GREMLIN Database
RSIV - Anti-sigma-V factor RsiV
UniProt: O05403 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (236)
Sequences: 918 (828)
Seq/√Len: 53.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_S260_G5.2871.00
56_L59_I4.8601.00
255_Y260_G4.5471.00
168_S255_Y3.7971.00
205_I250_I3.5621.00
163_E169_S3.5001.00
165_T168_S3.2851.00
141_S163_E3.1561.00
241_Y249_V2.8091.00
192_F197_Y2.6931.00
246_H271_T2.6281.00
243_T268_T2.4451.00
259_P262_M2.2731.00
254_E260_G2.2311.00
274_I277_L2.2301.00
171_T254_E2.1931.00
179_D182_N2.1161.00
242_I271_T2.0621.00
169_S260_G2.0471.00
206_K210_K2.0181.00
99_P146_Y1.9951.00
253_D256_E1.9921.00
249_V266_E1.9841.00
246_H268_T1.9681.00
207_E211_Q1.9541.00
209_M267_F1.9411.00
165_T169_S1.9151.00
188_L240_F1.8740.99
53_F56_L1.7670.99
208_Q211_Q1.7600.99
129_I133_S1.7440.99
237_D252_F1.7410.99
54_T57_V1.7390.99
150_T240_F1.7390.99
201_I250_I1.7350.99
170_Y254_E1.7120.99
204_N208_Q1.7020.99
209_M234_I1.6670.99
169_S254_E1.6640.99
175_Y251_S1.6540.99
184_I190_S1.6400.98
204_N207_E1.6170.98
205_I267_F1.6150.98
169_S255_Y1.6090.98
241_Y251_S1.5870.98
107_K110_E1.5440.98
186_L190_S1.5430.98
243_T249_V1.5420.98
53_F57_V1.5260.98
151_D180_K1.5230.98
255_Y263_G1.5160.97
165_T255_Y1.5130.97
168_S261_Y1.4970.97
118_L122_Q1.4780.97
117_Y176_I1.4690.97
188_L250_I1.4180.96
258_A262_M1.3890.96
188_L237_D1.3790.96
205_I234_I1.3740.95
199_K203_Q1.3360.95
165_T260_G1.3210.94
243_T246_H1.3130.94
50_A53_F1.2890.94
70_I73_I1.2880.94
253_D264_V1.2870.94
191_L240_F1.2610.93
208_Q267_F1.2580.93
237_D250_I1.2540.93
201_I277_L1.2470.92
251_S264_V1.2450.92
147_E159_R1.2430.92
149_V157_S1.2390.92
188_L248_L1.2300.92
166_Q170_Y1.2290.92
140_L167_A1.2290.92
54_T272_G1.2290.92
236_P250_I1.2120.91
258_A263_G1.2030.91
200_V203_Q1.2030.91
209_M257_V1.2000.91
124_L128_F1.1970.91
163_E167_A1.1950.91
111_N115_E1.1850.90
216_D221_Y1.1830.90
209_M252_F1.1760.90
127_E131_S1.1760.90
197_Y234_I1.1740.90
205_I209_M1.1630.89
239_T250_I1.1620.89
157_S175_Y1.1590.89
170_Y255_Y1.1530.89
113_I116_K1.1520.89
154_D181_K1.1360.88
239_T253_D1.1350.88
45_A49_A1.1330.88
177_T242_I1.1320.88
168_S263_G1.1310.88
168_S254_E1.1100.87
148_T158_I1.1050.87
192_F202_S1.0950.86
204_N274_I1.0940.86
95_D143_Y1.0930.86
259_P263_G1.0790.86
213_M258_A1.0770.86
155_L186_L1.0760.85
125_Y129_I1.0620.85
155_L177_T1.0600.85
175_Y240_F1.0570.84
161_N173_S1.0550.84
140_L166_Q1.0530.84
236_P252_F1.0470.84
160_R176_I1.0460.84
205_I269_I1.0410.84
110_E114_N1.0400.83
178_I185_L1.0390.83
88_E93_S1.0310.83
234_I278_L1.0220.82
113_I183_D1.0030.81
239_T256_E0.9980.81
242_I278_L0.9910.80
101_L148_T0.9870.80
186_L191_L0.9820.80
109_L183_D0.9810.80
173_S251_S0.9770.79
106_N110_E0.9730.79
101_L158_I0.9710.79
235_L256_E0.9630.78
204_N273_V0.9620.78
128_F132_T0.9490.77
175_Y239_T0.9400.77
158_I209_M0.9340.76
231_F234_I0.9320.76
46_A133_S0.9310.76
163_E170_Y0.9060.74
202_S231_F0.9020.74
202_S209_M0.8980.73
251_S266_E0.8960.73
149_V159_R0.8940.73
132_T274_I0.8920.73
52_L232_K0.8890.73
55_A59_I0.8880.73
179_D184_I0.8700.71
192_F278_L0.8670.71
108_E115_E0.8670.71
83_I90_D0.8610.70
116_K176_I0.8500.69
96_V161_N0.8500.69
106_N201_I0.8480.69
64_A124_L0.8470.69
123_Q127_E0.8440.69
255_Y261_Y0.8440.69
208_Q273_V0.8370.68
70_I75_K0.8360.68
215_E226_E0.8340.68
120_E128_F0.8330.68
146_Y157_S0.8310.67
198_I231_F0.8300.67
73_I80_I0.8230.67
51_I211_Q0.8230.67
156_L180_K0.8220.67
183_D267_F0.8210.67
129_I242_I0.8200.66
190_S240_F0.8170.66
46_A52_L0.8130.66
202_S234_I0.8120.66
270_P273_V0.8100.65
135_N138_G0.8070.65
146_Y158_I0.8040.65
167_A260_G0.7990.64
85_I241_Y0.7980.64
193_K276_N0.7950.64
153_P211_Q0.7910.64
212_Q265_T0.7900.64
186_L246_H0.7890.63
210_K215_E0.7780.62
137_K182_N0.7760.62
250_I267_F0.7760.62
188_L276_N0.7740.62
257_V267_F0.7720.62
49_A56_L0.7720.62
260_G271_T0.7710.62
188_L277_L0.7690.61
192_F276_N0.7690.61
54_T69_K0.7650.61
188_L192_F0.7650.61
175_Y266_E0.7650.61
62_D119_K0.7640.61
74_G77_V0.7630.61
215_E221_Y0.7600.61
107_K111_N0.7580.60
274_I278_L0.7570.60
151_D156_L0.7550.60
158_I189_K0.7530.60
209_M213_M0.7490.59
131_S134_K0.7440.59
151_D179_D0.7370.58
126_K129_I0.7370.58
249_V268_T0.7350.58
77_V205_I0.7350.58
148_T151_D0.7350.58
197_Y242_I0.7310.58
60_N134_K0.7300.57
148_T156_L0.7290.57
171_T260_G0.7270.57
206_K209_M0.7260.57
103_G245_D0.7200.56
257_V263_G0.7170.56
218_N221_Y0.7110.55
236_P267_F0.7100.55
92_S201_I0.7090.55
63_A66_A0.7030.55
254_E265_T0.7030.55
234_I252_F0.6990.54
46_A217_P0.6970.54
109_L113_I0.6950.54
254_E259_P0.6940.54
86_K91_Q0.6940.54
154_D226_E0.6850.53
227_D232_K0.6800.52
126_K130_Q0.6790.52
143_Y147_E0.6780.52
62_D78_K0.6780.52
258_A261_Y0.6780.52
62_D65_Q0.6770.52
120_E123_Q0.6760.52
41_W244_E0.6760.52
51_I54_T0.6750.52
122_Q126_K0.6740.52
185_L278_L0.6720.51
109_L182_N0.6720.51
166_Q169_S0.6700.51
147_E222_W0.6700.51
49_A207_E0.6670.51
51_I60_N0.6640.50
163_E171_T0.6640.50
93_S141_S0.6640.50
144_S162_I0.6620.50
253_D260_G0.6620.50
106_N112_S0.6590.50
207_E210_K0.6550.49
190_S279_V0.6510.49
230_P233_T0.6510.49
159_R173_S0.6510.49
253_D258_A0.6470.49
234_I257_V0.6390.48
44_S51_I0.6380.48
216_D267_F0.6360.47
68_S273_V0.6350.47
160_R175_Y0.6280.47
164_T170_Y0.6270.47
91_Q265_T0.6250.46
53_F58_N0.6250.46
83_I98_T0.6240.46
97_K145_D0.6230.46
48_A275_S0.6220.46
148_T157_S0.6220.46
140_L146_Y0.6220.46
63_A191_L0.6200.46
96_V258_A0.6200.46
202_S256_E0.6190.46
237_D267_F0.6180.46
69_K113_I0.6160.45
115_E118_L0.6140.45
202_S236_P0.6140.45
52_L55_A0.6130.45
188_L259_P0.6080.45
177_T279_V0.6050.44
170_Y253_D0.6030.44
52_L132_T0.5980.43
49_A145_D0.5970.43
100_A256_E0.5970.43
63_A102_S0.5960.43
201_I248_L0.5950.43
62_D66_A0.5950.43
186_L248_L0.5930.43
248_L271_T0.5920.43
214_K219_K0.5910.43
45_A134_K0.5900.43
175_Y183_D0.5870.42
115_E242_I0.5860.42
221_Y252_F0.5850.42
193_K197_Y0.5840.42
105_S108_E0.5840.42
163_E168_S0.5830.42
166_Q255_Y0.5830.42
99_P102_S0.5820.42
107_K181_K0.5820.42
265_T270_P0.5820.42
79_A82_F0.5810.42
111_N122_Q0.5810.42
189_K198_I0.5810.42
172_Q254_E0.5790.41
109_L112_S0.5770.41
197_Y236_P0.5760.41
197_Y201_I0.5760.41
144_S177_T0.5720.41
200_V204_N0.5650.40
71_P74_G0.5640.40
157_S185_L0.5640.40
42_P50_A0.5590.39
72_V81_T0.5580.39
172_Q253_D0.5570.39
178_I266_E0.5560.39
193_K196_R0.5560.39
67_M130_Q0.5550.39
238_Q250_I0.5530.39
117_Y177_T0.5530.39
102_S192_F0.5510.39
56_L61_P0.5490.38
107_K114_N0.5490.38
91_Q101_L0.5470.38
156_L248_L0.5470.38
64_A74_G0.5450.38
112_S184_I0.5440.38
117_Y242_I0.5410.38
53_F111_N0.5400.38
92_S99_P0.5390.37
85_I98_T0.5370.37
146_Y240_F0.5370.37
220_I227_D0.5350.37
96_V142_I0.5340.37
116_K238_Q0.5340.37
240_F278_L0.5330.37
223_L227_D0.5310.37
51_I243_T0.5300.37
70_I77_V0.5300.37
71_P272_G0.5290.36
157_S236_P0.5290.36
233_T238_Q0.5250.36
167_A254_E0.5240.36
57_V60_N0.5240.36
205_I208_Q0.5220.36
129_I258_A0.5210.36
53_F203_Q0.5200.36
142_I164_T0.5200.36
147_E185_L0.5190.35
152_T240_F0.5190.35
106_N228_A0.5170.35
63_A269_I0.5170.35
69_K72_V0.5160.35
124_L156_L0.5160.35
174_R178_I0.5150.35
63_A201_I0.5140.35
158_I170_Y0.5120.35
55_A130_Q0.5080.34
212_Q219_K0.5060.34
152_T180_K0.5060.34
252_F256_E0.5050.34
62_D77_V0.5050.34
76_I79_A0.5050.34
111_N114_N0.5030.34
71_P127_E0.5020.34
205_I256_E0.5000.34
165_T170_Y0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s5tA 2 0.7544 100 0.506 Contact Map
3cygA 1 0.7158 100 0.506 Contact Map
4e72A 1 0.7404 100 0.538 Contact Map
2hhiA 1 0.6947 100 0.569 Contact Map
2c1iA 1 0.586 94.5 0.914 Contact Map
4mfiA 1 0.7088 41.5 0.949 Contact Map
3zbiC 1 0.0877 24 0.955 Contact Map
4uu4A 1 0.4912 19.8 0.957 Contact Map
4r9fA 1 0.5088 18.9 0.957 Contact Map
3vejA 2 0.0772 14.8 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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