GREMLIN Database
YRHK - Uncharacterized protein YrhK
UniProt: O05401 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 96 (81)
Sequences: 206 (167)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_L60_A6.0241.00
45_F51_L5.5331.00
47_F60_A5.4001.00
36_G66_L3.4741.00
33_F71_T3.0950.99
24_Y79_H1.9640.88
49_D56_I1.8340.84
52_M56_I1.8140.84
25_K76_H1.7750.82
40_L64_L1.5780.74
44_F48_Y1.5240.71
48_Y51_L1.5220.71
49_D52_M1.4170.65
19_F23_R1.3980.64
61_I66_L1.3920.64
77_D80_Y1.3040.59
38_M68_I1.2790.57
55_G66_L1.2670.57
51_L64_L1.2630.56
29_T77_D1.2600.56
45_F58_L1.2240.54
47_F57_W1.2130.53
52_M55_G1.2070.53
10_Q65_L1.2050.53
51_L56_I1.2010.52
22_K26_V1.1830.51
41_V83_H1.1710.51
38_M65_L1.1640.50
67_L80_Y1.1430.49
21_K29_T1.0710.44
20_F67_L1.0670.44
37_A53_S1.0360.42
29_T73_R1.0280.42
49_D72_I1.0040.40
26_V74_L0.9700.38
20_F82_K0.9490.37
54_A82_K0.9420.37
27_L30_V0.9410.37
79_H83_H0.9400.37
11_K71_T0.9220.35
58_L65_L0.9070.35
33_F66_L0.8990.34
30_V37_A0.8790.33
68_I71_T0.8640.32
76_H84_V0.8620.32
47_F76_H0.8520.32
13_L37_A0.8510.32
51_L55_G0.8340.31
24_Y72_I0.8330.31
43_S46_F0.8310.30
21_K38_M0.8160.30
9_I22_K0.8030.29
25_K77_D0.8000.29
14_K61_I0.7990.29
16_Y83_H0.7960.29
31_N65_L0.7870.28
60_A64_L0.7850.28
18_L31_N0.7720.27
22_K77_D0.7710.27
8_D11_K0.7690.27
57_W74_L0.7580.27
28_Y77_D0.7530.26
83_H87_Q0.7510.26
31_N35_I0.7300.25
15_R71_T0.7300.25
24_Y58_L0.7170.25
34_I38_M0.7120.25
10_Q21_K0.6970.24
45_F54_A0.6870.23
35_I65_L0.6870.23
13_L18_L0.6850.23
75_I78_F0.6850.23
53_S87_Q0.6820.23
58_L61_I0.6800.23
11_K40_L0.6780.23
28_Y69_R0.6680.23
41_V58_L0.6490.22
47_F66_L0.6470.22
14_K74_L0.6460.22
10_Q50_R0.6460.22
75_I86_Q0.6430.21
9_I61_I0.6410.21
14_K18_L0.6390.21
17_E23_R0.6360.21
54_A72_I0.6350.21
7_H33_F0.6270.21
11_K30_V0.6210.21
7_H30_V0.6160.20
22_K36_G0.6120.20
44_F75_I0.6100.20
45_F77_D0.6050.20
68_I79_H0.5990.20
31_N38_M0.5980.20
16_Y75_I0.5970.20
35_I81_R0.5890.19
78_F81_R0.5890.19
64_L87_Q0.5840.19
24_Y40_L0.5830.19
14_K28_Y0.5730.19
57_W79_H0.5720.19
31_N69_R0.5640.18
36_G83_H0.5620.18
25_K85_E0.5570.18
20_F58_L0.5530.18
21_K28_Y0.5500.18
46_F59_F0.5490.18
34_I50_R0.5490.18
68_I82_K0.5450.18
26_V51_L0.5440.18
36_G60_A0.5420.18
48_Y53_S0.5360.17
31_N67_L0.5320.17
27_L61_I0.5310.17
7_H50_R0.5250.17
37_A78_F0.5220.17
20_F77_D0.5210.17
26_V48_Y0.5160.17
26_V77_D0.5160.17
23_R35_I0.5120.16
16_Y64_L0.5070.16
51_L54_A0.5040.16
38_M74_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bjuA 1 0.0417 13.8 0.929 Contact Map
3jsrA 1 0.4062 7 0.938 Contact Map
2kzkA 1 0.6458 4.9 0.943 Contact Map
4i3mA 2 0.3229 4.7 0.943 Contact Map
4i5sA 2 0.4062 4 0.945 Contact Map
2xq2A 2 0.7604 3.9 0.945 Contact Map
4bixA 2 0 3.5 0.946 Contact Map
2kzbA 1 0.6979 3.5 0.947 Contact Map
4ry2A 2 0.8958 3.4 0.947 Contact Map
4q4hA 1 0.9688 3.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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