GREMLIN Database
BOFC - Protein BofC
UniProt: O05391 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (144)
Sequences: 144 (124)
Seq/√Len: 10.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_E166_K2.8990.92
51_D99_S2.8430.91
142_M152_F2.7440.90
70_W88_F2.7420.90
107_V158_F2.6940.89
154_T166_K2.5170.85
42_H83_K2.4920.85
62_K88_F2.4590.84
63_V68_D2.3740.81
93_D139_E2.3090.80
145_N165_M2.1150.73
28_A107_V1.9470.66
95_I99_S1.9430.66
131_F134_D1.8880.64
62_K68_D1.8660.63
69_F151_P1.8410.62
92_M98_L1.7890.60
92_M140_S1.7670.59
47_K102_N1.7300.57
90_K112_V1.7060.56
59_K107_V1.6330.52
126_P152_F1.6270.52
128_Q158_F1.6080.51
135_L139_E1.6030.51
131_F140_S1.5580.49
102_N114_S1.5500.48
59_K162_I1.5300.48
157_E160_D1.5230.47
115_T163_E1.4500.44
35_H152_F1.4440.44
111_G130_F1.4270.43
54_V59_K1.4140.42
42_H116_F1.4120.42
61_E73_Y1.4050.42
116_F156_A1.3880.41
117_H124_S1.3350.39
105_I134_D1.3180.38
87_L115_T1.3000.37
38_P69_F1.2910.37
44_Q50_L1.2850.36
63_V81_Q1.2730.36
46_E89_R1.2720.36
105_I161_V1.2710.36
97_P168_Y1.2710.36
54_V126_P1.2440.35
47_K95_I1.2340.34
26_S30_G1.2170.34
95_I103_G1.2140.33
114_S164_H1.2120.33
77_T91_Q1.2070.33
38_P70_W1.2070.33
51_D73_Y1.2020.33
99_S115_T1.1810.32
78_L88_F1.1740.32
130_F139_E1.1700.32
55_S102_N1.1640.31
144_K148_K1.1540.31
66_M70_W1.1420.31
83_K125_E1.1390.30
95_I159_E1.1380.30
50_L56_I1.1360.30
72_A148_K1.1270.30
54_V133_I1.1120.29
94_D97_P1.1090.29
114_S165_M1.1070.29
103_G133_I1.0980.29
155_K162_I1.0950.29
112_V116_F1.0860.28
77_T80_E1.0830.28
35_H136_E1.0600.27
62_K66_M1.0600.27
107_V147_L1.0590.27
127_I138_L1.0570.27
119_R126_P1.0530.27
35_H75_G1.0320.26
45_L103_G1.0270.26
113_I158_F1.0230.26
113_I126_P1.0180.26
129_S163_E1.0150.26
67_D127_I1.0080.26
102_N158_F1.0010.25
129_S154_T0.9980.25
59_K161_V0.9960.25
105_I142_M0.9950.25
66_M156_A0.9750.24
112_V166_K0.9710.24
64_F71_A0.9520.24
53_D105_I0.9410.23
86_V93_D0.9400.23
131_F169_S0.9350.23
158_F164_H0.9280.23
47_K53_D0.9280.23
134_D142_M0.9230.23
127_I131_F0.9220.23
55_S98_L0.9140.22
142_M145_N0.9100.22
68_D71_A0.9090.22
161_V164_H0.8840.21
141_H159_E0.8780.21
47_K50_L0.8780.21
40_Q63_V0.8590.21
48_V152_F0.8540.20
114_S138_L0.8510.20
111_G161_V0.8510.20
44_Q85_Y0.8500.20
110_N148_K0.8470.20
69_F106_G0.8460.20
51_D163_E0.8450.20
87_L138_L0.8420.20
71_A148_K0.8420.20
81_Q151_P0.8350.20
37_E64_F0.8350.20
77_T140_S0.8310.20
47_K142_M0.8240.20
76_W98_L0.8190.19
44_Q56_I0.8180.19
72_A157_E0.8120.19
166_K169_S0.8070.19
25_P32_E0.8050.19
26_S107_V0.7920.19
74_A121_E0.7920.19
160_D163_E0.7920.19
74_A125_E0.7880.19
158_F165_M0.7850.18
75_G121_E0.7840.18
101_V139_E0.7840.18
60_H162_I0.7770.18
54_V129_S0.7670.18
86_V92_M0.7640.18
33_V36_Y0.7560.18
115_T160_D0.7540.18
76_W130_F0.7520.18
27_R30_G0.7510.17
25_P28_A0.7410.17
59_K165_M0.7230.17
55_S137_R0.7200.17
111_G150_I0.7190.17
46_E155_K0.7190.17
49_Y131_F0.7190.17
117_H125_E0.7180.17
51_D129_S0.7170.17
107_V135_L0.7140.17
65_S73_Y0.7130.16
107_V165_M0.7120.16
49_Y130_F0.6880.16
54_V154_T0.6870.16
116_F131_F0.6840.16
84_G165_M0.6830.16
56_I89_R0.6800.16
95_I163_E0.6790.16
75_G90_K0.6780.16
68_D81_Q0.6740.16
56_I90_K0.6710.15
69_F138_L0.6660.15
101_V151_P0.6630.15
95_I115_T0.6550.15
126_P167_T0.6540.15
132_Q155_K0.6510.15
52_G146_L0.6510.15
118_G146_L0.6510.15
146_L149_G0.6510.15
52_G149_G0.6510.15
52_G118_G0.6510.15
118_G149_G0.6510.15
86_V107_V0.6470.15
106_G116_F0.6450.15
36_Y91_Q0.6410.15
51_D103_G0.6400.15
38_P71_A0.6370.15
62_K70_W0.6360.15
85_Y127_I0.6360.15
54_V92_M0.6340.15
88_F106_G0.6330.15
43_V156_A0.6260.14
46_E57_E0.6230.14
128_Q135_L0.6230.14
47_K99_S0.6210.14
88_F138_L0.6180.14
60_H110_N0.6140.14
44_Q87_L0.6130.14
40_Q60_H0.6100.14
37_E82_K0.6070.14
61_E138_L0.6030.14
29_L116_F0.6020.14
58_H153_R0.5970.14
164_H169_S0.5960.14
87_L127_I0.5890.14
154_T162_I0.5850.13
75_G124_S0.5840.13
142_M165_M0.5840.13
115_T158_F0.5820.13
154_T159_E0.5770.13
113_I120_P0.5620.13
126_P154_T0.5600.13
64_F69_F0.5600.13
143_Q152_F0.5590.13
113_I152_F0.5520.13
44_Q151_P0.5520.13
159_E164_H0.5500.13
129_S166_K0.5490.13
92_M131_F0.5470.13
120_P132_Q0.5460.13
38_P64_F0.5450.13
29_L136_E0.5400.13
59_K99_S0.5340.12
96_S132_Q0.5320.12
94_D113_I0.5290.12
97_P141_H0.5270.12
62_K144_K0.5250.12
29_L33_V0.5230.12
157_E164_H0.5190.12
41_V82_K0.5140.12
150_I165_M0.5110.12
44_Q105_I0.5110.12
96_S131_F0.5060.12
88_F104_Y0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bw2A 1 0.8235 100 0.355 Contact Map
3bxwB 2 0.6824 29.7 0.95 Contact Map
1nt2B 2 0.3588 28.5 0.951 Contact Map
1vsy5 1 0.5059 8.2 0.961 Contact Map
4kysA 1 0.4882 7.8 0.962 Contact Map
4ro3A 2 0.2529 6.7 0.963 Contact Map
3gzfA 2 0.3059 5.2 0.965 Contact Map
2jxxA 1 0.4529 5.1 0.965 Contact Map
1em2A 1 0.6706 4.7 0.965 Contact Map
4c0dC 1 0.5059 4.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.