GREMLIN Database
GUAC - GMP reductase
UniProt: O05269 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 326 (264)
Sequences: 3499 (1265)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
304_K307_A4.4031.00
217_A296_S3.8131.00
155_R159_N3.3501.00
225_T309_R3.2071.00
125_N129_E3.0971.00
103_R107_E2.9941.00
89_S114_Y2.8501.00
79_K87_F2.8081.00
229_I233_F2.7191.00
155_R199_A2.7011.00
135_K143_V2.5871.00
148_V154_V2.5771.00
106_A141_S2.5641.00
303_T307_A2.4951.00
307_A310_N2.4921.00
211_R321_F2.4441.00
62_Y67_H2.4321.00
220_I293_L2.3961.00
135_K163_D2.3251.00
57_L61_G2.3171.00
64_Y67_H2.2871.00
158_E200_A2.2791.00
193_L206_A2.2181.00
306_N309_R2.1961.00
129_E132_Q2.1871.00
152_E312_D2.1761.00
62_Y65_V2.1371.00
65_V68_R2.1111.00
103_R137_H2.1021.00
98_E130_M2.0921.00
154_V196_C2.0671.00
64_Y68_R2.0591.00
305_L309_R2.0591.00
102_V134_L2.0451.00
153_A196_C2.0051.00
154_V158_E1.9671.00
102_V115_V1.9641.00
216_I227_V1.9511.00
229_I232_L1.9401.00
151_P199_A1.9331.00
62_Y68_R1.9151.00
54_A57_L1.8691.00
119_I127_V1.8681.00
200_A204_I1.8641.00
120_A299_Y1.8561.00
237_E278_H1.8531.00
148_V153_A1.8521.00
217_A308_I1.7831.00
115_V141_S1.7501.00
148_V196_C1.7401.00
156_E159_N1.7401.00
243_T250_L1.7161.00
237_E281_S1.6971.00
154_V200_A1.6931.00
131_I145_A1.6841.00
194_R198_K1.6721.00
63_F67_H1.6261.00
151_P198_K1.6081.00
60_N65_V1.5991.00
92_V102_V1.5871.00
222_F313_Y1.5660.99
238_E281_S1.5660.99
128_I132_Q1.5490.99
167_V204_I1.5400.99
117_I145_A1.5260.99
232_L289_M1.5240.99
197_A204_I1.5130.99
149_G185_T1.4850.99
60_N67_H1.4730.99
154_V204_I1.4680.99
133_H137_H1.4660.99
114_Y144_I1.4060.99
203_P225_T1.4050.99
60_N63_F1.3800.99
100_E103_R1.3710.99
103_R138_L1.3690.99
164_A203_P1.3620.99
164_A226_M1.3490.98
296_S308_I1.3370.98
158_E202_K1.3330.98
63_F68_R1.3210.98
90_I110_L1.3020.98
99_Y133_H1.2980.98
134_L143_V1.2720.98
97_E100_E1.2500.97
236_H285_T1.2350.97
142_F164_A1.2340.97
60_N68_R1.2290.97
246_K275_H1.2230.97
78_I81_M1.2160.97
144_I205_I1.2090.97
56_S59_E1.1820.96
117_I127_V1.1820.96
128_I156_E1.1790.96
158_E199_A1.1760.96
220_I309_R1.1730.96
302_G311_V1.1680.96
151_P155_R1.1650.96
297_I305_L1.1580.96
149_G169_I1.1580.96
216_I289_M1.1570.96
54_A61_G1.1530.96
225_T306_N1.1360.95
220_I305_L1.1280.95
54_A62_Y1.1230.95
191_A195_W1.1210.95
56_S60_N1.1170.95
110_L141_S1.1130.95
190_L222_F1.1120.95
117_I131_I1.1110.95
123_H156_E1.1050.95
60_N64_Y1.1030.95
233_F282_I1.1000.95
151_P195_W1.0860.94
82_N87_F1.0840.94
308_I311_V1.0780.94
233_F286_L1.0720.94
233_F320_I1.0650.94
196_C200_A1.0600.93
317_K320_I1.0520.93
103_R106_A1.0460.93
154_V199_A1.0250.92
145_A162_A1.0160.92
131_I143_V1.0150.92
302_G307_A1.0140.92
267_K295_S1.0080.92
102_V138_L1.0020.91
165_T200_A1.0010.91
265_E284_D0.9950.91
244_I275_H0.9940.91
70_E74_R0.9900.91
117_I134_L0.9820.90
200_A321_F0.9800.90
99_Y137_H0.9750.90
220_I308_I0.9740.90
143_V162_A0.9730.90
71_P76_D0.9710.90
92_V98_E0.9680.90
179_I321_F0.9630.90
295_S298_S0.9620.90
195_W198_K0.9610.89
92_V115_V0.9560.89
54_A60_N0.9430.89
190_L311_V0.9400.88
196_C199_A0.9360.88
128_I160_A0.9340.88
119_I126_A0.9190.87
184_G189_Q0.9170.87
316_V321_F0.9020.86
76_D80_D0.8870.85
142_F226_M0.8780.85
130_M133_H0.8770.85
71_P80_D0.8760.85
131_I162_A0.8720.84
229_I289_M0.8660.84
61_G81_M0.8630.84
296_S300_A0.8620.84
132_Q159_N0.8610.84
193_L204_I0.8610.84
151_P154_V0.8580.83
94_V126_A0.8560.83
246_K249_K0.8540.83
96_D100_E0.8540.83
154_V165_T0.8480.83
164_A202_K0.8450.82
236_H282_I0.8380.82
95_K265_E0.8320.81
54_A67_H0.8300.81
95_K98_E0.8250.81
67_H81_M0.8250.81
92_V117_I0.8160.80
200_A225_T0.8090.80
58_A81_M0.8070.79
164_A167_V0.8070.79
245_E250_L0.8060.79
56_S62_Y0.8050.79
171_P189_Q0.8050.79
244_I253_E0.7990.79
98_E102_V0.7950.78
281_S284_D0.7940.78
227_V233_F0.7920.78
58_A61_G0.7920.78
54_A81_M0.7890.78
142_F203_P0.7870.78
216_I293_L0.7760.77
102_V106_A0.7760.77
100_E104_Q0.7730.76
148_V165_T0.7720.76
181_T320_I0.7680.76
213_H289_M0.7680.76
276_V279_K0.7590.75
57_L62_Y0.7570.75
221_R311_V0.7490.74
70_E247_D0.7470.74
166_K171_P0.7460.74
282_I286_L0.7450.74
94_V130_M0.7440.74
81_M85_G0.7440.74
163_D202_K0.7410.73
258_A298_S0.7400.73
229_I282_I0.7390.73
135_K162_A0.7370.73
87_F114_Y0.7320.72
69_F73_T0.7320.72
75_I78_I0.7320.72
61_G67_H0.7290.72
217_A293_L0.7280.72
104_Q107_E0.7190.71
144_I164_A0.7170.71
152_E156_E0.7170.71
214_G218_K0.7160.71
99_Y103_R0.7140.71
63_F66_M0.7130.70
267_K287_I0.7120.70
134_L303_T0.7100.70
67_H78_I0.7080.70
129_E133_H0.7080.70
135_K139_P0.7070.70
97_E130_M0.7070.70
318_N321_F0.7020.69
171_P215_D0.7020.69
61_G65_V0.7000.69
151_P197_A0.6990.69
237_E243_T0.6890.68
76_D81_M0.6860.68
155_R200_A0.6860.68
312_D315_I0.6800.67
62_Y81_M0.6800.67
71_P75_I0.6790.67
101_F104_Q0.6760.66
216_I229_I0.6760.66
314_V318_N0.6760.66
86_L113_E0.6740.66
54_A65_V0.6730.66
151_P196_C0.6730.66
123_H152_E0.6730.66
178_K184_G0.6720.66
120_A181_T0.6720.66
56_S67_H0.6680.65
57_L65_V0.6680.65
99_Y102_V0.6670.65
75_I81_M0.6660.65
142_F305_L0.6650.65
127_V298_S0.6650.65
79_K83_A0.6630.65
56_S81_M0.6630.65
243_T284_D0.6620.65
135_K164_A0.6600.65
105_L110_L0.6530.64
58_A67_H0.6520.64
126_A129_E0.6510.63
131_I160_A0.6500.63
171_P178_K0.6500.63
54_A78_I0.6480.63
89_S92_V0.6460.63
198_K312_D0.6450.63
72_E75_I0.6440.63
107_E132_Q0.6430.63
302_G308_I0.6430.63
87_F226_M0.6370.62
94_V300_A0.6360.62
153_A156_E0.6340.61
132_Q136_K0.6340.61
196_C204_I0.6320.61
90_I105_L0.6320.61
96_D133_H0.6290.61
197_A201_S0.6280.61
176_I213_H0.6270.61
254_Y259_S0.6260.60
58_A86_L0.6230.60
81_M84_R0.6220.60
119_I153_A0.6210.60
189_Q192_A0.6200.60
297_I308_I0.6200.60
305_L310_N0.6200.60
171_P176_I0.6180.59
191_A194_R0.6180.59
257_S260_E0.6170.59
162_A165_T0.6120.59
261_F266_K0.6110.59
61_G82_N0.6090.58
136_K140_D0.6070.58
119_I258_A0.6070.58
205_I228_M0.6060.58
57_L76_D0.6050.58
178_K189_Q0.6040.58
57_L81_M0.6040.58
158_E203_P0.6040.58
96_D99_Y0.6030.58
103_R133_H0.6030.58
284_D287_I0.6020.57
61_G78_I0.6020.57
175_C259_S0.6020.57
127_V258_A0.6010.57
57_L64_Y0.6010.57
247_D275_H0.6000.57
174_V274_M0.5990.57
214_G291_Q0.5990.57
104_Q108_E0.5960.57
115_V119_I0.5920.56
172_G209_G0.5920.56
217_A220_I0.5890.56
59_E62_Y0.5890.56
125_N156_E0.5850.55
67_H75_I0.5850.55
131_I153_A0.5850.55
132_Q160_A0.5840.55
202_K225_T0.5840.55
211_R249_K0.5820.55
55_I64_Y0.5810.55
54_A58_A0.5810.55
175_C209_G0.5810.55
302_G310_N0.5810.55
232_L285_T0.5790.55
125_N128_I0.5780.54
300_A313_Y0.5760.54
202_K224_A0.5750.54
69_F81_M0.5750.54
56_S65_V0.5740.54
188_W291_Q0.5720.54
293_L296_S0.5690.53
141_S163_D0.5670.53
211_R264_G0.5660.53
155_R307_A0.5650.53
54_A59_E0.5650.53
137_H140_D0.5650.53
251_Y300_A0.5640.53
315_I320_I0.5640.53
61_G79_K0.5640.53
206_A225_T0.5640.53
56_S61_G0.5620.52
173_K257_S0.5620.52
102_V141_S0.5600.52
181_T299_Y0.5600.52
184_G209_G0.5600.52
171_P184_G0.5590.52
106_A110_L0.5570.52
93_G102_V0.5560.52
174_V258_A0.5550.52
217_A289_M0.5530.51
253_E275_H0.5530.51
55_I81_M0.5520.51
155_R158_E0.5510.51
72_E247_D0.5510.51
194_R197_A0.5500.51
257_S261_F0.5490.51
178_K270_E0.5480.51
183_F314_V0.5470.50
171_P192_A0.5450.50
136_K198_K0.5450.50
278_H281_S0.5450.50
244_I247_D0.5440.50
81_M86_L0.5410.50
57_L67_H0.5400.50
72_E194_R0.5390.49
152_E159_N0.5360.49
170_G184_G0.5350.49
57_L78_I0.5330.49
132_Q152_E0.5330.49
70_E73_T0.5310.48
76_D79_K0.5310.48
176_I258_A0.5280.48
266_K298_S0.5260.48
203_P226_M0.5250.48
117_I162_A0.5240.48
204_I306_N0.5240.48
94_V124_S0.5190.47
185_T191_A0.5190.47
262_Q285_T0.5190.47
234_A239_S0.5190.47
57_L60_N0.5170.47
209_G259_S0.5170.47
217_A265_E0.5170.47
66_M81_M0.5170.47
158_E204_I0.5160.47
241_G264_G0.5150.46
92_V134_L0.5150.46
288_E291_Q0.5140.46
250_L284_D0.5140.46
167_V176_I0.5070.45
58_A78_I0.5070.45
184_G208_G0.5060.45
93_G97_E0.5060.45
137_H141_S0.5050.45
214_G292_D0.5040.45
67_H71_P0.5040.45
94_V267_K0.5040.45
179_I320_I0.5040.45
247_D250_L0.5030.45
133_H136_K0.5030.45
128_I145_A0.5020.45
159_N198_K0.5010.45
120_A294_Q0.5010.45
194_R315_I0.5010.45
118_D121_H0.5000.45
148_V204_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.9049 100 0.492 Contact Map
2cu0A 4 0.9663 100 0.503 Contact Map
4zqmA 3 0.9571 100 0.516 Contact Map
4af0A 3 0.9632 100 0.517 Contact Map
1vrdA 3 0.9141 100 0.519 Contact Map
1jcnA 6 0.862 100 0.542 Contact Map
1zfjA 4 0.9785 100 0.549 Contact Map
2c6qA 4 0.9509 100 0.554 Contact Map
1eepA 4 0.9049 100 0.555 Contact Map
1me8A 3 0.9601 100 0.565 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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