GREMLIN Database
MCCB - Cystathionine gamma-lyase
UniProt: O05394 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (375)
Sequences: 10582 (5960)
Seq/√Len: 307.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_Q183_T3.5371.00
90_H117_T3.3151.00
128_E162_K3.1841.00
65_G209_V3.1761.00
264_E279_N3.1131.00
4_K364_D3.0471.00
373_G377_E2.9861.00
64_S183_T2.9351.00
257_R261_S2.7931.00
90_H132_R2.7681.00
317_F328_S2.6091.00
59_V207_L2.5341.00
271_T300_D2.4331.00
154_T288_T2.4081.00
154_T158_D2.3981.00
343_R347_L2.3941.00
137_A168_I2.3941.00
283_H287_K2.2821.00
262_F369_L2.2681.00
6_L61_E2.2571.00
178_F253_D2.2111.00
250_E254_Q2.1931.00
262_F373_G2.1571.00
157_A167_L2.0621.00
123_S126_E2.0201.00
300_D354_G2.0141.00
151_T156_M2.0131.00
231_G234_D1.9971.00
124_R155_L1.9951.00
53_T57_A1.9861.00
303_S306_R1.9671.00
161_K187_D1.9511.00
55_L238_L1.9411.00
193_A205_G1.9341.00
115_E132_R1.9251.00
332_V335_R1.9171.00
196_Y295_G1.9061.00
4_K246_G1.9001.00
259_I369_L1.8901.00
89_D136_K1.8831.00
169_V186_A1.8751.00
158_D162_K1.8371.00
251_A254_Q1.8341.00
117_T132_R1.8031.00
161_K167_L1.7751.00
86_N111_R1.7641.00
68_G209_V1.7521.00
125_E128_E1.7461.00
252_I295_G1.7431.00
3_K177_Y1.7431.00
365_A369_L1.7271.00
346_R353_D1.7161.00
255_N365_A1.7001.00
343_R353_D1.6991.00
52_R235_S1.6851.00
258_K365_A1.6631.00
90_H115_E1.6551.00
63_E191_H1.6521.00
261_S278_S1.6521.00
119_V130_A1.6421.00
300_D352_T1.6291.00
124_R159_I1.6231.00
167_L186_A1.6221.00
258_K369_L1.6201.00
258_K261_S1.6091.00
42_Y48_A1.5971.00
93_L105_M1.5951.00
138_I156_M1.5951.00
314_L330_I1.5951.00
65_G182_L1.5911.00
309_A313_N1.5881.00
301_I310_F1.5481.00
270_Q300_D1.5471.00
270_Q354_G1.5301.00
173_F323_L1.5201.00
180_Q291_A1.5161.00
138_I160_A1.5091.00
90_H135_T1.4941.00
128_E163_A1.4881.00
193_A238_L1.4831.00
342_P345_R1.4741.00
258_K366_E1.4721.00
213_K217_E1.4681.00
90_H134_N1.4631.00
304_E308_D1.4601.00
259_I360_V1.4561.00
205_G230_L1.4541.00
262_F266_H1.4441.00
10_G61_E1.4401.00
55_L70_A1.4371.00
193_A207_L1.4291.00
60_T68_G1.4261.00
317_F372_I1.4181.00
27_Q233_Q1.4111.00
155_L158_D1.4041.00
68_G207_L1.4021.00
315_K374_Q1.4011.00
131_I165_V1.3941.00
86_N89_D1.3821.00
131_I138_I1.3811.00
78_I139_Y1.3811.00
304_E353_D1.3801.00
157_A161_K1.3701.00
249_M252_I1.3681.00
154_T289_Q1.3671.00
278_S283_H1.3671.00
247_L362_I1.3631.00
71_F208_V1.3581.00
55_L207_L1.3531.00
230_L235_S1.3501.00
23_V54_A1.3381.00
42_Y53_T1.3301.00
93_L97_V1.3291.00
259_I372_I1.3271.00
125_E129_K1.3101.00
115_E134_N1.3071.00
140_I153_L1.3051.00
152_D155_L1.3001.00
266_H373_G1.2921.00
140_I167_L1.2911.00
131_I159_I1.2841.00
255_N362_I1.2801.00
317_F368_L1.2791.00
179_Q184_L1.2791.00
287_K293_F1.2711.00
358_I372_I1.2671.00
259_I368_L1.2581.00
182_L211_A1.2521.00
85_F91_V1.2501.00
168_I190_L1.2491.00
330_I356_I1.2481.00
35_K312_G1.2291.00
106_T118_F1.2221.00
316_L368_L1.2181.00
157_A186_A1.2171.00
148_L275_P1.2141.00
298_S355_L1.2111.00
76_A228_G1.2101.00
59_V209_V1.2071.00
253_D292_G1.2021.00
203_V238_L1.2021.00
154_T184_L1.1991.00
276_G293_F1.1951.00
256_A260_A1.1921.00
32_K318_T1.1901.00
264_E277_S1.1891.00
105_M116_S1.1881.00
283_H293_F1.1851.00
260_A277_S1.1741.00
284_E287_K1.1741.00
197_L242_I1.1691.00
193_A197_L1.1651.00
127_V156_M1.1621.00
198_G203_V1.1601.00
7_M246_G1.1541.00
326_V362_I1.1461.00
66_E213_K1.1421.00
251_A255_N1.1391.00
158_D161_K1.1391.00
202_D240_R1.1391.00
37_G312_G1.1341.00
246_G250_E1.1311.00
203_V234_D1.1291.00
166_L215_L1.1231.00
282_G285_L1.1221.00
92_V130_A1.1181.00
67_A213_K1.1141.00
286_A293_F1.1141.00
95_D149_K1.1121.00
81_V137_A1.1111.00
160_A167_L1.1081.00
261_S264_E1.1001.00
254_Q258_K1.0961.00
53_T56_E1.0931.00
138_I165_V1.0891.00
190_L208_V1.0851.00
148_L297_I1.0751.00
21_V318_T1.0741.00
205_G238_L1.0731.00
59_V197_L1.0721.00
85_F89_D1.0681.00
106_T110_N1.0501.00
58_L239_M1.0401.00
69_Y216_G1.0391.00
259_I365_A1.0391.00
369_L373_G1.0381.00
36_A312_G1.0331.00
283_H286_A1.0271.00
345_R348_E1.0231.00
153_L186_A1.0201.00
128_E159_I1.0181.00
126_E129_K1.0171.00
260_A272_L1.0161.00
37_G308_D1.0131.00
140_I169_V1.0121.00
284_E288_T1.0121.00
178_F292_G1.0101.00
247_L251_A1.0101.00
131_I163_A1.0031.00
201_S325_A0.9971.00
370_E373_G0.9931.00
233_Q237_L0.9931.00
121_T127_V0.9891.00
79_T104_V0.9861.00
305_E309_A0.9851.00
310_F372_I0.9831.00
58_L242_I0.9831.00
310_F330_I0.9811.00
73_S204_V0.9711.00
280_H283_H0.9681.00
52_R230_L0.9681.00
273_Y300_D0.9671.00
306_R354_G0.9631.00
371_D374_Q0.9631.00
198_G238_L0.9631.00
176_P191_H0.9611.00
310_F356_I0.9601.00
8_I362_I0.9581.00
253_D257_R0.9571.00
67_A216_G0.9531.00
78_I190_L0.9481.00
75_M78_I0.9471.00
182_L189_V0.9471.00
140_I151_T0.9441.00
215_L218_E0.9421.00
299_F358_I0.9411.00
122_S282_G0.9411.00
117_T130_A0.9361.00
67_A220_H0.9341.00
120_D126_E0.9301.00
177_Y250_E0.9291.00
139_Y168_I0.9291.00
214_E218_E0.9281.00
211_A216_G0.9271.00
173_F296_M0.9231.00
311_L330_I0.9191.00
246_G251_A0.9181.00
262_F376_L0.9171.00
93_L118_F0.9161.00
102_Y106_T0.9161.00
69_Y220_H0.9151.00
19_G34_P0.9131.00
263_L299_F0.9131.00
302_G306_R0.9091.00
243_K327_E0.9091.00
334_A346_R0.9081.00
153_L157_A0.9021.00
13_T57_A0.9011.00
96_D149_K0.9001.00
194_T204_V0.8961.00
256_A274_Y0.8951.00
45_S52_R0.8931.00
160_A165_V0.8921.00
25_I233_Q0.8921.00
93_L116_S0.8901.00
268_A376_L0.8891.00
64_S180_Q0.8891.00
47_T224_N0.8881.00
271_T354_G0.8861.00
317_F358_I0.8861.00
70_A207_L0.8841.00
259_I358_I0.8831.00
143_P179_Q0.8811.00
140_I156_M0.8791.00
261_S277_S0.8761.00
156_M167_L0.8711.00
174_N290_G0.8691.00
218_E221_F0.8681.00
66_E212_S0.8681.00
92_V119_V0.8611.00
150_I282_G0.8521.00
52_R70_A0.8511.00
193_A230_L0.8471.00
153_L179_Q0.8461.00
139_Y190_L0.8441.00
266_H376_L0.8431.00
71_F76_A0.8411.00
110_N115_E0.8411.00
308_D312_G0.8361.00
23_V239_M0.8341.00
85_F137_A0.8321.00
137_A166_L0.8311.00
366_E370_E0.8301.00
79_T226_T0.8251.00
124_R128_E0.8241.00
266_H377_E0.8231.00
179_Q289_Q0.8211.00
15_D18_T0.8191.00
6_L10_G0.8191.00
177_Y249_M0.8181.00
303_S354_G0.8141.00
313_N375_A0.8141.00
25_I236_W0.8131.00
257_R274_Y0.8101.00
188_I208_V0.8091.00
143_P289_Q0.8021.00
255_N259_I0.8021.00
297_I358_I0.8011.00
4_K251_A0.8001.00
257_R264_E0.7981.00
153_L184_L0.7981.00
317_F330_I0.7941.00
210_T216_G0.7921.00
80_A83_M0.7911.00
85_F114_I0.7881.00
221_F224_N0.7881.00
80_A168_I0.7861.00
71_F80_A0.7851.00
305_E308_D0.7820.99
159_I163_A0.7810.99
71_F223_Q0.7810.99
246_G364_D0.7810.99
3_K180_Q0.7790.99
230_L238_L0.7790.99
150_I285_L0.7780.99
3_K6_L0.7750.99
261_S265_N0.7740.99
101_T139_Y0.7730.99
197_L238_L0.7720.99
257_R292_G0.7710.99
66_E211_A0.7710.99
81_V208_V0.7650.99
258_K262_F0.7600.99
310_F314_L0.7590.99
273_Y280_H0.7570.99
5_T316_L0.7560.99
91_V137_A0.7560.99
91_V105_M0.7560.99
366_E369_L0.7560.99
188_I215_L0.7540.99
255_N360_V0.7530.99
20_A26_Y0.7520.99
262_F372_I0.7500.99
72_S228_G0.7460.99
124_R127_V0.7450.99
69_Y208_V0.7440.99
55_L193_A0.7440.99
90_H133_P0.7430.99
111_R218_E0.7420.99
254_Q365_A0.7410.99
86_N136_K0.7400.99
328_S358_I0.7380.99
216_G220_H0.7340.99
317_F360_V0.7340.99
191_H209_V0.7330.99
55_L197_L0.7330.99
214_E219_L0.7320.99
84_L215_L0.7310.99
121_T151_T0.7300.99
89_D134_N0.7250.99
161_K165_V0.7250.99
311_L356_I0.7250.99
343_R346_R0.7200.99
71_F228_G0.7170.99
27_Q203_V0.7170.99
184_L289_Q0.7150.99
274_Y297_I0.7150.99
306_R309_A0.7140.99
178_F249_M0.7120.99
117_T134_N0.7120.99
270_Q302_G0.7090.99
268_A306_R0.7090.99
171_N181_P0.7080.99
43_E47_T0.7060.99
253_D295_G0.7000.99
233_Q236_W0.6990.99
144_T147_L0.6990.99
171_N191_H0.6990.99
144_T149_K0.6990.99
84_L168_I0.6930.99
59_V70_A0.6930.99
237_L240_R0.6920.99
219_L223_Q0.6910.99
138_I161_K0.6900.99
66_E210_T0.6900.99
149_K282_G0.6890.99
92_V135_T0.6870.99
259_I262_F0.6870.99
178_F291_A0.6840.99
153_L167_L0.6830.99
216_G219_L0.6800.99
254_Q292_G0.6790.99
70_A230_L0.6780.99
63_E189_V0.6780.99
257_R276_G0.6770.99
268_A377_E0.6770.99
22_S236_W0.6760.99
126_E130_A0.6740.99
269_V299_F0.6720.98
67_A211_A0.6720.98
119_V127_V0.6700.98
59_V193_A0.6690.98
105_M139_Y0.6680.98
197_L245_L0.6680.98
27_Q236_W0.6670.98
119_V126_E0.6660.98
215_L219_L0.6630.98
30_T322_S0.6610.98
299_F356_I0.6610.98
48_A53_T0.6570.98
155_L159_I0.6530.98
150_I286_A0.6510.98
188_I210_T0.6510.98
273_Y298_S0.6500.98
85_F136_K0.6490.98
268_A301_I0.6490.98
81_V85_F0.6450.98
87_S113_G0.6440.98
269_V376_L0.6440.98
143_P174_N0.6420.98
56_E70_A0.6420.98
73_S229_V0.6420.98
3_K7_M0.6390.98
219_L224_N0.6370.98
150_I280_H0.6360.98
290_G293_F0.6360.98
196_Y296_M0.6330.98
142_T171_N0.6290.98
168_I188_I0.6270.98
310_F375_A0.6270.98
230_L234_D0.6260.98
91_V116_S0.6260.98
372_I376_L0.6250.98
252_I255_N0.6250.98
321_E331_S0.6250.98
217_E221_F0.6230.98
152_D288_T0.6210.97
310_F376_L0.6210.97
253_D293_F0.6200.97
370_E374_Q0.6190.97
127_V138_I0.6190.97
54_A239_M0.6180.97
285_L289_Q0.6180.97
260_A297_I0.6180.97
344_E348_E0.6140.97
309_A312_G0.6140.97
176_P197_L0.6140.97
128_E155_L0.6130.97
57_A61_E0.6120.97
123_S129_K0.6110.97
18_T26_Y0.6110.97
131_I135_T0.6100.97
285_L288_T0.6100.97
219_L222_V0.6080.97
313_N374_Q0.6080.97
28_V31_Y0.6070.97
102_Y118_F0.6060.97
122_S149_K0.6050.97
208_V219_L0.6050.97
330_I358_I0.6050.97
347_L352_T0.6030.97
334_A353_D0.6030.97
103_R107_K0.6020.97
72_S229_V0.6010.97
160_A163_A0.6010.97
55_L239_M0.6000.97
300_D355_L0.5980.97
171_N174_N0.5980.97
56_E68_G0.5980.97
303_S307_V0.5970.97
94_T121_T0.5960.97
243_K326_V0.5930.97
96_D144_T0.5920.97
204_V229_V0.5910.97
129_K133_P0.5910.97
214_E217_E0.5890.97
108_V225_S0.5890.97
3_K246_G0.5880.96
210_T215_L0.5880.96
264_E280_H0.5870.96
328_S372_I0.5830.96
53_T67_A0.5830.96
174_N286_A0.5810.96
27_Q231_G0.5770.96
217_E220_H0.5760.96
99_G338_H0.5760.96
81_V188_I0.5750.96
161_K164_G0.5750.96
203_V241_G0.5740.96
296_M323_L0.5730.96
30_T320_A0.5720.96
95_D120_D0.5710.96
92_V121_T0.5700.96
331_S336_M0.5700.96
34_P40_T0.5690.96
216_G224_N0.5680.96
301_I376_L0.5670.96
200_H240_R0.5660.96
6_L64_S0.5660.96
328_S368_L0.5660.96
265_N373_G0.5640.96
107_K221_F0.5640.96
347_L353_D0.5640.96
79_T83_M0.5630.96
78_I101_T0.5630.96
276_G283_H0.5630.96
21_V32_K0.5620.95
60_T67_A0.5620.95
109_L114_I0.5610.95
307_V354_G0.5610.95
260_A276_G0.5600.95
344_E347_L0.5590.95
138_I159_I0.5590.95
220_H223_Q0.5570.95
67_A210_T0.5570.95
191_H207_L0.5560.95
153_L169_V0.5560.95
51_T239_M0.5550.95
9_H318_T0.5550.95
330_I372_I0.5550.95
314_L317_F0.5540.95
132_R135_T0.5540.95
308_D335_R0.5500.95
342_P346_R0.5500.95
108_V222_V0.5490.95
341_I349_L0.5490.95
257_R277_S0.5480.95
80_A222_V0.5420.95
277_S283_H0.5420.95
92_V117_T0.5410.94
154_T183_T0.5410.94
16_E26_Y0.5380.94
320_A329_L0.5370.94
38_Q41_G0.5360.94
92_V138_I0.5360.94
270_Q301_I0.5350.94
250_E253_D0.5340.94
218_E222_V0.5310.94
57_A60_T0.5310.94
148_L298_S0.5280.94
95_D348_E0.5270.94
117_T135_T0.5270.94
196_Y252_I0.5260.94
18_T42_Y0.5250.94
307_V332_V0.5250.94
106_T345_R0.5240.93
108_V226_T0.5210.93
253_D256_A0.5200.93
142_T179_Q0.5200.93
36_A308_D0.5200.93
174_N179_Q0.5190.93
179_Q290_G0.5170.93
310_F313_N0.5170.93
341_I345_R0.5150.93
262_F265_N0.5140.93
49_N52_R0.5140.93
312_G319_I0.5130.93
151_T285_L0.5130.93
120_D123_S0.5120.93
177_Y246_G0.5120.93
78_I104_V0.5110.93
15_D20_A0.5070.92
159_I162_K0.5070.92
286_A290_G0.5060.92
66_E216_G0.5050.92
79_T82_M0.5050.92
166_L212_S0.5040.92
213_K216_G0.5030.92
36_A311_L0.5020.92
274_Y293_F0.5010.92
29_S204_V0.5010.92
257_R260_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ibjA 4 0.9974 100 0.37 Contact Map
1qgnA 4 0.9974 100 0.399 Contact Map
3cogA 4 1 100 0.413 Contact Map
3ri6A 4 0.8734 100 0.417 Contact Map
4iy7A 4 1 100 0.423 Contact Map
4kamA 4 0.9182 100 0.442 Contact Map
4itxA 4 0.9921 100 0.448 Contact Map
1e5eA 4 0.9947 100 0.455 Contact Map
3ndnA 4 0.9894 100 0.48 Contact Map
4oc9A 5 0.9921 100 0.482 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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