GREMLIN Database
YRBE - Uncharacterized oxidoreductase YrbE
UniProt: O05389 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 341 (314)
Sequences: 25590 (19030)
Seq/√Len: 1073.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_R85_E3.1861.00
80_A108_E3.1261.00
88_E112_A2.9771.00
84_K112_A2.7681.00
39_A43_K2.6851.00
146_T248_T2.6561.00
193_E220_T2.6521.00
80_A105_E2.5891.00
74_S82_M2.5721.00
84_K88_E2.5031.00
6_V30_K2.5031.00
127_R181_D2.4701.00
134_K137_T2.4621.00
8_G61_L2.4141.00
107_S312_L2.4131.00
84_K108_E2.3851.00
136_K140_E2.3501.00
92_H119_T2.3241.00
192_T222_E2.3121.00
33_A55_T2.2581.00
217_I321_A2.2091.00
78_V82_M2.2091.00
80_A84_K2.1561.00
296_E300_T2.1001.00
57_D60_D2.0871.00
87_A118_V2.0821.00
137_T141_N2.0791.00
134_K138_I2.0241.00
83_I95_C1.9981.00
17_K48_S1.9721.00
111_A115_K1.9231.00
81_Q85_E1.9111.00
88_E116_H1.8721.00
114_R309_N1.8661.00
53_Y64_D1.8401.00
112_A116_H1.8391.00
69_A294_F1.8381.00
38_Q41_R1.8351.00
74_S78_V1.8161.00
70_I86_A1.8051.00
7_T69_A1.7911.00
103_L319_R1.7841.00
92_H118_V1.7831.00
8_G67_I1.7221.00
138_I143_E1.7151.00
83_I109_A1.7011.00
26_I292_L1.6971.00
102_S105_E1.6941.00
28_H299_G1.6821.00
221_F227_A1.6821.00
107_S316_R1.6811.00
43_K47_D1.6781.00
136_K185_Y1.6691.00
87_A113_V1.6611.00
144_I247_G1.6571.00
63_H89_A1.6561.00
107_S111_A1.6521.00
112_A115_K1.6501.00
29_M295_A1.6241.00
198_G325_L1.6121.00
23_I71_F1.5651.00
58_Y85_E1.5611.00
62_L86_A1.5601.00
39_A56_S1.5531.00
110_L312_L1.5401.00
67_I91_K1.5281.00
110_L308_G1.5231.00
56_S60_D1.4981.00
120_L308_G1.4891.00
192_T220_T1.4881.00
6_V32_K1.4811.00
60_D63_H1.4691.00
44_S48_S1.4661.00
103_L107_S1.4651.00
88_E115_K1.4521.00
103_L316_R1.4371.00
101_F105_E1.4361.00
123_G290_E1.4231.00
148_H248_T1.4211.00
244_E253_A1.4151.00
313_Q316_R1.4081.00
80_A109_A1.4061.00
59_R63_H1.4011.00
151_K244_E1.3991.00
119_T301_N1.3751.00
85_E88_E1.3581.00
187_M225_A1.3571.00
135_I252_A1.3561.00
197_K220_T1.3531.00
42_I54_I1.3501.00
6_V68_D1.3471.00
87_A116_H1.3471.00
100_S109_A1.3421.00
55_T64_D1.3361.00
100_S106_T1.3331.00
60_D64_D1.3211.00
110_L309_N1.3131.00
106_T312_L1.3131.00
184_R313_Q1.3051.00
189_S222_E1.3041.00
85_E89_A1.3041.00
55_T61_L1.2871.00
90_K116_H1.2871.00
293_R297_A1.2801.00
72_I83_I1.2761.00
151_K230_D1.2681.00
46_A54_I1.2681.00
296_E302_Q1.2571.00
293_R305_P1.2531.00
12_A34_I1.2361.00
110_L114_R1.2341.00
108_E111_A1.2341.00
295_A299_G1.2281.00
35_S58_Y1.2231.00
195_Y218_T1.2141.00
35_S61_L1.2051.00
58_Y82_M1.2051.00
242_R253_A1.1971.00
87_A112_A1.1891.00
44_S47_D1.1781.00
5_I299_G1.1781.00
180_F317_I1.1691.00
25_R288_E1.1681.00
189_S223_N1.1671.00
184_R221_F1.1621.00
144_I250_G1.1561.00
72_I82_M1.1521.00
86_A93_I1.1491.00
319_R323_Q1.1471.00
61_L67_I1.1421.00
94_F123_G1.1361.00
191_V221_F1.1311.00
7_T29_M1.1281.00
58_Y62_L1.1201.00
62_L85_E1.1181.00
94_F290_E1.1141.00
108_E112_A1.1141.00
40_S43_K1.1111.00
320_A323_Q1.1021.00
307_T310_D1.0991.00
99_V106_T1.0961.00
5_I69_A1.0831.00
292_L296_E1.0831.00
5_I298_I1.0771.00
106_T315_G1.0771.00
132_F185_Y1.0771.00
147_P245_V1.0731.00
65_P91_K1.0661.00
21_Q25_R1.0661.00
92_H298_I1.0611.00
156_D160_P1.0591.00
183_A227_A1.0571.00
111_A114_R1.0481.00
75_P78_V1.0451.00
144_I252_A1.0381.00
10_I82_M1.0371.00
150_L227_A1.0311.00
33_A67_I1.0301.00
105_E108_E1.0241.00
184_R310_D1.0241.00
33_A61_L1.0131.00
289_E292_L1.0091.00
95_C120_L1.0071.00
100_S105_E1.0061.00
138_I141_N1.0041.00
137_T140_E0.9951.00
322_Q326_A0.9921.00
288_E292_L0.9911.00
40_S44_S0.9911.00
293_R296_E0.9871.00
191_V219_L0.9831.00
43_K54_I0.9781.00
107_S110_L0.9751.00
103_L312_L0.9721.00
150_L187_M0.9711.00
104_D108_E0.9681.00
144_I147_P0.9621.00
309_N313_Q0.9601.00
296_E301_N0.9571.00
66_D91_K0.9521.00
41_R44_S0.9501.00
82_M85_E0.9491.00
55_T60_D0.9471.00
42_I46_A0.9451.00
78_V81_Q0.9441.00
28_H292_L0.9441.00
42_I56_S0.9421.00
99_V120_L0.9411.00
244_E251_S0.9401.00
189_S313_Q0.9391.00
84_K109_A0.9381.00
293_R302_Q0.9351.00
104_D107_S0.9301.00
127_R310_D0.9301.00
32_K66_D0.9301.00
62_L89_A0.9281.00
21_Q48_S0.9261.00
92_H301_N0.9251.00
135_I254_A0.9201.00
216_V228_V0.9181.00
157_P160_P0.9171.00
320_A324_S0.9151.00
12_A36_D0.9121.00
71_F291_I0.9091.00
147_P247_G0.9091.00
80_A100_S0.9081.00
197_K226_M0.9071.00
121_Q294_F0.9071.00
43_K46_A0.9071.00
316_R320_A0.9061.00
17_K44_S0.9021.00
87_A93_I0.8941.00
77_A167_T0.8931.00
83_I93_I0.8931.00
36_D42_I0.8921.00
19_H71_F0.8921.00
140_E188_G0.8901.00
128_F293_R0.8881.00
39_A42_I0.8871.00
23_I291_I0.8841.00
153_T242_R0.8831.00
113_V120_L0.8721.00
64_D67_I0.8711.00
323_Q326_A0.8691.00
119_T297_A0.8611.00
99_V308_G0.8611.00
36_D41_R0.8551.00
28_H296_E0.8491.00
297_A302_Q0.8491.00
184_R314_A0.8481.00
125_N286_S0.8351.00
83_I87_A0.8341.00
242_R255_D0.8321.00
164_Y167_T0.8251.00
147_P187_M0.8231.00
19_H291_I0.8221.00
196_A321_A0.8211.00
180_F318_A0.8211.00
8_G33_A0.8201.00
45_W48_S0.8191.00
151_K228_V0.8171.00
152_I179_D0.8141.00
152_I243_V0.8131.00
7_T23_I0.8111.00
53_Y66_D0.8101.00
145_G250_G0.8101.00
113_V116_H0.8031.00
219_L227_A0.8011.00
72_I86_A0.8001.00
109_A120_L0.7971.00
32_K67_I0.7941.00
261_T264_V0.7931.00
133_K137_T0.7911.00
124_F177_I0.7901.00
26_I29_M0.7901.00
312_L316_R0.7861.00
32_K53_Y0.7831.00
303_E307_T0.7821.00
191_V317_I0.7791.00
197_K218_T0.7791.00
39_A54_I0.7791.00
8_G70_I0.7781.00
150_L245_V0.7741.00
87_A120_L0.7701.00
139_V247_G0.7691.00
34_I45_W0.7691.00
121_Q297_A0.7691.00
106_T110_L0.7681.00
15_I73_C0.7671.00
15_I19_H0.7651.00
16_G73_C0.7611.00
195_Y324_S0.7581.00
46_A51_I0.7561.00
297_A300_T0.7541.00
133_K289_E0.7531.00
20_V31_I0.7471.00
122_V311_G0.7461.00
9_I20_V0.7461.00
95_C99_V0.7461.00
119_T298_I0.7451.00
6_V67_I0.7441.00
10_I74_S0.7431.00
113_V308_G0.7391.00
297_A304_T0.7391.00
171_L231_N0.7381.00
8_G35_S0.7361.00
23_I29_M0.7361.00
150_L183_A0.7361.00
101_F168_S0.7311.00
30_K52_E0.7291.00
99_V122_V0.7291.00
164_Y210_G0.7291.00
156_D159_P0.7261.00
113_V118_V0.7231.00
153_T230_D0.7151.00
218_T226_M0.7141.00
220_T226_M0.7131.00
146_T223_N0.7121.00
7_T295_A0.7101.00
193_E197_K0.7101.00
294_F298_I0.7081.00
32_K64_D0.7041.00
76_T174_D0.7011.00
172_F318_A0.6991.00
177_I314_A0.6981.00
149_L246_F0.6971.00
176_S231_N0.6971.00
10_I58_Y0.6961.00
191_V222_E0.6961.00
310_D313_Q0.6961.00
132_F182_M0.6941.00
165_V210_G0.6941.00
17_K21_Q0.6941.00
199_A220_T0.6921.00
126_R129_D0.6891.00
213_D234_Q0.6881.00
136_K186_I0.6881.00
149_L226_M0.6871.00
165_V326_A0.6831.00
69_A92_H0.6831.00
262_V266_T0.6831.00
217_I229_I0.6821.00
161_N164_Y0.6811.00
119_T304_T0.6801.00
91_K118_V0.6781.00
90_K118_V0.6741.00
145_G247_G0.6711.00
287_Y290_E0.6691.00
97_K178_H0.6661.00
95_C109_A0.6611.00
38_Q43_K0.6601.00
308_G311_G0.6561.00
64_D91_K0.6561.00
187_M221_F0.6551.00
172_F215_A0.6541.00
119_T303_E0.6541.00
246_F251_S0.6531.00
79_H95_C0.6501.00
17_K45_W0.6491.00
84_K87_A0.6481.00
195_Y220_T0.6471.00
28_H295_A0.6471.00
196_A217_I0.6451.00
259_P262_V0.6441.00
59_R89_A0.6441.00
70_I91_K0.6441.00
15_I287_Y0.6421.00
258_R261_T0.6411.00
221_F225_A0.6411.00
184_R317_I0.6371.00
94_F121_Q0.6361.00
61_L64_D0.6361.00
169_G173_M0.6351.00
133_K305_P0.6341.00
55_T65_P0.6331.00
81_Q84_K0.6321.00
183_A221_F0.6241.00
315_G319_R0.6231.00
10_I35_S0.6181.00
45_W49_H0.6171.00
17_K41_R0.6171.00
136_K188_G0.6161.00
26_I288_E0.6151.00
170_G212_I0.6141.00
80_A112_A0.6141.00
139_V245_V0.6131.00
7_T71_F0.6121.00
81_Q108_E0.6121.00
69_A298_I0.6101.00
284_K288_E0.6091.00
77_A101_F0.6081.00
127_R185_Y0.6061.00
6_V66_D0.6031.00
83_I120_L0.6021.00
35_S55_T0.6011.00
212_I322_Q0.5991.00
124_F314_A0.5991.00
184_R189_S0.5991.00
176_S179_D0.5991.00
87_A109_A0.5971.00
214_T232_S0.5961.00
17_K49_H0.5961.00
20_V45_W0.5951.00
16_G21_Q0.5911.00
133_K185_Y0.5901.00
26_I295_A0.5891.00
180_F321_A0.5881.00
130_P289_E0.5881.00
289_E293_R0.5881.00
172_F217_I0.5871.00
12_A45_W0.5851.00
41_R45_W0.5851.00
162_I174_D0.5841.00
296_E299_G0.5831.00
14_R18_L0.5821.00
253_A263_E0.5821.00
95_C122_V0.5801.00
186_I245_V0.5781.00
232_S235_A0.5761.00
293_R304_T0.5741.00
121_Q293_R0.5731.00
201_L213_D0.5701.00
142_G146_T0.5681.00
12_A42_I0.5671.00
110_L113_V0.5671.00
135_I186_I0.5641.00
16_G45_W0.5641.00
183_A229_I0.5631.00
264_V267_A0.5631.00
173_M319_R0.5611.00
139_V186_I0.5591.00
146_T249_K0.5571.00
37_I74_S0.5571.00
198_G215_A0.5551.00
152_I183_A0.5541.00
121_Q290_E0.5531.00
125_N287_Y0.5521.00
21_Q24_S0.5521.00
219_L229_I0.5511.00
29_M69_A0.5511.00
218_T228_V0.5501.00
124_F181_D0.5501.00
199_A214_T0.5491.00
285_D288_E0.5491.00
147_P225_A0.5481.00
33_A53_Y0.5481.00
278_F281_E0.5471.00
182_M243_V0.5411.00
153_T240_D0.5401.00
181_D185_Y0.5391.00
181_D314_A0.5381.00
318_A322_Q0.5371.00
72_I79_H0.5331.00
113_V117_G0.5331.00
63_H85_E0.5311.00
216_V230_D0.5311.00
196_A215_A0.5291.00
202_V213_D0.5271.00
35_S56_S0.5271.00
15_I96_E0.5261.00
128_F306_C0.5261.00
9_I71_F0.5251.00
59_R81_Q0.5251.00
9_I31_I0.5251.00
162_I165_V0.5231.00
19_H23_I0.5221.00
22_N26_I0.5211.00
126_R181_D0.5201.00
68_D299_G0.5181.00
214_T230_D0.5161.00
258_R262_V0.5151.00
155_R230_D0.5141.00
314_A318_A0.5131.00
67_I70_I0.5131.00
71_F94_F0.5131.00
136_K139_V0.5131.00
216_V226_M0.5121.00
261_T266_T0.5121.00
133_K136_K0.5111.00
58_Y86_A0.5111.00
129_D286_S0.5101.00
184_R191_V0.5081.00
260_T263_E0.5081.00
149_L230_D0.5061.00
187_M223_N0.5051.00
5_I29_M0.5051.00
149_L228_V0.5041.00
102_S319_R0.5011.00
69_A295_A0.5011.00
259_P263_E0.5001.00
74_S79_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3euwA 4 0.9736 100 0.194 Contact Map
1h6dA 8 0.9883 100 0.196 Contact Map
3ezyA 4 0.9795 100 0.2 Contact Map
4mkxA 4 0.9707 100 0.204 Contact Map
3dtyA 4 0.956 100 0.204 Contact Map
1zh8A 2 0.9208 100 0.206 Contact Map
3v5nA 4 0.915 100 0.207 Contact Map
2nvwA 3 0.9501 100 0.209 Contact Map
3ceaA 4 0.9736 100 0.213 Contact Map
3db2A 2 0.9648 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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