BOFC - BACSU - GREMLIN Contacts

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BOFC - Protein BofC

UniProt:	O05391	Sequences: MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQLEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVNGYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFEDVIEHMKTYSG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	170 (144)
Sequences:	144 (124)
Seq/√Len:	10.3

BACSU - BOFC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_E	166_K	2.899	0.92
51_D	99_S	2.843	0.91
142_M	152_F	2.744	0.90
70_W	88_F	2.742	0.90
107_V	158_F	2.694	0.89
154_T	166_K	2.517	0.85
42_H	83_K	2.492	0.85
62_K	88_F	2.459	0.84
63_V	68_D	2.374	0.81
93_D	139_E	2.309	0.80
145_N	165_M	2.115	0.73
28_A	107_V	1.947	0.66
95_I	99_S	1.943	0.66
131_F	134_D	1.888	0.64
62_K	68_D	1.866	0.63
69_F	151_P	1.841	0.62
92_M	98_L	1.789	0.60
92_M	140_S	1.767	0.59
47_K	102_N	1.730	0.57
90_K	112_V	1.706	0.56
59_K	107_V	1.633	0.52
126_P	152_F	1.627	0.52
128_Q	158_F	1.608	0.51
135_L	139_E	1.603	0.51
131_F	140_S	1.558	0.49
102_N	114_S	1.550	0.48
59_K	162_I	1.530	0.48
157_E	160_D	1.523	0.47
115_T	163_E	1.450	0.44
35_H	152_F	1.444	0.44
111_G	130_F	1.427	0.43
54_V	59_K	1.414	0.42
42_H	116_F	1.412	0.42
61_E	73_Y	1.405	0.42
116_F	156_A	1.388	0.41
117_H	124_S	1.335	0.39
105_I	134_D	1.318	0.38
87_L	115_T	1.300	0.37
38_P	69_F	1.291	0.37
44_Q	50_L	1.285	0.36
63_V	81_Q	1.273	0.36
46_E	89_R	1.272	0.36
105_I	161_V	1.271	0.36
97_P	168_Y	1.271	0.36
54_V	126_P	1.244	0.35
47_K	95_I	1.234	0.34
26_S	30_G	1.217	0.34
95_I	103_G	1.214	0.33
114_S	164_H	1.212	0.33
77_T	91_Q	1.207	0.33
38_P	70_W	1.207	0.33
51_D	73_Y	1.202	0.33
99_S	115_T	1.181	0.32
78_L	88_F	1.174	0.32
130_F	139_E	1.170	0.32
55_S	102_N	1.164	0.31
144_K	148_K	1.154	0.31
66_M	70_W	1.142	0.31
83_K	125_E	1.139	0.30
95_I	159_E	1.138	0.30
50_L	56_I	1.136	0.30
72_A	148_K	1.127	0.30
54_V	133_I	1.112	0.29
94_D	97_P	1.109	0.29
114_S	165_M	1.107	0.29
103_G	133_I	1.098	0.29
155_K	162_I	1.095	0.29
112_V	116_F	1.086	0.28
77_T	80_E	1.083	0.28
35_H	136_E	1.060	0.27
62_K	66_M	1.060	0.27
107_V	147_L	1.059	0.27
127_I	138_L	1.057	0.27
119_R	126_P	1.053	0.27
35_H	75_G	1.032	0.26
45_L	103_G	1.027	0.26
113_I	158_F	1.023	0.26
113_I	126_P	1.018	0.26
129_S	163_E	1.015	0.26
67_D	127_I	1.008	0.26
102_N	158_F	1.001	0.25
129_S	154_T	0.998	0.25
59_K	161_V	0.996	0.25
105_I	142_M	0.995	0.25
66_M	156_A	0.975	0.24
112_V	166_K	0.971	0.24
64_F	71_A	0.952	0.24
53_D	105_I	0.941	0.23
86_V	93_D	0.940	0.23
131_F	169_S	0.935	0.23
158_F	164_H	0.928	0.23
47_K	53_D	0.928	0.23
134_D	142_M	0.923	0.23
127_I	131_F	0.922	0.23
55_S	98_L	0.914	0.22
142_M	145_N	0.910	0.22
68_D	71_A	0.909	0.22
161_V	164_H	0.884	0.21
141_H	159_E	0.878	0.21
47_K	50_L	0.878	0.21
40_Q	63_V	0.859	0.21
48_V	152_F	0.854	0.20
114_S	138_L	0.851	0.20
111_G	161_V	0.851	0.20
44_Q	85_Y	0.850	0.20
110_N	148_K	0.847	0.20
69_F	106_G	0.846	0.20
51_D	163_E	0.845	0.20
87_L	138_L	0.842	0.20
71_A	148_K	0.842	0.20
81_Q	151_P	0.835	0.20
37_E	64_F	0.835	0.20
77_T	140_S	0.831	0.20
47_K	142_M	0.824	0.20
76_W	98_L	0.819	0.19
44_Q	56_I	0.818	0.19
72_A	157_E	0.812	0.19
166_K	169_S	0.807	0.19
25_P	32_E	0.805	0.19
26_S	107_V	0.792	0.19
74_A	121_E	0.792	0.19
160_D	163_E	0.792	0.19
74_A	125_E	0.788	0.19
158_F	165_M	0.785	0.18
75_G	121_E	0.784	0.18
101_V	139_E	0.784	0.18
60_H	162_I	0.777	0.18
54_V	129_S	0.767	0.18
86_V	92_M	0.764	0.18
33_V	36_Y	0.756	0.18
115_T	160_D	0.754	0.18
76_W	130_F	0.752	0.18
27_R	30_G	0.751	0.17
25_P	28_A	0.741	0.17
59_K	165_M	0.723	0.17
55_S	137_R	0.720	0.17
111_G	150_I	0.719	0.17
46_E	155_K	0.719	0.17
49_Y	131_F	0.719	0.17
117_H	125_E	0.718	0.17
51_D	129_S	0.717	0.17
107_V	135_L	0.714	0.17
65_S	73_Y	0.713	0.16
107_V	165_M	0.712	0.16
49_Y	130_F	0.688	0.16
54_V	154_T	0.687	0.16
116_F	131_F	0.684	0.16
84_G	165_M	0.683	0.16
56_I	89_R	0.680	0.16
95_I	163_E	0.679	0.16
75_G	90_K	0.678	0.16
68_D	81_Q	0.674	0.16
56_I	90_K	0.671	0.15
69_F	138_L	0.666	0.15
101_V	151_P	0.663	0.15
95_I	115_T	0.655	0.15
126_P	167_T	0.654	0.15
132_Q	155_K	0.651	0.15
52_G	146_L	0.651	0.15
118_G	146_L	0.651	0.15
146_L	149_G	0.651	0.15
52_G	149_G	0.651	0.15
52_G	118_G	0.651	0.15
118_G	149_G	0.651	0.15
86_V	107_V	0.647	0.15
106_G	116_F	0.645	0.15
36_Y	91_Q	0.641	0.15
51_D	103_G	0.640	0.15
38_P	71_A	0.637	0.15
62_K	70_W	0.636	0.15
85_Y	127_I	0.636	0.15
54_V	92_M	0.634	0.15
88_F	106_G	0.633	0.15
43_V	156_A	0.626	0.14
46_E	57_E	0.623	0.14
128_Q	135_L	0.623	0.14
47_K	99_S	0.621	0.14
88_F	138_L	0.618	0.14
60_H	110_N	0.614	0.14
44_Q	87_L	0.613	0.14
40_Q	60_H	0.610	0.14
37_E	82_K	0.607	0.14
61_E	138_L	0.603	0.14
29_L	116_F	0.602	0.14
58_H	153_R	0.597	0.14
164_H	169_S	0.596	0.14
87_L	127_I	0.589	0.14
154_T	162_I	0.585	0.13
75_G	124_S	0.584	0.13
142_M	165_M	0.584	0.13
115_T	158_F	0.582	0.13
154_T	159_E	0.577	0.13
113_I	120_P	0.562	0.13
126_P	154_T	0.560	0.13
64_F	69_F	0.560	0.13
143_Q	152_F	0.559	0.13
113_I	152_F	0.552	0.13
44_Q	151_P	0.552	0.13
159_E	164_H	0.550	0.13
129_S	166_K	0.549	0.13
92_M	131_F	0.547	0.13
120_P	132_Q	0.546	0.13
38_P	64_F	0.545	0.13
29_L	136_E	0.540	0.13
59_K	99_S	0.534	0.12
96_S	132_Q	0.532	0.12
94_D	113_I	0.529	0.12
97_P	141_H	0.527	0.12
62_K	144_K	0.525	0.12
29_L	33_V	0.523	0.12
157_E	164_H	0.519	0.12
41_V	82_K	0.514	0.12
150_I	165_M	0.511	0.12
44_Q	105_I	0.511	0.12
96_S	131_F	0.506	0.12
88_F	104_Y	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bw2A	1	0.8235	100	0.355	Contact Map
3bxwB	2	0.6824	29.7	0.95	Contact Map
1nt2B	2	0.3588	28.5	0.951	Contact Map
1vsy5	1	0.5059	8.2	0.961	Contact Map
4kysA	1	0.4882	7.8	0.962	Contact Map
4ro3A	2	0.2529	6.7	0.963	Contact Map
3gzfA	2	0.3059	5.2	0.965	Contact Map
2jxxA	1	0.4529	5.1	0.965	Contact Map
1em2A	1	0.6706	4.7	0.965	Contact Map
4c0dC	1	0.5059	4.6	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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