GREMLIN Database
YULF - Uncharacterized oxidoreductase YulF
UniProt: O05265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (309)
Sequences: 25688 (19451)
Seq/√Len: 1106.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_Q82_L3.0371.00
124_T186_Y2.7871.00
81_V109_A2.7731.00
77_K105_E2.7601.00
197_D218_S2.7041.00
3_R27_Q2.6571.00
141_T243_E2.6101.00
104_E306_L2.6021.00
131_E134_K2.5791.00
85_N109_A2.5741.00
36_A40_G2.5611.00
71_S79_Q2.3731.00
133_K137_H2.3661.00
196_K220_D2.3561.00
77_K102_E2.3431.00
81_V85_N2.3391.00
5_A58_M2.3291.00
81_V105_E2.3121.00
89_H116_V2.2831.00
215_V315_A2.2471.00
84_M115_V2.1851.00
30_A52_F2.0951.00
317_K321_I2.0931.00
75_L79_Q2.0871.00
54_D57_E2.0541.00
108_S112_A2.0271.00
288_T292_E2.0101.00
131_E135_H1.9661.00
77_K81_V1.9521.00
111_K303_E1.9421.00
80_A92_C1.9291.00
50_H61_S1.9231.00
139_I242_G1.9211.00
134_K138_K1.9191.00
14_D45_K1.9081.00
40_G44_A1.8931.00
66_A286_F1.8851.00
84_M110_A1.8451.00
71_S75_L1.8021.00
104_E310_K1.8011.00
109_A113_N1.7981.00
78_E82_L1.7821.00
104_E108_S1.7771.00
89_H115_V1.7541.00
85_N113_N1.7301.00
25_D291_K1.7021.00
67_V83_F1.6881.00
35_S38_R1.6851.00
5_A64_F1.6841.00
100_T313_E1.6801.00
219_Y224_A1.6651.00
20_A68_Y1.6471.00
99_N102_E1.6151.00
4_F66_A1.6141.00
80_A106_M1.6101.00
26_F287_V1.6041.00
64_F88_K1.6041.00
23_I284_E1.5881.00
202_G319_M1.5741.00
117_L302_F1.5641.00
60_A86_H1.5501.00
53_S57_E1.5451.00
59_A83_F1.5431.00
120_A282_E1.5291.00
132_L247_I1.5281.00
196_K218_S1.5161.00
85_N112_A1.5141.00
194_A307_T1.5051.00
133_K190_V1.4961.00
55_L82_L1.4941.00
52_F61_S1.4841.00
41_E45_K1.4651.00
307_T310_K1.4581.00
107_I306_L1.4571.00
116_V293_N1.4551.00
98_S102_E1.4391.00
107_I302_F1.4341.00
77_K106_M1.4211.00
109_A112_A1.4201.00
146_T239_E1.3961.00
189_V194_A1.3921.00
56_Q60_A1.3851.00
36_A53_S1.3801.00
57_E60_A1.3761.00
194_A220_D1.3751.00
143_R243_E1.3741.00
97_A106_M1.3611.00
84_M113_N1.3501.00
97_A103_T1.3401.00
239_E248_V1.3391.00
52_F58_M1.3301.00
82_L85_N1.3271.00
288_T294_K1.3241.00
57_E61_S1.3161.00
189_V307_T1.3161.00
103_T306_L1.2961.00
39_A51_A1.2951.00
139_I245_G1.2911.00
82_L86_H1.2821.00
285_E289_L1.2661.00
100_T310_K1.2651.00
9_T31_V1.2641.00
32_Y55_L1.2561.00
100_T104_E1.2531.00
195_P219_Y1.2501.00
201_N218_S1.2361.00
3_R29_T1.2181.00
32_Y58_M1.1921.00
69_I80_A1.1891.00
69_I79_Q1.1851.00
185_I311_I1.1831.00
105_E108_S1.1831.00
285_E299_E1.1701.00
3_R65_D1.1701.00
55_L79_Q1.1661.00
83_F90_V1.1661.00
41_E44_A1.1661.00
87_G113_N1.1651.00
189_V219_Y1.1611.00
107_I303_E1.1571.00
146_T227_M1.1521.00
142_V240_I1.1511.00
37_E40_G1.1461.00
74_A172_L1.1431.00
237_P248_V1.1401.00
135_H138_K1.1381.00
84_M109_A1.1331.00
301_T304_R1.1321.00
96_F103_T1.1171.00
169_Q172_L1.1171.00
43_A51_A1.1131.00
284_E288_T1.1091.00
58_M64_F1.1061.00
189_V304_R1.1051.00
192_F223_E1.1041.00
287_V291_K1.1011.00
62_D88_K1.0961.00
199_K216_I1.0931.00
313_E317_K1.0911.00
72_P75_L1.0901.00
4_F26_F1.0891.00
30_A58_M1.0881.00
91_L120_A1.0881.00
248_V259_E1.0871.00
91_L282_E1.0811.00
55_L59_A1.0781.00
314_E317_K1.0781.00
22_D280_F1.0781.00
108_S111_K1.0691.00
103_T309_A1.0651.00
105_E109_A1.0601.00
89_H293_N1.0581.00
129_F190_V1.0571.00
317_K320_G1.0501.00
63_C88_K1.0491.00
314_E318_Q1.0411.00
188_A224_A1.0401.00
30_A64_F1.0391.00
139_I247_I1.0381.00
59_A82_L1.0371.00
145_F192_F1.0371.00
107_I111_K1.0241.00
81_V106_M1.0221.00
61_S64_F1.0111.00
102_E105_E1.0091.00
7_I79_Q1.0081.00
285_E294_K1.0071.00
16_F68_Y1.0021.00
139_I142_V0.9971.00
59_A86_H0.9951.00
92_C117_L0.9911.00
39_A53_S0.9901.00
97_A102_E0.9871.00
101_K104_E0.9771.00
145_F224_A0.9691.00
134_K137_H0.9561.00
125_F285_E0.9531.00
142_V242_G0.9531.00
18_E22_D0.9521.00
124_T304_R0.9431.00
281_Y284_E0.9401.00
89_H290_I0.9391.00
50_H63_C0.9381.00
106_M117_L0.9371.00
18_E45_K0.9311.00
80_A90_V0.9281.00
130_K299_E0.9281.00
38_R41_E0.9261.00
132_L249_I0.9251.00
96_F302_F0.9221.00
288_T293_N0.9201.00
9_T33_S0.9191.00
52_F57_E0.9161.00
280_F284_E0.9111.00
25_D284_E0.9071.00
37_E41_E0.9071.00
285_E288_T0.9061.00
101_K105_E0.9011.00
100_T306_L0.9001.00
110_A113_N0.8981.00
79_Q82_L0.8941.00
122_K278_A0.8941.00
77_K97_A0.8931.00
140_G245_G0.8891.00
303_E307_T0.8891.00
297_S301_T0.8891.00
195_P217_L0.8871.00
142_V192_F0.8851.00
140_G242_G0.8831.00
118_M286_F0.8771.00
316_R320_G0.8751.00
96_F117_L0.8731.00
310_K314_E0.8701.00
36_A39_A0.8611.00
214_T225_V0.8591.00
84_M90_V0.8541.00
31_V42_F0.8531.00
68_Y283_A0.8501.00
2_I290_I0.8501.00
92_C96_F0.8491.00
145_F240_I0.8481.00
36_A51_A0.8471.00
169_Q208_G0.8461.00
5_A30_A0.8451.00
39_A43_A0.8451.00
43_A48_A0.8441.00
69_I83_F0.8431.00
110_A117_L0.8411.00
75_L78_E0.8401.00
40_G43_A0.8391.00
40_G51_A0.8351.00
4_F20_A0.8351.00
200_A315_A0.8271.00
147_A238_A0.8271.00
185_I312_M0.8251.00
239_E246_T0.8241.00
146_T225_V0.8221.00
92_C106_M0.8191.00
289_L294_K0.8171.00
137_H193_G0.8161.00
104_E107_I0.8151.00
110_A115_V0.8141.00
80_A84_M0.8131.00
195_P311_I0.8121.00
170_P208_G0.8061.00
5_A32_Y0.8041.00
29_T63_C0.8031.00
33_S39_A0.8011.00
13_T18_E0.7971.00
148_S237_P0.7961.00
130_K134_K0.7961.00
73_N179_D0.7961.00
23_I26_F0.7961.00
29_T50_H0.7951.00
6_I17_L0.7941.00
199_K318_Q0.7921.00
25_D288_T0.7891.00
136_L242_G0.7891.00
145_F188_A0.7881.00
61_S88_K0.7851.00
289_L292_E0.7801.00
14_D41_E0.7791.00
20_A283_A0.7791.00
33_S38_R0.7781.00
244_D263_R0.7761.00
116_V289_L0.7761.00
118_M289_L0.7691.00
84_M117_L0.7691.00
20_A26_F0.7691.00
279_M282_E0.7661.00
98_S173_S0.7631.00
110_A302_F0.7631.00
217_L224_A0.7611.00
289_L298_E0.7601.00
116_V290_I0.7601.00
3_R64_F0.7601.00
2_I66_A0.7561.00
7_I71_S0.7541.00
12_I16_F0.7531.00
121_M182_V0.7521.00
170_P320_G0.7511.00
66_A89_H0.7481.00
16_F283_A0.7481.00
189_V308_T0.7461.00
13_T70_A0.7441.00
7_I55_L0.7421.00
176_S228_H0.7411.00
195_P220_D0.7391.00
181_G228_H0.7391.00
103_T107_I0.7341.00
175_G210_D0.7331.00
286_F290_I0.7311.00
257_R269_N0.7311.00
141_T244_D0.7311.00
210_D316_R0.7291.00
119_E305_S0.7261.00
306_L310_K0.7251.00
29_T61_S0.7221.00
177_L312_M0.7211.00
237_P250_D0.7201.00
12_I70_A0.7191.00
201_N216_I0.7181.00
147_A184_C0.7181.00
17_L28_L0.7151.00
192_F219_Y0.7141.00
29_T64_F0.7141.00
150_C227_M0.7131.00
12_I279_M0.7131.00
304_R307_T0.7131.00
174_N178_M0.7121.00
182_V308_T0.7091.00
96_F119_E0.7081.00
77_K109_A0.7071.00
258_V261_R0.7051.00
42_F45_K0.7041.00
179_D230_K0.7001.00
2_I291_K0.6961.00
285_E298_E0.6951.00
188_A219_Y0.6951.00
123_T126_L0.6931.00
25_D287_V0.6901.00
181_G184_C0.6891.00
5_A67_V0.6881.00
76_H92_C0.6871.00
141_T221_G0.6831.00
94_K183_Y0.6821.00
129_F187_P0.6791.00
177_L213_G0.6791.00
84_M106_M0.6781.00
148_S227_M0.6771.00
197_D201_N0.6761.00
58_M61_S0.6761.00
92_C119_E0.6741.00
7_I32_Y0.6731.00
87_G115_V0.6711.00
78_E105_E0.6711.00
27_Q49_A0.6711.00
35_S40_G0.6701.00
130_K281_Y0.6671.00
81_V84_M0.6651.00
241_Q246_T0.6601.00
9_T39_A0.6601.00
147_A188_A0.6571.00
200_A319_M0.6561.00
211_G231_I0.6561.00
186_Y190_V0.6541.00
121_M308_T0.6501.00
88_K115_V0.6501.00
80_A117_L0.6491.00
186_Y308_T0.6491.00
124_T190_V0.6481.00
203_Y218_S0.6471.00
42_F46_H0.6471.00
91_L118_M0.6461.00
4_F287_V0.6461.00
133_K191_L0.6391.00
200_A215_V0.6391.00
302_F305_S0.6381.00
191_L240_I0.6381.00
309_A313_E0.6341.00
205_L211_G0.6321.00
189_V311_I0.6311.00
229_S232_S0.6221.00
3_R63_C0.6211.00
121_M186_Y0.6171.00
9_T42_F0.6161.00
14_D18_E0.6141.00
294_K298_E0.6121.00
66_A290_I0.6111.00
116_V297_S0.6081.00
122_K279_M0.6071.00
194_A310_K0.6061.00
215_V226_L0.6061.00
136_L240_I0.6031.00
149_Y180_I0.6001.00
30_A50_H0.5991.00
144_R241_Q0.5981.00
17_L42_F0.5981.00
202_G213_G0.5971.00
183_Y186_Y0.5951.00
185_I315_A0.5951.00
118_M285_E0.5941.00
14_D46_H0.5891.00
14_D38_R0.5891.00
4_F68_Y0.5881.00
67_V88_K0.5881.00
200_A213_G0.5841.00
68_Y91_L0.5841.00
55_L83_F0.5811.00
56_Q78_E0.5801.00
132_L191_L0.5771.00
23_I280_F0.5771.00
23_I287_V0.5721.00
12_I93_E0.5721.00
130_K190_V0.5691.00
10_N70_A0.5691.00
259_E269_N0.5681.00
136_L191_L0.5671.00
308_T312_M0.5671.00
94_K179_D0.5661.00
294_K297_S0.5641.00
178_M313_E0.5631.00
34_R71_S0.5621.00
166_N169_Q0.5621.00
188_A226_L0.5611.00
10_N13_T0.5611.00
199_K218_S0.5581.00
171_E208_G0.5581.00
31_V51_A0.5571.00
78_E81_V0.5561.00
212_E229_S0.5561.00
216_I225_V0.5541.00
16_F70_A0.5541.00
123_T186_Y0.5541.00
65_D291_K0.5531.00
107_I110_A0.5521.00
135_H260_I0.5521.00
70_A93_E0.5521.00
69_I76_H0.5511.00
177_L215_V0.5501.00
14_D42_F0.5491.00
71_S76_H0.5471.00
93_E120_A0.5471.00
167_A179_D0.5461.00
26_F66_A0.5461.00
80_A110_A0.5451.00
13_T42_F0.5411.00
151_Q180_I0.5411.00
127_P281_Y0.5391.00
85_N105_E0.5371.00
288_T291_K0.5351.00
118_M282_E0.5331.00
7_I69_I0.5321.00
262_Y268_E0.5271.00
214_T227_M0.5231.00
52_F62_D0.5211.00
74_A98_S0.5211.00
212_E227_M0.5201.00
133_K193_G0.5181.00
43_A49_A0.5171.00
19_S23_I0.5161.00
2_I26_F0.5151.00
217_L226_L0.5151.00
312_M316_R0.5151.00
99_N313_E0.5141.00
185_I189_V0.5131.00
44_A51_A0.5121.00
192_F221_G0.5121.00
81_V113_N0.5111.00
56_Q86_H0.5111.00
144_R225_V0.5101.00
32_Y52_F0.5101.00
119_E183_Y0.5081.00
116_V298_E0.5071.00
6_I28_L0.5071.00
18_E21_A0.5061.00
298_E301_T0.5041.00
189_V195_P0.5041.00
144_R212_E0.5031.00
219_Y223_E0.5021.00
32_Y53_S0.5021.00
173_S209_V0.5011.00
101_K313_E0.5001.00
121_M183_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zh8A 2 0.9604 100 0.213 Contact Map
1h6dA 8 0.9787 100 0.214 Contact Map
3dtyA 4 0.9451 100 0.228 Contact Map
2nvwA 3 0.9604 100 0.231 Contact Map
3e9mA 2 0.9604 100 0.233 Contact Map
3v5nA 4 0.9268 100 0.239 Contact Map
4hadA 4 0.9299 100 0.243 Contact Map
3euwA 4 0.9573 100 0.244 Contact Map
3evnA 1 0.9512 100 0.247 Contact Map
4gqaA 4 0.9817 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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