FENR2 - BACSU - GREMLIN Contacts

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FENR2 - Ferredoxin--NADP reductase 2

UniProt:	O05268	Sequences: MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFKLVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAILGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGEDKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETNIEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	332 (285)
Sequences:	60314 (43130)
Seq/√Len:	2554.8

ECOLI - AHPF STHA NORW TRXB RCLA DLDH HCAD GSHR DHNA GLTD PRET NIRB AEGA YGFT FADH YGFK
BACSU - FENR2 FENR1 DHNA YPDA TRXB CZCO DLDH3 DLDH2 YJLD YUMB DLDH1 YUTJ GLTB NASB NASD
HALSA - P82854 Q9HP48 DLDH Q9HSN0 Q9HR27 O54535
SULSO - FENR Q97W27 Q97V69 Q97YT2 Q97XZ3 Q97VD9 Q97WE3 Q97WG1 Q97Z14 Q97Z19 Q97VJ3 Q97Y24 Q97U72 Q97VQ4 Q97UP4 Q980U1 Q97UV0 Q97ZB4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_A	239_I	3.834	1.00
38_S	89_A	3.351	1.00
156_R	179_E	3.274	1.00
214_E	225_V	3.055	1.00
181_S	207_L	3.014	1.00
179_E	205_N	2.806	1.00
216_I	225_V	2.749	1.00
9_D	113_K	2.702	1.00
223_Q	236_I	2.517	1.00
270_K	274_E	2.458	1.00
9_D	32_S	2.456	1.00
216_I	223_Q	2.419	1.00
228_E	235_E	2.321	1.00
102_K	109_T	2.291	1.00
207_L	235_E	2.271	1.00
225_V	236_I	2.270	1.00
156_R	240_D	2.263	1.00
132_E	214_E	2.230	1.00
158_A	183_I	2.214	1.00
10_I	26_G	2.186	1.00
22_T	116_I	2.185	1.00
213_A	227_E	2.176	1.00
158_A	224_L	2.135	1.00
34_K	85_C	2.132	1.00
127_R	249_V	2.117	1.00
261_D	268_V	2.113	1.00
11_T	36_I	2.103	1.00
211_V	227_E	2.101	1.00
196_V	200_H	2.051	1.00
7_V	111_Y	2.050	1.00
36_I	110_H	2.034	1.00
8_Y	34_K	2.015	1.00
11_T	103_L	2.007	1.00
156_R	181_S	1.975	1.00
116_I	310_A	1.964	1.00
11_T	110_H	1.929	1.00
101_F	279_G	1.836	1.00
213_A	225_V	1.826	1.00
104_V	109_T	1.814	1.00
7_V	113_K	1.789	1.00
95_K	277_I	1.767	1.00
9_D	34_K	1.747	1.00
105_T	108_E	1.739	1.00
223_Q	238_E	1.726	1.00
216_I	236_I	1.714	1.00
156_R	238_E	1.671	1.00
185_R	211_V	1.661	1.00
18_V	283_A	1.611	1.00
114_T	279_G	1.606	1.00
136_Q	217_G	1.596	1.00
125_K	251_S	1.588	1.00
112_S	115_V	1.581	1.00
210_F	228_E	1.549	1.00
92_S	104_V	1.538	1.00
155_R	240_D	1.536	1.00
183_I	237_L	1.517	1.00
261_D	276_N	1.512	1.00
181_S	205_N	1.510	1.00
125_K	249_V	1.503	1.00
102_K	111_Y	1.498	1.00
94_E	97_A	1.497	1.00
141_N	145_F	1.491	1.00
226_L	237_L	1.460	1.00
307_V	311_K	1.454	1.00
11_T	34_K	1.429	1.00
11_T	112_S	1.426	1.00
116_I	283_A	1.425	1.00
263_E	266_S	1.422	1.00
32_S	83_T	1.417	1.00
101_F	105_T	1.410	1.00
141_N	144_Y	1.409	1.00
217_G	222_E	1.404	1.00
207_L	210_F	1.399	1.00
125_K	253_G	1.386	1.00
105_T	110_H	1.384	1.00
215_L	242_L	1.377	1.00
65_R	68_E	1.376	1.00
210_F	226_L	1.364	1.00
156_R	178_K	1.361	1.00
226_L	235_E	1.359	1.00
12_I	19_G	1.359	1.00
227_E	234_K	1.357	1.00
213_A	234_K	1.331	1.00
281_F	313_Y	1.327	1.00
12_I	23_A	1.320	1.00
303_A	307_V	1.314	1.00
306_A	310_A	1.307	1.00
210_F	235_E	1.293	1.00
119_A	286_I	1.289	1.00
226_L	234_K	1.276	1.00
114_T	310_A	1.263	1.00
23_A	35_I	1.257	1.00
74_K	78_A	1.249	1.00
281_F	309_N	1.243	1.00
140_K	144_Y	1.242	1.00
157_V	173_L	1.232	1.00
89_A	106_N	1.227	1.00
228_E	234_K	1.225	1.00
15_G	37_E	1.217	1.00
181_S	239_I	1.208	1.00
114_T	281_F	1.203	1.00
225_V	234_K	1.199	1.00
221_I	242_L	1.198	1.00
263_E	268_V	1.191	1.00
10_I	116_I	1.183	1.00
187_D	209_P	1.183	1.00
95_K	280_F	1.181	1.00
94_E	102_K	1.179	1.00
274_E	278_E	1.173	1.00
25_Y	308_N	1.154	1.00
56_Y	59_A	1.146	1.00
25_Y	28_M	1.141	1.00
162_G	184_H	1.141	1.00
130_E	134_A	1.139	1.00
254_P	257_N	1.138	1.00
263_E	288_T	1.132	1.00
34_K	110_H	1.119	1.00
71_N	75_E	1.116	1.00
93_V	115_V	1.115	1.00
215_L	221_I	1.105	1.00
277_I	280_F	1.105	1.00
167_V	182_I	1.102	1.00
183_I	226_L	1.101	1.00
118_T	283_A	1.098	1.00
217_G	221_I	1.096	1.00
10_I	31_A	1.089	1.00
154_G	178_K	1.081	1.00
91_E	106_N	1.060	1.00
26_G	307_V	1.059	1.00
56_Y	61_F	1.058	1.00
305_T	309_N	1.056	1.00
18_V	299_G	1.049	1.00
184_H	208_T	1.046	1.00
269_V	287_C	1.043	1.00
94_E	104_V	1.037	1.00
29_R	311_K	1.034	1.00
8_Y	11_T	1.033	1.00
269_V	273_M	1.028	1.00
198_N	201_A	1.027	1.00
36_I	85_C	1.027	1.00
188_K	192_H	1.021	1.00
76_Q	80_F	1.014	1.00
160_L	242_L	1.010	1.00
218_E	223_Q	1.003	1.00
157_V	241_D	1.000	1.00
267_I	286_I	0.998	1.00
40_P	87_E	0.997	1.00
174_E	204_V	0.984	1.00
193_E	197_E	0.982	1.00
13_I	117_I	0.980	1.00
267_I	282_A	0.976	1.00
91_E	104_V	0.959	1.00
8_Y	32_S	0.957	1.00
157_V	178_K	0.957	1.00
197_E	201_A	0.955	1.00
114_T	313_Y	0.951	1.00
171_L	175_P	0.944	1.00
197_E	200_H	0.936	1.00
194_H	198_N	0.936	1.00
29_R	308_N	0.932	1.00
283_A	306_A	0.932	1.00
43_G	46_L	0.929	1.00
144_Y	148_D	0.929	1.00
25_Y	29_R	0.924	1.00
274_E	313_Y	0.923	1.00
27_G	82_Q	0.921	1.00
218_E	238_E	0.916	1.00
218_E	222_E	0.914	1.00
75_E	78_A	0.912	1.00
158_A	237_L	0.911	1.00
218_E	221_I	0.911	1.00
198_N	202_S	0.907	1.00
140_K	143_H	0.906	1.00
299_G	303_A	0.906	1.00
175_P	202_S	0.904	1.00
41_Q	74_K	0.902	1.00
212_P	224_L	0.896	1.00
174_E	179_E	0.895	1.00
57_D	60_G	0.893	1.00
273_M	305_T	0.890	1.00
170_A	182_I	0.888	1.00
221_I	238_E	0.887	1.00
282_A	286_I	0.883	1.00
56_Y	60_G	0.880	1.00
172_M	176_I	0.879	1.00
36_I	90_V	0.879	1.00
273_M	306_A	0.878	1.00
34_K	112_S	0.877	1.00
7_V	32_S	0.872	1.00
22_T	283_A	0.871	1.00
159_I	170_A	0.869	1.00
166_A	184_H	0.866	1.00
26_G	31_A	0.865	1.00
75_E	79_K	0.864	1.00
85_C	110_H	0.861	1.00
205_N	235_E	0.854	1.00
181_S	237_L	0.853	1.00
10_I	114_T	0.853	1.00
177_A	180_V	0.851	1.00
92_S	257_N	0.851	1.00
115_V	280_F	0.850	1.00
210_F	227_E	0.846	1.00
13_I	119_A	0.843	1.00
70_I	74_K	0.835	1.00
22_T	303_A	0.833	1.00
274_E	279_G	0.831	1.00
196_V	208_T	0.831	1.00
68_E	72_N	0.830	1.00
117_I	286_I	0.830	1.00
150_Q	153_A	0.829	1.00
162_G	189_F	0.828	1.00
19_G	23_A	0.826	1.00
285_D	299_G	0.825	1.00
36_I	105_T	0.825	1.00
269_V	282_A	0.823	1.00
9_D	31_A	0.822	1.00
215_L	224_L	0.821	1.00
193_E	196_V	0.821	1.00
281_F	310_A	0.816	1.00
273_M	287_C	0.810	1.00
8_Y	114_T	0.807	1.00
133_N	136_Q	0.805	1.00
34_K	83_T	0.803	1.00
90_V	103_L	0.802	1.00
9_D	111_Y	0.801	1.00
141_N	244_V	0.798	1.00
183_I	210_F	0.797	1.00
158_A	242_L	0.795	1.00
87_E	107_E	0.793	1.00
72_N	75_E	0.792	1.00
287_C	302_E	0.791	1.00
25_Y	304_P	0.790	1.00
262_I	268_V	0.786	1.00
26_G	310_A	0.786	1.00
22_T	306_A	0.785	1.00
24_F	28_M	0.783	1.00
140_K	145_F	0.776	1.00
253_G	256_K	0.775	1.00
160_L	244_V	0.772	1.00
19_G	118_T	0.770	1.00
183_I	207_L	0.769	1.00
78_A	83_T	0.768	1.00
57_D	61_F	0.767	1.00
31_A	311_K	0.764	1.00
96_Q	102_K	0.763	1.00
306_A	309_N	0.760	1.00
12_I	22_T	0.759	1.00
10_I	310_A	0.756	1.00
69_L	72_N	0.753	1.00
27_G	33_V	0.753	1.00
160_L	212_P	0.752	1.00
77_M	80_F	0.751	1.00
184_H	191_A	0.750	1.00
116_I	306_A	0.749	1.00
160_L	246_Y	0.749	1.00
272_T	309_N	0.748	1.00
173_L	176_I	0.747	1.00
44_G	48_A	0.746	1.00
13_I	90_V	0.744	1.00
142_L	145_F	0.744	1.00
133_N	214_E	0.743	1.00
68_E	71_N	0.743	1.00
71_N	74_K	0.742	1.00
23_A	33_V	0.742	1.00
144_Y	147_D	0.735	1.00
196_V	206_V	0.733	1.00
23_A	82_Q	0.730	1.00
239_I	242_L	0.730	1.00
171_L	174_E	0.728	1.00
87_E	106_N	0.727	1.00
43_G	48_A	0.724	1.00
282_A	287_C	0.722	1.00
195_S	199_L	0.720	1.00
95_K	101_F	0.719	1.00
72_N	76_Q	0.717	1.00
15_G	35_I	0.715	1.00
274_E	309_N	0.712	1.00
156_R	239_I	0.709	1.00
207_L	237_L	0.707	1.00
58_V	61_F	0.706	1.00
298_S	302_E	0.703	1.00
8_Y	113_K	0.703	1.00
9_D	112_S	0.701	1.00
189_F	208_T	0.697	1.00
163_G	247_G	0.697	1.00
199_L	206_V	0.696	1.00
121_N	248_F	0.694	1.00
279_G	313_Y	0.693	1.00
45_Q	48_A	0.686	1.00
101_F	277_I	0.685	1.00
42_L	86_L	0.684	1.00
70_I	73_L	0.679	1.00
26_G	33_V	0.674	1.00
59_A	62_P	0.669	1.00
283_A	310_A	0.669	1.00
44_G	47_S	0.668	1.00
67_Q	71_N	0.667	1.00
254_P	258_W	0.667	1.00
304_P	308_N	0.665	1.00
73_L	76_Q	0.657	1.00
255_I	258_W	0.655	1.00
207_L	226_L	0.655	1.00
129_L	244_V	0.651	1.00
200_H	205_N	0.651	1.00
172_M	175_P	0.651	1.00
12_I	118_T	0.650	1.00
21_F	303_A	0.650	1.00
174_E	202_S	0.649	1.00
145_F	148_D	0.649	1.00
9_D	110_H	0.646	1.00
155_R	178_K	0.642	1.00
35_I	84_I	0.640	1.00
273_M	309_N	0.640	1.00
194_H	197_E	0.640	1.00
169_W	243_I	0.640	1.00
114_T	314_M	0.639	1.00
8_Y	83_T	0.637	1.00
275_T	282_A	0.636	1.00
129_L	134_A	0.635	1.00
31_A	113_K	0.635	1.00
97_A	109_T	0.633	1.00
188_K	196_V	0.630	1.00
97_A	102_K	0.627	1.00
15_G	42_L	0.626	1.00
31_A	310_A	0.624	1.00
101_F	108_E	0.622	1.00
134_A	244_V	0.622	1.00
268_V	276_N	0.620	1.00
67_Q	70_I	0.619	1.00
77_M	82_Q	0.617	1.00
21_F	25_Y	0.616	1.00
170_A	204_V	0.616	1.00
92_S	95_K	0.615	1.00
215_L	222_E	0.615	1.00
36_I	112_S	0.614	1.00
220_K	223_Q	0.613	1.00
174_E	203_K	0.610	1.00
128_K	244_V	0.608	1.00
161_G	247_G	0.606	1.00
283_A	303_A	0.606	1.00
281_F	306_A	0.604	1.00
182_I	206_V	0.603	1.00
101_F	280_F	0.601	1.00
101_F	106_N	0.601	1.00
37_E	43_G	0.600	1.00
301_G	304_P	0.598	1.00
171_L	176_I	0.597	1.00
131_L	134_A	0.595	1.00
137_Y	217_G	0.595	1.00
18_V	118_T	0.593	1.00
184_H	187_D	0.589	1.00
155_R	179_E	0.588	1.00
288_T	302_E	0.587	1.00
37_E	86_L	0.586	1.00
22_T	307_V	0.586	1.00
10_I	307_V	0.586	1.00
27_G	81_D	0.586	1.00
66_A	70_I	0.585	1.00
217_G	220_K	0.584	1.00
274_E	281_F	0.582	1.00
58_V	62_P	0.582	1.00
170_A	180_V	0.581	1.00
155_R	241_D	0.580	1.00
12_I	35_I	0.580	1.00
217_G	223_Q	0.577	1.00
66_A	73_L	0.576	1.00
128_K	135_E	0.576	1.00
258_W	262_I	0.575	1.00
308_N	312_A	0.575	1.00
42_L	84_I	0.572	1.00
260_L	277_I	0.569	1.00
192_H	196_V	0.568	1.00
127_R	130_E	0.565	1.00
39_L	46_L	0.563	1.00
157_V	243_I	0.562	1.00
149_L	152_F	0.561	1.00
301_G	305_T	0.559	1.00
104_V	107_E	0.558	1.00
117_I	254_P	0.558	1.00
184_H	189_F	0.556	1.00
21_F	24_F	0.556	1.00
129_L	246_Y	0.555	1.00
21_F	300_F	0.554	1.00
188_K	191_A	0.552	1.00
310_A	314_M	0.552	1.00
209_P	228_E	0.550	1.00
37_E	84_I	0.550	1.00
156_R	221_I	0.547	1.00
195_S	198_N	0.547	1.00
90_V	105_T	0.546	1.00
128_K	134_A	0.545	1.00
167_V	199_L	0.545	1.00
136_Q	214_E	0.544	1.00
274_E	277_I	0.542	1.00
302_E	306_A	0.538	1.00
12_I	33_V	0.538	1.00
297_A	300_F	0.536	1.00
166_A	245_N	0.536	1.00
169_W	172_M	0.533	1.00
256_K	262_I	0.533	1.00
127_R	246_Y	0.533	1.00
169_W	245_N	0.531	1.00
142_L	241_D	0.531	1.00
33_V	82_Q	0.531	1.00
259_G	262_I	0.531	1.00
297_A	301_G	0.527	1.00
22_T	310_A	0.526	1.00
35_I	82_Q	0.526	1.00
64_I	68_E	0.524	1.00
159_I	166_A	0.524	1.00
262_I	267_I	0.523	1.00
221_I	240_D	0.521	1.00
137_Y	140_K	0.521	1.00
183_I	239_I	0.520	1.00
158_A	181_S	0.518	1.00
90_V	95_K	0.517	1.00
137_Y	141_N	0.517	1.00
119_A	254_P	0.516	1.00
260_L	276_N	0.513	1.00
252_L	262_I	0.513	1.00
115_V	279_G	0.511	1.00
296_I	300_F	0.511	1.00
134_A	215_L	0.510	1.00
27_G	32_S	0.508	1.00
295_L	298_S	0.507	1.00
117_I	282_A	0.506	1.00
300_F	304_P	0.503	1.00
42_L	74_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3lzwA	2	0.991	100	0.226	Contact Map
3ab1A	2	0.9819	100	0.283	Contact Map
2zbwA	2	0.9789	100	0.285	Contact Map
3f8dA	2	0.9187	100	0.308	Contact Map
2q7vA	2	0.9187	100	0.315	Contact Map
2q0lA	2	0.9066	100	0.316	Contact Map
4usrA	1	0.9036	100	0.317	Contact Map
3ctyA	2	0.9096	100	0.322	Contact Map
4usqA	3	0.8886	100	0.327	Contact Map
1vdcA	2	0.9127	100	0.327	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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