GREMLIN Database
MCCA - O-acetylserine dependent cystathionine beta-synthase
UniProt: O05393 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (280)
Sequences: 21178 (11236)
Seq/√Len: 671.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_A90_A3.9111.00
29_A285_N3.3721.00
128_K131_Q3.3331.00
18_R29_A3.0501.00
246_N275_E2.5861.00
162_M287_V2.5801.00
172_T200_V2.5781.00
100_R104_Q2.5731.00
253_E257_K2.5571.00
54_D58_S2.5011.00
93_C132_L2.4941.00
13_N164_E2.4341.00
205_V243_T2.4191.00
96_E117_P2.3411.00
89_K112_S2.3371.00
54_D149_V2.3241.00
56_L88_L2.2581.00
198_K238_E2.2551.00
91_I112_S2.2441.00
66_V91_I2.2031.00
131_Q135_E2.1781.00
31_Y285_N2.0421.00
13_N165_A2.0371.00
53_R86_Y2.0331.00
187_A235_H2.0301.00
91_I114_I2.0151.00
206_G244_D2.0081.00
269_A288_T2.0051.00
160_P189_F2.0021.00
281_S284_T1.9901.00
243_T246_N1.9801.00
187_A199_T1.9521.00
146_K229_D1.9341.00
16_L287_V1.8981.00
155_Y192_E1.8691.00
194_N197_V1.8131.00
177_A201_I1.7961.00
202_V272_A1.7801.00
56_L59_G1.7771.00
200_V238_E1.7641.00
173_F190_L1.7571.00
143_L146_K1.7401.00
254_A262_I1.7361.00
40_G81_L1.7031.00
155_Y188_S1.6911.00
130_I134_T1.6881.00
253_E274_L1.6351.00
170_I287_V1.6341.00
254_A270_L1.6261.00
31_Y166_L1.6201.00
250_L271_Y1.6051.00
18_R31_Y1.5991.00
173_F186_T1.5721.00
191_K237_D1.5621.00
18_R23_D1.5571.00
103_Q115_H1.5561.00
171_H285_N1.5521.00
222_I268_A1.5511.00
171_H284_T1.5411.00
49_D53_R1.5311.00
238_E279_K1.5291.00
32_A290_F1.4981.00
56_L86_Y1.4901.00
104_Q107_Q1.4771.00
71_T76_G1.4631.00
159_G186_T1.4551.00
172_T284_T1.4351.00
103_Q107_Q1.4161.00
172_T281_S1.4021.00
117_P120_D1.3911.00
174_V276_E1.3811.00
250_L274_L1.3761.00
114_I128_K1.3711.00
183_F236_F1.3511.00
121_G124_G1.3501.00
51_L147_N1.3491.00
120_D124_G1.3441.00
25_P253_E1.3431.00
159_G190_L1.3411.00
100_R103_Q1.3361.00
126_I130_I1.3301.00
174_V202_V1.3081.00
133_E141_C1.3001.00
210_N241_T1.2901.00
169_N285_N1.2881.00
246_N271_Y1.2871.00
53_R57_D1.2751.00
159_G189_F1.2701.00
94_V106_M1.2631.00
271_Y275_E1.2601.00
262_I290_F1.2551.00
172_T198_K1.2541.00
205_V241_T1.2531.00
50_M156_K1.2501.00
189_F193_K1.2411.00
106_M111_A1.2401.00
276_E279_K1.2371.00
166_L170_I1.2331.00
188_S232_D1.2311.00
21_N258_E1.2231.00
19_L32_A1.2181.00
25_P257_K1.2041.00
190_L197_V1.1981.00
250_L270_L1.1981.00
54_D57_D1.1971.00
93_C128_K1.1961.00
163_W193_K1.1891.00
163_W189_F1.1851.00
160_P164_E1.1841.00
123_Q127_Q1.1771.00
66_V89_K1.1761.00
249_R253_E1.1681.00
183_F199_T1.1651.00
130_I133_E1.1531.00
17_L34_L1.1511.00
76_G106_M1.1471.00
266_S290_F1.1451.00
15_P37_M1.1411.00
208_I211_G1.1361.00
201_I239_I1.1351.00
103_Q113_I1.1321.00
16_L166_L1.1121.00
240_Y272_A1.1081.00
242_V271_Y1.1071.00
16_L162_M1.0991.00
50_M153_T1.0951.00
246_N249_R1.0941.00
52_I67_I1.0931.00
276_E280_A1.0911.00
163_W194_N1.0881.00
200_V240_Y1.0871.00
218_K248_F1.0831.00
275_E278_K1.0801.00
255_A261_L1.0711.00
183_F201_I1.0671.00
127_Q131_Q1.0431.00
245_E249_R1.0421.00
50_M54_D1.0411.00
219_T247_A1.0411.00
127_Q130_I1.0381.00
122_M125_A1.0351.00
128_K132_L1.0301.00
27_G282_A1.0291.00
94_V115_H1.0281.00
58_S149_V1.0221.00
30_V273_A1.0171.00
67_I83_A1.0121.00
166_L287_V1.0101.00
52_I86_Y1.0091.00
162_M170_I1.0061.00
20_K24_V1.0041.00
252_K256_E0.9991.00
79_L90_A0.9991.00
50_M53_R0.9981.00
48_G78_G0.9971.00
172_T286_I0.9921.00
124_G127_Q0.9921.00
68_I139_S0.9901.00
84_R90_A0.9751.00
251_V267_G0.9681.00
52_I82_S0.9641.00
81_L109_L0.9641.00
151_P230_Y0.9631.00
78_G82_S0.9621.00
21_N257_K0.9561.00
210_N239_I0.9551.00
132_L137_E0.9501.00
186_T289_V0.9471.00
240_Y275_E0.9441.00
51_L142_V0.9431.00
68_I132_L0.9411.00
273_A288_T0.9401.00
262_I266_S0.9391.00
96_E120_D0.9371.00
107_Q112_S0.9271.00
198_K237_D0.9231.00
65_G138_N0.9171.00
154_Y158_L0.9151.00
129_A133_E0.9101.00
80_A111_A0.9051.00
131_Q134_T0.9031.00
133_E139_S0.9011.00
21_N24_V0.8971.00
184_A230_Y0.8921.00
177_A183_F0.8891.00
175_A186_T0.8881.00
189_F192_E0.8871.00
155_Y189_F0.8841.00
277_A280_A0.8811.00
10_L49_D0.8701.00
222_I265_S0.8631.00
34_L290_F0.8611.00
174_V273_A0.8581.00
69_E92_F0.8551.00
28_V284_T0.8511.00
156_K160_P0.8511.00
269_A291_P0.8471.00
68_I129_A0.8471.00
261_L294_S0.8451.00
104_Q108_A0.8441.00
208_I225_E0.8431.00
183_F232_D0.8391.00
55_A59_G0.8361.00
270_L290_F0.8321.00
174_V200_V0.8311.00
266_S291_P0.8281.00
250_L253_E0.8271.00
19_L270_L0.8211.00
120_D127_Q0.8211.00
160_P193_K0.8201.00
107_Q115_H0.8191.00
217_H223_G0.8101.00
55_A140_Y0.8101.00
218_K244_D0.8031.00
68_I133_E0.8021.00
91_I132_L0.8021.00
158_L186_T0.8011.00
172_T276_E0.7971.00
23_D26_E0.7951.00
65_G89_K0.7931.00
66_V139_S0.7921.00
174_V272_A0.7921.00
28_V286_I0.7901.00
132_L135_E0.7841.00
153_T156_K0.7831.00
209_L232_D0.7771.00
14_T38_N0.7771.00
81_L85_K0.7771.00
188_S192_E0.7751.00
163_W190_L0.7741.00
275_E279_K0.7701.00
77_I106_M0.7681.00
84_R109_L0.7681.00
34_L37_M0.7661.00
172_T280_A0.7651.00
170_I197_V0.7641.00
198_K284_T0.7621.00
129_A141_C0.7611.00
158_L289_V0.7601.00
226_F229_D0.7601.00
91_I139_S0.7561.00
28_V283_G0.7511.00
169_N194_N0.7421.00
166_L285_N0.7381.00
158_L182_T0.7381.00
56_L60_K0.7311.00
19_L258_E0.7301.00
247_A268_A0.7301.00
26_E253_E0.7301.00
50_M149_V0.7301.00
92_F106_M0.7291.00
232_D235_H0.7281.00
177_A239_I0.7271.00
270_L288_T0.7271.00
60_K88_L0.7261.00
274_L278_K0.7161.00
24_V27_G0.7161.00
240_Y279_K0.7131.00
248_F264_S0.7101.00
233_K236_F0.7061.00
67_I88_L0.7041.00
262_I267_G0.7021.00
20_K23_D0.6991.00
77_I105_I0.6991.00
186_T190_L0.6971.00
32_A288_T0.6971.00
41_G293_S0.6931.00
280_A284_T0.6931.00
176_G291_P0.6921.00
29_A283_G0.6911.00
116_T120_D0.6891.00
48_G82_S0.6881.00
158_L162_M0.6881.00
43_I182_T0.6871.00
170_I285_N0.6851.00
173_F289_V0.6841.00
22_F274_L0.6841.00
148_R230_Y0.6811.00
151_P188_S0.6791.00
70_A141_C0.6781.00
143_L147_N0.6781.00
89_K139_S0.6731.00
164_E193_K0.6711.00
26_E274_L0.6701.00
70_A122_M0.6691.00
90_A111_A0.6691.00
209_L239_I0.6691.00
32_A270_L0.6691.00
98_F220_E0.6681.00
23_D29_A0.6671.00
93_C114_I0.6651.00
11_I45_D0.6641.00
148_R151_P0.6641.00
67_I142_V0.6641.00
238_E276_E0.6611.00
116_T128_K0.6591.00
204_P222_I0.6591.00
12_G39_P0.6581.00
209_L227_I0.6581.00
96_E115_H0.6551.00
51_L149_V0.6511.00
227_I230_Y0.6501.00
100_R107_Q0.6471.00
54_D60_K0.6461.00
47_L51_L0.6441.00
163_W168_G0.6401.00
175_A183_F0.6361.00
232_D236_F0.6321.00
102_K220_E0.6311.00
93_C116_T0.6301.00
173_F197_V0.6301.00
16_L31_Y0.6271.00
33_K161_E0.6271.00
19_L22_F0.6261.00
177_A209_L0.6231.00
141_C184_A0.6221.00
254_A258_E0.6191.00
176_G269_A0.6181.00
28_V277_A0.6151.00
163_W166_L0.6141.00
254_A290_F0.6141.00
76_G92_F0.6121.00
57_D64_G0.6111.00
22_F270_L0.6111.00
112_S137_E0.6091.00
60_K140_Y0.6081.00
98_F103_Q0.6071.00
251_V264_S0.6071.00
68_I93_C0.6061.00
191_K234_S0.6051.00
200_V276_E0.6021.00
11_I49_D0.6001.00
67_I90_A0.5991.00
51_L150_N0.5971.00
174_V286_I0.5971.00
94_V103_Q0.5961.00
34_L260_L0.5931.00
45_D81_L0.5911.00
73_G76_G0.5911.00
254_A260_L0.5901.00
244_D248_F0.5891.00
80_A106_M0.5881.00
202_V268_A0.5861.00
266_S269_A0.5821.00
162_M186_T0.5811.00
12_G38_N0.5811.00
191_K235_H0.5811.00
10_L37_M0.5791.00
36_M293_S0.5781.00
121_G125_A0.5781.00
22_F250_L0.5771.00
202_V240_Y0.5741.00
221_G265_S0.5741.00
80_A90_A0.5731.00
23_D30_V0.5701.00
89_K137_E0.5661.00
201_I236_F0.5661.00
124_G128_K0.5651.00
272_A276_E0.5651.00
94_V98_F0.5651.00
40_G109_L0.5641.00
122_M126_I0.5641.00
133_E137_E0.5641.00
39_P45_D0.5631.00
151_P231_M0.5621.00
242_V268_A0.5611.00
206_G215_H0.5591.00
91_I137_E0.5591.00
69_E79_L0.5571.00
270_L274_L0.5561.00
105_I108_A0.5561.00
122_M144_Q0.5551.00
153_T188_S0.5541.00
173_F199_T0.5541.00
47_L75_T0.5511.00
22_F253_E0.5511.00
114_I132_L0.5471.00
249_R252_K0.5441.00
16_L165_A0.5421.00
64_G89_K0.5421.00
36_M260_L0.5391.00
153_T157_T0.5391.00
128_K135_E0.5371.00
212_G215_H0.5371.00
51_L140_Y0.5351.00
203_E210_N0.5351.00
79_L92_F0.5351.00
10_L53_R0.5341.00
149_V153_T0.5331.00
70_A129_A0.5331.00
231_M236_F0.5311.00
203_E208_I0.5261.00
22_F26_E0.5261.00
32_A254_A0.5240.99
22_F257_K0.5220.99
184_A188_S0.5210.99
64_G138_N0.5210.99
132_L139_S0.5190.99
105_I261_L0.5160.99
79_L142_V0.5160.99
25_P274_L0.5150.99
130_I143_L0.5150.99
126_I129_A0.5140.99
154_Y157_T0.5140.99
200_V237_D0.5120.99
70_A142_V0.5120.99
28_V282_A0.5090.99
59_G140_Y0.5090.99
125_A129_A0.5060.99
186_T189_F0.5060.99
160_P192_E0.5060.99
244_D247_A0.5040.99
166_L169_N0.5040.99
113_I117_P0.5030.99
162_M289_V0.5020.99
92_F111_A0.5020.99
71_T92_F0.5020.99
47_L151_P0.5010.99
70_A126_I0.5000.99
151_P184_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y7lA 2 0.9772 100 0.119 Contact Map
4ofxA 2 0.9121 100 0.127 Contact Map
4ql4A 2 0.8893 100 0.129 Contact Map
2pqmA 2 0.9967 100 0.133 Contact Map
4r2vA 2 0.9902 100 0.136 Contact Map
3pc3A 2 1 100 0.138 Contact Map
2eguA 2 0.8795 100 0.139 Contact Map
1z7wA 2 1 100 0.14 Contact Map
3x44A 3 0.987 100 0.14 Contact Map
3vc3A 2 1 100 0.142 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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