YRHG - BACSU - GREMLIN Contacts

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YRHG - Uncharacterized transporter YrhG

UniProt:	O05399	Sequences: MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYLLDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISVKELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLISAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAGSFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (245)
Sequences:	2188 (1487)
Seq/√Len:	95.0

ECOLI - FOCA YFDC FOCB NIRC
BACSU - YRHG YWCJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_L	238_I	7.021	1.00
159_L	234_I	4.522	1.00
32_G	115_M	3.880	1.00
158_V	232_A	3.800	1.00
183_A	187_L	3.647	1.00
95_L	102_V	3.506	1.00
33_F	122_F	3.121	1.00
29_L	115_M	3.068	1.00
113_T	233_F	3.030	1.00
234_I	238_I	2.937	1.00
40_A	123_V	2.913	1.00
155_F	231_P	2.794	1.00
45_L	195_A	2.486	1.00
211_I	225_F	2.469	1.00
17_G	94_A	2.380	1.00
125_Y	129_H	2.264	1.00
84_I	88_M	2.254	1.00
70_P	190_W	2.083	1.00
167_W	243_F	2.067	1.00
29_L	111_I	2.063	1.00
95_L	105_L	2.028	1.00
105_L	109_W	1.968	1.00
25_L	111_I	1.854	1.00
22_K	104_E	1.836	1.00
154_S	157_K	1.832	1.00
181_D	184_G	1.831	1.00
87_N	108_N	1.806	1.00
79_A	248_Y	1.795	1.00
33_F	118_I	1.766	1.00
17_G	20_K	1.752	1.00
109_W	237_V	1.737	1.00
84_I	237_V	1.736	1.00
215_I	225_F	1.732	1.00
106_A	110_G	1.731	1.00
153_M	161_S	1.720	1.00
163_I	238_I	1.700	1.00
95_L	100_I	1.698	1.00
37_A	167_W	1.697	1.00
113_T	204_V	1.673	1.00
74_I	186_I	1.672	1.00
179_A	184_G	1.653	1.00
124_A	216_F	1.636	1.00
29_L	118_I	1.634	1.00
28_L	111_I	1.623	1.00
75_L	171_L	1.598	1.00
215_I	222_W	1.598	1.00
46_D	65_G	1.589	1.00
145_A	148_Q	1.578	1.00
88_M	109_W	1.569	1.00
79_A	174_W	1.554	1.00
117_L	208_M	1.535	1.00
126_F	160_I	1.524	1.00
226_I	230_I	1.472	1.00
29_L	33_F	1.463	1.00
204_V	233_F	1.456	1.00
125_Y	216_F	1.456	1.00
221_T	224_Q	1.444	1.00
10_A	253_H	1.426	1.00
156_G	160_I	1.423	0.99
94_A	100_I	1.416	0.99
110_G	114_I	1.410	0.99
175_L	188_G	1.400	0.99
45_L	194_M	1.383	0.99
9_I	178_G	1.352	0.99
31_L	251_A	1.344	0.99
15_E	99_K	1.319	0.99
153_M	158_V	1.317	0.99
63_L	194_M	1.313	0.99
41_L	167_W	1.302	0.99
243_F	247_I	1.291	0.99
178_G	182_A	1.291	0.99
50_I	142_K	1.282	0.99
66_A	198_A	1.269	0.99
103_K	107_I	1.262	0.99
126_F	164_G	1.228	0.98
157_K	161_S	1.221	0.98
121_L	216_F	1.219	0.98
67_A	190_W	1.217	0.98
102_V	106_A	1.216	0.98
179_A	182_A	1.214	0.98
101_S	104_E	1.206	0.98
162_A	231_P	1.202	0.98
237_V	241_A	1.194	0.98
57_W	60_L	1.188	0.98
207_N	228_N	1.181	0.98
211_I	215_I	1.181	0.98
71_V	195_A	1.179	0.98
43_Y	210_V	1.177	0.98
50_I	65_G	1.172	0.98
148_Q	152_D	1.171	0.98
45_L	198_A	1.170	0.98
78_L	182_A	1.169	0.98
230_I	234_I	1.152	0.98
155_F	234_I	1.137	0.98
34_L	247_I	1.131	0.97
37_A	40_A	1.125	0.97
244_V	248_Y	1.119	0.97
233_F	237_V	1.099	0.97
47_I	146_V	1.096	0.97
24_P	27_S	1.095	0.97
49_V	64_I	1.094	0.97
149_G	152_D	1.091	0.97
13_A	177_F	1.088	0.97
81_A	248_Y	1.085	0.97
165_C	205_V	1.081	0.97
41_L	168_L	1.079	0.97
93_M	245_G	1.079	0.97
137_G	141_E	1.077	0.97
113_T	229_I	1.073	0.96
44_L	199_I	1.064	0.96
72_G	197_V	1.059	0.96
205_V	208_M	1.051	0.96
114_I	118_I	1.048	0.96
18_M	99_K	1.047	0.96
96_F	249_F	1.045	0.96
242_V	246_L	1.045	0.96
96_F	246_L	1.043	0.96
117_L	121_L	1.042	0.96
28_L	107_I	1.040	0.96
77_V	189_I	1.036	0.96
124_A	213_A	1.028	0.95
213_A	217_A	1.027	0.95
54_P	57_W	1.014	0.95
167_W	244_V	1.007	0.95
142_K	145_A	1.006	0.95
216_F	222_W	0.997	0.95
31_L	82_E	0.996	0.95
97_S	249_F	0.985	0.94
41_L	123_V	0.979	0.94
227_G	231_P	0.973	0.94
47_I	143_T	0.965	0.94
76_V	81_A	0.960	0.93
67_A	194_M	0.959	0.93
141_E	145_A	0.958	0.93
155_F	159_L	0.956	0.93
25_L	29_L	0.954	0.93
38_F	81_A	0.945	0.93
224_Q	227_G	0.938	0.93
15_E	19_K	0.935	0.93
159_L	162_A	0.930	0.92
74_I	191_F	0.930	0.92
143_T	213_A	0.925	0.92
162_A	233_F	0.924	0.92
38_F	248_Y	0.915	0.92
26_P	250_I	0.912	0.92
137_G	140_L	0.907	0.91
129_H	160_I	0.907	0.91
108_N	112_V	0.903	0.91
15_E	18_M	0.894	0.91
76_V	162_A	0.891	0.91
155_F	227_G	0.890	0.91
113_T	117_L	0.881	0.90
82_E	87_N	0.880	0.90
18_M	22_K	0.876	0.90
84_I	205_V	0.863	0.89
34_L	38_F	0.858	0.89
47_I	209_F	0.857	0.89
123_V	167_W	0.857	0.89
21_I	100_I	0.850	0.89
60_L	64_I	0.849	0.88
161_S	202_Q	0.845	0.88
121_L	212_P	0.841	0.88
141_E	144_I	0.838	0.88
204_V	229_I	0.837	0.88
174_W	248_Y	0.836	0.88
150_K	206_A	0.832	0.87
77_V	173_V	0.829	0.87
150_K	166_N	0.825	0.87
51_G	142_K	0.824	0.87
112_V	174_W	0.823	0.87
49_V	68_V	0.821	0.87
169_V	196_F	0.820	0.87
12_A	177_F	0.817	0.86
151_L	224_Q	0.815	0.86
52_D	66_A	0.803	0.86
158_V	162_A	0.797	0.85
79_A	171_L	0.796	0.85
231_P	234_I	0.788	0.84
90_S	94_A	0.786	0.84
92_A	96_F	0.785	0.84
167_W	171_L	0.785	0.84
95_L	106_A	0.782	0.84
102_V	105_L	0.778	0.84
11_E	15_E	0.777	0.84
132_G	157_K	0.777	0.84
229_I	233_F	0.776	0.84
70_P	218_G	0.772	0.83
84_I	233_F	0.772	0.83
30_V	247_I	0.768	0.83
122_F	125_Y	0.764	0.83
124_A	212_P	0.763	0.83
150_K	196_F	0.762	0.82
79_A	175_L	0.762	0.82
150_K	207_N	0.757	0.82
166_N	196_F	0.756	0.82
147_A	211_I	0.756	0.82
54_P	61_S	0.756	0.82
70_P	74_I	0.754	0.82
28_L	112_V	0.754	0.82
25_L	110_G	0.750	0.81
40_A	209_F	0.749	0.81
38_F	75_L	0.749	0.81
147_A	214_A	0.745	0.81
142_K	146_V	0.744	0.81
84_I	113_T	0.744	0.81
78_L	178_G	0.742	0.81
175_L	192_P	0.740	0.81
165_C	232_A	0.735	0.80
155_F	158_V	0.732	0.80
31_L	174_W	0.732	0.80
151_L	215_I	0.731	0.80
168_L	189_I	0.729	0.80
53_L	58_G	0.725	0.79
67_A	74_I	0.725	0.79
82_E	112_V	0.724	0.79
172_A	196_F	0.724	0.79
138_P	141_E	0.723	0.79
242_V	247_I	0.719	0.79
196_F	206_A	0.719	0.79
196_F	207_N	0.718	0.79
113_T	205_V	0.716	0.78
104_E	107_I	0.716	0.78
121_L	124_A	0.712	0.78
32_G	112_V	0.707	0.77
144_I	214_A	0.704	0.77
204_V	232_A	0.703	0.77
85_T	165_C	0.703	0.77
89_M	186_I	0.701	0.77
131_V	161_S	0.696	0.76
88_M	240_G	0.694	0.76
212_P	216_F	0.688	0.76
128_G	216_F	0.688	0.76
14_I	97_S	0.688	0.76
46_D	50_I	0.684	0.75
88_M	92_A	0.671	0.74
225_F	229_I	0.668	0.73
8_E	11_E	0.662	0.73
226_I	231_P	0.662	0.73
166_N	207_N	0.658	0.72
174_W	252_Y	0.658	0.72
202_Q	207_N	0.658	0.72
174_W	244_V	0.657	0.72
146_V	210_V	0.656	0.72
30_V	251_A	0.653	0.72
151_L	214_A	0.652	0.72
98_R	102_V	0.650	0.71
110_G	230_I	0.649	0.71
168_L	192_P	0.646	0.71
215_I	220_F	0.645	0.71
74_I	189_I	0.645	0.71
75_L	168_L	0.643	0.71
186_I	191_F	0.643	0.71
209_F	212_P	0.640	0.70
35_G	86_G	0.638	0.70
47_I	210_V	0.636	0.70
95_L	98_R	0.636	0.70
53_L	60_L	0.629	0.69
11_E	14_I	0.629	0.69
91_V	94_A	0.628	0.69
218_G	224_Q	0.626	0.68
240_G	245_G	0.614	0.67
8_E	180_Q	0.614	0.67
222_W	226_I	0.613	0.67
20_K	209_F	0.609	0.66
140_L	144_I	0.608	0.66
223_G	226_I	0.606	0.66
131_V	160_I	0.606	0.66
117_L	120_A	0.603	0.66
127_F	164_G	0.602	0.65
114_I	134_T	0.600	0.65
31_L	81_A	0.600	0.65
46_D	197_V	0.594	0.64
169_V	193_I	0.590	0.64
241_A	245_G	0.586	0.63
79_A	178_G	0.585	0.63
12_A	16_A	0.583	0.63
32_G	35_G	0.582	0.63
166_N	228_N	0.581	0.63
170_C	245_G	0.580	0.63
67_A	187_L	0.580	0.63
68_V	194_M	0.579	0.62
171_L	244_V	0.573	0.62
52_D	59_S	0.573	0.62
84_I	240_G	0.573	0.62
89_M	252_Y	0.573	0.62
32_G	111_I	0.572	0.62
166_N	169_V	0.572	0.62
33_F	243_F	0.570	0.61
84_I	204_V	0.569	0.61
89_M	170_C	0.563	0.60
149_G	219_S	0.561	0.60
90_S	100_I	0.561	0.60
165_C	196_F	0.560	0.60
72_G	112_V	0.560	0.60
18_M	100_I	0.560	0.60
184_G	187_L	0.560	0.60
170_C	202_Q	0.560	0.60
143_T	214_A	0.557	0.60
86_G	149_G	0.557	0.60
98_R	101_S	0.555	0.59
33_F	37_A	0.555	0.59
71_V	75_L	0.553	0.59
166_N	170_C	0.553	0.59
223_G	227_G	0.552	0.59
49_V	111_I	0.551	0.59
53_L	61_S	0.551	0.59
196_F	202_Q	0.551	0.59
248_Y	252_Y	0.550	0.59
11_E	118_I	0.550	0.59
23_L	28_L	0.549	0.58
92_A	241_A	0.546	0.58
123_V	205_V	0.540	0.57
166_N	193_I	0.540	0.57
176_S	188_G	0.539	0.57
155_F	230_I	0.539	0.57
239_G	244_V	0.539	0.57
28_L	108_N	0.539	0.57
78_L	179_A	0.537	0.57
228_N	232_A	0.536	0.57
57_W	70_P	0.535	0.57
77_V	101_S	0.535	0.57
14_I	253_H	0.535	0.57
14_I	17_G	0.534	0.56
207_N	232_A	0.533	0.56
178_G	252_Y	0.533	0.56
73_L	189_I	0.532	0.56
194_M	198_A	0.532	0.56
39_I	43_Y	0.530	0.56
11_E	99_K	0.529	0.56
82_E	108_N	0.528	0.56
64_I	109_W	0.528	0.56
106_A	238_I	0.527	0.55
25_L	107_I	0.527	0.55
43_Y	209_F	0.526	0.55
95_L	104_E	0.524	0.55
117_L	226_I	0.524	0.55
75_L	195_A	0.524	0.55
70_P	193_I	0.523	0.55
29_L	162_A	0.523	0.55
41_L	90_S	0.520	0.54
153_M	156_G	0.519	0.54
91_V	112_V	0.518	0.54
72_G	182_A	0.518	0.54
69_F	196_F	0.515	0.54
158_V	231_P	0.515	0.54
148_Q	219_S	0.514	0.54
21_I	108_N	0.514	0.54
120_A	209_F	0.514	0.54
20_K	32_G	0.513	0.53
16_A	19_K	0.513	0.53
42_G	68_V	0.512	0.53
89_M	244_V	0.512	0.53
64_I	201_F	0.512	0.53
29_L	101_S	0.511	0.53
133_L	161_S	0.510	0.53
53_L	57_W	0.510	0.53
212_P	215_I	0.509	0.53
100_I	166_N	0.507	0.53
158_V	227_G	0.505	0.52
114_I	226_I	0.504	0.52
78_L	189_I	0.504	0.52
22_K	220_F	0.503	0.52
178_G	188_G	0.503	0.52
89_M	241_A	0.503	0.52
197_V	206_A	0.501	0.52
140_L	214_A	0.501	0.52
66_A	173_V	0.500	0.52
68_V	79_A	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kcuA	3	0.8647	100	0.072	Contact Map
3klyA	3	0.8835	100	0.079	Contact Map
3tdsE	3	0.9774	100	0.106	Contact Map
4fc4A	3	0.9173	100	0.129	Contact Map
3llqA	3	0.8496	88.5	0.933	Contact Map
3cn5A	3	0.8271	82.2	0.938	Contact Map
3iyzA	3	0.7782	75.7	0.942	Contact Map
3zojA	3	0.8985	75.2	0.942	Contact Map
4nefA	4	0.8421	68.5	0.945	Contact Map
2zz9A	3	0.7707	64.9	0.946	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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