GREMLIN Database
RHAM - L-rhamnose mutarotase
UniProt: O05263 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 104 (101)
Sequences: 855 (565)
Seq/√Len: 56.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_H57_E3.6821.00
72_V75_R2.7511.00
31_E35_A2.5061.00
5_A53_F2.4081.00
19_K23_D2.3991.00
40_H55_Y2.3441.00
25_I30_A2.3411.00
3_R99_E2.2541.00
87_N91_S2.0201.00
9_F85_K1.9941.00
10_V15_Y1.9011.00
7_I51_R1.8701.00
31_E34_K1.8500.99
28_E72_V1.7750.99
15_Y50_G1.7230.99
6_S54_A1.6830.99
21_R83_L1.6620.99
17_E20_Q1.6500.99
42_S55_Y1.5940.98
3_R42_S1.5470.98
39_H59_E1.5370.98
11_H85_K1.5040.98
70_T73_C1.4940.98
15_Y47_E1.4760.97
58_I64_W1.4640.97
74_Q78_K1.4410.97
40_H102_Y1.4340.97
20_Q24_D1.4260.97
7_I46_D1.3930.96
99_E102_Y1.3730.96
42_S102_Y1.3680.96
26_W72_V1.3260.95
47_E98_K1.2730.94
36_H67_M1.2580.93
3_R102_Y1.2420.93
3_R57_E1.2410.93
36_H66_K1.2350.93
46_D49_T1.2260.93
9_F51_R1.2230.93
33_L38_A1.2200.92
34_K39_H1.2160.92
17_E21_R1.2100.92
11_H14_K1.1670.91
73_C77_W1.1610.90
21_R80_M1.1500.90
32_A67_M1.1330.89
21_R79_S1.1130.88
19_K98_K1.1040.88
66_K69_D1.0940.88
52_L100_V1.0680.86
78_K90_F1.0650.86
47_E50_G1.0460.85
7_I49_T1.0300.84
30_A101_F1.0290.84
45_L52_L1.0250.84
32_A70_T1.0150.83
78_K86_T0.9980.82
33_L72_V0.9820.81
67_M73_C0.9640.80
38_A56_L0.9630.80
65_R68_A0.9620.80
19_K47_E0.9270.77
5_A43_I0.9210.77
33_L67_M0.9200.77
61_E74_Q0.9100.76
32_A36_H0.8960.75
44_F57_E0.8910.74
30_A103_L0.8720.73
36_H70_T0.8600.72
58_I62_E0.8550.71
4_K61_E0.8530.71
46_D51_R0.8510.71
34_K59_E0.8350.70
7_I53_F0.8270.69
56_L64_W0.8080.67
4_K56_L0.7800.64
20_Q65_R0.7780.64
34_K103_L0.7760.64
2_K96_D0.7720.63
4_K64_W0.7630.63
44_F99_E0.7560.62
35_A70_T0.7550.62
21_R52_L0.7380.60
4_K44_F0.7380.60
69_D74_Q0.7370.60
14_K83_L0.7310.59
60_D65_R0.7300.59
19_K100_V0.7270.59
32_A73_C0.7190.58
78_K81_A0.7160.58
46_D50_G0.7120.57
89_D92_P0.7030.56
33_L36_H0.6990.56
42_S57_E0.6940.55
3_R55_Y0.6920.55
58_I94_A0.6900.55
38_A67_M0.6900.55
6_S56_L0.6870.55
29_M32_A0.6720.53
22_H76_W0.6650.52
44_F55_Y0.6620.52
62_E66_K0.6610.52
79_S83_L0.6610.52
71_E95_I0.6580.51
7_I95_I0.6510.51
65_R69_D0.6340.49
58_I63_K0.6300.48
25_I29_M0.6300.48
3_R44_F0.6290.48
80_M83_L0.6280.48
4_K58_I0.6280.48
74_Q77_W0.6240.48
61_E65_R0.6200.47
35_A66_K0.6190.47
36_H58_I0.6180.47
56_L70_T0.6100.46
36_H63_K0.6060.46
41_Y101_F0.6020.45
33_L56_L0.6020.45
54_A83_L0.5950.45
39_H103_L0.5930.44
46_D89_D0.5920.44
89_D93_V0.5910.44
9_F50_G0.5820.43
5_A38_A0.5820.43
37_G80_M0.5780.43
39_H102_Y0.5740.42
57_E99_E0.5710.42
25_I103_L0.5620.41
33_L77_W0.5610.41
32_A35_A0.5600.41
87_N93_V0.5560.40
2_K62_E0.5550.40
54_A73_C0.5510.40
59_E63_K0.5490.40
38_A43_I0.5470.39
8_M93_V0.5460.39
64_W73_C0.5450.39
2_K58_I0.5380.39
33_L103_L0.5370.38
77_W84_M0.5320.38
36_H73_C0.5320.38
9_F61_E0.5300.38
3_R58_I0.5280.38
80_M101_F0.5280.38
8_M77_W0.5150.36
57_E102_Y0.5130.36
15_Y98_K0.5110.36
3_R40_H0.5100.36
31_E99_E0.5070.35
41_Y52_L0.5050.35
12_Q88_S0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlwA 3 1 100 0.142 Contact Map
1x8dA 2 1 100 0.145 Contact Map
4dpoA 2 0.8942 96.7 0.842 Contact Map
4dn9A 3 0.9231 95.9 0.853 Contact Map
4hl9A 2 0.8942 95.8 0.855 Contact Map
1y0hA 2 0.9038 95.2 0.861 Contact Map
2gffA 2 0.9327 94.7 0.865 Contact Map
1x7vA 5 0.8942 94.4 0.866 Contact Map
3gz7A 2 0.9038 94.1 0.868 Contact Map
3e8oA 2 0.8846 93.6 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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