GREMLIN Database
YRHH - Putative methyltransferase YrhH
UniProt: O05400 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 180 (144)
Sequences: 22734 (17356)
Seq/√Len: 1446.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_I67_S2.5161.00
72_K93_H2.5151.00
41_R64_S2.4941.00
129_Y162_F2.3861.00
68_I94_G2.2611.00
46_G114_T2.0911.00
109_V128_I2.0781.00
132_L136_G2.0381.00
66_K92_F2.0371.00
66_K106_F1.9521.00
78_I91_V1.9351.00
37_Q40_D1.8991.00
101_F106_F1.8701.00
43_L106_F1.8631.00
120_D123_L1.8121.00
75_V91_V1.7841.00
127_E130_R1.7691.00
40_D108_K1.7651.00
45_I128_I1.7611.00
122_R159_D1.7351.00
53_F65_L1.7291.00
114_T118_C1.7251.00
64_S90_E1.6751.00
107_N133_Q1.6511.00
109_V132_L1.6501.00
45_I96_P1.6421.00
128_I138_F1.6241.00
122_R126_R1.6121.00
54_K82_N1.6111.00
70_P95_Y1.6001.00
116_Q142_I1.5811.00
122_R156_L1.5591.00
94_G100_P1.5581.00
41_R66_K1.5361.00
75_V93_H1.5321.00
72_K76_R1.5091.00
47_I53_F1.4781.00
92_F101_F1.4731.00
118_C124_A1.4521.00
66_K90_E1.4511.00
154_I158_K1.3931.00
42_I108_K1.3841.00
53_F67_S1.3701.00
111_S114_T1.3651.00
36_I40_D1.3591.00
132_L138_F1.3421.00
121_I156_L1.3341.00
82_N91_V1.3161.00
41_R106_F1.3071.00
113_H116_Q1.3041.00
117_S142_I1.3031.00
96_P114_T1.2751.00
122_R160_Q1.2651.00
41_R105_T1.2641.00
127_E131_V1.2611.00
132_L162_F1.2561.00
42_I56_I1.2541.00
41_R107_N1.2481.00
41_R133_Q1.2421.00
44_E47_I1.2331.00
54_K81_A1.2291.00
126_R160_Q1.2061.00
77_Q80_R1.1881.00
102_D105_T1.1851.00
125_L157_L1.1801.00
69_D75_V1.1721.00
96_P118_C1.1591.00
103_D130_R1.1481.00
82_N89_G1.1371.00
67_S91_V1.1361.00
66_K101_F1.0931.00
56_I110_F1.0681.00
52_V112_L1.0651.00
99_I131_V1.0631.00
47_I78_I1.0571.00
129_Y160_Q1.0371.00
69_D74_K1.0341.00
155_Q159_D1.0321.00
73_R76_R1.0191.00
112_L141_S1.0121.00
99_I127_E1.0121.00
57_T88_N0.9911.00
71_S74_K0.9891.00
113_H117_S0.9851.00
115_V118_C0.9791.00
113_H141_S0.9731.00
75_V79_S0.9681.00
55_S59_K0.9671.00
33_S168_I0.9661.00
23_T26_I0.9571.00
23_T27_E0.9531.00
85_N88_N0.9461.00
123_L126_R0.9461.00
95_Y98_D0.9451.00
49_N74_K0.9321.00
29_M33_S0.9241.00
76_R79_S0.9141.00
55_S58_K0.9021.00
124_A128_I0.8831.00
52_V110_F0.8821.00
67_S78_I0.8741.00
36_I39_N0.8721.00
154_I167_V0.8711.00
113_H143_D0.8681.00
125_L160_Q0.8461.00
46_G111_S0.8431.00
116_Q143_D0.8391.00
50_G78_I0.8351.00
109_V131_V0.8301.00
30_M139_Y0.8291.00
115_V124_A0.8261.00
53_F91_V0.8151.00
29_M32_D0.8091.00
111_S128_I0.8041.00
29_M168_I0.8041.00
49_N81_A0.7981.00
45_I109_V0.7981.00
43_L131_V0.7971.00
100_P127_E0.7911.00
115_V125_L0.7751.00
47_I75_V0.7721.00
43_L109_V0.7641.00
54_K58_K0.7601.00
97_E120_D0.7601.00
51_T55_S0.7501.00
155_Q158_K0.7451.00
77_Q81_A0.7441.00
150_E154_I0.7411.00
40_D107_N0.7391.00
79_S91_V0.7391.00
111_S140_I0.7361.00
152_T155_Q0.7361.00
52_V55_S0.7331.00
97_E124_A0.7331.00
111_S118_C0.7321.00
101_F131_V0.7321.00
98_D123_L0.7321.00
51_T81_A0.7301.00
123_L127_E0.7271.00
39_N61_K0.7251.00
35_D137_R0.7141.00
81_A84_K0.7121.00
68_I99_I0.7061.00
97_E118_C0.7031.00
80_R84_K0.7001.00
28_H32_D0.7001.00
108_K137_R0.6931.00
106_F131_V0.6921.00
79_S83_R0.6891.00
112_L116_Q0.6871.00
125_L153_Y0.6851.00
111_S138_F0.6821.00
125_L156_L0.6801.00
128_I132_L0.6761.00
98_D127_E0.6731.00
140_I157_L0.6731.00
47_I69_D0.6671.00
115_V140_I0.6581.00
42_I65_L0.6551.00
156_L159_D0.6481.00
25_T28_H0.6461.00
28_H55_S0.6451.00
68_I92_F0.6351.00
53_F89_G0.6341.00
24_K28_H0.6291.00
54_K57_T0.6241.00
32_D59_K0.6231.00
105_T133_Q0.6211.00
104_R134_I0.6171.00
49_N77_Q0.6161.00
108_K136_G0.6161.00
74_K113_H0.6111.00
97_E123_L0.6021.00
101_F105_T0.5991.00
76_R80_R0.5971.00
39_N60_L0.5891.00
52_V116_Q0.5871.00
117_S143_D0.5851.00
94_G99_I0.5841.00
30_M33_S0.5831.00
43_L68_I0.5831.00
103_D131_V0.5831.00
51_T54_K0.5761.00
152_T156_L0.5681.00
112_L142_I0.5661.00
144_T150_E0.5621.00
164_D167_V0.5611.00
144_T148_E0.5591.00
44_E68_I0.5591.00
73_R77_Q0.5531.00
79_S82_N0.5481.00
121_I124_A0.5471.00
138_F162_F0.5471.00
96_P124_A0.5431.00
103_D127_E0.5411.00
142_I153_Y0.5401.00
126_R129_Y0.5311.00
45_I68_I0.5291.00
42_I110_F0.5281.00
97_E119_T0.5251.00
36_I108_K0.5231.00
27_E143_D0.5201.00
158_K164_D0.5131.00
121_I125_L0.5111.00
158_K165_L0.5111.00
49_N113_H0.5111.00
37_Q61_K0.5101.00
27_E112_L0.5101.00
27_E52_V0.5081.00
50_G91_V0.5061.00
30_M34_I0.5061.00
114_T117_S0.5051.00
52_V56_I0.5031.00
83_R86_M0.5011.00
72_K79_S0.5011.00
31_I59_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4obxA 2 0.9611 100 0.356 Contact Map
4pneA 2 0.9833 100 0.369 Contact Map
2o57A 2 0.9889 100 0.371 Contact Map
3ujcA 1 0.9333 100 0.386 Contact Map
1vl5A 1 0.8611 100 0.391 Contact Map
4fsdA 1 0.8667 100 0.392 Contact Map
4kriA 1 0.9944 100 0.394 Contact Map
4ineA 2 0.9944 100 0.395 Contact Map
4iv0A 1 0.9556 100 0.395 Contact Map
3bkxA 2 0.9944 100 0.396 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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