GREMLIN Database
YRHO - Uncharacterized protein YrhO
UniProt: O05405 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (234)
Sequences: 2320 (1863)
Seq/√Len: 121.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_A156_Q3.7211.00
18_E53_S3.3061.00
25_L60_V3.0721.00
130_A197_G3.0531.00
18_E57_R3.0411.00
133_R199_D2.8781.00
17_Y43_P2.8651.00
22_Y26_L2.8071.00
46_K49_E2.7451.00
135_L199_D2.6951.00
130_A134_I2.5101.00
161_T232_I2.4841.00
137_E234_D2.3811.00
59_D78_L2.3741.00
17_Y46_K2.3261.00
51_L60_V2.2081.00
15_T53_S2.1741.00
115_G118_E2.1581.00
28_E31_L2.1371.00
128_L152_Q2.1291.00
32_T35_A2.0721.00
125_A129_S2.0561.00
87_E94_E1.9881.00
51_L70_Y1.9571.00
15_T18_E1.9531.00
199_D228_T1.9311.00
119_I215_A1.9181.00
159_I183_E1.9111.00
126_C203_V1.8511.00
126_C201_E1.8231.00
161_T235_L1.7541.00
137_E163_I1.7511.00
231_I235_L1.7311.00
21_A47_I1.7301.00
17_Y40_S1.7121.00
187_E238_M1.6981.00
24_A39_K1.6931.00
43_P46_K1.6881.00
17_Y42_V1.6811.00
21_A50_V1.6461.00
151_K155_E1.6401.00
146_I150_L1.6051.00
16_E20_K1.6041.00
196_S228_T1.5941.00
61_F71_V1.5891.00
22_Y75_A1.5811.00
34_Y38_K1.5771.00
136_L195_Y1.5651.00
163_I234_D1.5501.00
19_S23_L1.5031.00
134_I197_G1.5001.00
21_A42_V1.4881.00
81_N85_K1.4731.00
122_K217_W1.4721.00
21_A36_V1.4661.00
153_A158_V1.4561.00
111_W122_K1.4551.00
185_T235_L1.4391.00
221_V225_M1.4381.00
127_I134_I1.4341.00
135_L228_T1.4201.00
14_F59_D1.3731.00
30_P69_Q1.3731.00
127_I197_G1.3721.00
130_A153_A1.3401.00
44_R48_Y1.3361.00
124_K152_Q1.3281.00
27_Q39_K1.3271.00
122_K125_A1.3231.00
134_I153_A1.3201.00
17_Y49_E1.3161.00
24_A40_S1.3131.00
127_I160_V1.3111.00
152_Q155_E1.3071.00
43_P50_V1.3031.00
31_L39_K1.3001.00
137_E191_R1.2831.00
169_V186_E1.2701.00
228_T232_I1.2621.00
96_Y99_K1.2561.00
224_V228_T1.2540.99
113_I217_W1.2500.99
59_D82_R1.2410.99
28_E39_K1.2400.99
97_F101_E1.2330.99
17_Y50_V1.2280.99
127_I153_A1.2200.99
176_Y179_D1.2120.99
88_E92_Q1.2080.99
40_S47_I1.2080.99
147_E151_K1.2010.99
136_L162_I1.1930.99
110_I223_L1.1890.99
76_K94_E1.1780.99
111_W219_M1.1700.99
36_V47_I1.1670.99
10_K16_E1.1620.99
86_A89_H1.1460.99
134_I160_V1.1390.99
42_V47_I1.1360.99
52_E56_I1.1150.99
43_P47_I1.0990.99
63_S71_V1.0950.99
87_E91_D1.0930.99
89_H93_A1.0920.99
55_V62_V1.0900.99
122_K126_C1.0780.98
166_G186_E1.0750.98
26_L75_A1.0690.98
24_A36_V1.0630.98
131_K200_S1.0600.98
235_L238_M1.0580.98
83_R93_A1.0560.98
178_H182_S1.0520.98
25_L51_L1.0410.98
147_E150_L1.0230.98
35_A38_K1.0120.98
78_L83_R1.0120.98
200_S219_M1.0040.98
17_Y21_A1.0000.97
45_S49_E1.0000.97
137_E190_G0.9960.97
79_I82_R0.9950.97
119_I214_R0.9930.97
92_Q96_Y0.9890.97
216_A223_L0.9880.97
140_K165_Y0.9870.97
141_E193_L0.9850.97
91_D94_E0.9820.97
34_Y45_S0.9790.97
137_E220_H0.9760.97
137_E194_V0.9650.97
196_S224_V0.9620.97
164_A184_I0.9560.97
18_E50_V0.9460.96
86_A90_F0.9440.96
9_L13_N0.9410.96
88_E91_D0.9410.96
196_S202_V0.9380.96
53_S56_I0.9300.96
127_I150_L0.9260.96
120_L145_E0.9260.96
123_V195_Y0.9220.96
124_K149_E0.9200.96
10_K19_S0.9050.95
47_I60_V0.9020.95
187_E237_L0.9010.95
123_V193_L0.8970.95
153_A197_G0.8910.95
40_S50_V0.8890.95
201_E217_W0.8830.95
88_E95_K0.8820.95
137_E230_V0.8800.95
79_I86_A0.8760.95
123_V127_I0.8750.95
58_G115_G0.8660.94
201_E219_M0.8650.94
9_L19_S0.8630.94
226_P230_V0.8630.94
128_L149_E0.8550.94
84_L88_E0.8540.94
177_L181_S0.8530.94
33_G44_R0.8500.94
196_S231_I0.8490.94
99_K102_Q0.8310.93
157_G198_D0.8290.93
187_E234_D0.8280.93
240_I243_K0.8270.93
33_G48_Y0.8250.93
135_L196_S0.8180.92
86_A93_A0.8160.92
62_V67_T0.8110.92
135_L161_T0.8110.92
220_H225_M0.8090.92
57_R85_K0.8010.92
28_E84_L0.8010.92
192_W226_P0.8010.92
136_L160_V0.7930.91
98_E102_Q0.7920.91
42_V48_Y0.7910.91
12_L203_V0.7810.91
130_A198_D0.7800.90
55_V60_V0.7710.90
174_N179_D0.7690.90
181_S203_V0.7640.90
179_D182_S0.7560.89
150_L154_A0.7520.89
135_L232_I0.7490.89
111_W217_W0.7470.88
22_Y73_V0.7450.88
165_Y193_L0.7400.88
32_T70_Y0.7350.88
25_L36_V0.7340.88
237_L241_L0.7320.87
135_L231_I0.7290.87
155_E200_S0.7270.87
45_S105_N0.7250.87
122_K219_M0.7200.87
83_R86_A0.7180.86
148_A152_Q0.7180.86
139_W205_G0.7160.86
24_A31_L0.7110.86
133_R159_I0.7080.86
218_T227_I0.7070.86
120_L146_I0.7030.85
126_C217_W0.7010.85
133_R198_D0.6960.85
172_F176_Y0.6950.85
106_D132_K0.6950.85
116_R120_L0.6950.85
37_A47_I0.6940.85
17_Y33_G0.6910.84
115_G119_I0.6910.84
93_A97_F0.6900.84
113_I118_E0.6870.84
37_A44_R0.6860.84
140_K143_F0.6860.84
90_F94_E0.6840.84
82_R86_A0.6830.84
38_K44_R0.6830.84
133_R228_T0.6820.84
37_A60_V0.6810.83
42_V46_K0.6790.83
92_Q151_K0.6790.83
221_V224_V0.6770.83
175_V196_S0.6760.83
75_A79_I0.6760.83
74_P175_V0.6750.83
93_A96_Y0.6730.83
128_L156_Q0.6730.83
174_N177_L0.6730.83
166_G169_V0.6730.83
126_C197_G0.6720.83
109_N219_M0.6720.83
150_L160_V0.6700.82
116_R212_D0.6700.82
52_E55_V0.6650.82
57_R126_C0.6640.82
24_A27_Q0.6630.82
43_P49_E0.6620.82
75_A101_E0.6610.82
171_D174_N0.6610.82
202_V227_I0.6600.82
23_L26_L0.6600.82
194_V230_V0.6580.81
175_V178_H0.6570.81
35_A39_K0.6570.81
87_E130_A0.6550.81
234_D237_L0.6550.81
174_N178_H0.6530.81
49_E52_E0.6520.81
32_T48_Y0.6500.81
81_N206_I0.6460.80
188_Y243_K0.6450.80
19_S48_Y0.6430.80
58_G218_T0.6350.79
98_E101_E0.6350.79
23_L27_Q0.6330.79
150_L177_L0.6320.79
178_H241_L0.6320.79
129_S201_E0.6300.78
123_V169_V0.6280.78
154_A164_A0.6260.78
152_Q179_D0.6260.78
73_V78_L0.6250.78
132_K159_I0.6210.77
136_L146_I0.6190.77
194_V231_I0.6190.77
123_V139_W0.6190.77
113_I215_A0.6180.77
138_I142_D0.6180.77
164_A193_L0.6170.77
85_K89_H0.6160.77
109_N220_H0.6150.77
125_A178_H0.6140.77
17_Y48_Y0.6140.77
44_R214_R0.6060.76
229_E233_H0.6060.76
113_I122_K0.6020.75
132_K199_D0.6020.75
78_L112_N0.5910.74
55_V70_Y0.5900.74
203_V217_W0.5880.74
33_G70_Y0.5870.73
122_K215_A0.5870.73
218_T223_L0.5840.73
133_R232_I0.5830.73
206_I220_H0.5830.73
136_L177_L0.5830.73
59_D73_V0.5820.73
84_L87_E0.5750.72
175_V182_S0.5680.71
60_V70_Y0.5670.71
239_E242_K0.5670.71
32_T44_R0.5660.71
144_K147_E0.5660.71
25_L33_G0.5660.71
54_L89_H0.5630.70
206_I214_R0.5620.70
139_W165_Y0.5600.70
167_D170_S0.5590.70
158_V198_D0.5570.70
69_Q203_V0.5570.70
25_L70_Y0.5540.69
97_F125_A0.5530.69
36_V40_S0.5520.69
175_V195_Y0.5510.69
184_I187_E0.5490.68
202_V205_G0.5490.68
146_I216_A0.5480.68
158_V199_D0.5480.68
149_E222_G0.5440.68
194_V227_I0.5420.67
163_I233_H0.5420.67
127_I147_E0.5410.67
156_Q198_D0.5400.67
34_Y37_A0.5380.67
121_E125_A0.5380.67
43_P110_I0.5360.67
140_K197_G0.5250.65
170_S186_E0.5250.65
93_A101_E0.5240.65
66_N204_A0.5180.64
142_D171_D0.5170.64
76_K98_E0.5170.64
138_I193_L0.5160.64
17_Y20_K0.5160.64
206_I218_T0.5160.64
59_D164_A0.5130.63
34_Y46_K0.5120.63
135_L220_H0.5120.63
235_L240_I0.5120.63
149_E223_L0.5120.63
122_K203_V0.5110.63
137_E226_P0.5100.63
31_L45_S0.5080.62
65_G212_D0.5070.62
190_G193_L0.5070.62
47_I230_V0.5050.62
191_R226_P0.5050.62
91_D129_S0.5050.62
88_E116_R0.5040.62
37_A45_S0.5030.62
141_E144_K0.5030.62
123_V174_N0.5030.62
61_F73_V0.5020.62
92_Q176_Y0.5020.62
48_Y52_E0.5020.62
83_R97_F0.5000.61
131_K171_D0.5000.61
139_W191_R0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.9455 100 0.39 Contact Map
2f5tX 2 0.5709 99.4 0.748 Contact Map
1byrA 2 0.4982 99 0.789 Contact Map
4ggjA 2 0.5636 99 0.795 Contact Map
1sfxA 3 0.3673 98.6 0.818 Contact Map
1ku9A 2 0.4982 98.6 0.82 Contact Map
3r0aA 2 0.3818 98.5 0.825 Contact Map
4urjA 1 0.5345 98.5 0.825 Contact Map
1qgpA 1 0.2618 98.5 0.827 Contact Map
4nb5A 4 0.4982 98.4 0.831 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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