GREMLIN Database
FENR2 - Ferredoxin--NADP reductase 2
UniProt: O05268 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (285)
Sequences: 60314 (43130)
Seq/√Len: 2554.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_A239_I3.8341.00
38_S89_A3.3511.00
156_R179_E3.2741.00
214_E225_V3.0551.00
181_S207_L3.0141.00
179_E205_N2.8061.00
216_I225_V2.7491.00
9_D113_K2.7021.00
223_Q236_I2.5171.00
270_K274_E2.4581.00
9_D32_S2.4561.00
216_I223_Q2.4191.00
228_E235_E2.3211.00
102_K109_T2.2911.00
207_L235_E2.2711.00
225_V236_I2.2701.00
156_R240_D2.2631.00
132_E214_E2.2301.00
158_A183_I2.2141.00
10_I26_G2.1861.00
22_T116_I2.1851.00
213_A227_E2.1761.00
158_A224_L2.1351.00
34_K85_C2.1321.00
127_R249_V2.1171.00
261_D268_V2.1131.00
11_T36_I2.1031.00
211_V227_E2.1011.00
196_V200_H2.0511.00
7_V111_Y2.0501.00
36_I110_H2.0341.00
8_Y34_K2.0151.00
11_T103_L2.0071.00
156_R181_S1.9751.00
116_I310_A1.9641.00
11_T110_H1.9291.00
101_F279_G1.8361.00
213_A225_V1.8261.00
104_V109_T1.8141.00
7_V113_K1.7891.00
95_K277_I1.7671.00
9_D34_K1.7471.00
105_T108_E1.7391.00
223_Q238_E1.7261.00
216_I236_I1.7141.00
156_R238_E1.6711.00
185_R211_V1.6611.00
18_V283_A1.6111.00
114_T279_G1.6061.00
136_Q217_G1.5961.00
125_K251_S1.5881.00
112_S115_V1.5811.00
210_F228_E1.5491.00
92_S104_V1.5381.00
155_R240_D1.5361.00
183_I237_L1.5171.00
261_D276_N1.5121.00
181_S205_N1.5101.00
125_K249_V1.5031.00
102_K111_Y1.4981.00
94_E97_A1.4971.00
141_N145_F1.4911.00
226_L237_L1.4601.00
307_V311_K1.4541.00
11_T34_K1.4291.00
11_T112_S1.4261.00
116_I283_A1.4251.00
263_E266_S1.4221.00
32_S83_T1.4171.00
101_F105_T1.4101.00
141_N144_Y1.4091.00
217_G222_E1.4041.00
207_L210_F1.3991.00
125_K253_G1.3861.00
105_T110_H1.3841.00
215_L242_L1.3771.00
65_R68_E1.3761.00
210_F226_L1.3641.00
156_R178_K1.3611.00
226_L235_E1.3591.00
12_I19_G1.3591.00
227_E234_K1.3571.00
213_A234_K1.3311.00
281_F313_Y1.3271.00
12_I23_A1.3201.00
303_A307_V1.3141.00
306_A310_A1.3071.00
210_F235_E1.2931.00
119_A286_I1.2891.00
226_L234_K1.2761.00
114_T310_A1.2631.00
23_A35_I1.2571.00
74_K78_A1.2491.00
281_F309_N1.2431.00
140_K144_Y1.2421.00
157_V173_L1.2321.00
89_A106_N1.2271.00
228_E234_K1.2251.00
15_G37_E1.2171.00
181_S239_I1.2081.00
114_T281_F1.2031.00
225_V234_K1.1991.00
221_I242_L1.1981.00
263_E268_V1.1911.00
10_I116_I1.1831.00
187_D209_P1.1831.00
95_K280_F1.1811.00
94_E102_K1.1791.00
274_E278_E1.1731.00
25_Y308_N1.1541.00
56_Y59_A1.1461.00
25_Y28_M1.1411.00
162_G184_H1.1411.00
130_E134_A1.1391.00
254_P257_N1.1381.00
263_E288_T1.1321.00
34_K110_H1.1191.00
71_N75_E1.1161.00
93_V115_V1.1151.00
215_L221_I1.1051.00
277_I280_F1.1051.00
167_V182_I1.1021.00
183_I226_L1.1011.00
118_T283_A1.0981.00
217_G221_I1.0961.00
10_I31_A1.0891.00
154_G178_K1.0811.00
91_E106_N1.0601.00
26_G307_V1.0591.00
56_Y61_F1.0581.00
305_T309_N1.0561.00
18_V299_G1.0491.00
184_H208_T1.0461.00
269_V287_C1.0431.00
94_E104_V1.0371.00
29_R311_K1.0341.00
8_Y11_T1.0331.00
269_V273_M1.0281.00
198_N201_A1.0271.00
36_I85_C1.0271.00
188_K192_H1.0211.00
76_Q80_F1.0141.00
160_L242_L1.0101.00
218_E223_Q1.0031.00
157_V241_D1.0001.00
267_I286_I0.9981.00
40_P87_E0.9971.00
174_E204_V0.9841.00
193_E197_E0.9821.00
13_I117_I0.9801.00
267_I282_A0.9761.00
91_E104_V0.9591.00
8_Y32_S0.9571.00
157_V178_K0.9571.00
197_E201_A0.9551.00
114_T313_Y0.9511.00
171_L175_P0.9441.00
197_E200_H0.9361.00
194_H198_N0.9361.00
29_R308_N0.9321.00
283_A306_A0.9321.00
43_G46_L0.9291.00
144_Y148_D0.9291.00
25_Y29_R0.9241.00
274_E313_Y0.9231.00
27_G82_Q0.9211.00
218_E238_E0.9161.00
218_E222_E0.9141.00
75_E78_A0.9121.00
158_A237_L0.9111.00
218_E221_I0.9111.00
198_N202_S0.9071.00
140_K143_H0.9061.00
299_G303_A0.9061.00
175_P202_S0.9041.00
41_Q74_K0.9021.00
212_P224_L0.8961.00
174_E179_E0.8951.00
57_D60_G0.8931.00
273_M305_T0.8901.00
170_A182_I0.8881.00
221_I238_E0.8871.00
282_A286_I0.8831.00
56_Y60_G0.8801.00
172_M176_I0.8791.00
36_I90_V0.8791.00
273_M306_A0.8781.00
34_K112_S0.8771.00
7_V32_S0.8721.00
22_T283_A0.8711.00
159_I170_A0.8691.00
166_A184_H0.8661.00
26_G31_A0.8651.00
75_E79_K0.8641.00
85_C110_H0.8611.00
205_N235_E0.8541.00
181_S237_L0.8531.00
10_I114_T0.8531.00
177_A180_V0.8511.00
92_S257_N0.8511.00
115_V280_F0.8501.00
210_F227_E0.8461.00
13_I119_A0.8431.00
70_I74_K0.8351.00
22_T303_A0.8331.00
274_E279_G0.8311.00
196_V208_T0.8311.00
68_E72_N0.8301.00
117_I286_I0.8301.00
150_Q153_A0.8291.00
162_G189_F0.8281.00
19_G23_A0.8261.00
285_D299_G0.8251.00
36_I105_T0.8251.00
269_V282_A0.8231.00
9_D31_A0.8221.00
215_L224_L0.8211.00
193_E196_V0.8211.00
281_F310_A0.8161.00
273_M287_C0.8101.00
8_Y114_T0.8071.00
133_N136_Q0.8051.00
34_K83_T0.8031.00
90_V103_L0.8021.00
9_D111_Y0.8011.00
141_N244_V0.7981.00
183_I210_F0.7971.00
158_A242_L0.7951.00
87_E107_E0.7931.00
72_N75_E0.7921.00
287_C302_E0.7911.00
25_Y304_P0.7901.00
262_I268_V0.7861.00
26_G310_A0.7861.00
22_T306_A0.7851.00
24_F28_M0.7831.00
140_K145_F0.7761.00
253_G256_K0.7751.00
160_L244_V0.7721.00
19_G118_T0.7701.00
183_I207_L0.7691.00
78_A83_T0.7681.00
57_D61_F0.7671.00
31_A311_K0.7641.00
96_Q102_K0.7631.00
306_A309_N0.7601.00
12_I22_T0.7591.00
10_I310_A0.7561.00
69_L72_N0.7531.00
27_G33_V0.7531.00
160_L212_P0.7521.00
77_M80_F0.7511.00
184_H191_A0.7501.00
116_I306_A0.7491.00
160_L246_Y0.7491.00
272_T309_N0.7481.00
173_L176_I0.7471.00
44_G48_A0.7461.00
13_I90_V0.7441.00
142_L145_F0.7441.00
133_N214_E0.7431.00
68_E71_N0.7431.00
71_N74_K0.7421.00
23_A33_V0.7421.00
144_Y147_D0.7351.00
196_V206_V0.7331.00
23_A82_Q0.7301.00
239_I242_L0.7301.00
171_L174_E0.7281.00
87_E106_N0.7271.00
43_G48_A0.7241.00
282_A287_C0.7221.00
195_S199_L0.7201.00
95_K101_F0.7191.00
72_N76_Q0.7171.00
15_G35_I0.7151.00
274_E309_N0.7121.00
156_R239_I0.7091.00
207_L237_L0.7071.00
58_V61_F0.7061.00
298_S302_E0.7031.00
8_Y113_K0.7031.00
9_D112_S0.7011.00
189_F208_T0.6971.00
163_G247_G0.6971.00
199_L206_V0.6961.00
121_N248_F0.6941.00
279_G313_Y0.6931.00
45_Q48_A0.6861.00
101_F277_I0.6851.00
42_L86_L0.6841.00
70_I73_L0.6791.00
26_G33_V0.6741.00
59_A62_P0.6691.00
283_A310_A0.6691.00
44_G47_S0.6681.00
67_Q71_N0.6671.00
254_P258_W0.6671.00
304_P308_N0.6651.00
73_L76_Q0.6571.00
255_I258_W0.6551.00
207_L226_L0.6551.00
129_L244_V0.6511.00
200_H205_N0.6511.00
172_M175_P0.6511.00
12_I118_T0.6501.00
21_F303_A0.6501.00
174_E202_S0.6491.00
145_F148_D0.6491.00
9_D110_H0.6461.00
155_R178_K0.6421.00
35_I84_I0.6401.00
273_M309_N0.6401.00
194_H197_E0.6401.00
169_W243_I0.6401.00
114_T314_M0.6391.00
8_Y83_T0.6371.00
275_T282_A0.6361.00
129_L134_A0.6351.00
31_A113_K0.6351.00
97_A109_T0.6331.00
188_K196_V0.6301.00
97_A102_K0.6271.00
15_G42_L0.6261.00
31_A310_A0.6241.00
101_F108_E0.6221.00
134_A244_V0.6221.00
268_V276_N0.6201.00
67_Q70_I0.6191.00
77_M82_Q0.6171.00
21_F25_Y0.6161.00
170_A204_V0.6161.00
92_S95_K0.6151.00
215_L222_E0.6151.00
36_I112_S0.6141.00
220_K223_Q0.6131.00
174_E203_K0.6101.00
128_K244_V0.6081.00
161_G247_G0.6061.00
283_A303_A0.6061.00
281_F306_A0.6041.00
182_I206_V0.6031.00
101_F280_F0.6011.00
101_F106_N0.6011.00
37_E43_G0.6001.00
301_G304_P0.5981.00
171_L176_I0.5971.00
131_L134_A0.5951.00
137_Y217_G0.5951.00
18_V118_T0.5931.00
184_H187_D0.5891.00
155_R179_E0.5881.00
288_T302_E0.5871.00
37_E86_L0.5861.00
22_T307_V0.5861.00
10_I307_V0.5861.00
27_G81_D0.5861.00
66_A70_I0.5851.00
217_G220_K0.5841.00
274_E281_F0.5821.00
58_V62_P0.5821.00
170_A180_V0.5811.00
155_R241_D0.5801.00
12_I35_I0.5801.00
217_G223_Q0.5771.00
66_A73_L0.5761.00
128_K135_E0.5761.00
258_W262_I0.5751.00
308_N312_A0.5751.00
42_L84_I0.5721.00
260_L277_I0.5691.00
192_H196_V0.5681.00
127_R130_E0.5651.00
39_L46_L0.5631.00
157_V243_I0.5621.00
149_L152_F0.5611.00
301_G305_T0.5591.00
104_V107_E0.5581.00
117_I254_P0.5581.00
184_H189_F0.5561.00
21_F24_F0.5561.00
129_L246_Y0.5551.00
21_F300_F0.5541.00
188_K191_A0.5521.00
310_A314_M0.5521.00
209_P228_E0.5501.00
37_E84_I0.5501.00
156_R221_I0.5471.00
195_S198_N0.5471.00
90_V105_T0.5461.00
128_K134_A0.5451.00
167_V199_L0.5451.00
136_Q214_E0.5441.00
274_E277_I0.5421.00
302_E306_A0.5381.00
12_I33_V0.5381.00
297_A300_F0.5361.00
166_A245_N0.5361.00
169_W172_M0.5331.00
256_K262_I0.5331.00
127_R246_Y0.5331.00
169_W245_N0.5311.00
142_L241_D0.5311.00
33_V82_Q0.5311.00
259_G262_I0.5311.00
297_A301_G0.5271.00
22_T310_A0.5261.00
35_I82_Q0.5261.00
64_I68_E0.5241.00
159_I166_A0.5241.00
262_I267_I0.5231.00
221_I240_D0.5211.00
137_Y140_K0.5211.00
183_I239_I0.5201.00
158_A181_S0.5181.00
90_V95_K0.5171.00
137_Y141_N0.5171.00
119_A254_P0.5161.00
260_L276_N0.5131.00
252_L262_I0.5131.00
115_V279_G0.5111.00
296_I300_F0.5111.00
134_A215_L0.5101.00
27_G32_S0.5081.00
295_L298_S0.5071.00
117_I282_A0.5061.00
300_F304_P0.5031.00
42_L74_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lzwA 2 0.991 100 0.226 Contact Map
3ab1A 2 0.9819 100 0.283 Contact Map
2zbwA 2 0.9789 100 0.285 Contact Map
3f8dA 2 0.9187 100 0.308 Contact Map
2q7vA 2 0.9187 100 0.315 Contact Map
2q0lA 2 0.9066 100 0.316 Contact Map
4usrA 1 0.9036 100 0.317 Contact Map
3ctyA 2 0.9096 100 0.322 Contact Map
4usqA 3 0.8886 100 0.327 Contact Map
1vdcA 2 0.9127 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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