GREMLIN Database
RHAA - L-rhamnose isomerase
UniProt: O05264 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (414)
Sequences: 332 (167)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_S237_V5.0901.00
7_Y21_V4.7970.99
235_S290_V4.7230.99
151_P155_E4.5560.99
80_A84_I4.4370.99
68_Q72_E4.3610.99
134_L161_C4.3510.99
389_S393_Q4.3050.98
78_E124_L4.1550.98
168_G181_T3.5330.95
205_E209_R3.5290.95
79_K82_S3.4310.94
203_L244_Y3.3650.93
159_R163_A3.3510.93
89_R177_T3.2880.92
169_E173_K3.2310.92
367_R370_E3.2020.91
311_I320_V3.1880.91
44_E66_K3.1100.90
408_E412_Q3.1010.90
40_G337_W3.0990.90
204_K251_N3.0200.89
22_E393_Q2.7620.83
29_E394_M2.7520.83
115_E119_K2.7350.83
80_A338_T2.6120.80
139_K153_I2.6080.80
181_T220_N2.5940.79
183_I211_F2.5390.78
208_D247_Y2.5290.77
107_D159_R2.4900.76
147_S238_V2.4730.76
24_A352_L2.4710.76
98_E116_N2.3610.72
47_E106_R2.3610.72
35_I341_T2.3290.71
97_A109_L2.3200.71
269_S303_E2.3120.70
361_Q365_E2.2460.68
206_S210_I2.1780.66
32_P89_R2.1550.65
22_E389_S2.0990.63
31_V317_L2.0810.62
40_G73_L2.0640.61
84_I338_T2.0410.60
102_E112_Q2.0260.60
345_I390_Y2.0120.59
259_T307_I2.0080.59
143_G237_V1.9780.58
215_I219_H1.9680.57
272_I282_L1.9460.57
199_P202_R1.9330.56
256_L283_A1.9300.56
259_T287_S1.9130.55
54_S140_A1.9040.55
256_L363_Q1.8990.55
17_W378_F1.8780.54
6_N385_A1.8200.51
74_R98_E1.7970.50
370_E407_K1.7930.50
259_T268_V1.7880.50
283_A363_Q1.7830.50
308_A344_M1.7690.49
170_Y174_E1.7600.49
144_L149_P1.7320.48
300_L350_Y1.7240.47
221_L281_K1.7060.47
118_V174_E1.6820.46
385_A388_D1.6750.45
367_R407_K1.6430.44
172_G323_G1.6080.43
180_L283_A1.6070.43
165_R222_D1.5460.40
28_L348_L1.5410.40
23_E26_R1.5390.40
378_F381_Y1.5370.40
118_V170_Y1.5250.39
211_F253_K1.5240.39
4_K8_D1.5180.39
301_D304_L1.5050.38
115_E174_E1.5000.38
185_I203_L1.4760.37
53_L136_S1.4690.37
267_T303_E1.4470.36
158_I205_E1.4370.36
159_R162_I1.4370.36
281_K321_A1.4350.36
180_L363_Q1.4230.35
128_L171_F1.4050.35
127_G175_L1.3960.34
47_E89_R1.3920.34
335_A369_T1.3840.34
203_L224_I1.3800.34
19_I24_A1.3780.34
23_E27_Q1.3720.33
81_L90_V1.3670.33
193_P196_R1.3640.33
32_P177_T1.3610.33
94_A109_L1.3600.33
335_A339_I1.3570.33
172_G219_H1.3530.33
312_V317_L1.3520.33
111_P171_F1.3520.33
165_R172_G1.3430.32
241_H245_L1.3350.32
109_L163_A1.3310.32
262_F268_V1.3300.32
33_I88_H1.3250.32
123_N126_L1.3180.31
180_L256_L1.3180.31
339_I372_L1.3090.31
105_E163_A1.2990.31
286_V324_L1.2880.30
19_I378_F1.2790.30
201_K205_E1.2670.30
111_P170_Y1.2630.29
58_D99_T1.2610.29
73_L337_W1.2580.29
163_A166_R1.2580.29
88_H390_Y1.2550.29
246_A275_M1.2430.29
335_A402_W1.2400.29
82_S125_G1.2170.28
143_G233_S1.2160.28
121_A128_L1.2140.28
12_Q386_I1.2040.27
335_A403_L1.2010.27
228_L262_F1.1990.27
173_K219_H1.1810.27
59_V253_K1.1780.27
58_D270_N1.1740.26
169_E219_H1.1740.26
15_E21_V1.1730.26
401_A411_Q1.1700.26
377_E399_K1.1690.26
31_V352_L1.1680.26
286_V344_M1.1660.26
59_V304_L1.1620.26
168_G220_N1.1610.26
108_E112_Q1.1610.26
47_E59_V1.1560.26
74_R120_W1.1560.26
390_Y394_M1.1520.26
169_E174_E1.1510.26
204_K250_T1.1480.26
83_L397_P1.1470.26
276_L316_A1.1440.26
31_V308_A1.1370.25
185_I244_Y1.1350.25
389_S392_E1.1350.25
262_F269_S1.1300.25
162_I209_R1.1180.25
211_F222_D1.1180.25
286_V323_G1.1170.25
79_K405_D1.1170.25
148_H153_I1.1070.24
272_I311_I1.1070.24
21_V148_H1.1030.24
272_I320_V1.0980.24
59_V329_A1.0940.24
59_V237_V1.0900.24
388_D398_V1.0890.24
199_P335_A1.0870.24
335_A372_L1.0780.23
224_I244_Y1.0780.23
28_L70_P1.0780.23
163_A402_W1.0760.23
63_Y410_E1.0730.23
203_L222_D1.0710.23
26_R30_Q1.0610.23
58_D181_T1.0570.23
88_H299_V1.0510.23
144_L245_L1.0480.23
231_L272_I1.0450.23
95_I372_L1.0430.22
345_I407_K1.0420.22
362_L370_E1.0320.22
115_E118_V1.0260.22
199_P236_Y1.0260.22
221_L326_F1.0210.22
94_A242_E1.0200.22
241_H287_S1.0170.22
202_R369_T1.0110.22
268_V384_G1.0070.21
50_K152_D1.0050.21
9_S385_A1.0050.21
201_K277_L0.9980.21
78_E123_N0.9920.21
315_H318_E0.9850.21
120_W165_R0.9800.21
19_I212_S0.9710.20
213_E252_H0.9700.20
237_V270_N0.9690.20
199_P402_W0.9660.20
274_S344_M0.9650.20
107_D162_I0.9600.20
193_P375_M0.9590.20
32_P106_R0.9580.20
89_R175_L0.9550.20
241_H383_F0.9540.20
21_V209_R0.9490.20
105_E278_Y0.9490.20
139_K152_D0.9490.20
106_R316_A0.9440.20
123_N412_Q0.9440.20
215_I220_N0.9430.20
40_G387_W0.9360.20
146_L206_S0.9340.19
169_E215_I0.9290.19
11_K21_V0.9290.19
330_S375_M0.9260.19
132_P199_P0.9220.19
356_N363_Q0.9210.19
214_E253_K0.9190.19
194_S363_Q0.9160.19
54_S57_I0.9150.19
267_T343_N0.9080.19
413_V416_K0.9070.19
146_L203_L0.9030.19
246_A274_S0.9010.19
202_R335_A0.8980.19
338_T390_Y0.8940.18
303_E343_N0.8920.18
77_L90_V0.8920.18
274_S357_G0.8880.18
19_I62_N0.8880.18
66_K300_L0.8870.18
89_R321_A0.8820.18
33_I341_T0.8810.18
180_L321_A0.8810.18
102_E110_K0.8790.18
144_L189_Y0.8760.18
162_I301_D0.8750.18
140_A366_G0.8680.18
241_H274_S0.8680.18
47_E177_T0.8680.18
272_I304_L0.8680.18
248_A255_C0.8650.18
99_T164_C0.8580.18
316_A320_V0.8570.18
90_V281_K0.8550.17
33_I126_L0.8550.17
287_S304_L0.8540.17
354_L363_Q0.8500.17
142_D317_L0.8470.17
392_E399_K0.8450.17
192_I299_V0.8440.17
195_D198_T0.8410.17
155_E159_R0.8410.17
13_A399_K0.8410.17
251_N322_I0.8400.17
20_D386_I0.8350.17
172_G222_D0.8330.17
164_C289_P0.8330.17
69_T72_E0.8310.17
255_C363_Q0.8290.17
118_V171_F0.8260.17
89_R106_R0.8200.17
321_A363_Q0.8190.17
106_R300_L0.8190.17
175_L242_E0.8190.17
172_G220_N0.8180.17
297_V331_I0.8150.17
246_A279_T0.8130.17
209_R212_S0.8120.16
189_Y369_T0.8110.16
185_I207_L0.8100.16
255_C283_A0.8090.16
181_T237_V0.8090.16
330_S380_T0.8080.16
6_N9_S0.7980.16
144_L283_A0.7970.16
199_P369_T0.7970.16
271_K391_C0.7950.16
35_I84_I0.7910.16
274_S334_V0.7900.16
53_L171_F0.7900.16
256_L262_F0.7870.16
380_T383_F0.7840.16
263_H271_K0.7840.16
257_L262_F0.7840.16
286_V322_I0.7830.16
217_E321_A0.7800.16
308_A347_A0.7790.16
183_I308_A0.7790.16
66_K106_R0.7790.16
337_W387_W0.7780.16
81_L246_A0.7700.16
98_E363_Q0.7670.15
317_L334_V0.7650.15
283_A306_E0.7650.15
159_R383_F0.7630.15
28_L126_L0.7610.15
24_A319_K0.7600.15
169_E383_F0.7600.15
228_L371_R0.7580.15
88_H139_K0.7570.15
8_D412_Q0.7570.15
203_L257_L0.7560.15
203_L241_H0.7560.15
166_R322_I0.7550.15
143_G326_F0.7550.15
306_E309_L0.7540.15
21_V386_I0.7540.15
372_L385_A0.7530.15
405_D412_Q0.7530.15
105_E220_N0.7530.15
323_G344_M0.7500.15
217_E253_K0.7430.15
123_N248_A0.7430.15
163_A199_P0.7410.15
127_G132_P0.7390.15
50_K144_L0.7380.15
87_K125_G0.7380.15
85_P263_H0.7380.15
405_D408_E0.7340.15
100_N343_N0.7310.15
250_T386_I0.7310.15
186_P280_D0.7250.15
298_V307_I0.7240.15
54_S289_P0.7230.15
305_R350_Y0.7220.15
180_L281_K0.7210.15
386_I405_D0.7200.14
412_Q416_K0.7180.14
21_V24_A0.7180.14
300_L347_A0.7170.14
332_N410_E0.7160.14
43_I334_V0.7160.14
109_L159_R0.7150.14
358_Y361_Q0.7150.14
120_W222_D0.7140.14
324_L344_M0.7140.14
181_T215_I0.7130.14
25_L273_S0.7130.14
221_L321_A0.7130.14
84_I377_E0.7090.14
104_V305_R0.7040.14
185_I300_L0.7030.14
228_L233_S0.7020.14
228_L341_T0.7020.14
335_A343_N0.7020.14
66_K219_H0.7010.14
22_E26_R0.7000.14
221_L254_L0.6990.14
275_M316_A0.6980.14
31_V312_V0.6980.14
283_A354_L0.6980.14
256_L354_L0.6960.14
15_E25_L0.6950.14
50_K413_V0.6900.14
51_G269_S0.6870.14
89_R170_Y0.6870.14
116_N170_Y0.6840.14
69_T282_L0.6830.14
59_V115_E0.6830.14
216_S304_L0.6830.14
168_G345_I0.6810.14
121_A171_F0.6810.14
93_H96_Y0.6810.14
120_W371_R0.6800.14
181_T304_L0.6790.14
245_L272_I0.6790.14
48_V103_A0.6780.14
256_L306_E0.6760.14
51_G66_K0.6740.14
35_I118_V0.6730.14
140_A153_I0.6720.14
226_S263_H0.6720.14
106_R311_I0.6710.14
363_Q371_R0.6710.14
13_A17_W0.6700.13
104_V231_L0.6690.13
58_D237_V0.6680.13
72_E235_S0.6680.13
15_E386_I0.6680.13
290_V357_G0.6680.13
52_E237_V0.6650.13
22_E286_V0.6640.13
223_S256_L0.6630.13
237_V253_K0.6630.13
275_M283_A0.6630.13
263_H391_C0.6630.13
4_K22_E0.6620.13
3_I389_S0.6620.13
71_E112_Q0.6620.13
134_L330_S0.6610.13
269_S301_D0.6610.13
99_T168_G0.6600.13
319_K351_A0.6600.13
362_L367_R0.6590.13
162_I309_L0.6580.13
52_E59_V0.6580.13
299_V372_L0.6560.13
48_V54_S0.6560.13
51_G54_S0.6550.13
274_S279_T0.6550.13
189_Y202_R0.6530.13
43_I67_A0.6520.13
54_S104_V0.6510.13
248_A279_T0.6500.13
374_L378_F0.6490.13
120_W246_A0.6470.13
151_P218_Q0.6470.13
226_S264_P0.6450.13
103_A185_I0.6430.13
153_I179_C0.6410.13
67_A73_L0.6410.13
186_P207_L0.6390.13
24_A31_V0.6390.13
166_R219_H0.6370.13
203_L207_L0.6350.13
132_P256_L0.6340.13
170_Y360_K0.6340.13
107_D334_V0.6340.13
217_E390_Y0.6330.13
286_V343_N0.6310.13
11_K116_N0.6300.13
165_R323_G0.6300.13
163_A201_K0.6300.13
120_W172_G0.6290.13
70_P317_L0.6290.13
111_P168_G0.6290.13
161_C210_I0.6280.13
47_E98_E0.6270.13
59_V390_Y0.6270.13
106_R320_V0.6270.13
109_L228_L0.6270.13
322_I348_L0.6260.13
43_I91_N0.6250.13
95_I299_V0.6240.13
37_C93_H0.6240.13
337_W369_T0.6230.13
237_V241_H0.6230.13
94_A195_D0.6220.13
81_L124_L0.6220.13
161_C381_Y0.6210.13
90_V126_L0.6210.13
124_L268_V0.6210.13
237_V329_A0.6210.13
98_E120_W0.6200.13
259_T262_F0.6200.13
143_G366_G0.6200.13
248_A251_N0.6190.13
176_G406_I0.6190.13
99_T280_D0.6180.13
299_V344_M0.6180.13
255_C275_M0.6160.12
168_G215_I0.6160.12
224_I248_A0.6160.12
81_L278_Y0.6160.12
272_I362_L0.6150.12
67_A76_D0.6150.12
282_L319_K0.6150.12
148_H185_I0.6140.12
233_S270_N0.6130.12
133_T305_R0.6130.12
244_Y323_G0.6130.12
289_P301_D0.6120.12
163_A314_N0.6100.12
273_S310_E0.6100.12
256_L356_N0.6070.12
245_L274_S0.6070.12
186_P221_L0.6050.12
22_E143_G0.6040.12
273_S373_A0.6040.12
150_D252_H0.6040.12
98_E139_K0.6000.12
22_E108_E0.5990.12
165_R211_F0.5990.12
118_V309_L0.5990.12
147_S253_K0.5980.12
166_R213_E0.5950.12
332_N417_R0.5940.12
70_P301_D0.5940.12
119_K277_L0.5940.12
98_E371_R0.5920.12
107_D156_F0.5910.12
48_V106_R0.5900.12
22_E357_G0.5900.12
32_P348_L0.5900.12
404_Y407_K0.5880.12
241_H244_Y0.5880.12
172_G207_L0.5880.12
69_T317_L0.5880.12
88_H287_S0.5880.12
299_V304_L0.5870.12
20_D23_E0.5850.12
24_A349_L0.5850.12
316_A363_Q0.5840.12
148_H228_L0.5830.12
306_E363_Q0.5810.12
21_V90_V0.5810.12
127_G195_D0.5790.12
179_C282_L0.5780.12
222_D326_F0.5780.12
14_Y97_A0.5780.12
189_Y345_I0.5770.12
89_R279_T0.5770.12
334_V373_A0.5760.12
165_R219_H0.5760.12
53_L170_Y0.5750.12
208_D353_L0.5740.12
196_R224_I0.5730.12
165_R371_R0.5730.12
97_A226_S0.5730.12
73_L76_D0.5720.12
69_T73_L0.5720.12
134_L148_H0.5710.12
262_F318_E0.5710.12
47_E66_K0.5690.12
77_L176_G0.5690.12
324_L377_E0.5680.12
235_S380_T0.5670.12
369_T402_W0.5670.12
263_H291_R0.5660.12
83_L269_S0.5650.12
140_A145_T0.5650.12
15_E20_D0.5640.12
100_N166_R0.5640.12
32_P47_E0.5630.12
40_G369_T0.5600.11
394_M398_V0.5590.11
95_I133_T0.5590.11
226_S303_E0.5580.11
368_Y408_E0.5580.11
237_V330_S0.5560.11
122_K183_I0.5540.11
70_P335_A0.5540.11
168_G183_I0.5540.11
183_I300_L0.5540.11
178_P221_L0.5510.11
25_L387_W0.5510.11
11_K68_Q0.5500.11
248_A344_M0.5500.11
222_D244_Y0.5490.11
7_Y320_V0.5490.11
311_I334_V0.5480.11
88_H153_I0.5480.11
148_H257_L0.5470.11
300_L305_R0.5470.11
37_C96_Y0.5460.11
246_A371_R0.5460.11
408_E411_Q0.5430.11
78_E253_K0.5430.11
111_P236_Y0.5430.11
361_Q408_E0.5420.11
194_S352_L0.5410.11
164_C210_I0.5410.11
138_E388_D0.5400.11
146_L185_I0.5400.11
91_N196_R0.5390.11
194_S375_M0.5380.11
350_Y380_T0.5380.11
149_P306_E0.5350.11
12_Q318_E0.5340.11
32_P48_V0.5340.11
274_S349_L0.5340.11
373_A403_L0.5320.11
194_S356_N0.5320.11
14_Y276_L0.5310.11
8_D357_G0.5310.11
69_T312_V0.5310.11
370_E403_L0.5310.11
67_A91_N0.5290.11
165_R203_L0.5280.11
19_I335_A0.5270.11
58_D106_R0.5270.11
99_T270_N0.5260.11
219_H222_D0.5260.11
139_K379_K0.5260.11
108_E159_R0.5260.11
343_N369_T0.5260.11
63_Y414_L0.5250.11
175_L179_C0.5250.11
197_L277_L0.5240.11
132_P186_P0.5240.11
5_A8_D0.5220.11
162_I334_V0.5210.11
371_R375_M0.5210.11
147_S159_R0.5200.11
169_E218_Q0.5200.11
58_D231_L0.5200.11
316_A350_Y0.5190.11
247_Y251_N0.5180.11
132_P202_R0.5170.11
78_E183_I0.5160.11
195_D348_L0.5160.11
134_L180_L0.5160.11
74_R372_L0.5160.11
144_L389_S0.5160.11
169_E304_L0.5150.11
140_A259_T0.5150.11
12_Q21_V0.5150.11
141_A153_I0.5150.11
98_E345_I0.5140.11
145_T203_L0.5130.11
134_L140_A0.5120.11
13_A16_K0.5120.11
134_L141_A0.5110.11
209_R334_V0.5100.11
287_S321_A0.5100.11
247_Y353_L0.5090.11
262_F305_R0.5080.11
62_N333_R0.5080.11
223_S309_L0.5080.11
180_L198_T0.5070.11
161_C164_C0.5070.11
334_V414_L0.5050.11
81_L126_L0.5040.11
207_L323_G0.5040.11
66_K364_E0.5040.11
257_L272_I0.5040.11
357_G395_G0.5030.11
350_Y363_Q0.5020.11
221_L280_D0.5020.11
115_E211_F0.5010.11
76_D91_N0.5010.11
132_P161_C0.5000.11
85_P271_K0.5000.11
140_A248_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d8wA 4 0.9481 100 0.343 Contact Map
3p14A 2 0.9505 100 0.533 Contact Map
3m0mA 4 0.9175 100 0.772 Contact Map
1a0cA 4 0.9057 100 0.884 Contact Map
1muwA 4 0.8396 99.9 0.9 Contact Map
3ktcA 4 0.7476 99.8 0.921 Contact Map
1xlaA 4 0.8113 97.9 0.964 Contact Map
1ximA 4 0.8184 97.6 0.966 Contact Map
1bxbA 4 0.8278 97.5 0.967 Contact Map
3tc3A 1 0.6439 97.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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