GREMLIN Database
YRHP - Uncharacterized membrane protein YrhP
UniProt: O05406 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (197)
Sequences: 12879 (9042)
Seq/√Len: 644.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_T119_F5.2811.00
85_G201_V3.5771.00
86_V90_F3.3371.00
4_L160_I3.0181.00
191_V194_K2.8981.00
71_T74_K2.7411.00
82_I204_G2.6441.00
116_K120_M2.4711.00
190_K194_K2.3811.00
39_Y115_Y2.2831.00
75_Y79_A2.2331.00
50_F123_S2.1991.00
83_Y87_K2.1941.00
89_F194_K2.1491.00
29_T37_G2.0731.00
24_L40_N2.0471.00
89_F197_G2.0441.00
78_A208_G1.9781.00
198_I202_G1.9151.00
10_I139_I1.8931.00
87_K90_F1.8781.00
47_G127_I1.8711.00
85_G197_G1.8361.00
8_I164_L1.8021.00
21_D44_L1.7701.00
22_T172_L1.7231.00
37_G173_V1.7031.00
82_I201_V1.6971.00
78_A204_G1.6951.00
36_A118_S1.6661.00
68_I71_T1.6651.00
180_K184_K1.6541.00
28_N32_Y1.6361.00
92_K194_K1.6131.00
70_F74_K1.6121.00
15_V164_L1.5661.00
16_I168_W1.5631.00
71_T75_Y1.5511.00
120_M124_L1.5121.00
93_S194_K1.4921.00
42_L119_F1.4841.00
8_I160_I1.4791.00
49_S162_T1.4781.00
82_I86_V1.4391.00
61_V65_K1.4341.00
29_T173_V1.4241.00
52_T158_A1.4061.00
119_F123_S1.4031.00
37_G41_I1.3941.00
40_N122_G1.3941.00
28_N40_N1.3901.00
191_V195_I1.3841.00
26_M176_I1.3811.00
41_I173_V1.3511.00
165_A169_F1.3361.00
123_S127_I1.3171.00
68_I72_T1.3101.00
136_Y161_L1.3041.00
114_Y117_T1.3011.00
80_Y84_L1.2821.00
38_R174_Y1.2741.00
72_T76_L1.2701.00
34_P174_Y1.2671.00
188_F191_V1.2511.00
75_Y78_A1.2441.00
7_Y157_L1.2421.00
185_N188_F1.2301.00
178_Y181_K1.2091.00
187_K191_V1.1871.00
75_Y208_G1.1801.00
117_T120_M1.1741.00
21_D126_N1.1711.00
53_V57_L1.1571.00
28_N121_Q1.1431.00
168_W172_L1.1401.00
15_V165_A1.1381.00
24_L28_N1.1301.00
7_Y11_A1.1281.00
24_L125_S1.1231.00
197_G201_V1.1221.00
171_F175_I1.1191.00
85_G204_G1.1181.00
201_V205_I1.1121.00
3_S6_A1.1111.00
45_A166_V1.1071.00
32_Y36_A1.1021.00
35_K39_Y1.1011.00
45_A162_T1.0981.00
21_D165_A1.0871.00
34_P177_D1.0841.00
30_L176_I1.0541.00
21_D125_S1.0511.00
90_F93_S1.0511.00
149_N152_Q1.0501.00
22_T169_F1.0491.00
5_L9_P1.0431.00
150_I153_Q1.0421.00
178_Y182_W1.0371.00
6_A9_P1.0351.00
91_A193_Q1.0341.00
25_V29_T1.0331.00
43_G119_F1.0311.00
38_R170_L1.0301.00
80_Y83_Y1.0271.00
11_A161_L1.0221.00
117_T121_Q1.0211.00
25_V169_F1.0201.00
27_K31_R1.0161.00
151_N154_L1.0161.00
202_G206_K1.0131.00
48_L126_N1.0111.00
31_R35_K0.9961.00
187_K190_K0.9861.00
47_G123_S0.9791.00
21_D48_L0.9711.00
50_F127_I0.9671.00
93_S96_S0.9601.00
48_L132_T0.9581.00
6_A10_I0.9571.00
194_K198_I0.9421.00
113_R117_T0.9411.00
34_P170_L0.9261.00
184_K188_F0.9251.00
51_W133_V0.9141.00
195_I198_I0.9141.00
145_N153_Q0.9121.00
58_G63_I0.9091.00
25_V173_V0.9071.00
4_L163_L0.8911.00
34_P173_V0.8841.00
8_I12_A0.8771.00
51_W127_I0.8771.00
23_M196_T0.8741.00
12_A164_L0.8731.00
46_T123_S0.8731.00
148_G153_Q0.8711.00
124_L128_L0.8671.00
48_L51_W0.8631.00
35_K115_Y0.8421.00
201_V204_G0.8311.00
63_I66_S0.8231.00
112_K116_K0.8221.00
52_T136_Y0.8191.00
10_I13_M0.8191.00
38_R173_V0.8131.00
76_L79_A0.8131.00
87_K91_A0.8111.00
58_G65_K0.8101.00
21_D169_F0.8071.00
43_G123_S0.8061.00
22_T168_W0.8051.00
23_M27_K0.8041.00
189_Q193_Q0.8041.00
138_T142_Q0.7971.00
11_A15_V0.7921.00
79_A82_I0.7911.00
170_L174_Y0.7871.00
41_I170_L0.7841.00
192_F196_T0.7691.00
83_Y86_V0.7661.00
166_V170_L0.7661.00
128_L137_V0.7661.00
36_A39_Y0.7561.00
89_F201_V0.7501.00
45_A165_A0.7431.00
78_A82_I0.7411.00
88_S197_G0.7381.00
90_F94_M0.7351.00
69_L72_T0.7321.00
22_T26_M0.7321.00
9_P13_M0.7291.00
182_W188_F0.7291.00
66_S69_L0.7271.00
51_W132_T0.7261.00
118_S121_Q0.7211.00
47_G126_N0.7211.00
175_I178_Y0.7161.00
60_S64_A0.7151.00
51_W126_N0.7111.00
44_L48_L0.7101.00
57_L61_V0.7081.00
169_F172_L0.7041.00
26_M172_L0.7011.00
13_M17_I0.7011.00
95_F98_D0.6981.00
15_V169_F0.6971.00
51_W137_V0.6961.00
25_V40_N0.6951.00
39_Y118_S0.6911.00
66_S70_F0.6911.00
86_V201_V0.6901.00
15_V22_T0.6871.00
5_L8_I0.6861.00
149_N153_Q0.6851.00
52_T169_F0.6851.00
51_W55_A0.6781.00
4_L8_I0.6771.00
44_L126_N0.6751.00
25_V44_L0.6751.00
182_W185_N0.6731.00
48_L165_A0.6711.00
32_Y118_S0.6661.00
181_K185_N0.6661.00
61_V64_A0.6621.00
28_N31_R0.6621.00
38_R41_I0.6581.00
15_V168_W0.6571.00
46_T50_F0.6551.00
41_I45_A0.6541.00
145_N148_G0.6531.00
195_I199_I0.6481.00
174_Y178_Y0.6461.00
29_T176_I0.6461.00
93_S190_K0.6451.00
10_I14_M0.6431.00
76_L128_L0.6421.00
18_P131_K0.6411.00
67_V71_T0.6361.00
155_I158_A0.6361.00
176_I179_A0.6351.00
79_A83_Y0.6341.00
36_A115_Y0.6331.00
48_L162_T0.6331.00
92_K95_F0.6331.00
72_T75_Y0.6331.00
126_N132_T0.6301.00
22_T125_S0.6291.00
48_L136_Y0.6271.00
20_A129_N0.6271.00
40_N118_S0.6221.00
48_L161_L0.6211.00
136_Y165_A0.6201.00
77_G134_L0.6171.00
17_I22_T0.6161.00
188_F192_F0.6151.00
163_L167_L0.6151.00
148_G152_Q0.6141.00
11_A160_I0.6131.00
156_I160_I0.6041.00
126_N169_F0.6041.00
56_I158_A0.5981.00
162_T166_V0.5941.00
73_I77_G0.5891.00
152_Q156_I0.5891.00
85_G89_F0.5891.00
50_F53_V0.5891.00
55_A60_S0.5871.00
21_D132_T0.5821.00
55_A133_V0.5811.00
182_W186_S0.5771.00
152_Q155_I0.5771.00
55_A136_Y0.5711.00
12_A16_I0.5671.00
167_L171_F0.5661.00
51_W60_S0.5641.00
42_L45_A0.5631.00
15_V48_L0.5601.00
44_L132_T0.5581.00
132_T169_F0.5571.00
27_K193_Q0.5561.00
115_Y119_F0.5561.00
202_G205_I0.5551.00
34_P178_Y0.5521.00
133_V137_V0.5511.00
203_F206_K0.5491.00
180_K183_M0.5471.00
132_T165_A0.5461.00
40_N125_S0.5441.00
53_V158_A0.5421.00
17_I193_Q0.5371.00
116_K119_F0.5371.00
108_A111_P0.5350.99
139_I161_L0.5340.99
175_I179_A0.5330.99
37_G40_N0.5320.99
155_I159_S0.5310.99
34_P37_G0.5310.99
38_R42_L0.5290.99
20_A88_S0.5280.99
52_T162_T0.5260.99
161_L165_A0.5210.99
14_M135_V0.5210.99
135_V139_I0.5190.99
183_M186_S0.5180.99
121_Q125_S0.5170.99
169_F173_V0.5160.99
109_S112_K0.5130.99
66_S71_T0.5130.99
33_G36_A0.5130.99
159_S163_L0.5060.99
36_A114_Y0.5060.99
45_A169_F0.5060.99
7_Y160_I0.5050.99
112_K115_Y0.5040.99
172_L176_I0.5040.99
151_N155_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.9238 50.9 0.914 Contact Map
3wdoA 1 0.8619 39.5 0.92 Contact Map
4m64A 1 0.9524 33.9 0.922 Contact Map
2cfqA 1 0.9048 23.4 0.929 Contact Map
4ikvA 1 0.5095 20 0.931 Contact Map
2gfpA 2 0.9286 19 0.931 Contact Map
1pw4A 1 0.519 18 0.932 Contact Map
4w6vA 1 0.4762 17.9 0.932 Contact Map
3j1zP 8 0.8143 12.6 0.937 Contact Map
4c7rA 3 0.3095 12.4 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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