y395_S1.7900.85
46_G258_H1.7820.85
5_L35_F1.7680.85
99_I190_I1.7220.83
9_M35_F1.7190.83
63_L295_V1.7170.83
104_L125_M1.7080.82
66_A114_G1.6990.82
346_T387_H1.6860.82
313_K316_D1.6690.81
64_L292_A1.6530.80
234_R284_R1.6520.80
20_K409_S1.6510.80
162_R352_D1.6500.80
75_D288_H1.6460.80
298_L394_A1.6310.79
3_T6_G1.6070.78
170_D255_G1.6020.78
135_N138_V1.5920.78
152_G160_A1.5800.77
53_I82_L1.5630.76
250_V254_L1.5570.76
95_V201_R1.5480.75
428_L432_T1.5420.75
163_A377_A1.5410.75
232_L275_Y1.5340.75
21_K325_I1.5220.74
69_F240_L1.5130.74
164_I171_P1.5090.74
140_A403_L1.5000.73
3_T318_I1.4930.73
106_M186_I1.4890.73
382_M426_T1.4820.72
9_M361_I1.4820.72
2_L317_A1.4810.72
346_T385_P1.4730.72
417_W420_I1.4440.70
349_L387_H1.4430.70
405_M410_F1.4280.69
75_D287_E1.4020.68
346_T393_V1.4000.68
235_P284_R1.3980.68
178_L382_M1.3960.67
51_E54_Q1.3760.66
359_V376_I1.3700.66
382_M429_A1.3660.66
409_S412_R1.3650.66
105_A121_T1.3610.65
318_I349_L1.3580.65
26_V271_L1.3570.65
181_T432_T1.3410.64
240_L269_L1.3330.64
62_L248_I1.3300.64
184_G326_I1.3240.63
34_V250_V1.3230.63
75_D284_R1.3080.62
346_T351_N1.3050.62
394_A432_T1.2910.61
243_F431_I1.2870.61
149_I189_V1.2870.61
4_I8_S1.2860.61
237_L240_L1.2770.60
90_V100_G1.2760.60
47_D51_E1.2760.60
14_T351_N1.2720.60
331_G369_Y1.2690.60
359_V380_S1.2660.60
403_L410_F1.2640.60
9_M347_F1.2640.60
321_S377_A1.2610.59
407_L410_F1.2570.59
5_L289_S1.2550.59
388_L393_V1.2440.58
88_S107_L1.2440.58
138_V413_F1.2360.58
73_L270_A1.2270.57
118_Y388_L1.2270.57
235_P275_Y1.2230.57
152_G159_P1.2220.57
87_L191_F1.2180.57
351_N388_L1.2160.57
62_L152_G1.2150.56
37_L42_G1.2060.56
380_S399_L1.1920.55
354_Y380_S1.1900.55
188_C192_L1.1760.54
187_A246_I1.1570.53
419_V422_S1.1540.53
227_L280_M1.1530.52
113_D298_L1.1530.52
88_S253_V1.1500.52
386_V393_V1.1470.52
93_D201_R1.1430.52
109_A147_L1.1390.52
302_A353_A1.1370.51
207_V210_E1.1300.51
141_T413_F1.1300.51
342_S354_Y1.1270.51
335_P436_T1.1040.49
129_Y140_A1.1040.49
105_A146_S1.1040.49
157_G160_A1.1030.49
135_N413_F1.0960.49
377_A380_S1.0840.48
113_D123_S1.0820.48
144_M410_F1.0820.48
45_I404_K1.0820.48
400_V407_L1.0820.48
78_L245_V1.0740.47
24_P67_I1.0720.47
131_R365_A1.0710.47
113_D116_T1.0710.47
115_T347_F1.0690.47
237_L273_I1.0680.47
164_I169_L1.0670.47
140_A410_F1.0650.47
76_A97_I1.0630.47
245_V248_I1.0610.47
36_A41_F1.0520.46
349_L388_L1.0490.46
316_D320_G1.0490.46
179_L183_L1.0450.45
175_F182_M1.0430.45
34_V243_F1.0420.45
148_S425_I1.0380.45
393_V397_V1.0380.45
118_Y147_L1.0370.45
63_L298_L1.0370.45
351_N386_V1.0370.45
170_D333_F1.0360.45
339_A426_T1.0340.45
178_L356_F1.0320.45
246_I427_L1.0300.45
389_M416_K1.0300.45
135_N199_K1.0250.44
14_T387_H1.0250.44
349_L385_P1.0230.44
71_G105_A1.0220.44
128_L249_M1.0220.44
165_S330_M1.0140.43
237_L429_A1.0080.43
119_M123_S1.0080.43
108_I113_D1.0080.43
400_V405_M1.0070.43
5_L49_I1.0000.43
244_L270_A0.9910.42
178_L381_I0.9880.42
174_F377_A0.9870.42
141_T410_F0.9840.42
243_F247_S0.9770.41
159_P200_E0.9740.41
60_A136_P0.9720.41
4_I187_A0.9710.41
388_L395_S0.9710.41
188_C420_I0.9700.41
82_L349_L0.9700.41
22_V27_A0.9680.41
115_T160_A0.9610.40
413_F416_K0.9580.40
139_M286_A0.9570.40
115_T299_V0.9560.40
130_K133_G0.9560.40
163_A359_V0.9510.40
191_F195_L0.9450.39
380_S385_P0.9450.39
346_T386_V0.9380.39
11_T15_I0.9370.39
150_V404_K0.9350.39
69_F78_L0.9350.39
346_T384_Q0.9350.39
387_H393_V0.9340.38
34_V37_L0.9330.38
98_A138_V0.9320.38
60_A396_T0.9310.38
385_P393_V0.9300.38
347_F393_V0.9290.38
325_I361_I0.9280.38
4_I51_E0.9260.38
240_L244_L0.9260.38
21_K133_G0.9210.38
105_A143_A0.9200.38
161_T397_V0.9180.37
99_I103_V0.9160.37
358_M365_A0.9100.37
86_I133_G0.9080.37
131_R386_V0.9070.37
362_F376_I0.9060.37
265_I269_L0.9050.37
190_I427_L0.9020.37
183_L431_I0.9010.36
63_L299_V0.9000.36
177_P378_R0.8980.36
321_S339_A0.8940.36
69_F273_I0.8890.36
140_A399_L0.8890.36
268_V309_L0.8860.36
4_I225_A0.8840.35
96_K399_L0.8840.35
105_A232_L0.8830.35
351_N397_V0.8810.35
389_M417_W0.8810.35
14_T349_L0.8790.35
69_F269_L0.8790.35
13_F113_D0.8780.35
21_K58_S0.8770.35
148_S410_F0.8770.35
351_N393_V0.8750.35
187_A191_F0.8750.35
9_M393_V0.8750.35
349_L386_V0.8670.34
271_L308_I0.8660.34
279_K285_I0.8630.34
187_A236_R0.8600.34
17_I90_V0.8570.34
29_T371_I0.8560.34
142_L189_V0.8500.33
80_D361_I0.8490.33
74_I113_D0.8440.33
335_P354_Y0.8430.33
384_Q399_L0.8430.33
80_D233_K0.8420.33
242_L329_S0.8400.33
232_L236_R0.8380.33
118_Y387_H0.8350.33
99_I325_I0.8350.33
198_R202_N0.8350.33
343_I419_V0.8340.33
181_T434_A0.8310.32
331_G366_A0.8300.32
309_L403_L0.8250.32
105_A125_M0.8240.32
60_A165_S0.8210.32
195_L199_K0.8210.32
347_F351_N0.8200.32
408_G412_R0.8180.32
247_S251_F0.8160.32
187_A279_K0.8150.31
275_Y365_A0.8150.31
142_L196_M0.8150.31
71_G90_V0.8080.31
115_T152_G0.8050.31
69_F138_V0.8040.31
12_V34_V0.8030.31
284_R289_S0.8010.31
18_M99_I0.7980.31
109_A153_M0.7960.30
210_E427_L0.7960.30
169_L285_I0.7960.30
346_T349_L0.7940.30
6_G111_D0.7910.30
30_I268_V0.7880.30
90_V350_S0.7860.30
42_G72_I0.7850.30
83_I422_S0.7770.29
45_I363_A0.7770.29
106_M146_S0.7750.29
165_S202_N0.7740.29
18_M329_S0.7700.29
251_F256_T0.7700.29
406_D409_S0.7670.29
102_A106_M0.7670.29
5_L9_M0.7660.29
109_A347_F0.7660.29
3_T9_M0.7660.29
137_M405_M0.7650.29
336_V435_I0.7650.29
3_T128_L0.7620.29
426_T435_I0.7600.28
62_L128_L0.7600.28
97_I325_I0.7590.28
8_S174_F0.7570.28
103_V431_I0.7560.28
257_K265_I0.7550.28
346_T350_S0.7500.28
164_I174_F0.7490.28
63_L109_A0.7480.28
14_T152_G0.7440.28
51_E215_T0.7430.28
74_I116_T0.7410.27
11_T98_A0.7410.27
419_V423_L0.7400.27
71_G196_M0.7400.27
326_I371_I0.7400.27
131_R430_I0.7400.27
19_T27_A0.7390.27
378_R434_A0.7380.27
276_P312_T0.7380.27
429_A435_I0.7370.27
354_Y359_V0.7370.27
8_S35_F0.7360.27
288_H361_I0.7330.27
143_A147_L0.7330.27
280_M304_V0.7330.27
118_Y410_F0.7320.27
176_V179_L0.7310.27
385_P407_L0.7300.27
107_L293_I0.7300.27
84_E256_T0.7270.27
23_S324_S0.7270.27
24_P264_L0.7260.27
236_R275_Y0.7220.27
134_M145_L0.7210.26
227_L230_E0.7200.26
72_I398_L0.7180.26
41_F44_G0.7180.26
5_L59_S0.7170.26
118_Y386_V0.7150.26
184_G254_L0.7150.26
205_G208_Q0.7150.26
209_L246_I0.7130.26
80_D309_L0.7130.26
346_T388_L0.7120.26
59_S315_V0.7120.26
304_V308_I0.7090.26
69_F73_L0.7090.26
1_M266_G0.7090.26
191_F199_K0.7090.26
298_L411_Q0.7080.26
63_L398_L0.7080.26
88_S243_F0.7070.26
31_T55_T0.7070.26
232_L237_L0.7060.26
67_I345_F0.7050.26
267_F271_L0.7040.26
275_Y284_R0.7030.26
91_K420_I0.7030.26
71_G287_E0.7030.26
388_L396_T0.6970.25
14_T388_L0.6970.25
384_Q387_H0.6910.25
105_A410_F0.6910.25
284_R305_F0.6890.25
15_I31_T0.6880.25
94_P399_L0.6860.25
120_I372_E0.6860.25
205_G209_L0.6850.25
185_G425_I0.6820.25
28_L346_T0.6810.24
396_T414_A0.6810.24
187_A243_F0.6780.24
69_F180_P0.6780.24
61_A83_I0.6770.24
199_K265_I0.6760.24
19_T28_L0.6760.24
326_I331_G0.6720.24
14_T386_V0.6710.24
18_M48_M0.6690.24
299_V342_S0.6680.24
147_L355_Y0.6680.24
187_A212_R0.6670.24
16_L196_M0.6670.24
172_S255_G0.6660.24
389_M411_Q0.6660.24
66_A296_V0.6640.24
60_A414_A0.6620.24
397_V407_L0.6620.24
257_K423_L0.6590.23
67_I81_P0.6580.23
198_R300_F0.6570.23
10_V261_V0.6570.23
98_A409_S0.6570.23
93_D96_K0.6570.23
109_A351_N0.6560.23
163_A300_F0.6560.23
62_L397_V0.6550.23
381_I397_V0.6540.23
299_V350_S0.6540.23
23_S300_F0.6540.23
115_T402_M0.6540.23
354_Y362_F0.6520.23
13_F338_V0.6510.23
264_L309_L0.6510.23
350_S386_V0.6510.23
11_T328_S0.6500.23
1_M28_L0.6500.23
14_T59_S0.6480.23
5_L38_I0.6480.23
33_I37_L0.6460.23
243_F246_I0.6450.23
268_V272_T0.6450.23
30_I428_L0.6440.23
388_L394_A0.6440.23
91_K119_M0.6420.23
357_G384_Q0.6420.23
326_I337_I0.6410.23
339_A389_M0.6410.23
67_I292_A0.6410.23
89_I100_G0.6410.23
9_M349_L0.6390.23
140_A405_M0.6380.22
322_L340_L0.6370.22
24_P278_V0.6370.22
12_V340_L0.6360.22
71_G116_T0.6340.22
291_N345_F0.6340.22
71_G289_S0.6330.22
30_I99_I0.6320.22
187_A319_A0.6280.22
153_M338_V0.6270.22
208_Q211_P0.6260.22
366_A376_I0.6250.22
147_L388_L0.6250.22
62_L393_V0.6240.22
347_F350_S0.6230.22
1_M174_F0.6230.22
224_A283_E0.6210.22
179_L374_V0.6200.22
38_I423_L0.6190.22
280_M283_E0.6170.22
176_V194_F0.6170.22
34_V43_K0.6150.21
197_G203_R0.6130.21
154_T290_G0.6130.21
246_I250_V0.6110.21
322_L427_L0.6090.21
347_F419_V0.6070.21
238_I242_L0.6060.21
259_P309_L0.6050.21
167_L377_A0.6050.21
397_V422_S0.6010.21
59_S165_S0.6000.21
240_L272_T0.5990.21
298_L356_F0.5980.21
306_A349_L0.5980.21
246_I283_E0.5970.21
165_S361_I0.5970.21
29_T404_K0.5970.21
318_I405_M0.5960.21
161_T309_L0.5950.21
1_M291_N0.5940.21
89_I412_R0.5930.21
323_I371_I0.5910.20
103_V427_L0.5910.20
94_P387_H0.5900.20
15_I37_L0.5900.20
188_C424_V0.5900.20
93_D399_L0.5890.20
236_R340_L0.5890.20
25_I297_L0.5890.20
341_T428_L0.5880.20
91_K120_I0.5880.20
243_F427_L0.5870.20
32_P314_M0.5840.20
302_A383_G0.5830.20
18_M50_L0.5830.20
334_F421_T0.5830.20
354_Y436_T0.5830.20
12_V16_L0.5820.20
24_P69_F0.5800.20
94_P140_A0.5800.20
173_D373_P0.5800.20
194_F198_R0.5790.20
355_Y408_G0.5780.20
31_T183_L0.5770.20
87_L128_L0.5760.20
68_L411_Q0.5740.20
24_P397_V0.5740.20
165_S285_I0.5720.20
157_G426_T0.5700.20
340_L427_L0.5690.20
298_L350_S0.5690.20
83_I161_T0.5680.19
69_F259_P0.5680.19
154_T171_P0.5680.19
333_F337_I0.5660.19
273_I283_E0.5660.19
118_Y144_M0.5660.19
278_V397_V0.5650.19
202_N268_V0.5640.19
132_I404_K0.5630.19
103_V423_L0.5630.19
61_A79_F0.5630.19
153_M402_M0.5620.19
104_L116_T0.5620.19
68_L275_Y0.5610.19
199_K202_N0.5600.19
158_G200_E0.5590.19
243_F348_V0.5590.19
359_V398_L0.5590.19
2_L6_G0.5580.19
164_I313_K0.5570.19
330_M333_F0.5560.19
12_V31_T0.5560.19
149_I421_T0.5560.19
396_T407_L0.5560.19
113_D295_V0.5550.19
153_M381_I0.5530.19
285_I298_L0.5530.19
37_L47_D0.5530.19
332_G335_P0.5520.19
292_A365_A0.5500.19
264_L398_L0.5500.19
40_G83_I0.5500.19
7_F345_F0.5490.19
134_M404_K0.5480.19
60_A150_V0.5480.19
208_Q214_I0.5470.19
19_T228_E0.5470.19
53_I252_I0.5470.19
227_L236_R0.5470.19
231_Q247_S0.5460.19
206_I209_L0.5460.19
299_V389_M0.5450.19
406_D412_R0.5440.19
44_G330_M0.5440.19
142_L149_I0.5430.18
302_A393_V0.5420.18
28_L355_Y0.5420.18
71_G121_T0.5410.18
69_F204_I0.5410.18
72_I293_I0.5400.18
323_I361_I0.5400.18
347_F386_V0.5390.18
147_L351_N0.5390.18
103_V209_L0.5390.18
3_T299_V0.5380.18
372_E375_E0.5380.18
24_P338_V0.5370.18
296_V305_F0.5370.18
361_I424_V0.5370.18
83_I143_A0.5370.18
385_P422_S0.5360.18
20_K406_D0.5360.18
172_S269_L0.5350.18
130_K404_K0.5350.18
315_V405_M0.5340.18
210_E431_I0.5340.18
178_L414_A0.5330.18
243_F280_M0.5320.18
115_T295_V0.5320.18
317_A321_S0.5300.18
87_L99_I0.5300.18
340_L428_L0.5300.18
95_V204_I0.5300.18
30_I248_I0.5290.18
108_I262_L0.5280.18
76_A377_A0.5280.18
10_V273_I0.5280.18
351_N385_P0.5270.18
226_T229_S0.5270.18
305_F397_V0.5250.18
202_N412_R0.5250.18
33_I261_V0.5250.18
43_K431_I0.5230.18
9_M346_T0.5230.18
143_A299_V0.5230.18
28_L104_L0.5210.18
117_T145_L0.5210.18
55_T435_I0.5210.18
242_L246_I0.5200.18
7_F180_P0.5190.18
90_V128_L0.5190.18
180_P245_V0.5180.18
128_L293_I0.5150.17
83_I337_I0.5140.17
82_L165_S0.5140.17
97_I128_L0.5140.17
321_S354_Y0.5140.17
8_S224_A0.5130.17
15_I91_K0.5120.17
92_G299_V0.5110.17
350_S387_H0.5110.17
394_A402_M0.5110.17
23_S168_G0.5100.17
313_K361_I0.5080.17
94_P351_N0.5070.17
21_K82_L0.5060.17
95_V142_L0.5060.17
261_V359_V0.5060.17
118_Y349_L0.5060.17
94_P380_S0.5060.17
2_L412_R0.5050.17
119_M413_F0.5050.17
101_S424_V0.5050.17
168_G246_I0.5050.17
144_M399_L0.5050.17
103_V283_E0.5040.17
367_S373_P0.5030.17
392_L396_T0.5030.17
229_S423_L0.5030.17
296_V394_A0.5020.17
30_I340_L0.5020.17
4_I247_S0.5020.17
354_Y382_M0.5010.17
302_A350_S0.5010.17
83_I413_F0.5010.17
300_F382_M0.5000.17
59_S405_M0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0cA 3 0.9589 100 0.807 Contact Map
4f35D 2 0.8973 100 0.821 Contact Map
4r1iA 2 0.9749 100 0.823 Contact Map
2a65A 2 0.4566 73.8 0.974 Contact Map
4dx5A 3 0.3699 59.9 0.976 Contact Map
3w9iA 3 0.3516 53.1 0.977 Contact Map
3aqpA 1 0.3447 36.8 0.979 Contact Map
4k0jA 3 0.3311 32.3 0.98 Contact Map
2mofA 1 0.0868 29.4 0.98 Contact Map
4mt1A 3 0.3584 14.9 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0135 seconds.